CCR2 Antibody (48607) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCR2 is a G-protein linked seven transmembrane domain spanning chemokine receptor that preferentially binds monocyte chemoattractant proteins-1 and -3 (MCP-1 and MCP-3). Two isoforms of this receptor (CCR2A and CCR2B) are expressed on cell surfaces as a result of alternate splicing from the same gene. These two CCR2 variants differ only at their intracellular carboxyl terminals, with the CCR2A form possessing 14 additional amino acids. This may provide a mechanism by which cells responding to similar extracellular ligands can activate different intracellular second messengers. Cells that respond to the action of MCP-1 and therefore are likely to express CCR2 receptors, include monocytes, T cells, NK cells, basophils, mast cells and dendritic cells. A recent report suggests that B cells may also express CCR2 receptors. The recognition that a variety of chemokine receptors, including CCR2, can serve as HIV fusion co-factors and as facilitators of T cell recruitment during inflammation makes chemokine receptor monitoring an important exercise in elucidating the HIV infection process and the regulation of inflammatory reactions.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Primate - Macaca mulatta (Rhesus Macaque).

We have publications tested in 2 applications: CAR-T (Flow Cytometry), Flow Cytometry.

Showing Publications 1 - 10 of 44. Show All 44 Publications. Collapse Publications.

Publications using FAB151P	Applications	Species
Thomas M. Shroka, Irina Kufareva, Catherina L. Salanga, Tracy M. Handel The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms Science Signaling 1/31/2023 [PMID: 36719944]
Elena Masselli, Cecilia Carubbi, Giulia Pozzi, Antonio Percesepe, Rita Campanelli, Laura Villani et al. Impact of the rs1024611 Polymorphism of CCL2 on the Pathophysiology and Outcome of Primary Myelofibrosis Cancers (Basel) 5/22/2021 [PMID: 34067466]
KA Krychtiuk, M Lenz, B Richter, PJ Hohensinne, SP Kastl, A Mangold, K Huber, C Hengstenbe, J Wojta, G Heinz, WS Speidl Monocyte subsets predict mortality after cardiac arrest J Leukoc Biol, 2020-10-05;0(0):. 2020-10-05 [PMID: 33020969] (Flow Cytometry, Human)	Flow Cytometry	Human
S Sbrana, J Campolo, A Clemente, L Bastiani, A Cecchettin, E Ceccherini, C Caselli, D Neglia, O Parodi, D Chiappino, JM Smit, AJ Scholte, G Pelosi, S Rocchiccio Blood Monocyte Phenotype Fingerprint of Stable Coronary Artery Disease: A Cross-Sectional Substudy of SMARTool Clinical Trial Biomed Res Int, 2020-07-27;2020(0):8748934. 2020-07-27 [PMID: 32802883] (Flow Cytometry, Human)	Flow Cytometry	Human
Martin J. Scott, Amanda Jowett, Martin Orecchia, Peter Ertl, Larissa Ouro-Gnao, Julia Ticehurst et al. Rapid identification of highly potent human anti-GPCR antagonist monoclonal antibodies mAbs 4/29/2020 [PMID: 32343620]
J Cantero-Pé, J Grau-Expós, C Serra-Pein, DA Rosero, L Luque-Ball, A Astorga-Ga, J Castellví, T Sanhueza, G Tapia, B Lloveras, MA Fernández, JG Prado, JM Solé-Seden, A Tarrats, C Lecumberri, L Mañalich-B, C Centeno-Me, V Falcó, MJ Buzon, M Genescà Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa Nat Commun, 2019-10-18;10(1):4739. 2019-10-18 [PMID: 31628331] (Flow Cytometry, Human)	Flow Cytometry	Human
Siew-Min Ong, Karen Teng, Evan Newell, Hao Chen, Jinmiao Chen, Thomas Loy et al. A Novel, Five-Marker Alternative to CD16–CD14 Gating to Identify the Three Human Monocyte Subsets Frontiers in Immunology 7/26/2019 [PMID: 31402918]
