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LGR5

Stemness is responsible for onset and metastasis of colorectal cancer

GPR49/LGR5: Stem Cells and the WNT Signaling Pathway

GPR49/LGR5 (G protein-coupled receptor 49/leucine-rich repeat-containing G protein-coupled receptor 5) is also known by the names FEX, GPR67, GRP49, HG38, and MGC117008). It is an orphan receptor and structurally related to members of the mammalian large transmembrane glycoprotein hormone receptor family (FSH-R, TSH-R, and LH-R).