Which is your best CXCR4 for immunohistochemistry in paraffin tissues? I would like to detect it in paraffin embedded tissues from human breast cancer samples.

Name: CXCR4 Antibody (44716) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB172
Rating: 5 (2 reviews)

CXCR4 antibody (NB100-74396) is our best selling product among all the CXCR4 antibodies and it has been validated for IHC-P in human cervical carcinoma tissue sections. NB100-74396 has been cited in at least 7 research publications. Additionally, here is a list of all of our CXCR4 antibodies that has been verified in IHC-P in human samples.

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CXCR4 Antibody (44716) [Unconjugated]

(87 Publications)

(2 Reviews)

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Jurkat human acute T cell leukemia cell line was stained with Mouse Anti-Human CXCR4 Monoclonal Antibody (Catalog # MAB172, filled histogram) or isotype control antibody (Catalog # MAB004, open histogram), followed by ...read more

CXCR4 was detected in immersion fixed paraffin-embedded sections of human lymph node using 15 µg/mL Human CXCR4 Monoclonal Antibody (Catalog # MAB172) overnight at 4 °C. Tissue was stained with the Anti-Mouse ...read more

CXCR4 was detected in immersion fixed paraffin-embedded sections of human spleen using Mouse Anti-Human CXCR4 Monoclonal Antibody (Catalog # MAB172) at 15 µg/mL overnight at 4 °C. Before incubation with the primary ...read more

Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF‑1 alpha (Catalog # 350-NS) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR4 in a dose-dependent manner (orange line). The amount of cells ...read more

CXCR4 neutralization leads to attenuation of the CD44+/CD133+ prostate progenitor population.(A) DU145 cells were plated in 96-well low-attachment plates at 100 cells per well (5 replicates) and the spheres were grown ...read more

Immunohistochemical staining for MIF and CXCR4 in human esophageal carcinoma. Our data showed low expression levels of MIF (a) and CXCR4 (c) (X 400) and high expression levels of MIF (b) and CXCR4 (d), compared with the ...read more

Product Details

Summary

Reactivity	HuSpecies Glossary
Applications	Flow, IHC, B/N, CyTOF-ready
Clone	44716
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated
Concentration	LYOPH

Order Details

View Available Conjugates

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 FAB172U-100UG

Alexa Fluor 405 FAB172V-100UG

Alexa Fluor 488 FAB172G-100UG

Alexa Fluor 532 FAB172X

Alexa Fluor 594 FAB172T-100UG

Alexa Fluor 647 FAB172R-100UG

Alexa Fluor 700 FAB172N-100UG

Alexa Fluor 750 FAB172S-100UG

Allophycocyanin FAB172A

Allophycocyanin/Cy7 FAB172APCCY7

CoraFluor 1 FAB172CL1

DyLight 350 FAB172D

DyLight 405 FAB172E

DyLight 488 FAB172K

DyLight 550 FAB172L

DyLight 594 FAB172M

DyLight 650 FAB172W

DyLight 680 FAB172Y

DyLight 755 FAB172Z

FITC FAB172F

HRP FAB172H

Janelia Fluor 525 FAB172JF525

Janelia Fluor 549 FAB172I

Janelia Fluor 646 FAB172J

Janelia Fluor 669 FAB172JF669

PE FAB172P

PE/Atto594 FAB172PEATT594

PE/Cy5.5 FAB172PECY55

PE/Cy7 FAB172PECY7

PerCP FAB172C

mFluor Violet 450 SE FAB172MFV450

mFluor Violet 500 SE FAB172MFV500

mFluor Violet 610 SE FAB172MFV610

View Available Formulations

Catalog# & Formulation	Size	Price
Carrier Free MAB172-SP

Carrier Free FAB172V-100UG

Carrier Free FAB172U-100UG

Carrier Free FAB172T-100UG

Carrier Free FAB172S-100UG

Carrier Free FAB172R-100UG

Carrier Free FAB172N-100UG

Carrier Free FAB172G-100UG

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Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB172U-100UG
Alexa Fluor 405	FAB172V-100UG
Alexa Fluor 488	FAB172G-100UG
Alexa Fluor 532	FAB172X
Alexa Fluor 594	FAB172T-100UG
Alexa Fluor 647	FAB172R-100UG
Alexa Fluor 700	FAB172N-100UG
Alexa Fluor 750	FAB172S-100UG
Allophycocyanin	FAB172A
Allophycocyanin/Cy7	FAB172APCCY7
CoraFluor 1	FAB172CL1
DyLight 350	FAB172D
DyLight 405	FAB172E
DyLight 488	FAB172K
DyLight 550	FAB172L
DyLight 594	FAB172M
DyLight 650	FAB172W
DyLight 680	FAB172Y
DyLight 755	FAB172Z
FITC	FAB172F
HRP	FAB172H
Janelia Fluor 525	FAB172JF525
Janelia Fluor 549	FAB172I
Janelia Fluor 646	FAB172J
Janelia Fluor 669	FAB172JF669
PE	FAB172P
PE/Atto594	FAB172PEATT594
PE/Cy5.5	FAB172PECY55
PE/Cy7	FAB172PECY7
PerCP	FAB172C
mFluor Violet 450 SE	FAB172MFV450
mFluor Violet 500 SE	FAB172MFV500
mFluor Violet 610 SE	FAB172MFV610

