CCR2 Antibody (48607) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCR2 is a G-protein linked seven transmembrane domain spanning chemokine receptor that preferentially binds monocyte chemoattractant proteins-1 and -3 (MCP-1 and MCP-3). Two isoforms of this receptor (CCR2A and CCR2B) are expressed on cell surfaces as a result of alternate splicing from the same gene. These two CCR2 variants differ only at their intracellular carboxyl terminals, with the CCR2A form possessing 14 additional amino acids. This may provide a mechanism by which cells responding to similar extracellular ligands can activate different intracellular second messengers. Cells that respond to the action of MCP-1 and therefore are likely to express CCR2 receptors, include monocytes, T cells, NK cells, basophils, mast cells and dendritic cells. A recent report suggests that B cells may also express CCR2 receptors. The recognition that a variety of chemokine receptors, including CCR2, can serve as HIV fusion co-factors and as facilitators of T cell recruitment during inflammation makes chemokine receptor monitoring an important exercise in elucidating the HIV infection process and the regulation of inflammatory reactions.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Primate - Cholrocebus pygerythrus (Vervet Monkey).

We have publications tested in 6 applications: Cell Culture, Flow Cytometry, ICC, IHC, IHC-P, Neutralization.

Showing Publications 1 - 10 of 43. Show All 43 Publications. Collapse Publications.

Publications using MAB150	Applications	Species
Bueto-Beni, C;Tafuni, A;Chelko, SP;Sheppard, MN;Field, E;Tollit, J;Heenan, IK;Barnes, A;Taylor, MR;Mestroni, L;Kaski, JP;Saffitz, JE;Asimaki, A; Innate Immune Signaling in Hearts and Buccal Mucosa Cells of Patients with Arrhythmogenic Cardiomyopathy bioRxiv : the preprint server for biology 2023-07-27 [PMID: 37649905] (IHC, Human)	IHC	Human
L Pradhan, D Moore, EM Ovadia, SL Swedzinski, T Cossette, RA Sikes, K van Golen, AM Kloxin Dynamic bioinspired coculture model for probing ER+ breast cancer dormancy in the bone marrow niche Science Advances, 2023-03-08;9(10):eade3186. 2023-03-08 [PMID: 36888709] (Neutralization, Human)	Neutralization	Human
GA Enten, X Gao, HR Strzelinsk, M Weche, SB Liggett, M Majetschak alpha1B/D-adrenoceptors regulate chemokine receptor-mediated leukocyte migration via formation of heteromeric receptor complexes Proceedings of the National Academy of Sciences of the United States of America, 2022-05-10;119(20):e2123511119. 5/10/2022 [PMID: 35537053]
Johnson BE, Creason AL, Stommel JM et al. An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer Cell reports. Medicine 2/15/2022 [PMID: 35243422]
Shengli Song, Miriam Manook, Jean Kwun, Annette M. Jackson, Stuart J. Knechtle, Garnett Kelsoe A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines Communications Biology 2021-11-25 [PMID: 34824350]
Bogdan A. Luca, Chloé B. Steen, Magdalena Matusiak, Armon Azizi, Sushama Varma, Chunfang Zhu et al. Atlas of clinically distinct cell states and ecosystems across human solid tumors Cell 2021-10-01 [PMID: 34597583]
WB Fang, D Sofia Acev, C Smart, B Zinda, N Alissa, K Warren, G Fraga, LC Huang, Y Shyr, W Li, L Xie, V Staggs, Y Hong, F Behbod, N Cheng Expression of CCL2/CCR2 signaling proteins in breast carcinoma cells is associated with invasive progression Scientific Reports, 2021-04-22;11(1):8708. 2021-04-22 [PMID: 33888841] (Cell Culture, Human)	Cell Culture	Human