M Yao, W Fang, C Smart, Q Hu, S Huang, N Alvarez, P Fields, N Cheng CCR2 chemokine receptors enhance growth and cell cycle progression of breast cancer cells through SRC and PKC activation Mol. Cancer Res., 2018-11-16;0(0):. 11/16/2018 [PMID: 30446625]
E Armas-Gonz, MJ Domínguez-, A Díaz-Martí, M Arce-Franc, J Castro-Her, G Danelon, V Hernández-, S Bustabad-R, A Cantabrana, M Uguccioni, F Díaz-Gonzá Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis Arthritis Res. Ther., 2018-06-07;20(1):114. 2018-06-07 [PMID: 29880013] (Flow Cytometry, Human)	Flow Cytometry	Human
Karoline Walscheid Phenotypic changes of peripheral blood mononuclear cells upon corticosteroid treatment in idiopathic intermediate uveitis Clin. Immunol, 2016-10-28;0(0):. 2016-10-28 [PMID: 27989897] (Flow Cytometry, Human)	Flow Cytometry	Human
Extensive Characterization and Comparison of Endothelial Cells Derived from Dermis and Adipose Tissue: Potential Use in Tissue Engineering PLoS ONE, 2016-11-30;11(11):e0167056. 2016-11-30 [PMID: 27902740] (Flow Cytometry, Human)	Flow Cytometry	Human
Downregulation of Blood Monocyte HLA-DR in ICU Patients Is Also Present in Bone Marrow Cells PLoS ONE, 2016-11-28;11(11):e0164489. 2016-11-28 [PMID: 27893741] (Flow Cytometry, Human)	Flow Cytometry	Human
Lau G, Labrecque J, Metz M, Vaz R, Fricker S Specificity for a CCR5 Inhibitor Is Conferred by a Single Amino Acid Residue: ROLE OF ILE198. J Biol Chem, 2015-03-12;290(17):11041-51. 2015-03-12 [PMID: 25767113] (Flow Cytometry, Human)	Flow Cytometry	Human
Carvallo L, Lopez L, Che F, Lim J, Eugenin E, Williams D, Nieves E, Calderon T, Madrid-Aliste C, Fiser A, Weiss L, Angeletti R, Berman J Buprenorphine decreases the CCL2-mediated chemotactic response of monocytes. J Immunol, 2015-02-25;194(7):3246-58. 2015-02-25 [PMID: 25716997] (Flow Cytometry, Human)	Flow Cytometry	Human
Falk M, Singh A, Faber C, Nissen M, Hviid T, Sorensen T CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine/Chemokine Receptor Complex in Patients with AMD. PLoS ONE, 2014-12-15;9(12):e112473. 2014-12-15 [PMID: 25503251] (Flow Cytometry, Human)	Flow Cytometry	Human
Bednar F, Song C, Bardi G, Cornwell W, Rogers T Cross-desensitization of CCR1, but not CCR2, following activation of the formyl peptide receptor FPR1. J Immunol, 2014-04-28;192(11):5305-13. 2014-04-28 [PMID: 24778447] (Flow Cytometry, Human)	Flow Cytometry	Human
Morandi , Fabio, Di Carlo , Emma, Ferrone , Soldano, Petretto , Andrea, Pistoia , Vito, Airoldi , Irma IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation. J Immunol, 2014-02-19;192(6):2634-42. 2014-02-19 [PMID: 24554774] (Flow Cytometry, Human)	Flow Cytometry	Human
Chiara Vasco, Alessandra Canazza, Ambra Rizzo, Adele Mossa, Elena Corsini, Antonio Silvani et al. Circulating T regulatory cells migration and phenotype in glioblastoma patients: an in vitro study Journal of Neuro-Oncology 12/1/2013 [PMID: 24005771]
Kenneth Ky Liu, Katerina Dorovini-Zis Differential Regulation of CD4+ T Cell Adhesion to Cerebral Microvascular Endothelium by the beta -Chemokines CCL2 and CCL3 International Journal of Molecular Sciences 11/30/2012 [PMID: 23203188]
Ebtisam Al-ofi, Seth B. Coffelt, Dilly O. Anumba Monocyte Subpopulations from Pre-Eclamptic Patients Are Abnormally Skewed and Exhibit Exaggerated Responses to Toll-Like Receptor Ligands PLoS ONE 7/27/2012 [PMID: 22848746]