CXCR4 Antibody (44716) [Unconjugated] Summary

Immunogen	3T3 cells transfected with human CXCR4
Specificity	Detects human CXCR4. It will also react with cells expressing feline CXCR4 but not rat CXCR4.
Source	N/A
Isotype	IgG2b
Clonality	Monoclonal
Host	Mouse
Gene	CXCR4
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Applications/Dilutions

Dilutions

CyTOF-ready
Flow Cytometry 0.25 ug/10^6 cells
Immunohistochemistry 8-25 ug/mL
Neutralization 2.5-12 ug/mL

Reviewed Applications

Read 2 Reviews rated 5

using
MAB172 in the following applications:

Flow Cytometry

Publications

Read Publications using
MAB172 in the following applications:

Binding Assay
1 publication
ELISA Detection
1 publication
Flow Cytometry
9 publications
Functional Assay
2 publications
ICC
13 publications
IHC
12 publications
IHC-Fr
6 publications
IHC-P
14 publications
Immunoprecipitation
1 publication
Neutralization
4 publications
Western Blot
1 publication

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCR4 Antibody (44716) [Unconjugated]

CD184
chemokine (C-X-C motif) receptor 4
chemokine (C-X-C motif), receptor 4 (fusin)
C-X-C chemokine receptor type 4
CXCR4
CXC-R4
CXCR-4
D2S201E
D2S201ESDF-1 receptor
FB22
Fusin
HM89
HM89NPYRL
HSY3RR
LAP3
LAP-3
LCR1
LESTR
LESTRCD184 antigen
Leukocyte-derived seven transmembrane domain receptor
leukocyte-derived seven-transmembrane-domain receptor
lipopolysaccharide-associated protein 3
neuropeptide Y receptor Y3
NPY3R
NPY3RWHIM
NPYR
NPYRL
NPYY3R
pCXCR4
seven transmembrane helix receptor
seven-transmembrane-segment receptor, spleen
Stromal cell-derived factor 1 receptor
WHIMS

Background

CXCR4, also known as CD184, is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T-cell tropic HIV-1 and -2 viral entry into cells. While primarily a membrane protein, CXCR4 undergoes trafficking and internalization in response to stimulation with phorbol esters and ligand (1). Cytoplasmic and nuclear localization of CXCR4 has been observed in colorectal and renal carcinomas (2,3) and it has been used as the basis of prognosis and metastatic state (3,4,5).

Orsini, M.J. et al. (1999) J. Biol. Chem. 274:31076.
Zagzag, D. et al. (2005) Cancer Res. 65:6178.
Speetjens, F.M. et al. (2009) Cancer Microenvironment 2:1.
Wang, L. et al. (2009) Oncology Reports 22:1333.
Amara, S. et al. (2015) Cancer Biomark. 15:869.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CXCR4 Antibody (MAB172)(87)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Rabbit.

We have publications tested in 11 applications: Binding Assay, ELISA Detection, Flow Cytometry, Functional Assay, ICC, IHC, IHC-Fr, IHC-P, Immunoprecipitation, Neutralization, Western Blot.

Showing Publications 1 - 10 of 87. Show All 87 Publications.

