Carm1 Antibody - BSA Free

Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. PRMT4 belongs to a family of proteins that catalyzes the methylation of arginine residues. The PRMT proteins are recruited by C-terminal activation domain 2 of the SRC (steroid receptor coactivator) GRIP1, whereas p300 interacts with activation domain 1 in the C terminus. CARM1 can methylate histone H3 in vitro, and a mutation in the putative S-adenosylmethionine binding domain of CARM1 substantially reduces both methyltransferase and coactivator activities suggesting that coactivator mediated methylation of proteins in the transcription machinery may contribute to transcriptional regulation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 8 of 8.

Publications using NB200-342	Applications	Species
Feng D, Gao J, Liu R et al. CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A Protein & Cell 2024-10-01 [PMID: 38476024]
Li S, Cheng D et al. The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3 beta/beta-Catenin/cyclinD1 Signaling Pathway. Int J Biol Sci 2017-09-20 [PMID: 28924379] (WB, Human)	WB	Human
Li S, Cheng D, Zhu B, Yang Q. The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3B/B-Catenin/cyclinD1 Signaling Pathway Int J Mol Sci. 2017-07-18 [PMID: 27455247] (Human)		Human
Ljubicic V, Khogali S, Renaud JM et al. Chronic AMPK stimulation attenuates adaptive signaling in dystrophic skeletal muscle. Am J Physiol Cell Physiol 2012-01-01 [PMID: 21940670]
Hubers L, Valderrama-Carvajal H, Laframboise J et al. HuD interacts with survival motor neuron protein and can rescue spinal muscular atrophy-like neuronal defects. Hum Mol Genet 2011-02-01 [PMID: 21088113]
Carascossa S, Dudek P, Cenni B et al. CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen receptor alpha by cAMP. Genes Dev 2010-04-01 [PMID: 20360387]
Harrison MJ, Tang YH, Dowhan DH et al. Protein arginine methyltransferase 6 regulates multiple aspects of gene expression. Nucleic Acids Res 2010-04-01 [PMID: 20047962]
Dacwag CS, Bedford MT, Sif S et al. Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. Mol Cell Biol 2009-04-01 [PMID: 19188441]

Array NB200-342

• Carm1 Antibodies
• Carm1 Lysate
• Carm1 Proteins