Guan-Da Syu, Shih-Chin Wang, Guangzhong Ma, Shuang Liu, Donna Pearce, Atish Prakash et al. Development and application of a high-content virion display human GPCR array Nature Communications 2019-04-30 [PMID: 31040288]
Cassetta L, Fragkogianni S, Sims AH et al. Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets. Cancer Cell. 4/15/2019 [PMID: 30930117]
LM Petti, SA Marlatt, Y Luo, EH Scheideman, A Shelar, D DiMaio Regulation of C-C chemokine receptor 5 (CCR5) stability by Lys-197 and by transmembrane protein aptamers that target it for lysosomal degradation J. Biol. Chem., 2018-04-20;0(0):. 2018-04-20 [PMID: 29678881] (Flow Cytometry)	Flow Cytometry
G Sebastiani, G Ventriglia, A Stabilini, C Socci, C Morsiani, A Laurenzi, L Nigi, C Formichi, B Mfarrej, A Petrelli, G Fousteri, TM Brusko, F Dotta, M Battaglia Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression Sci Rep, 2017-07-31;7(1):6897. 2017-07-31 [PMID: 28761107] (Flow Cytometry, Human)	Flow Cytometry	Human
J Przybyl, M Kowalewska, A Quattrone, B Dewaele, V Vanspauwen, S Varma, S Vennam, AM Newman, M Swierniak, E Baku?a-Zal, JA Siedlecki, M Bidzinski, J Cools, M van de Rij, M Debiec-Ryc Macrophage infiltration and genetic landscape of undifferentiated uterine sarcomas JCI Insight, 2017-06-02;2(11):. 2017-06-02 [PMID: 28570276] (IHC, Human)	IHC	Human
JC Nieto, C Zamora, E Cantó, E Garcia-Pla, J Gordillo, MA Ortiz, C Juárez, S Vidal CSF-1 regulates the function of monocytes in Crohn's disease patients in remission Sci Rep, 2017-03-07;7(1):92. 2017-03-07 [PMID: 28273887] (Flow Cytometry, Human)	Flow Cytometry	Human
Zaidoon Al-Jaderi Glatiramer Acetate, Dimethyl Fumarate, and Monomethyl Fumarate Upregulate the Expression of CCR10 on the Surface of Natural Killer Cells and Enhance Their Chemotaxis and Cytotoxicity Front Immunol, 2016-10-19;7(0):437. 2016-10-19 [PMID: 27807435] (Flow Cytometry, Human)	Flow Cytometry	Human
Evidence for chemokine synergy during neutrophil migration in ARDS Thorax, 2016-08-05;0(0):. 2016-08-05 [PMID: 27496101] (Flow Cytometry, Human)	Flow Cytometry	Human
Williams D, Anastos K, Morgello S, Berman J JAM-A and ALCAM are therapeutic targets to inhibit diapedesis across the BBB of CD14+CD16+ monocytes in HIV-infected individuals. J Leukoc Biol, 2014-11-24;97(2):401-12. 2014-11-24 [PMID: 25420915] (Flow Cytometry, Human)	Flow Cytometry	Human
Chandrasekaran , Prabha, Moore , Victoria, Buckley , Monica, Spurrier , Joshua, Kehrl , John H, Venkatesan , Sundarar HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanism. PLoS ONE, 2014-01-29;9(1):e86998. 2014-01-29 [PMID: 24489825] (Flow Cytometry, Human)	Flow Cytometry	Human
Pei X, Sun Q, Zhang Y, Wang P, Peng X, Guo C, Xu E, Zheng Y, Mo X, Ma J, Chen D, Zhang Y, Zhang Y, Song Q, Guo S, Shi T, Zhang Z, Ma D, Wang Y PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2. J Immunol, 2014-01-17;192(4):1878-86. 2014-01-17 [PMID: 24442440] (Flow Cytometry, Human)	Flow Cytometry	Human
Di Pardo A, Alberti S, Maglione V, Amico E, Cortes E, Elifani F, Battaglia G, Busceti C, Nicoletti F, Vonsattel J, Squitieri F Changes of peripheral TGF-beta1 depend on monocytes-derived macrophages in Huntington disease. Mol Brain, 2013-12-13;6(0):55. 2013-12-13 [PMID: 24330808] (Flow Cytometry, Human)	Flow Cytometry	Human
