CCR2 Antibody (48607) [PerCP (Peridinin-chlorophyll Protein Complex)]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCR2 is a G-protein linked seven transmembrane domain spanning chemokine receptor that preferentially binds monocyte chemoattractant proteins-1 and -3 (MCP-1 and MCP-3). Two isoforms of this receptor (CCR2A and CCR2B) are expressed on cell surfaces as a result of alternate splicing from the same gene. These two CCR2 variants differ only at their intracellular carboxyl terminals, with the CCR2A form possessing 14 additional amino acids. This may provide a mechanism by which cells responding to similar extracellular ligands can activate different intracellular second messengers. Cells that respond to the action of MCP-1 and therefore are likely to express CCR2 receptors, include monocytes, T cells, NK cells, basophils, mast cells and dendritic cells. A recent report suggests that B cells may also express CCR2 receptors. The recognition that a variety of chemokine receptors, including CCR2, can serve as HIV fusion co-factors and as facilitators of T cell recruitment during inflammation makes chemokine receptor monitoring an important exercise in elucidating the HIV infection process and the regulation of inflammatory reactions.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 4 of 4.

Publications using FAB151C	Applications	Species
S Sureshchan, C Stull, BJK Ligh, SB Nguyen, KA Grant, I Messaoudi Chronic heavy drinking drives distinct transcriptional and epigenetic changes in splenic macrophages EBioMedicine, 2019-04-18;0(0):. 2019-04-18 [PMID: 31005514] (Flow Cytometry, Human)	Flow Cytometry	Human
Rita Campanelli Tie2 Expressing Monocytes in the Spleen of Patients with Primary Myelofibrosis PLoS ONE, 2016-06-09;11(6):e0156990. 2016-06-09 [PMID: 27281335] (Flow Cytometry, Human)	Flow Cytometry	Human
Falk M, Singh A, Faber C, Nissen M, Hviid T, Sorensen T CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine/Chemokine Receptor Complex in Patients with AMD. PLoS ONE, 2014-12-15;9(12):e112473. 2014-12-15 [PMID: 25503251] (Flow Cytometry, Human)	Flow Cytometry	Human
Miles , Brodie, Zakhary , Ibrahim, El-Awady , Ahmed, Scisci , Elizabet, Carrion , Julio, O'Neill , John C, Rawlings , Aaron, Stern , J Kobi, Susin , Cristian, Cutler , Christop Secondary lymphoid organ homing phenotype of human myeloid dendritic cells disrupted by an intracellular oral pathogen. Infect Immun, 2013-10-14;82(1):101-11. 2013-10-14 [PMID: 24126519] (Flow Cytometry, Human)	Flow Cytometry	Human

Array FAB151C

• CCR2 Antibodies
• CCR2 ELISA Kit
• CCR2 Lysates
• CCR2 Proteins