Publications using MAB172	Applications	Species
Bhaba K. Das, Aarthi Kannan, Graham J. Velasco, Mikaela D. Kunika, Nils Lambrecht, Quy Nguyen et al. Single-cell dissection of Merkel cell carcinoma heterogeneity unveils transcriptomic plasticity and therapeutic vulnerabilities Cell Reports Medicine 7/18/2023 [PMID: 37421947]
Veronica Azcutia, Matthias Kelm, Seonyoung Kim, Anny-Claude Luissint, Sven Flemming, Lisa Abernathy-Close et al. Distinct stimulus-dependent neutrophil dynamics revealed by real-time imaging of intestinal mucosa after acute injury PNAS Nexus 11/4/2022 [PMID: 36712325]
C D'Alterio, A Giardino, G Scognamigl, G Butturini, L Portella, G Guardascio, I Frigerio, M Montella, S Gobbo, G Martignoni, V Napolitano, F De Vita, F Tatangelo, R Franco, S Scala CXCR4-CXCL12-CXCR7 and PD-1/PD-L1 in Pancreatic Cancer: CXCL12 Predicts Survival of Radically Resected Patients Cells, 2022-10-22;11(21):. 2022-10-22 [PMID: 36359736] (IHC, Human)	IHC	Human
M Tobiume, A Mitsuhashi, A Saijo, H Ogino, T Afroj, H Ogawa, H Goto, S Sato, A Abe, K Haji, R Ozaki, H Takizawa, Y Nishioka Analysis of the chemotactic factors for tumor-infiltrating fibrocytes and their prognostic significances in lung cancer Oncology Letters, 2022-09-30;24(5):417. 2022-09-30 [PMID: 36245829] (IHC, Human)	IHC	Human
C D'Alterio, A Spina, L Arenare, P Chiodini, M Napolitano, F Galdiero, L Portella, V Simeon, S Signoriell, F Raspaglies, D Lorusso, C Pisano, N Colombo, GF Zannoni, NS Losito, R De Cecio, G Scognamigl, D Califano, D Russo, V Tuninetti, MC Piccirillo, P Gargiulo, F Perrone, S Pignata, S Scala Biological Role of Tumor/Stromal CXCR4-CXCL12-CXCR7 in MITO16A/MaNGO-OV2 Advanced Ovarian Cancer Patients Cancers, 2022-04-06;14(7):. 2022-04-06 [PMID: 35406620] (IHC, Human)	IHC	Human
Wellemans V, Benhassou H, Fuselier E, Bellesort F, Dury S, Lebargy F, Dormoy V, Fichel C, Naour R, Gounni A, Lamkhioued B Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells. iScience, 2021-11-14;24(12):103433. 2021-11-14 [PMID: 34917892] (Flow Cytometry, Human)	Flow Cytometry	Human
H Jayakumar, A Seetharama, S Sunder Sin, H Dhandapani, J Subramani, S Ganeshraja, R Thangaraja, P Ramanathan Combination of IDO1high and CCL19low expression in the tumor tissue reduces survival in HPV positive cervical cancer Journal of reproductive immunology, 2021-11-23;149(0):103454. 2021-11-23 [PMID: 34856521] (IHC, Human)	IHC	Human
M Armani-Tou, Z Zhou, R Gasser, I Staropoli, V Cantaloube, Y Benureau, J Garcia-Per, M Pérez-Olme, V Lorin, B Puissant-L, L Assoumou, C Delaugerre, JD Lelièvre, Y Lévy, H Mouquet, G Martin-Blo, J Alcami, F Arenzana-S, J Izopet, P Colin, B Lagane Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis PloS Pathogens, 2021-04-19;17(4):e1009526. 2021-04-19 [PMID: 33872329] (Binding Assay, Human)	Binding Assay	Human
Kristanto Yuli Yarso, Monica Bellynda, Akhmad Azmiardi, Brian Wasita, Didik Setyo Heriyanto, Indwiani Astuti et al. Chemotherapy Negates the Effect of SDF1 mRNA to Distant Metastasis and Poor Overall Survival in Breast Cancer Patients Asian Pacific Journal of Cancer Prevention 3/1/2021 [PMID: 33773539]
Adrien Guérard, Victor Laurent, Gaëlle Fromont, David Estève, Julia Gilhodes, Edith Bonnelye et al. The Chemokine Receptor CCR3 Is Potentially Involved in the Homing of Prostate Cancer Cells to Bone: Implication of Bone-Marrow Adipocytes International Journal of Molecular Sciences 2/17/2021 [PMID: 33671469]
Choi YW, Kim YH, Oh SY et al. Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer Advanced Science 1/4/2021 [PMID: 33643790]
D Liu, A Steins, R Klaassen, AP van der Za, RJ Bennink, G van Tienho, MG Besselink, MF Bijlsma, HWM van Laarho Soluble Compounds Released by Hypoxic Stroma Confer Invasive Properties to Pancreatic Ductal Adenocarcinoma Biomedicines, 2020-10-22;8(11):. 2020-10-22 [PMID: 33105540] (Flow Cytometry, Human)	Flow Cytometry	Human
A McQuade, YJ Kang, J Hasselmann, A Jairaman, A Sotelo, M Coburn, SK Shabestari, JP Chadarevia, G Fote, CH Tu, E Danhash, J Silva, E Martinez, C Cotman, GA Prieto, LM Thompson, JS Steffan, I Smith, H Davtyan, M Cahalan, H Cho, M Blurton-Jo Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease Nat Commun, 2020-10-23;11(1):5370. 2020-10-23 [PMID: 33097708] (IHC, Mouse)	IHC	Mouse
Paola Vallejo-Armenta, Clara Santos-Cuevas, Juan Soto-Andonaegui, Rosa M. Villanueva-Pérez, Jorge I. González-Díaz, Francisco O. García-Pérez et al. 99mTc-CXCR4-L for Imaging of the Chemokine-4 Receptor Associated with Brain Tumor Invasiveness: Biokinetics, Radiation Dosimetry, and Proof of Concept in Humans Contrast Media & Molecular Imaging 4/27/2020 [PMID: 32410920]
