Name: STAT5a/b Antibody [Unconjugated] - Pan Specific
Brand: Novus Biologicals
SKU: AF2168
Price: 399 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, MuSpecies Glossary
Applications	WB, Simple Western, ChIP
Clonality	Polyclonal
Host	Rabbit
Conjugate	Unconjugated
Concentration	LYOPH

Immunogen	Human STAT5a and STAT5b synthetic peptide aa 219-390
Specificity	Detects endogenous human and mouse STAT5A and STAT5B in Western blots.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Rabbit
Gene	STAT5A
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Publications using AF2168	Applications	Species
Li H, Chumroenphat T, Boonarsa P et al. Evaluation of Roasting and Grilling Effects on Chemical Composition, Volatile Profiles, and Toxicity of Stink Bugs (Tessaratoma papillosa): Implications for Utilization as Functional Food Ingredients Foods (Basel, Switzerland) 2023-08-15 [PMID: 37628053] Details: Tessaratoma papillosa
Basu, R;Brody, R;Sandbhor, U;Kulkarni, P;Davis, E;Swegan, D;Caggiano, LJ;Brenya, E;Neggers, S;Kopchick, JJ; Structure and function of a dual antagonist of the human growth hormone and prolactin receptors with site-specific PEG conjugates The Journal of biological chemistry 2023-07-11 [PMID: 37442239] (Western Blot, Human)	Western Blot	Human
KA Read, DM Jones, S Pokhrel, EDS Hales, A Varkey, JA Tuazon, CD Eisele, O Abdouni, A Saadey, MR Leonard, RT Warren, MD Powell, JM Boss, EA Hemann, JS Yount, G Xin, HE Ghoneim, CJ Lio, AG Freud, PL Collins, KJ Oestreich Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity Nature Communications, 2023-03-24;14(1):1652. 2023-03-24 [PMID: 36964178] (ChIP, Mouse)	ChIP	Mouse
Duy Pham, Daniel J Silberger, Kim N Nguyen, Min Gao, Casey T Weaver, Robin D Hatton Batf stabilizes Th17 cell development via impaired Stat5 recruitment of Ets1‐Runx1 complexes The EMBO Journal 2023-04-17 [PMID: 36917143]
Futoon Abedrabbu Al-Rawashde, Abdullah Saleh Al-wajeeh, Mansoureh Nazari Vishkaei, Hanan Kamel M. Saad, Muhammad Farid Johan, Wan Rohani Wan Taib et al. Thymoquinone Inhibits JAK/STAT and PI3K/Akt/ mTOR Signaling Pathways in MV4-11 and K562 Myeloid Leukemia Cells Pharmaceuticals (Basel) 2022-09-08 [PMID: 36145344]
Al-Rawashde FA, Wan Taib WR, Ismail I et al. Thymoquinone Induces Downregulation of BCR-ABL/JAK/STAT Pathway and Apoptosis in K562 Leukemia Cells Asian Pacific journal of cancer prevention : APJCP 12/1/2021 [PMID: 34967577]
Angel Lin, Weam Othman Elbezanti, Alexis Schirling, Adel Ahmed, Rachel Van Duyne, Simon Cocklin et al. Alprazolam Prompts HIV-1 Transcriptional Reactivation and Enhances CTL Response Through RUNX1 Inhibition and STAT5 Activation Frontiers in Neurology 2021-07-22 [PMID: 34367046]
Xiaojing Yue, Daniela Samaniego‐Castruita, Edahí González‐Avalos, Xiang Li, Benjamin G Barwick, Anjana Rao Whole‐genome analysis of TET dioxygenase function in regulatory T cells EMBO reports 2021-08-04 [PMID: 34288360]
GM Wiedemann, EK Santosa, S Grassmann, S Sheppard, JB Le Luduec, NM Adams, C Dang, KC Hsu, JC Sun, CM Lau Deconvoluting global cytokine signaling networks in natural killer cells Nature Immunology, 2021-04-15;0(0):. 2021-04-15 [PMID: 33859404] (ChIP, Mouse)	ChIP	Mouse
AM Schoepf, S Salcher, P Obexer, R Gust Tackling resistance in chronic myeloid leukemia: Novel cell death modulators with improved efficacy European Journal of Medicinal Chemistry, 2021-02-18;216(0):113285. 2021-02-18 [PMID: 33662676] (Western Blot, Human)	Western Blot	Human
GM Wiedemann, S Grassmann, CM Lau, M Rapp, AV Villarino, C Friedrich, G Gasteiger, JJ O'Shea, JC Sun Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells Cell Reports, 2020-12-15;33(11):108498. 2020-12-15 [PMID: 33326784] (ChIP, Flow Cytometry, Mouse)	ChIP, Flow Cytometry	Mouse
B Heizmann, S Le Gras, C Simand, P Marchal, S Chan, P Kastner Ikaros antagonizes DNA binding by STAT5 in pre-B cells PLoS ONE, 2020-11-12;15(11):e0242211. 2020-11-12 [PMID: 33180866] (ChIP, Mouse)	ChIP	Mouse
Yin Xiao, Musga Qureischi, Lena Dietz, Martin Vaeth, Subrahmanya D. Vallabhapurapu, Stefan Klein-Hessling et al. Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity Journal of Experimental Medicine 2021-01-04 [PMID: 32986812]
