Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Antibody

JARID1B (Jumonji AT-rich interactive domain 1B) is a member of the JARID 1 family of proteins that catalyze the demethylation of histones on lysine. The Jarid 1 family members include JARID1A, JARID1B, JARID1C and JARID1D. The members of this family possess a Jumonji C (JmjC) and Jumonji N (JmjN) domain as well as one ARID (AT-rich interactive domain) and three PHD-type zinc fingers. As histone demethylases, JARID 1 proteins function as transcriptional repressors. JARID1B expression is largely restricted to testis and may play a critical role in tumorigenesis as it has been found to be upregulated in prostate and breast cancer. Alternative names for JARID1B include retinoblastoma-binding protein 2 homolog 1, RBP2-H1, cancer/testis antigen 31, CT31, PLU-1, PUT1, and KDM5B.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 6 applications: Chemotaxis, FLOW, ICC/IF, IF/IHC, IP, WB.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using NB100-97821	Applications	Species
Smith T, White T, Chen Z, Stewart LV. The KDM5 inhibitor PBIT reduces proliferation of castration-resistant prostate cancer cells via cell cycle arrest and the induction of senescence. Experimental cell research 2024-04-08 [PMID: 38462208]
Chauvistré H, Shannan B, Daignault-Mill SM et al. Persister state-directed transitioning and vulnerability in melanoma Nature communications 2022-06-01 [PMID: 35650266] (WB, ICC/IF, FLOW, Human)	WB, ICC/IF, FLOW	Human
Li G, Kanagasabai T, Lu W et al. KDM5B Is Essential for the Hyperactivation of PI3K/AKT Signaling in Prostate Tumorigenesis Cancer Research 2020-11-01 [PMID: 32868382]
Webster MR, Fane ME, Alicea GM Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma Mol. Cell 2019-12-11 [PMID: 31836388]
Vogel FCE, Bordag N, Zugner E et al. Targeting the H3K4 demethylase KDM5B reprograms the metabolome and phenotype of melanoma cells J. Invest. Dermatol. 2019-06-20 [PMID: 31229500]
Shannan B, Matschke J, Chauvistre H et al. Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV600E inhibition in melanoma Eur. J. Cancer 2019-03-01 [PMID: 30721788] (FLOW, Human)	FLOW	Human
Boyle SE, Fedele CG, Corbin V et al. CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity. Cancer Res. 2016-06-20 [PMID: 27325642] (IF/IHC, Human)	IF/IHC	Human
Lu W, Liu S, Li B et al. SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination. Oncotarget 2015-01-20 [PMID: 25596733] (IF/IHC)	IF/IHC
Nabanita Mukherjee, Steven N. Reuland, Yan Lu, Yuchun Luo, Karoline Lambert, Mayumi Fujita, William A Robinson, Steven E Robinson, David A. Norris, Yiqun G. Shellman Combining a BCL2 Inhibitor with the Retinoid Derivative Fenretinide Targets Melanoma Cells Including Melanoma Initiating Cells The Journal of investigative dermatology 2014-10-26 [PMID: 25350317]
Stanisz H, Saul S, Muller CS et al. Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry. Pigment Cell Melanoma Res 2014-01-29 [PMID: 24472175] (WB, Human)	WB	Human
Roesch A, Vultur A, Bogeski I et al. Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells. Cancer Cell 2013-06-10 [PMID: 23764003] (WB, Human)	WB	Human
Chauvistre H, Daignault SM, Shannan B, Ju RJ The Janus-faced role of KDM5B heterogeneity in melanoma: differentiation as a situational driver of both growth arrest and drug-resistance bioRxiv 2020-01-01 (ICC/IF, Human)	ICC/IF	Human
Zhang S, Cai W, Liu X et al. Ablation of Histone Demethylase KDM5B in Melanoma Augments Anti-Tumor Immunity through Upregulation of Retroelements Research Square 2020-11-06 (IP, Chemotaxis)	IP, Chemotaxis
Zhang SM, Cai WL, Liu X Et al. KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements Nature 2021-10-01 [PMID: 34671158] (Chemotaxis)	Chemotaxis
Show All 14 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IHC-P	Human	10/06/2015	View Summary Application Immunohistochemistry-Paraffin Sample Tested MCF7 Species Human Lot A1

Array NB100-97821

• Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Antibodies
• Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Lysate
• Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Proteins