Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Antibody [Janelia Fluor® 646]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Janelia Fluor 646

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Reviews & Publications
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Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Antibody [Janelia Fluor® 646] Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 1494 and 1544 of human Jumonji, AT rich interactive domain 1B (NP_006609.3).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KDM5B
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Antibody [Janelia Fluor® 646]

  • CT31
  • CT31FLJ10538
  • EC 1.14.11
  • EC 1.14.11.-
  • homolog 1A
  • Jarid1B
  • JARID1BFLJ16281
  • Jumonji, AT rich interactive domain 1B (RBP2-like)
  • jumonji, AT rich interactive domain 1B
  • KDM5B
  • Lysine (K)specific Demethylase 5B
  • Lysine (K)-specific Demethylase 5B
  • PLU-1
  • PLU-1FLJ12459
  • PLU1FLJ23670
  • PUT1
  • RBBP2H1
  • RBBP2H1AFLJ12491
  • RBP2-H1
  • Retinoblastoma-binding protein 2 homolog 1

Background

JARID1B (Jumonji AT-rich interactive domain 1B) is a member of the JARID 1 family of proteins that catalyze the demethylation of histones on lysine. The Jarid 1 family members include JARID1A, JARID1B, JARID1C and JARID1D. The members of this family possess a Jumonji C (JmjC) and Jumonji N (JmjN) domain as well as one ARID (AT-rich interactive domain) and three PHD-type zinc fingers. As histone demethylases, JARID 1 proteins function as transcriptional repressors. JARID1B expression is largely restricted to testis and may play a critical role in tumorigenesis as it has been found to be upregulated in prostate and breast cancer. Alternative names for JARID1B include retinoblastoma-binding protein 2 homolog 1, RBP2-H1, cancer/testis antigen 31, CT31, PLU-1, PUT1, and KDM5B.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol KDM5B