J Zheng, D Qu, C Wang, L Ding, W Zhou Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling BMC Pregnancy Childbirth, 2020-02-10;20(1):87. 2020-02-10 [PMID: 32041571] (ICC, IHC, Neutralization, Human)	ICC, IHC, Neutralization	Human
Q Zhu, R Luo, J Gu, Y Hou, Z Chen, F Xu, L Wang, W Mao, C Lu, D Ge High CXCR4 Expression Predicts a Poor Prognosis in Resected Lung Adenosquamous Carcinoma J Cancer, 2020-01-01;11(4):810-818. 2020-01-01 [PMID: 31949484] (IHC, Human)	IHC	Human
I González, PS Bauer, WC Chapman, Z Alipour, R Rais, J Liu, D Chatterjee Clinicopathologic determinants of pathologic treatment response in neoadjuvant treated rectal adenocarcinoma Ann Diagn Pathol, 2019-12-14;45(0):151452. 2019-12-14 [PMID: 31945621] (IHC, Human)	IHC	Human
JA van Ipenbu, NE de Waard, NC Naus, MJ Jager, D Paridaens, RM Verdijk Chemokine Receptor Expression Pattern Correlates to Progression of Conjunctival Melanocytic Lesions Invest. Ophthalmol. Vis. Sci., 2019-07-01;60(8):2950-2957. 2019-07-01 [PMID: 31305861] (IHC-P, Human)	IHC-P	Human
R Giampieri, F Piva, G Occhipinti, A Bittoni, A Righetti, S Pagliarett, A Murrone, F Bianchi, C Amantini, M Giulietti, G Ricci, G Principato, G Santoni, R Berardi, S Cascinu Clinical impact of different exosomes' protein expression in pancreatic ductal carcinoma patients treated with standard first line palliative chemotherapy PLoS ONE, 2019-05-02;14(5):e0215990. 2019-05-02 [PMID: 31048929] (ELISA Detection, Human)	ELISA Detection	Human
Cheyenne L Runyan, Stacia Z McIntosh, Marlie M Maestas, Kelsey E Quinn, Ben P Boren, Ryan L Ashley CXCR4 signaling at the ovine fetal–maternal interface regulates vascularization, CD34+ cell presence, and autophagy in the endometrium† Biology of Reproduction 7/1/2019 [PMID: 31004477]
I Del Molino, GC Wilkins, A Meeson, S Ali, JA Kirby Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12 Int J Mol Sci, 2018-11-14;19(11):. 2018-11-14 [PMID: 30441765] (IHC-P, Human)	IHC-P	Human
JE Yoon, Y Kim, S Kwon, M Kim, YH Kim, JH Kim, TJ Park, HY Kang Senescent fibroblasts drive ageing pigmentation: ?A potential therapeutic target for senile lentigo Theranostics, 2018-09-09;8(17):4620-4632. 2018-09-09 [PMID: 30279727] (ICC, IHC-P, Human)	ICC, IHC-P	Human
Diego Sbrissa, Louie Semaan, Barani Govindarajan, Yanfeng Li, Nicholas J. Caruthers, Paul M. Stemmer et al. A novel cross-talk between CXCR4 and PI4KIII alpha in prostate cancer cells. Oncogene 1/1/2019 [PMID: 30111818]
MJ Chau, TC Deveau, X Gu, YS Kim, Y Xu, SP Yu, L Wei Delayed and repeated intranasal delivery of bone marrow stromal cells increases regeneration and functional recovery after ischemic stroke in mice BMC Neurosci, 2018-04-12;19(1):20. 2018-04-12 [PMID: 29649974] (ICC, Rat)	ICC	Rat
Y Kitawaki, Y Nakamura, F Kubota-Nak, Y Yamazaki, Y Miki, S Hata, K Ise, K Kikuchi, R Morimoto, F Satoh, H Sasano Tumor Microenvironment in Functional Adrenocortical Adenomas: Immune Cell Infiltration in Cortisol-producing Adrenocortical Adenoma Hum. Pathol., 2018-03-27;0(0):. 2018-03-27 [PMID: 29596893] (IHC-P, Human)	IHC-P	Human
W Tang, Y Chen, X Wang, Y Chen, J Zhang, Z Lin Expression of CXC-motif-chemokine 12 and the receptor C-X-C receptor 4 in glioma and theeffect on peritumoral brain edema Oncol Lett, 2017-12-08;15(2):2501-2507. 2017-12-08 [PMID: 29434965] (IHC-P, Human)	IHC-P	Human
J Zhang, C Liu, X Mo, H Shi, S Li Mechanisms by which CXCR4/CXCL12 cause metastatic behavior in pancreatic cancer Oncol Lett, 2017-12-05;15(2):1771-1776. 2017-12-05 [PMID: 29434873] (IHC, Human)	IHC	Human
N.S. Sanchez, K.E. Quinn, A.K. Ashley, R.L. Ashley In the ovine pituitary, CXCR4 is localized in gonadotropes and somatotropes and increases with elevated serum progesterone Domestic Animal Endocrinology 1/1/2018 [PMID: 29157995]
Harsh Samarendra, Keaton Jones, Tatjana Petrinic, Michael A Silva, Srikanth Reddy, Zahir Soonawalla et al. A meta-analysis of CXCL12 expression for cancer prognosis British Journal of Cancer 6/27/2017 [PMID: 28535157]
Kim YH, Choi YW, Lee J et al. Senescent tumor cells lead the collective invasion in thyroid cancer Nat Commun. 5/9/2017 [PMID: 28489070]
L Mercurio, S Cecchetti, A Ricci, A Pacella, G Cigliana, G Bozzuto, F Podo, E Iorio, G Carpinelli Phosphatidylcholine-specific phospholipase C inhibition down- regulates CXCR4 expression and interferes with proliferation, invasion and glycolysis in glioma cells PLoS ONE, 2017-04-19;12(4):e0176108. 4/19/2017 [PMID: 28423060]
M Fareh, F Almairac, L Turchi, F Burel-Vand, P Paquis, D Fontaine, S Lacas-Gerv, MP Junier, H Chneiweiss, T Virolle Cell-based therapy using miR-302-367 expressing cells represses glioblastoma growth Cell Death Dis, 2017-03-30;8(3):e2713. 2017-03-30 [PMID: 28358371] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Vashendriya V V Hira Cathepsin K cleavage of SDF-1? inhibits its chemotactic activity towards glioblastoma stem-like cells Biochim. Biophys. Acta, 2016-12-28;0(0):. 2016-12-28 [PMID: 28040478] (Flow Cytometry, Human)	Flow Cytometry	Human
