Species: Hu
Applications: Flow, IHC, B/N, CyTOF-ready
Host: Mouse Monoclonal
Species: Mu
Applications: Flow, IHC, B/N, CyTOF-ready, ICC/IF
Host: Rat Monoclonal
Species: Hu
Applications: Flow, B/N, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Description
CD184, also known as fusin or CXCR4, is a 45 kD seven transmembrane G-protein-linked CXC chemokine receptor. CD184 is widely expressed on blood and tissue cells, including B and T cells, monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes/platelets, lymphoid, myeloid precursor cells, endothelial cells, epithelial cells, astrocytes, and neurons, among other tissue cells. CD184 is the receptor for CXC chemokine SDF-1, mediates blood cell migration, and is involved in B lympho- and myelopoiesis, cardiogenesis, blood vessel formation and cerebellar development. CXCR4 is also a coreceptor of X4 HIV-1 and an alternative receptor for some isolates of HIV-2. The 12G5 antibody has been reported to block CD4-independent infection by HIV-2 and CD4-dependent infection by some T cell-tropic isolates of HIV-1.
Bioinformatics
Entrez |
Mouse Rat Human |
Uniprot |
Human Human Human Human Human Mouse |
Product By Gene ID |
7852 |
Alternate Names |
- CD184
- chemokine (C-X-C motif) receptor 4
- chemokine (C-X-C motif), receptor 4 (fusin)
- C-X-C chemokine receptor type 4
- CXC-R4
- CXCR-4
- D2S201ESDF-1 receptor
- FB22
- Fusin
- fusin
- HM89NPYRL
- HSY3RR
- LAP3
- LCR1
- LESTRCD184 antigen
- Leukocyte-derived seven transmembrane domain receptor
- leukocyte-derived seven-transmembrane-domain receptor
- lipopolysaccharide-associated protein 3
- neuropeptide Y receptor Y3
- NPY3RWHIM
- NPYR
- NPYY3R
- pCXCR4
- seven transmembrane helix receptor
- seven-transmembrane-segment receptor, spleen
- Stromal cell-derived factor 1 receptor
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