Vujanovic , Lazar, Ballard , Wenners, Thorne , Stephen, Vujanovic , Nikola L, Butterfield , Lisa H Adenovirus-engineered human dendritic cells induce natural killer cell chemotaxis via CXCL8/IL-8 and CXCL10/IP-10. Oncoimmunology, 2012-07-01;1(4):448-457. 2012-07-01 [PMID: 22754763] (Flow Cytometry, Human)	Flow Cytometry	Human
Badr G, Lefevre EA, Mohany M Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis. PLoS ONE, 2011-09-01;6(9):e23741. 2011-09-01 [PMID: 21912642] (Flow Cytometry, Human)	Flow Cytometry	Human
Craddock J, Lu A, Bear A, Pule M, Brenner M, Rooney C, Foster A Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b. J Immunother, 2010-10-01;33(8):780-8. 2010-10-01 [PMID: 20842059] (CAR-T (Flow Cytometry), Human)	CAR-T (Flow Cytometry)	Human
Rohrl J, Yang D, Oppenheim JJ, Hehlgans T Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2. J. Immunol., 2010-05-17;184(12):6688-94. 2010-05-17 [PMID: 20483750] (Flow Cytometry, Human)	Flow Cytometry	Human
Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. J. Immunol., 2010-02-17;184(6):2886-98. 2010-02-17 [PMID: 20164417] (Flow Cytometry, Human)	Flow Cytometry	Human
Erik Fung, Laura Esposito, John A. Todd, Linda S. Wicker Multiplexed immunophenotyping of human antigen-presenting cells in whole blood by polychromatic flow cytometry Nature Protocols 2/6/2010 [PMID: 20134434]
Carbone T, Nasorri F, Pennino D CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses. J. Immunol., 2009-12-11;184(2):1102-10. 2009-12-11 [PMID: 20008290] (Flow Cytometry, Human)	Flow Cytometry	Human
Tsujioka H, Imanishi T, Ikejima H, Kuroi A, Takarada S, Tanimoto T, Kitabata H, Okochi K, Arita Y, Ishibashi K, Komukai K, Kataiwa H, Nakamura N, Hirata K, Tanaka A, Akasaka T Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction. J. Am. Coll. Cardiol., 2009-07-07;54(2):130-8. 2009-07-07 [PMID: 19573729] (Flow Cytometry, Human)	Flow Cytometry	Human
Barroso-Gonzalez J, El Jaber-Vazdekis N, Garcia-Exposito L, Machado JD, Zarate R, Ravelo AG, Estevez-Braun A, Valenzuela-Fernandez A The Lupane-type Triterpene 30-Oxo-calenduladiol Is a CCR5 Antagonist with Anti-HIV-1 and Anti-chemotactic Activities. J. Biol. Chem., 2009-04-22;284(24):16609-20. 2009-04-22 [PMID: 19386595] (Flow Cytometry, Human)	Flow Cytometry	Human
Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J. Immunol., 2008-12-01;181(11):8053-67. 2008-12-01 [PMID: 19017998] (Flow Cytometry, Human)	Flow Cytometry	Human
Ling B, Veazey RS, Marx PA Nonpathogenic CCR2-tropic SIVrcm after serial passage and its effect on SIVmac infection of Indian rhesus macaques. Virology, 2008-07-26;379(1):38-44. 2008-07-26 [PMID: 18662820] (Flow Cytometry, Primate - Macaca mulatta (Rhesus Macaque))	Flow Cytometry	Primate - Macaca mulatta (Rhesus Macaque)
Montecucco F, Steffens S, Burger F, Pelli G, Monaco C, Mach F C-reactive protein (CRP) induces chemokine secretion via CD11b/ICAM-1 interaction in human adherent monocytes. J. Leukoc. Biol., 2008-06-30;84(4):1109-19. 2008-06-30 [PMID: 18591415] (Flow Cytometry, Human)	Flow Cytometry	Human
Maru SV, Holloway KA, Flynn G, Lancashire CL, Loughlin AJ, Male DK, Romero IA Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation. J. Neuroimmunol., 2008-06-09;199(1):35-45. 2008-06-09 [PMID: 18538864] (Flow Cytometry, Human)	Flow Cytometry	Human
Pokkali S, Das SD, R L Expression of CXC and CC type of chemokines and its receptors in tuberculous and non-tuberculous effusions. Cytokine, 2008-01-28;41(3):307-14. 2008-01-28 [PMID: 18226915] (Flow Cytometry, Human)	Flow Cytometry	Human