L Liu, W Wang, J Matz, C Ye, L Bracq, J Delon, JT Kimata, Z Chen, S Benichou, P Zhou The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1 J. Virol., 2016-11-14;90(23):10642-10659. 2016-11-14 [PMID: 27654286] (Functional Assay, Human)	Functional Assay	Human
Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices Proc Natl Acad Sci USA, 2016-08-19;0(0):. 2016-08-19 [PMID: 27543332] (IHC-Fr, Human)	IHC-Fr	Human
Yijie Geng, Bradley Feng A small molecule-based strategy for endothelial differentiation and three-dimensional morphogenesis from human embryonic stem cells Heliyon 7/25/2016 [PMID: 27512727]
Mercurio L, Ajmone-Cat M, Cecchetti S, Ricci A, Bozzuto G, Molinari A, Manni I, Pollo B, Scala S, Carpinelli G, Minghetti L Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model. J Exp Clin Cancer Res, 2016-03-25;35(0):55. 2016-03-25 [PMID: 27015814] (ICC, Human)	ICC	Human
Liisa K. Kanninen, Pauliina Porola, Johanna Niklander, Melina M. Malinen, Anne Corlu, Christiane Guguen-Guillouzo et al. Hepatic differentiation of human pluripotent stem cells on human liver progenitor HepaRG-derived acellular matrix Experimental Cell Research 2/15/2016 [PMID: 26854693]
CJ Coke, KA Scarlett, MA Chetram, KJ Jones, BJ Sandifer, AS Davis, AI Marcus, CV Hinton Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveals a Mechanism for Regulation of Tumor Progression J. Biol. Chem., 2016-02-03;291(19):9991-10005. 2016-02-03 [PMID: 26841863] (Neutralization, Human)	Neutralization	Human
Victor Laurent, Adrien Guérard, Catherine Mazerolles, Sophie Le Gonidec, Aurélie Toulet, Laurence Nieto et al. Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity Nature Communications 1/12/2016 [PMID: 26756352]
Fujita T, Chiwaki F, Takahashi R, Aoyagi K, Yanagihara K, Nishimura T, Tamaoki M, Komatsu M, Komatsuzaki R, Matsusaki K, Ichikawa H, Sakamoto H, Yamada Y, Fukagawa T, Katai H, Konno H, Ochiya T, Yoshida T, Sasaki H Identification and Characterization of CXCR4-Positive Gastric Cancer Stem Cells. PLoS ONE, 2015-06-25;10(6):e0130808. 2015-06-25 [PMID: 26110809] (IHC, Human)	IHC	Human
YUKI AKAZAWA, TOMOKAZU HASEGAWA, YOSHITAKA YOSHIMURA, NAOYUKI CHOSA, TAKEYOSHI ASAKAWA, KIMIKO UEDA et al. Recruitment of mesenchymal stem cells by stromal cell-derived factor 1 alpha in pulp cells from deciduous teeth International Journal of Molecular Medicine 8/1/2015 [PMID: 26082290]
Michele Cioffi, Crescenzo D’Alterio, Rosalba Camerlingo, Virginia Tirino, Claudia Consales, Anna Riccio et al. Identification of a distinct population of CD133(+)CXCR4(+) cancer stem cells in ovarian cancer Scientific Reports 5/28/2015 [PMID: 26020117]
D.A. Gibson, E. Greaves, H.O.D. Critchley, P.T.K. Saunders Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2 Human Reproduction 6/1/2015 [PMID: 25820695]
Pilling D, Cox N, Vakil V, Verbeek J, Gomer R The long pentraxin PTX3 promotes fibrocyte differentiation. PLoS ONE, 2015-03-16;10(3):e0119709. 2015-03-16 [PMID: 25774777] (IHC-Fr, Human)	IHC-Fr	Human
Maria Neve Polimeno, Caterina Ierano, Crescenzo D'Alterio, Nunzia Simona Losito, Maria Napolitano, Luigi Portella et al. CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not Cellular & Molecular Immunology 7/1/2015 [PMID: 25363530]
Hu , Weidong, Liu , Yue, Zhou , Wenhui, Si , Lianlian, Ren , Liang CXCL16 and CXCR6 are coexpressed in human lung cancer in vivo and mediate the invasion of lung cancer cell lines in vitro. PLoS ONE, 2014-06-04;9(6):e99056. 2014-06-04 [PMID: 24897301] (ICC, IHC-P, Human)	ICC, IHC-P	Human
Hartmann N, Giese N, Giese T, Poschke I, Offringa R, Werner J, Ryschich E Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer. Clin Cancer Res, 2014-04-24;20(13):3422-33. 2014-04-24 [PMID: 24763614] (IHC, Human)	IHC	Human
Jarajapu Y, Hazra S, Segal M, Li Calzi S, Jadhao C, Qian K, Mitter S, Raizada M, Boulton M, Grant M Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanisms. PLoS ONE, 2014-04-08;9(4):e93965. 2014-04-08 [PMID: 24713821] (Flow Cytometry, Human)	Flow Cytometry	Human
Zgraggen , Silvana, Huggenberger , Reto, Kerl , Katrin, Detmar , Michael An important role of the SDF-1/CXCR4 axis in chronic skin inflammation. PLoS ONE, 2014-04-02;9(4):e93665. 2014-04-02 [PMID: 24695674] (IHC-P, Human)	IHC-P	Human
Yin X, Johns S, Kim D, Mikulski Z, Salanga C, Handel T, Macal M, Zuniga E, Fuster M Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node. J Immunol, 2014-02-03;192(5):2133-42. 2014-02-03 [PMID: 24493818] (Functional Assay, Human)	Functional Assay	Human