W Elbezanti, A Lin, A Schirling, A Jackson, M Marshall, RV Duyne, F Maldarelli, L Sardo, Z Klase Benzodiazepines Drive Alteration of Chromatin at the Integrated HIV-1 LTR Viruses, 2020-02-09;12(2):. 2020-02-09 [PMID: 32050449] (Neutralization, Human)	Neutralization	Human
SH Yip, N Romanò, P Gustafson, DJ Hodson, EJ Williams, IC Kokay, AO Martin, P Mollard, DR Grattan, SJ Bunn Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons Cell Rep, 2019-02-12;26(7):1787-1799.e5. 2019-02-12 [PMID: 30759390] (Western Blot, Mouse)	Western Blot	Mouse
Walter K. Mowel, Sam J. McCright, Jonathan J. Kotzin, Magalie A. Collet, Asli Uyar, Xin Chen et al. Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA Immunity 2017-09-01 [PMID: 28930659]
SS Ganaie, W Zou, P Xu, X Deng, S Kleiboeker, J Qiu Phosphorylated STAT5 directly facilitates parvovirus B19 DNA replication in human erythroid progenitors through interaction with the MCM complex PLoS Pathog., 2017-05-01;13(5):e1006370. 2017-05-01 [PMID: 28459842] (Western Blot, Human)	Western Blot	Human
L Mokada-Gop, A Boeser, CH Lehmann, F Drepper, D Dudziak, B Warscheid, D Voehringer Identification of Novel STAT6-Regulated Proteins in Mouse B Cells by Comparative Transcriptome and Proteome Analysis J. Immunol, 2017-03-27;0(0):. 2017-03-27 [PMID: 28348271] (Western Blot, Mouse)	Western Blot	Mouse
Wagatsuma K, Tani-ichi S, Liang B, Shitara S, Ishihara K, Abe M, Miyachi H, Kitano S, Hara T, Nanno M, Ishikawa H, Sakimura K, Nakao M, Kimura H, Ikuta K STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRgamma Locus. J Immunol, 2015-07-20;195(4):1804-14. 2015-07-20 [PMID: 26195811] (ChIP, Mouse)	ChIP	Mouse
Richard A, Tan C, Hawley E, Gomez-Rodriguez J, Goswami R, Yang X, Cruz A, Penumetcha P, Hayes E, Pelletier M, Gabay O, Walsh M, Ferdinand J, Keane-Myers A, Choi Y, O'Shea J, Al-Shamkhani A, Kaplan M, Gery I, Siegel R, Meylan F The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells. J Immunol, 2015-03-18;194(8):3567-82. 2015-03-18 [PMID: 25786692] (ChIP, Mouse)	ChIP	Mouse
Lina Han, Peng Qiu, Zhihong Zeng, Jeffrey L Jorgensen, Duncan H Mak, Jared K Burks et al. Single-cell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells Cytometry Part A 2015-04-01 [PMID: 25598437]
Zhang W, Gao C, Konopleva M, Chen Y, Jacamo R, Borthakur G, Cortes J, Ravandi F, Ramachandran A, Andreeff M Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. Clin Cancer Res, 2014-03-11;20(9):2363-74. 2014-03-11 [PMID: 24619500] (Western Blot, Mouse)	Western Blot	Mouse
Liao W, Spolski R, Li P, Du N, West E, Ren M, Mitra S, Leonard W Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression. Proc Natl Acad Sci U S A, 2014-02-18;111(9):3508-13. 2014-02-18 [PMID: 24550509] (ChIP, Mouse)	ChIP	Mouse
Zhang , Qian, Wang , Hong Yi, Wei , Fang, Liu , Xiaobin, Paterson , Jennifer, Roy , Darshan, Mihova , Daniela, Woetmann , Anders, Ptasznik , Andrzej, Odum , Niels, Schuster , Stephen, Marafioti , Teresa, Riley , James L, Wasik , Mariusz Cutaneous T cell lymphoma expresses immunosuppressive CD80 (B7-1) cell surface protein in a STAT5-dependent manner. J Immunol, 2014-02-12;192(6):2913-9. 2014-02-12 [PMID: 24523507] (ChIP, Functional Assay, Human)	ChIP, Functional Assay	Human
Huang Y, Zitta K, Bein B et al. An insert-based enzymatic cell culture system to rapidly and reversibly induce hypoxia: investigations of hypoxia-induced cell damage, protein expression and phosphorylation in neuronal IMR-32 cells. Dis Model Mech. 9/25/2013 [PMID: 24046359]
JÁN KRIŠKA, PETER SOLÁR, LENKA VARINSKÁ, ZUZANA SOLÁROVÁ, PATRÍCIA KIMÁKOVÁ, JÁN MOJŽIŠ et al. Human erythropoietin increases the pro-angiogenic potential of A2780 ovarian adenocarcinoma cells under hypoxic conditions Oncology Reports 2013-09-01 [PMID: 23807540]
Peter Solár, Gabriela Hrčková, Lenka Varinská, Zuzana Solárová, Ján Kriška, Ivana Uhrínová et al. Location and the functionality of erythropoietin receptor(s) in A2780 cells Oncology Reports 2012-04-30 [PMID: 22552716]
Zhu J, Guo L, Min B, Watson CJ, Hu-Li J, Young HA, Tsichlis PN, Paul WE Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. Immunity, 2002-05-01;16(5):733-44. 2002-05-01 [PMID: 12049724] (Western Blot, Mouse)	Western Blot	Mouse
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Carrier Free AF2168-SP