KAT3B/p300 Antibody (RW105) - BSA Free

In the eukaryotic genome, chromatin dynamicity is crucial for regulation of processes requiring access to genetic information and is regulated by several different factors including post-translational modifications of histone/non-histone components, especially via acetylation process which is catalyzed by enzymes known as lysine acetyltransferases (KATs). Among different KATs, KAT3B/ p300 and its homologue KAT3A/CBP (CREB-binding protein) are extensively studied KATs with well known cellular functions. KAT3B/ p300 and KAT3A/CBP have been shown to directly interact with several different DNA-binding transcription factors which includes nuclear hormone receptors, CREB, c-Fos, C-Jun/v-Jun, c-Myb/v-Myb, TFIIB and MyoD. Moreover, both KAT3B/p300 and KAT3A/CBP have been shown to exert HAT (histone acetyltransferase) activity, capable of acetylating all four core histone particles in nucleosomes and to play a key role in activating chromatin for transcription. KAT3B/p300 is a potent transcriptional coactivator that has been shown to regulate various biological processes such as cellular proliferation, differentiation, cell cycle, apoptosis, and response to genetic damage, and KAT3B/ p300 dysfunction interfering with these processes implicates in the pathogenesis of several diseases such as cancer, cardiac diseases, diabetes mellitus, and HIV.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: Chemotaxis, EM, IP, In-vitro, WB.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using NB100-616	Applications	Species
Javadi S, Li Y, Shen J et al. Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of Fragile X Syndrome BMC Med 2022-05-13 [PMID: 35549943]
Qin YP, Yu HB, Yuan SY et al. KAT2A Promotes Hepatitis B Virus Transcription and Replication Through Epigenetic Regulation of cccDNA Minichromosome Frontiers in Microbiology 2022-01-24 [PMID: 35140694]
Haiquan Lu, Yajing Lyu, Linh Tran, Jie Lan, Yangyiran Xie, Yongkang Yang, Naveena L Murugan, Yueyang J Wang, Gregg L Semenza HIF-1 recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast cancer stem cells. Cell reports 2022-02-10 [PMID: 34592152]
Britta Kunkemoeller, Kuangyang Chen, Sam M Lockhart, Xuanchun Wang, Christian Rask-Madsen The transcriptional coregulator CITED2 suppresses expression of IRS-2 and impairs insulin signaling in endothelial cells. American journal of physiology. Endocrinology and metabolism 2021-09-20 [PMID: 34151583]
Dhar SS, Zhao D, Lin T et al. MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes Mol. Cell 2018-06-07 [PMID: 29861161] (Chemotaxis, Mouse)	Chemotaxis	Mouse
He M, Zheng B, Zhang Y et al. KLF4 mediates the link between TGF-beta1-induced gene transcription and H3 acetylation in vascular smooth muscle cells. FASEB J 2015-09-01 [PMID: 26082460]
Yi P, Wang Z, Feng Q et al. Structure of a biologically active estrogen receptor-coactivator complex on DNA Mol. Cell 2015-03-19 [PMID: 25728767] (EM, In-vitro)	EM, In-vitro
Byun SW, Chang YJ, Chung IS et al. Helicobacter pylori decreases p27 expression through the delta opioid receptor-mediated inhibition of histone acetylation within the p27 promoter Cancer Lett 2012-08-03 [PMID: 22867947] (Chemotaxis, Human)	Chemotaxis	Human
Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev;13(1):64-75. 1999-01-01 [PMID: 9887100]
Nemethova M, Wintersberger E. Polyomavirus large T antigen binds the transcriptional coactivator protein p300. J Virol;73(2):1734-9. 1999-02-01 [PMID: 9882390] (WB, IP, Mouse)	WB, IP	Mouse
Eckner R et al. Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev;1 (19):2478-90. 1996-10-01 [PMID: 8843199]
Eckner R et al. Association of p300 and CBP with simian virus 40 large T antigen. Mol Cell Biol;16(7):3454-64. 1996-07-01 [PMID: 8668161] (IP, Mouse)	IP	Mouse
Eckner R et al. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev;8(8):869-84. 1994-04-15 [PMID: 7523245] (WB, Human)	WB	Human
Show All 13 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	KD	Mouse	06/23/2023	View Summary Application Knockdown Validated Sample Tested Mouse brain Species Mouse Lot E-1 Comments Comments ***Novus Innovators Program - new species or application used on a primary antibody.*** WB protocol is 6% gel for running, 40V overnight transfer membrane. primary Ab 1:500, secondary Ab 1:5000.

Array NB100-616

• KAT3B/p300 Antibodies
• KAT3B/p300 ELISA Kits
• KAT3B/p300 Proteins