Corticotropin Releasing Factor Antibody (2B11)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin dificiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta CRH is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 4 of 4.

Publications using H00001392-M02	Applications	Species
Wang B, Parobchak N, Martin A et al. Screening a small molecule library to identify inhibitors of NF-?B inducing kinase and pro-labor genes in human placenta. Sci Rep. 2018-01-26 [PMID: 29374256]
Wang B, Parobchak N, Rosen M et al. Negative effects of progesterone receptor isoform-A on human placental activity of the non-canonical NF-kB signaling. J Clin Endocrinol Metab. 2013-11-25 [PMID: 24276461]
Wang B, Palomares K, Parobchak N et al. Glucocorticoid Receptor Signaling Contributes to Constitutive Activation of the Noncanonical NF-kB Pathway in Term Human Placenta. Mol Endocrinol. 2012-11-26 [PMID: 23239753]
Wang B, Parobchak N, Rosen T. RelB/NF-kB2 Regulates Corticotropin-Releasing Hormone in the Human Placenta. Mol Endocrinol. 2012-05-08 [PMID: 22734038]

Array H00001392-M02

• Corticotropin Releasing Factor Antibodies
• Corticotropin Releasing Factor ELISA Kits
• Corticotropin Releasing Factor Lysate