CXCR4

By Jamshed Arslan, Pharm. D., PhD.

By Jamshed Arslan Pharm.D.

LAMP2 belongs to the family of membrane glycoproteins who confer selectins with carbohydrate ligands. LAMP2 has been implicated in tumor cell metastasis, as well as overall protection, maintenance, and adhesion of the lysosome. It appears that LAMP2 may protect the lysosomal membrane from autophagy, as well as maintain the required acidic environment necessary for proper function.  LAMP2 is a single-pass type I membrane protein that shuttles between endosomes, lysosomes, and the plasma membrane.

The CXCR4 (C-X-C chemokine receptor type 4) protein is one member of the G-protein coupled receptor (GPCR1) family. As a multipass membrane protein that is found in several tissues, it is the receptor for the C-X-C chemokine CXCL12/SDF-1. The CXCR4 ligand works by modulating intracellular calcium ion levels and activating the MAPK1/MAPK3 signal pathways. CXCR4 is also a receptor for extracellular ubiquitin, which produces enhanced levels of intracellular calcium and reduced levels of cellular cAMP.

CXCR4 (C-X-C chemokine receptor type 4) is a member of the G-protein coupled receptor (GPCR1) family. It is expressed as a multipass membrane protein in several tissues where it acts as the receptor for the C-X-C chemokine CXCL12/SDF-1. This ligand increases intracellular calcium ion levels and enhances activation of the MAPK1/MAPK3 cascade.