Manley , Nathan C, Caso , Javier R, Works , Melissa, Cutler , Andrew B, Zemlyak , Ilona, Sun , Guohua, Munhoz , Carolina, Chang , Sydney, Sorrells , Shawn F, Ermini , Florian, Decker , Johannes, Bertrand , Anthony, Dinkel , Klaus M, Steinberg , Gary K, Sapolsky , Robert M Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat. PLoS ONE, 2013-04-16;8(4):e61789. 2013-04-16 [PMID: 23613937] (Flow Cytometry, Rat)	Flow Cytometry	Rat
Koenig C, Fischer-Posovszky P, Rojewski M, Tews D, Schrezenmeier H, Wabitsch M, Gierschik P, Moepps B Absence of CC chemokine receptors 2a and 2b from human adipose lineage cells. Mol Cell Endocrinol, 2013-01-29;369(1):72-85. 2013-01-29 [PMID: 23376609] (Flow Cytometry, Human)	Flow Cytometry	Human
Duluc , D, Gannevat , J, Anguiano , E, Zurawski , S, Carley , M, Boreham , M, Stecher , J, Dullaers , M, Banchereau , J, Oh , S Functional diversity of human vaginal APC subsets in directing T-cell responses. Mucosal Immunol, 2012-11-07;6(3):626-38. 2012-11-07 [PMID: 23131784] (Flow Cytometry, Human)	Flow Cytometry	Human
Sun Jin Baek, Sung Keun Kang, Jeong Chan Ra In vitro migration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors Experimental and Molecular Medicine 2011-10-31 [PMID: 21847008]
Silvia Volpe, Sylvia Thelen, Thomas Pertel, Martin J. Lohse, Marcus Thelen Polarization of Migrating Monocytic Cells Is Independent of PI 3-Kinase Activity PLoS ONE 2010-04-15 [PMID: 20419163]
Ingersoll MA, Spanbroek R, Lottaz C Comparison of gene expression profiles between human and mouse monocyte subsets. Blood, 2009-11-12;115(3):e10-9. 2009-11-12 [PMID: 19965649] (Flow Cytometry, Human)	Flow Cytometry	Human
Jung DW, Che ZM, Kim J, Kim K, Kim KY, Williams D, Kim J Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7. Int. J. Cancer, 2010-07-15;127(2):332-44. 2010-07-15 [PMID: 19937793] (Neutralization, Human)	Neutralization	Human
Dagouassat M, Suffee N, Hlawaty H, Haddad O, Charni F, Laguillier C, Vassy R, Martin L, Schischmanoff PO, Gattegno L, Oudar O, Sutton A, Charnaux N Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells. Int. J. Cancer, 2010-03-01;126(5):1095-108. 2010-03-01 [PMID: 19642141] (Neutralization, Human)	Neutralization	Human
Fifadara NH, Aye CC, Raghuwanshi SK, Richardson RM, Ono SJ CCR1 expression and signal transduction by murine BMMC results in secretion of TNF-alpha, TGFbeta-1 and IL-6. Int. Immunol., 2009-07-10;21(8):991-1001. 2009-07-10 [PMID: 19592420] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Pacheco-Rodriguez G, Kumaki F, Steagall WK, Zhang Y, Ikeda Y, Lin JP, Billings EM, Moss J Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene. J. Immunol., 2009-02-01;182(3):1270-7. 2009-02-01 [PMID: 19155472] (IHC-P, Human)	IHC-P	Human
Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J. Immunol., 2008-12-01;181(11):8053-67. 2008-12-01 [PMID: 19017998] (Flow Cytometry, ICC, IHC-P, Neutralization, Human)	Flow Cytometry, ICC, IHC-P, Neutralization	Human
Weigt SS, Elashoff RM, Keane MP, Strieter RM, Gomperts BN, Xue YY, Ardehali A, Gregson AL, Kubak B, Fishbein MC, Saggar R, Ross DJ, Lynch JP, Zisman DA, Belperio JA Altered levels of CC chemokines during pulmonary CMV predict BOS and mortality post-lung transplantation. Am. J. Transplant., 2008-07-01;8(7):1512-22. 2008-07-01 [PMID: 18513272] (IHC-P, Human)	IHC-P	Human