Hoque , Md Tamji, Windus , Louisa C, Lovitt , Carrie J, Avery , Vicky M PCaAnalyser: a 2D-image analysis based module for effective determination of prostate cancer progression in 3D culture. PLoS ONE, 2013-11-20;8(11):e79865. 2013-11-20 [PMID: 24278197] (ICC, Human)	ICC	Human
Brennecke P, Arlt M, Muff R, Campanile C, Gvozdenovic A, Husmann K, Holzwarth N, Cameroni E, Ehrensperger F, Thelen M, Born W, Fuchs B Expression of the chemokine receptor CXCR7 in CXCR4-expressing human 143B osteosarcoma cells enhances lung metastasis of intratibial xenografts in SCID mice. PLoS ONE, 2013-09-10;8(9):e74045. 2013-09-10 [PMID: 24040160] (IHC-P, Human)	IHC-P	Human
Gassenmaier M, Chen D, Buchner A, Henkel L, Schiemann M, Mack B, Schendel D, Zimmermann W, Pohla H CXC chemokine receptor 4 is essential for maintenance of renal cell carcinoma-initiating cells and predicts metastasis. Stem Cells, 2013-08-01;31(8):1467-76. 2013-08-01 [PMID: 23630186] (IHC-P, Human)	IHC-P	Human
O'Boyle , G, Swidenbank , I, Marshall , H, Barker , C E, Armstrong , J, White , S A, Fricker , S P, Plummer , R, Wright , M, Lovat , P E Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070. Br J Cancer, 2013-03-28;108(8):1634-40. 2013-03-28 [PMID: 23538388] (IHC, Human)	IHC	Human
Zhang , Lin, Ye , Shu-Biao, Ma , Gang, Tang , Xiao-Fen, Chen , Shi-Ping, He , Jia, Liu , Wan-Li, Xie , Dan, Zeng , Yi-Xin, Li , Jiang The expressions of MIF and CXCR4 protein in tumor microenvironment are adverse prognostic factors in patients with esophageal squamous cell carcinoma. J Transl Med, 2013-03-08;11(0):60. 2013-03-08 [PMID: 23497377] (IHC-P, Human)	IHC-P	Human
Ayesha S. Don-Salu-Hewage, Siu Yuen Chan, Kathleen M. McAndrews, Mahandranauth A. Chetram, Michelle R. Dawson, Danaya A. Bethea et al. Cysteine (C)-X-C Receptor 4 Undergoes Transportin 1-Dependent Nuclear Localization and Remains Functional at the Nucleus of Metastatic Prostate Cancer Cells PLoS ONE 2/28/2013 [PMID: 23468933]
Fengyan Jin, Huifan Ji, Chunshu Jia, Ulf Brockmeier, Dirk M. Hermann, Eric Metzen et al. Synergistic Antitumor Effects of Endostar in Combination with Oxaliplatin via Inhibition of HIF and CXCR4 in the Colorectal Cell Line SW1116 PLoS ONE 10/10/2012 [PMID: 23071744]
Linhui Wang, Wei Chen, Li Gao, Qing Yang, Bing Liu, Zhenjie Wu et al. High expression of CXCR4, CXCR7 and SDF-1 predicts poor survival in renal cell carcinoma World Journal of Surgical Oncology 12/1/2012 [PMID: 23039915]
A Popple, L G Durrant, I Spendlove, P Rolland, I V Scott, S Deen et al. The chemokine, CXCL12, is an independent predictor of poor survival in ovarian cancer British Journal of Cancer 3/27/2012 [PMID: 22415233]
Anna Dubrovska, Jimmy Elliott, Richard J. Salamone, Gennady D. Telegeev, Alexander E. Stakhovsky, Ihor B. Schepotin et al. CXCR4 Expression in Prostate Cancer Progenitor Cells PLoS ONE 2/16/2012 [PMID: 22359577]
Lorena Hernandez, Marco A O Magalhaes, Salvatore J Coniglio, John S Condeelis, Jeffrey E Segall Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis Breast Cancer Research 12/9/2011 [PMID: 22152016]
Peter Dorfmüller, Marie-Camille Chaumais, Maria Giannakouli, Ingrid Durand-Gasselin, Nicolas Raymond, Elie Fadel et al. Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension Respiratory Research 12/1/2011 [PMID: 21906276]
Tatiana Smirnova, Alfred Adomako, Joseph Locker, Nico Van Rooijen, Michael B. Prystowsky, Jeffrey E. Segall In Vivo Invasion of Head and Neck Squamous Cell Carcinoma Cells Does Not Require Macrophages The American Journal of Pathology 6/1/2011 [PMID: 21641405]
Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev IS, Tacheuchi S, Mouri H, Yamashita K, Ohtsubo K, Yano S The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer. Clin. Cancer Res., 2011-04-11;17(11):3619-30. 2011-04-11 [PMID: 21482691] (IHC-P, Human)	IHC-P	Human
Massod Rahimi, Theodore A. Toth, Careen K. Tang CXCR4 suppression attenuates EGFRvIII-mediated invasion and induces p38 MAPK-dependent protein trafficking and degradation of EGFRvIII in breast cancer cells Cancer Letters 7/1/2011 [PMID: 21454012]
Patricia A Cronin, Jiang H Wang, H Paul Redmond Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4 BMC Cancer 12/1/2010 [PMID: 20492653]
Arvidsson Y, Bergstrom A, Arvidsson L et al. Hypoxia stimulates CXCR4 signalling in ileal carcinoids. Endocr Relat Cancer 6/1/2010 [PMID: 20071457]
Rahimi Massod, George Jessica, Tang Careen et al. EGFR variant-mediated invasion by enhanced CXCR4 expression through transcriptional and post-translational mechanisms. International Journal of Cancer 1/1/2010 [PMID: 19830694]
