Jak2 Antibody (53B7) - BSA Free

Jak2 is a member of the Janus family tyrosine kinases (Jaks), whose function is to transduce extracellular signals from cytokines and interferons. Jaks associate with cytokine receptors; upon ligand binding, Jaks phosphorylate the receptor. The phosphorylated receptors are bound by SH2-containing proteins, one class of which is the signal transducers and activators of transcription (STATs). Activated STATs, then, translocate to the nucleus to mediate gene transcription (1,2). Tyr1007/1008 of Jak2 are the homologous Tyr1054/1055 in Tyk2, and phosphorylation at these residues is needed for Tyk2 activation (3). A chromosomal aberration involving Jak2 is found in a form of pre-B acute myeloid leukemia (4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NBP2-59451	Applications	Species
Ng ASN, Zhang S, Mak VCY et al. AKTIP loss is enriched in ER alpha -positive breast cancer for tumorigenesis and confers endocrine resistance Cell reports 2022-12-13 [PMID: 36516775] (WB, Human)	WB	Human
Futoon Abedrabbu Al-Rawashde, Abdullah Saleh Al-wajeeh, Mansoureh Nazari Vishkaei, Hanan Kamel M. Saad, Muhammad Farid Johan, Wan Rohani Wan Taib et al. Thymoquinone Inhibits JAK/STAT and PI3K/Akt/ mTOR Signaling Pathways in MV4-11 and K562 Myeloid Leukemia Cells Pharmaceuticals (Basel) 2022-09-08 [PMID: 36145344]
Al-Rawashde FA, Wan Taib WR, Ismail I et al. Thymoquinone Induces Downregulation of BCR-ABL/JAK/STAT Pathway and Apoptosis in K562 Leukemia Cells Asian Pacific journal of cancer prevention : APJCP 2021-12-01 [PMID: 34967577] (WB, Human)	WB	Human

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Human	12/06/2021	View Summary Application Western Blot Sample Tested TF-1 human erythroleukemic cell line Species Human Lot 53B7
Enlarge	5 reviewed by: Verified Customer	MiAr	Human	12/07/2020	View Summary Application Microarray Sample Tested EDTA Plasma Species Human Lot A1643501
Enlarge	5 reviewed by: Jie Lan	WB	Human	12/02/2018	View Summary Application Western Blot Sample Tested MCF7 cell line Species Human Lot A1

Array NBP2-59451

• Jak2 Antibodies
• Jak2 Proteins