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IFN-alpha/beta R1 Antibody [Unconjugated]

 (9 Publications)
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Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, K562 human chronic myelogenous leukemia cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human IFN‑ alpha / beta  R1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF245) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). A specific band was detected for IFN‑ alpha / beta  R1 at approximately 110-120 kDa (as indicated). This experiment was conducted under reducing conditions and using Western Blot Buffer Group 1.
Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, K562 human chronic myelogenous leukemia cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human IFN‑ alpha / beta ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, CyTOF-ready
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Biotin
BAF245
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
AF245-SP
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IFN-alpha/beta R1 Antibody [Unconjugated] Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IFN-alpha / beta  R1
Lys28-Lys436
Accession # AAA52730
Specificity
Detects human IFN‑ alpha / beta R1 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant mouse IFN‑ alpha / beta  RI is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
IFNAR1
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 2.5 ug/10^6 cells
  • Western Blot 0.1-1 ug/mL
Publications
Read Publications using
AF245 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

Sold under license from Pestka Biomedical Laboratories, Inc. d/b/a PBL Interferon Source. For research use only. Not for resale. Not for diagnostic, therapeutic or clinical purposes.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IFN-alpha/beta R1 Antibody [Unconjugated]

  • alpha-type antiviral protein
  • AVP
  • beta-type antiviral protein
  • CRF2-1
  • Cytokine receptor class-II member 1
  • Cytokine receptor family 2 member 1
  • human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC
  • IFN-alpha/beta R1
  • IFN-alpha/beta receptor 1
  • IFN-alpha-REC
  • IFNAR
  • IFNAR1
  • IFN-aR1
  • IFNBR
  • IFNbR1
  • IFN-bR1
  • IFN-R-1
  • interferon (alpha, beta and omega) receptor 1
  • interferon alpha/beta receptor 1
  • interferon-alpha/beta receptor alpha chain
  • interferon-beta receptor 1
  • Type I interferon receptor 1

Background

Type I interferons (IFN-alpha , IFN-beta , IFN-omega ) bind to the type I IFN receptor, also called the IFN alpha/beta receptor. This receptor is composed of two chains, IFN-alpha / beta R1 and R2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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IFN-alpha/beta R1
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AF245
IFN-alpha/beta R1 Antibody [Unconjugated]
Species: Hu
Applications: WB, Flow, CyTOF-ready

Publications for IFN-alpha/beta R1 Antibody (AF245)(9)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Flow Cytometry, ICC, Neutralization, Western Blot.


Filter By Application
Flow Cytometry
(2)
ICC
(1)
Neutralization
(3)
Western Blot
(1)
All Applications
Filter By Species
Human
(6)
Mouse
(1)
All Species
Showing Publications 1 - 9 of 9.
Publications using AF245 Applications Species
Y Han, L Tan, T Zhou, L Yang, L Carrau, LA Lacko, M Saeed, J Zhu, Z Zhao, BE Nilsson-Pa, FT Lira Neto, C Cahir, AM Giani, JC Chai, Y Li, X Dong, D Moroziewic, NYSCF Glob, D Paull, T Zhang, S Koo, C Tan, R Danziger, Q Ba, L Feng, Z Chen, A Zhong, GJ Wise, JZ Xiang, H Wang, RE Schwartz, BR tenOever, SA Noggle, CM Rice, Q Qi, T Evans, S Chen A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants Cell Stem Cell, 2022-10-06;29(10):1475-1490.e6. 2022-10-06 [PMID: 36206731] (ICC, Human) ICC Human
Benjamin Krämer, Rainer Knoll, Lorenzo Bonaguro, Michael ToVinh, Jan Raabe, Rosario Astaburuaga-García et al. Early IFN-alpha signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19 Immunity 11/1/2021 [PMID: 34592166]
Sabrina Rueschenbaum, Chengcong Cai, Matthias Schmidt, Katharina Schwarzkopf, Ulf Dittmer, Stefan Zeuzem et al. Translation of IRF-1 Restricts Hepatic Interleukin-7 Production to Types I and II Interferons: Implications for Hepatic Immunity Frontiers in Immunology 1/14/2021 [PMID: 33584648]
Trisomy 21 consistently activates the interferon response Elife, 2016-07-29;5(0):. 2016-07-29 [PMID: 27472900] (Western Blot, Human) Western Blot Human
Le Saout C, Hasley R, Imamichi H, Tcheung L, Hu Z, Luckey M, Park J, Durum S, Smith M, Rupert A, Sneller M, Lane H, Catalfamo M Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis. PLoS Pathog, 2014-03-06;10(3):e1003976. 2014-03-06 [PMID: 24603698] (Flow Cytometry, Human) Flow Cytometry Human
Suto A, Nakajima H, Tokumasa N, Takatori H, Kagami S, Suzuki K, Iwamoto I Murine plasmacytoid dendritic cells produce IFN-gamma upon IL-4 stimulation. J. Immunol., 2005-11-01;175(9):5681-9. 2005-11-01 [PMID: 16237058] (Neutralization, Mouse) Neutralization Mouse
Sakamoto E, Hato F, Kato T, Sakamoto C, Akahori M, Hino M, Kitagawa S Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2. J. Leukoc. Biol., 2005-04-21;78(1):301-9. 2005-04-21 [PMID: 15845643] (Neutralization, Human) Neutralization Human
Lin RJ, Liao CL, Lin E, Lin YL Blocking of the alpha interferon-induced Jak-Stat signaling pathway by Japanese encephalitis virus infection. J. Virol., 2004-09-01;78(17):9285-94. 2004-09-01 [PMID: 15308723] (Flow Cytometry, Human) Flow Cytometry Human
Qu C, Moran TM, Randolph GJ Autocrine type I IFN and contact with endothelium promote the presentation of influenza A virus by monocyte-derived APC. J. Immunol., 2003-01-15;170(2):1010-8. 2003-01-15 [PMID: 12517968] (Neutralization, Human) Neutralization Human

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Bioinformatics

Gene Symbol IFNAR1
Uniprot