Species: Hu, Mu, Rt, Md, Pm
Applications: WB, Flow, Func, ICC/IF, IP, MS, ChIP, KD
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Md, Pm
Applications: WB, Flow, ICC/IF, IP
Host: Mouse Monoclonal
Species: Hu, Rt
Applications: WB, IHC, IP, ChIP
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
p300 is a relatively stable and ubiquitously expressed nuclear phosphoprotein which is conserved among a variety of mammalian species. It is actively synthesized and phosphorylated in both quiescent and proliferating cells. Cyclic AMP-responsive enhancer binding protein (CREB) binding protein (CBP) and p300 are closely related transcriptional coactivators and have been shown to directly interact with many different DNA-binding transcription factors including nuclear hormone receptors, CREB, c-Fos, C-Jun/v-Jun, c-Myb/v-Myb, TFIIB and MyoD. Both CBP and p300 have been shown to display histone acetyltransferase (HAT) activity, capable of acetylating all four core histone particles in nucleosomes. As a result of HAT activity, it has been suggested CBP and p300 may play a direct role in activating chromatin for transcription.
Bioinformatics
| Entrez |
Rat
Human
Mouse
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
2033 |
| Alternate Names |
- E1A binding protein p300
- E1A-associated protein p300
- E1A-binding protein, 300kD
- EC 2.3.1
- EC 2.3.1.48
- histone acetyltransferase p300
- KAT3B
- p300 HAT
- P300
- p300
- RSTS2
|
