CX3CR1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CX3CR1 (CX₃C chemokine receptor 1; also fractalkine receptor, GPCR13 and V28) is a 40 kDa (predicted) member of the δ-group of rhodopsin GPCRs. It is expressed on astrocytes, microglia, macrophages, Th1 and Tc1 T cells, NK cells, mouse Gr1^lo monocytes plus smooth muscle and mast cells. CX₃CR1 mediates adhesion to fractalkine, promotes avid binding of integrins to their ligands, and extends the life of monocytes. Mouse CX3CR1 is a 7-transmembrane protein that is 354 amino acids (aa) in length. It contains a 32 aa N-terminal extracellular region that shows no glycosylation, and a 56 aa C-terminal cytoplasmic domain. Over aa 1‑32, 91‑104, 169‑196 and 258‑274 collectively, mouse CX₃CR1 shares 96% and 77% aa identity with rat and human CX₃CR1, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 8 applications: Flow Cytometry, ICC, IHC, IHC-Fr, Immunocytochemistry, Immunohistochemistry, In Vivo, Western Blot.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using AF5825	Applications	Species
Evans, LMP;Gawron, J;Sim, FJ;Laura Feltri, M;Marziali, LN; Human iPSC-derived myelinating organoids and globoid cells to study Krabbe Disease bioRxiv : the preprint server for biology 2024-07-23 [PMID: 39091729] (Immunohistochemistry, Immunocytochemistry, Human)	Immunohistochemistry, Immunocytochemistry	Human
Long, J;Liu, H;Qiu, Z;Xiao, Z;Lu, Z; Glabridin Therapy Reduces Chronic Allodynia, Spinal Microgliosis, and Dendritic Spine Generation by Inhibiting Fractalkine-CX3CR1 Signaling in a Mouse Model of Tibial Fractures Brain sciences 2023-04-29 [PMID: 37239211] (In Vivo, Mouse)	In Vivo	Mouse
Chia‐Yu Wu, Pei‐Wen Peng, Ting‐Yi Renn, Chia‐Jung Lee, Tsung‐Ming Chang, Augusta I‐Chin Wei et al. CX3CL1 induces cell migration and invasion through ICAM‐1 expression in oral squamous cell carcinoma cells Journal of Cellular and Molecular Medicine 2023-06-01 [PMID: 37082943]
Kurt Brassington, Peter Kanellakis, Anh Cao, Ban-Hock Toh, Karlheinz Peter, Alex Bobik et al. Crosstalk between cytotoxic CD8+ T cells and stressed cardiomyocytes triggers development of interstitial cardiac fibrosis in hypertensive mouse hearts Frontiers in Immunology 2022-11-22 [PMID: 36483558]
Jingjing Zhang, Yufei Liu, Xinyao Liu, Song Li, Cheng Cheng, Sheng Chen et al. Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model Translational Neurodegeneration 2018-12-21 [PMID: 30607245]
T Tsubaki, T Kadonosono, S Sakurai, T Shiozawa, T Goto, S Sakai, T Kuchimaru, T Sakamoto, H Watanabe, G Kondoh, S Kizaka-Kon Novel adherent CD11b+Gr-1+tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment Oncotarget, 2018-01-29;9(13):11209-11226. 2018-01-29 [PMID: 29541408] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
KH Han, BM Arlian, MS Macauley, JC Paulson, RA Lerner Migration-based selections of antibodies that convert bone marrow into trafficking microglia-like cells that reduce brain amyloid ? Proc. Natl. Acad. Sci. U.S.A., 2018-01-02;0(0):. 2018-01-02 [PMID: 29295920] (IHC, Mouse)	IHC	Mouse
T Yano, M Ohira, R Nakano, Y Tanaka, H Ohdan Hepatectomy leads to loss of TRAIL-expressing liver NK cells via downregulation of the CXCL9-CXCR3 axis in mice PLoS ONE, 2017-10-31;12(10):e0186997. 2017-10-31 [PMID: 29088306] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
K Mussar, S Pardike, TM Hohl, G Hardiman, V Cirulli, L Crisa A CCR2+ myeloid cell niche required for pancreatic ? cell growth JCI Insight, 2017-08-03;2(15):. 2017-08-03 [PMID: 28768911] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
R Saika, H Sakuma, D Noto, S Yamaguchi, T Yamamura, S Miyake MicroRNA-101a regulates microglial morphology and inflammation J Neuroinflammation, 2017-05-30;14(1):109. 2017-05-30 [PMID: 28558818] (ICC, Mouse)	ICC	Mouse
Selective suppression of the ? isoform of p38 MAPK rescues late-stage tau pathology Alzheimers Res Ther, 2016-12-15;8(1):54. 2016-12-15 [PMID: 27974048] (IHC-Fr, Mouse)	IHC-Fr	Mouse
MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice J Am Heart Assoc, 2016-09-15;5(9):. 2016-09-15 [PMID: 27633389] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Kowalewska P, Patrick A, Fox-Robichaud A Syndecan-1 in the mouse parietal peritoneum microcirculation in inflammation. PLoS ONE, 2014-09-03;9(9):e104537. 2014-09-03 [PMID: 25184228] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Wen-Hui Tsai, Chung-Hung Shih, Shan-Yu Feng, I-Ting Li, Shao-Chi Chang, Yu-Chieh Lin et al. CX3CL1(+) Microparticles Mediate the Chemoattraction of Alveolar Macrophages toward Apoptotic Acute Promyelocytic Leukemic Cells Cellular Physiology and Biochemistry 2014-01-20 [PMID: 24603149]
Soehnlein Oliver, Drechsler Maik, Doring Yvonne et al. Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes. EMBO Mol Med. 3/1/2013 [PMID: 23417922]
Shah R, Hinkle CC, Ferguson JF, Mehta NN, Li M, Qu L, Lu Y, Putt ME, Ahima RS, Reilly MP Fractalkine is a novel human adipochemokine associated with type 2 diabetes. Diabetes, 2011-05-01;60(5):1512-8. 2011-05-01 [PMID: 21525510] (Western Blot, Human)	Western Blot	Human
Show All 16 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	WB	Human	01/08/2015	View Summary Application Western Blot Sample Tested See PMID 21888931 Species Human

Array AF5825

• CX3CR1 Antibodies
• CX3CR1 ELISA Kits
• CX3CR1 Proteins