Franciszkiewicz K, Le Floc'h A, Jalil A, Vigant F, Robert T, Vergnon I, Mackiewicz A, Benihoud K, Validire P, Chouaib S, Combadiere C, Mami-Chouaib F Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer Res., 2009-07-28;69(15):6249-55. 2009-07-28 [PMID: 19638592] (Flow Cytometry, Human)	Flow Cytometry	Human
Pfeiffer M, Hartmann TN, Leick M, Catusse J, Schmitt-Graeff A, Burger M Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancer. Br. J. Cancer, 2009-05-19;100(12):1949-56. 2009-05-19 [PMID: 19455144] (Immunoprecipitation, Human)	Immunoprecipitation	Human
Feng Hong, Ana Tuyama, Ting Fang Lee, Johnny Loke, Ritu Agarwal, Xin Cheng et al. Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation Hepatology 6/2/2010 [PMID: 19434726]
Hansson M, Olesen DR, Peterslund JM, Engberg N, Kahn M, Winzi M, Klein T, Maddox-Hyttel P, Serup P A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev. Biol., 2009-04-07;330(2):286-304. 2009-04-07 [PMID: 19358838] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Gilbert DC, Chandler I, McIntyre A, Goddard NC, Gabe R, Huddart RA, Shipley J Clinical and biological significance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents. J. Pathol., 2009-01-01;217(1):94-102. 2009-01-01 [PMID: 18839394] (ICC, IHC-P, Human)	ICC, IHC-P	Human
Williams CK, Segarra M, Sierra Mde L, Sainson RC, Tosato G, Harris AL Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells. Cancer Res., 2008-03-15;68(6):1889-95. 2008-03-15 [PMID: 18339870] (Neutralization, Human)	Neutralization	Human
Tait LR, Pauley RJ, Santner SJ, Heppner GH, Heng HH, Rak JW, Miller FR Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts. Int. J. Cancer, 2007-05-15;120(10):2127-34. 2007-05-15 [PMID: 17266026] (ICC, Human)	ICC	Human
Misao Y, Takemura G, Arai M, Ohno T, Onogi H, Takahashi T, Minatoguchi S, Fujiwara T, Fujiwara H Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF. Cardiovasc. Res., 2006-05-09;71(3):455-65. 2006-05-09 [PMID: 16769043] (IHC-P, Rabbit)	IHC-P	Rabbit
Marchal-Somme J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, Crestani B, Soler P Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis. J. Immunol., 2006-05-15;176(10):5735-9. 2006-05-15 [PMID: 16670278] (IHC-Fr, Human)	IHC-Fr	Human
Scala S, Giuliano P, Ascierto PA, Ierano C, Franco R, Napolitano M, Ottaiano A, Lombardi ML, Luongo M, Simeone E, Castiglia D, Mauro F, De Michele I, Calemma R, Botti G, Caraco C, Nicoletti G, Satriano RA, Castello G Human melanoma metastases express functional CXCR4. Clin. Cancer Res., 2006-04-15;12(8):2427-33. 2006-04-15 [PMID: 16638848] (ICC, IHC-Fr, IHC-P, Human)	ICC, IHC-Fr, IHC-P	Human
Haringman JJ, Smeets TJ, Reinders-Blankert P Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis. Ann. Rheum. Dis., 2005-08-17;65(3):294-300. 2005-08-17 [PMID: 16107514] (IHC-Fr, Human)	IHC-Fr	Human
Meller S, Winterberg F, Gilliet M, Muller A, Lauceviciute I, Rieker J, Neumann NJ, Kubitza R, Gombert M, Bunemann E, Wiesner U, Franken-Kunkel P, Kanzler H, Dieu-Nosjean MC, Amara A, Ruzicka T, Lehmann P, Zlotnik A, Homey B Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus. Arthritis Rheum., 2005-05-01;52(5):1504-16. 2005-05-01 [PMID: 15880822] (IHC-Fr, Human)	IHC-Fr	Human
Liao TS, Yurgelun MB, Chang SS, Zhang HZ, Murakami K, Blaine TA, Parisien MV, Kim W, Winchester RJ, Lee FY Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone. J. Orthop. Res., 2005-01-01;23(1):203-9. 2005-01-01 [PMID: 15607894] (ICC, Human)	ICC	Human
Zhang Y, Foudi A, Geay JF, Berthebaud M, Buet D, Jarrier P, Jalil A, Vainchenker W, Louache F Intracellular localization and constitutive endocytosis of CXCR4 in human CD34+ hematopoietic progenitor cells. Stem Cells, 2004-01-01;22(6):1015-29. 2004-01-01 [PMID: 15536192] (ICC, Human)	ICC	Human
Mori T, Doi R, Koizumi M, Toyoda E, Ito D, Kami K, Masui T, Fujimoto K, Tamamura H, Hiramatsu K, Fujii N, Imamura M CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer. Mol. Cancer Ther., 2004-01-01;3(1):29-37. 2004-01-01 [PMID: 14749473] (ICC, Human)	ICC	Human
Cardones AR, Murakami T, Hwang ST CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin. Cancer Res., 2003-10-15;63(20):6751-7. 2003-10-15 [PMID: 14583470] (Flow Cytometry, Human)	Flow Cytometry	Human
Nguyen DH, Taub D CXCR4 function requires membrane cholesterol: implications for HIV infection. J. Immunol., 2002-04-15;168(8):4121-6. 2002-04-15 [PMID: 11937572] (Flow Cytometry, Neutralization, Human)	Flow Cytometry, Neutralization	Human
Campbell J, Qin S, Unutmaz D, Soler D, Murphy K, Hodge M, Wu L, Butcher E Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. J Immunol, 2001-06-01;166(11):6477-82. 2001-06-01 [PMID: 11359797] (Flow Cytometry, Human)	Flow Cytometry	Human
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Reviews for CXCR4 Antibody (MAB172) (2) 52

