SOCS-1 Antibody

The suppressor of cytokine signaling (SOCS) family of proteins (SOCS1-SOCS7 and CIS) inhibit cytokine production by a classical negative feedback mechanism. These proteins are upregulated in response to cytokine stimulation followed by inhibition of cytokine-inducing signal pathway. Role of each members of the family has been determined by gene knockout experiments (1). SOCS1 also known as JAB and (STAT)-induced STAT inhibitor 1 (SSI-1) is an SH2-domain-containing protein that is induced by and negatively regulates signaling by a number of cytokines including interleukin-4 (IL-4), IL-6, interferon (IFN)-gamma, prolactin, growth hormone, and erythropoietin (1). SOCS1/JAB is rapidly induced by LPS and negatively regulates LPS signaling (2). SOCS1 (-/-) mice are very sensitive to LPS. These mice die prematurely, probably due to uncontrolled IFN-g signaling (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 5 of 5.

Publications using NB100-56637	Applications	Species
Sheikh T, Sen E p53 affects epigenetic signature on SOCS1 promoter in response to TLR4 inhibition Cytokine 2021-01-18 [PMID: 33476981] (WB, Human)	WB	Human
Bunda S, Kommaraju K, Heir P, Ohh M. SOCS-1 Mediates Ubiquitylation and Degradation of GM-CSF Receptor. PLoS One. 2013-09-26 [PMID: 24086733] (WB, Human)	WB	Human
Russell RC, Sufan RI, Zhou B et al. Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. Nat Med 2011-07-01 [PMID: 21685897]
Pellegrini M, Calzascia T, Toe JG et al. IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology. Cell. 2011-02-02 [PMID: 21295337]
Prele CM, Woodward EA, Bisley J et al. SOCS1 regulates the IFN but not NFkappaB pathway in TLR-stimulated human monocytes and macrophages. J Immunol. 2008-12-01 [PMID: 19017994] (WB, Human) Details: WB (human monocytes), Fig. 1C, 4A, 5F.	WB	Human

Images	Ratings	Applications	Species	Date	Details
	1 reviewed by: Maud TUSSEAU	Simple Western	Human	06/28/2021	View Summary Application Simple Western Sample Tested Brain,EBV-transformed lymphoblastoid B-cell lines from Healthy control Species Human Lot 111302C-04 Comments Comments ***Novus Innovators Program - new species or application used on a primary antibody. Samples : LCL : EBV-transformed lymphoblastoid B-cell lines from Healthy control (Ctle) : Concentrations : 0,5 – 1 – 2 mg/mL (total protein concentration) SOCS1 antibody dilution : 1/10 – 1/50 – 1/100

Array NB100-56637

• SOCS-1 Antibodies
• SOCS-1 Lysate
• SOCS-1 Proteins