Jarid1A Antibody

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 7 of 7.

Publications using NB110-40499	Applications	Species
Smith T, White T, Chen Z, Stewart LV. The KDM5 inhibitor PBIT reduces proliferation of castration-resistant prostate cancer cells via cell cycle arrest and the induction of senescence. Experimental cell research 2024-04-08 [PMID: 38462208]
Huang Z, Wang H, Yang M Long non-coding RNA tumor protein 73 antisense RNA 1 influences an interaction between lysine demethylase 5A and promoter of tumor protein 73 to enhance the malignancy of colorectal cancer Human cell 2022-07-27 [PMID: 35896939]
Mitsui E, Yoshida S, Shinoda Y et al. Identification of ryuvidine as a KDM5A inhibitor Sci Rep 2019-07-09 [PMID: 31289306] (WB)	WB
Chai S Y, Smith R, Fitter J T et al. Increased progesterone receptor A expression in labouring human myometrium is associated with decreased promoter occupancy by the histone demethylase JARID1A. Mol Hum Reprod. 2014-05-01 [PMID: 24442343] (Human)		Human
Liefke R, Oswald F, Alvarado C et al. Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. Genes Dev 2010-03-01 [PMID: 20231316]
Ge Z, Li W, Wang N et al. Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase. FASEB J 2010-02-01 [PMID: 19762557]
Tsai WW, Nguyen TT, Shi Y et al. p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. Mol Cell Biol 2008-09-01 [PMID: 18573881]

Array NB110-40499

• Jarid1A Antibodies
• Jarid1A Kit
• Jarid1A Protein