Freeman CM, Curtis JL, Chensue SW CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity. Am. J. Pathol., 2007-07-19;171(3):767-76. 2007-07-19 [PMID: 17640964] (Flow Cytometry, Human)	Flow Cytometry	Human
Dhillon NK, Pinson D, Dhillon S, Tawfik O, Danley M, Davis M, Nemon O, Mayo M, Kumar A, Tsai YJ, Kumar A, Buch S Bleomycin treatment causes enhancement of virus replication in the lungs of SHIV-infected macaques. Am. J. Physiol. Lung Cell Mol. Physiol., 2007-01-12;292(5):L1233-40. 2007-01-12 [PMID: 17220371] (Flow Cytometry, Primate - Macaca mulatta (Rhesus Macaque))	Flow Cytometry	Primate - Macaca mulatta (Rhesus Macaque)
Bestebroer J, Poppelier MJ, Ulfman LH, Lenting PJ, Denis CV, van Kessel KP, van Strijp JA, de Haas CJ Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling. Blood, 2007-04-01;109(7):2936-43. 2007-04-01 [PMID: 17132726] (Flow Cytometry, Human)	Flow Cytometry	Human
Muller A, Sonkoly E, Eulert C, Gerber PA, Kubitza R, Schirlau K, Franken-Kunkel P, Poremba C, Snyderman C, Klotz LO, Ruzicka T, Bier H, Zlotnik A, Whiteside TL, Homey B, Hoffmann TK Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy. Int. J. Cancer, 2006-05-01;118(9):2147-57. 2006-05-01 [PMID: 16331601] (Flow Cytometry, Human)	Flow Cytometry	Human
Gessler P, Pretre R, Hohl V, Rousson V, Fischer J, Dahinden C CXC-chemokine stimulation of neutrophils correlates with plasma levels of myeloperoxidase and lactoferrin and contributes to clinical outcome after pediatric cardiac surgery. Shock, 2004-12-01;22(6):513-20. 2004-12-01 [PMID: 15545821] (Flow Cytometry, Human)	Flow Cytometry	Human
Piovan E, Tosello V, Indraccolo S, Cabrelle A, Baesso I, Trentin L, Zamarchi R, Tamamura H, Fujii N, Semenzato G, Chieco-Bianchi L, Amadori A Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation. Blood, 2004-09-28;105(3):931-9. 2004-09-28 [PMID: 15454484] (Flow Cytometry, Human)	Flow Cytometry	Human
Casazza S, Zappia E, Pistorio A, Gambini C Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis. Proc. Natl. Acad. Sci. U.S.A., 2004-07-19;101(30):11064-9. 2004-07-19 [PMID: 15263096] (Flow Cytometry, Human)	Flow Cytometry	Human
Liu LY, Jarjour NN, Busse WW, Kelly EA Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge. J. Allergy Clin. Immunol., 2003-09-01;112(3):556-62. 2003-09-01 [PMID: 13679815] (Flow Cytometry, Human)	Flow Cytometry	Human
Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS. J. Leukoc. Biol., 2003-05-01;73(5):584-90. 2003-05-01 [PMID: 12714572] (Flow Cytometry, Human)	Flow Cytometry	Human
Vanbervliet B, Homey B, Durand I, Massacrier C, Ait-Yahia S, de Bouteiller O, Vicari A, Caux C Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: possible role at inflamed epithelial surfaces. Eur J Immunol, 2002-01-01;32(1):231-42. 2002-01-01 [PMID: 11782014] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 44 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	Flow	Human	01/21/2015	View Summary Application Flow Cytometry Sample Tested See PMID: 24005868 Species Human
	4 reviewed by: Verified Customer	Flow	Human	01/21/2015	View Summary Application Flow Cytometry Sample Tested See PMID: 24005771 Species Human
	5 reviewed by: Verified Customer	Flow	Human	01/21/2015	View Summary Application Flow Cytometry Sample Tested See PMID: 24005868 Species Human
	4 reviewed by: Verified Customer	Flow	Human	01/21/2015	View Summary Application Flow Cytometry Sample Tested See PMID: 24005771 Species Human

Array FAB151P

• CCR2 Antibodies
• CCR2 ELISA Kit
• CCR2 Lysates
• CCR2 Proteins