SOAT1 Antibody

SOAT1 (sterol O-acyltransferase 1), also designated ACAT1, is a homotetrameric enzyme that catalyzes the formation of cholesterol esters from cholesterol and long-chain fatty acyl coenzyme A. The gene encoding human SOAT1 maps to chromosome 1 and is expressed as a protein that localizes to the endoplasmic reticulum (ER) in several tissues, including liver, kidney, adrenal glands and macrophages. SOAT1 is involved in cellular cholesterol homeostasis as well as in foam cell formation and the subsequent progression of atherosclerosis. Several SOAT inhibitors have been developed for the treatment of atherosclerosis. SOAT2 (sterol O-acyltransferase 2), also known as ACAT2 (acyl coenzyme A), participates in lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. SOAT2 is an integral membrane protein that localizes to the ER of human intestinal cells. SOAT2 deficiency contributes to severe mental retardation and hypotonus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Hamster.

We have publications tested in 5 applications: Flow Cytometry, ICC/IF, IF/IHC, IP, WB.

Showing Publications 1 - 7 of 7.

Publications using NB400-141	Applications	Species
Heisler DB, Johnson KA, Ma DH et al. A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection eLife 2023-01-25 [PMID: 36695568] (Flow Cytometry)	Flow Cytometry
Chen D, Xia S, Zhang R Et Al. Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells Molecular cell 2021-07-12 [PMID: 34289383]
Ren M, Xu H, Xia H et al. Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis Cell death discovery 2021-05-29 [PMID: 34052835] (IF/IHC, Mouse)	IF/IHC	Mouse
Hai Q, Ritchey B, Robinet P et al. Quantitative Trait Locus Mapping of Macrophage Cholesterol Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as a Causal Modifier Variant Arterioscler. Thromb. Vasc. Biol. 2017-11-02 [PMID: 29097366] (WB, Mouse)	WB	Mouse
Bhathena J, Martoni C, Kulamarva A et al. Oral Probiotic Microcapsule Formulation Ameliorates Non-Alcoholic Fatty Liver Disease in Bio F1B Golden Syrian Hamsters PLoS One 2013-01-01 [PMID: 23554890] (WB, Hamster)	WB	Hamster
Song, J, Kost, C K, Jr, Martin, D S. Androgens augment renal vascular responses to ANG II in New Zealand genetically hypertensive rats. Am J Physiol Regul Integr Comp Physiol;290(6):R1608-15. 2006-06-01 [PMID: 16469840]
Chang, CC et al. Regulation and immunolocalization of acyl-coenzyme A: cholesterol acyltransferase in mammalian cells as studied with specific antibodies. J Biol Chem;270(49):29532-40. 1995-12-08 [PMID: 7493995] (IP, ICC/IF, WB, Human)	IP, ICC/IF, WB	Human

Array NB400-141

• SOAT1 Antibodies
• SOAT1 Lysate
• SOAT1 Proteins