Gouwy M, Struyf S, Noppen S, Schutyser E, Springael JY, Parmentier M, Proost P, Van Damme J Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events. Mol. Pharmacol., 2008-05-09;74(2):485-95. 2008-05-09 [PMID: 18469140] (Flow Cytometry, Human)	Flow Cytometry	Human
Burt D, Salvidio G, Tarabra E, Barutta F, Pinach S, Dentelli P, Camussi G, Perin PC, Gruden G The monocyte chemoattractant protein-1/cognate CC chemokine receptor 2 system affects cell motility in cultured human podocytes. Am. J. Pathol., 2007-11-30;171(6):1789-99. 2007-11-30 [PMID: 18055544] (ICC, Human)	ICC	Human
Ponte AL, Marais E, Gallay N, Langonne A, Delorme B, Herault O, Charbord P, Domenech J The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells, 2007-03-29;25(7):1737-45. 2007-03-29 [PMID: 17395768] (Flow Cytometry, Human)	Flow Cytometry	Human
Eugenin EA, Dyer G, Calderon TM, Berman JW HIV-1 tat protein induces a migratory phenotype in human fetal microglia by a CCL2 (MCP-1)-dependent mechanism: possible role in NeuroAIDS. Glia, 2005-03-01;49(4):501-10. 2005-03-01 [PMID: 15578658] (ICC, Human)	ICC	Human
Lim HW, Hillsamer P, Kim CH Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J. Clin. Invest., 2004-12-01;114(11):1640-9. 2004-12-01 [PMID: 15578096] (ICC, Human)	ICC	Human
Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, Stingl G, Rot A, Maurer D Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J. Immunol., 2004-12-01;173(11):6592-602. 2004-12-01 [PMID: 15557149] (Flow Cytometry, Human)	Flow Cytometry	Human
Perrier P, Martinez FO, Locati M, Bianchi G, Nebuloni M, Vago G, Bazzoni F, Sozzani S, Allavena P, Mantovani A Distinct transcriptional programs activated by interleukin-10 with or without lipopolysaccharide in dendritic cells: induction of the B cell-activating chemokine, CXC chemokine ligand 13. J. Immunol., 2004-06-01;172(11):7031-42. 2004-06-01 [PMID: 15153525] (Neutralization, Human)	Neutralization	Human
Metelitsa LS, Wu HW, Wang H, Yang Y, Warsi Z, Asgharzadeh S, Groshen S, Wilson SB, Seeger RC Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2. J. Exp. Med., 2004-05-03;199(9):1213-21. 2004-05-03 [PMID: 15123743] (Flow Cytometry, Human)	Flow Cytometry	Human
Nakayama EE, Tanaka Y, Nagai Y, Iwamoto A, Shioda T A CCR2-V64I polymorphism affects stability of CCR2A isoform. AIDS, 2004-03-26;18(5):729-38. 2004-03-26 [PMID: 15075507] (Flow Cytometry, Human, Primate - Cholrocebus pygerythrus (Vervet Monkey))	Flow Cytometry	Human, Primate - Cholrocebus pygerythrus (Vervet Monkey)
Annels NE, Willemze AJ, van der Velden VH, Faaij CM, van Wering E, Sie-Go DM, Egeler RM, van Tol MJ, Révész T Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL. Blood, 2003-12-04;103(7):2806-8. 2003-12-04 [PMID: 14656893] (Flow Cytometry, Human)	Flow Cytometry	Human
Campbell J, Qin S, Unutmaz D, Soler D, Murphy K, Hodge M, Wu L, Butcher E Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. J Immunol, 2001-06-01;166(11):6477-82. 2001-06-01 [PMID: 11359797] (Flow Cytometry, Human)	Flow Cytometry	Human
Lee B, Sharron M, Blanpain C, Doranz BJ, Vakili J, Setoh P, Berg E, Liu G, Guy HR, Durell SR, Parmentier M, Chang CN, Price K, Tsang M, Doms RW Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function. J. Biol. Chem., 1999-04-02;274(14):9617-26. 1999-04-02 [PMID: 10092648] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 43 Publications. Collapse Publications.

Array MAB150

• CCR2 Antibodies
• CCR2 ELISA Kit
• CCR2 Lysates
• CCR2 Proteins