CD46 Antibody (344519)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD46, also known as MCP, is a type I membrane protein that functions as a cofactor for Complement Factor I-mediated inactivation of complement components C3b and C4b. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. The extracellular region of CD46 contains four tandem Sushi domains. At least fourteen transcript variants encode isoforms with deletions or substitutions following the fourth Sushi domain. Within corresponding regions, human CD46 shares 50% amino acid sequence identity with mouse and rat CD46.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Functional Assay, ICC, Western Blot.

Showing Publications 1 - 3 of 3.

Publications using MAB2005	Applications	Species
U Ellinghaus, A Cortini, CL Pinder, GL Friec, C Kemper, TJ Vyse Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus Eur. J. Immunol., 2017-05-22;0(0):. 2017-05-22 [PMID: 28444759] (Functional Assay, Human)	Functional Assay	Human
Johnson J, Borisevich V, Rockx B, Parks G A novel factor I activity in Nipah virus inhibits human complement pathways through cleavage of C3b. J Virol, 2014-10-29;89(2):989-98. 2014-10-29 [PMID: 25355897] (Western Blot, Human)	Western Blot	Human
Johnson JB, Grant K, Parks GD The paramyxoviruses simian virus 5 and mumps virus recruit host cell CD46 to evade complement-mediated neutralization. J. Virol., 2009-05-20;83(15):7602-11. 2009-05-20 [PMID: 19457998] (ICC, Human)	ICC	Human

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	IF	Human	02/16/2015	View Summary Application Immunofluorescence Sample Tested See PMID 24163703 Species Human

Array MAB2005

• CD46 Antibodies
• CD46 Proteins
• CD46 Proteins and Enzymes