SOCS-3 Antibody (516919) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Suppressor of cytokine signaling 3 (SOCS-3), also known as CIS3, is a widely expressed 30 kDa protein that inhibits signal transduction induced by multiple cytokines including Erythropoietin, IL-6, LIF, Oncostatin M, and Leptin. It binds downstream signaling molecules such as JAK kinases and targets them for ubiquitin-mediated degradation, essential in a negative feedback control loop. Human SOCS-3 shares 96% aa sequence identity with mouse and rat SOCS-3.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC-P, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using MAB5696	Applications	Species
R Chakrabort, H Hu, C Darido, K Vickery, S Ranganatha ML218 HCl Is More Efficient Than Capsaicin in Inhibiting Bacterial Antigen-Induced Cal 27 Oral Cancer Cell Proliferation International Journal of Molecular Sciences, 2021-11-22;22(22):. 2021-11-22 [PMID: 34830441] (Western Blot, Human)	Western Blot	Human
R Chakrabort, K Vickery, C Darido, S Ranganatha, H Hu Bacterial Antigens Reduced the Inhibition Effect of Capsaicin on Cal 27 Oral Cancer Cell Proliferation International Journal of Molecular Sciences, 2021-08-12;22(16):. 2021-08-12 [PMID: 34445392] (Western Blot, Human)	Western Blot	Human
Masahiro Yasuda, Sivapratha Nagappan-Chettiar, Erin M. Johnson-Venkatesh, Hisashi Umemori An activity-dependent determinant of synapse elimination in the mammalian brain Neuron 2021-04-01 [PMID: 33770504]
BX Ross, N Gao, X Cui, TJ Standiford, J Xu, FX Yu IL-24 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas J. Immunol, 2017-03-22;0(0):. 2017-03-22 [PMID: 28330899] (Western Blot, Mouse)	Western Blot	Mouse
D.G. Walker, A.M. Whetzel, L.-F. Lue Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer’s disease brains and human microglia Neuroscience 2015-08-27 [PMID: 25286386]
Vartoukian S, Tilakaratne W, Seoudi N, Bombardieri M, Bergmeier L, Tappuni A, Fortune F Dysregulation of the suppressor of cytokine signalling 3-signal transducer and activator of transcription-3 pathway in the aetiopathogenesis of Sjogren's syndrome. Clin Exp Immunol, 2014-09-01;177(3):618-29. 2014-09-01 [PMID: 24827536] (IHC-P, Western Blot, Human)	IHC-P, Western Blot	Human

Array MAB5696

• SOCS-3 Antibodies
• SOCS-3 ELISA Kits
• SOCS-3 Proteins