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Tyk2 Antibody (307214) [Unconjugated]

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Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line and K562 human chronic myelogenous leukemia cell line. PVDF membrane was probed with 1 µg/mL of Human Tyk2 Monoclonal Antibody (Catalog # MAB3427) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for Tyk2 at approximately 130 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 3.
Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line and K562 human chronic myelogenous leukemia cell line. PVDF membrane was probed with 1 µg/mL of Human Tyk2 Monoclonal Antibody (Catalog # ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
307214
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB3427-SP
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Tyk2 Antibody (307214) [Unconjugated] Summary

Immunogen
E. coli-derived recombinant human Tyk2
Pro2-Leu51
Accession # P29597
Specificity
Detects human Tyk2 in Western blots.
Source
N/A
Isotype
IgG3
Clonality
Monoclonal
Host
Mouse
Gene
TYK2
Purity Statement
Protein A or G purified from hybridoma culture supernatant
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Reviewed Applications
Read 1 Review rated 5
using
MAB3427 in the following application:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in TBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Tyk2 Antibody (307214) [Unconjugated]

  • EC 2.7.10
  • EC 2.7.10.2
  • JTK1
  • non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • tyrosine kinase 2

Background

Tyk2 belongs to the Janus family of intracellular tyrosine kinases that are activated by receptors for many cytokines. Activation of Tyk2 occurs via phosphorylation at two adjacent tyrosine residues, Y1054 and Y1055, within the kinase domain. Tyk2 is required for interferon beta -mediated tyrosine phosphorylation of STAT3 and interferon receptor 1. Mice lacking Tyk2 are susceptible to parasitic infection but resistant to autoimmune arthritis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Tyk2 Antibody (MAB3427) (0)

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Review for Tyk2 Antibody (MAB3427) (1) 51

Average Rating: 5
(Based on 1 review)
We have 1 review tested in 1 species: Human.

Reviews using MAB3427:
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(1)
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Images Ratings Applications Species Date Details
Western Blot Tyk2 MAB3427
Enlarge 		5
reviewed by:
Verified Customer
 WB Human 04/04/2020
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Summary

ApplicationWestern Blot
Sample TestedHuman breast cancer cell line SKBR3 and Positive control
SpeciesHuman
LotXNV031603A

Product General Protocols

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FAQs for Tyk2 Antibody (MAB3427) (0)

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Secondary Antibodies

 

Isotype Controls

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Recent Reviews

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Western Blot Tyk2 MAB3427
Enlarge
 Verified Customer
04/04/2020
Application: WB
Species: Human
read this review

Bioinformatics

Gene Symbol TYK2
Uniprot