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10/27/2018

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Application	Flow Cytometry
Sample Tested	SUDHL-6 and Ramos cells,SU-DHL-6 cell line
Species	Human
Lot	AVB1116121

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Cell line stained with human CXCR4 for 45 min and secondary antibody anti-mouse FITC for 45min (Isotype control and unstained cell used in experiment)

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Application	Flow Cytometry
Sample Tested	Jurkat
Species	Human
Lot	AVB1116121

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FAQs for CXCR4 Antibody (MAB172). (Showing 1 - 1 of 1 FAQs).

Which is your best CXCR4 for immunohistochemistry in paraffin tissues? I would like to detect it in paraffin embedded tissues from human breast cancer samples.
- CXCR4 antibody (NB100-74396) is our best selling product among all the CXCR4 antibodies and it has been validated for IHC-P in human cervical carcinoma tissue sections. NB100-74396 has been cited in at least 7 research publications. Additionally, here is a list of all of our CXCR4 antibodies that has been verified in IHC-P in human samples.

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Stemness is responsible for onset and metastasis of colorectal cancer
By Jamshed Arslan, Pharm. D., PhD. Colorectal cancer stem cells are a rare subpopulation of colorectal cancer cells that can self-renew and initiate and sustain tumor growth when transplanted into an animal host.1,2 C... Read full blog post.

LAMP2: Protector of the lysosome
LAMP2 belongs to the family of membrane glycoproteins who confer selectins with carbohydrate ligands. LAMP2 has been implicated in tumor cell metastasis, as well as overall protection, maintenance, and adhesion of the lysosome. It appears that LAMP2 m... Read full blog post.

CXCR4 Studies on Neural and Stem Cells
The CXCR4 (C-X-C chemokine receptor type 4) protein is one member of the G-protein coupled receptor (GPCR1) family. As a multipass membrane protein that is found in several tissues, it is the receptor for the C-X-C chemokine CXCL12/SDF-1. The CXCR4 li... Read full blog post.

Understanding CXCR4 and SDF1
CXCR4 (C-X-C chemokine receptor type 4) is a member of the G-protein coupled receptor (GPCR1) family. It is expressed as a multipass membrane protein in several tissues where it acts as the receptor for the C-X-C chemokine CXCL12/SDF-1. This ligand in... Read full blog post.

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Mouse IgG2b Isotype Control (20116) [Unconjugated]
MAB004

1 µg/lane of Recombinant Human TNF-alpha was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.

TNF-alpha [Unconjugated]
210-TA-005

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CXCR4

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

CXCR4 Antibody (44716) [Unconjugated]

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Publications for CXCR4 Antibody (MAB172)(87)

Reviews for CXCR4 Antibody (MAB172) (2) 52

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FAQs for CXCR4 Antibody (MAB172). (Showing 1 - 1 of 1 FAQs).

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