NLRP3/NALP3 Antibody - BSA Free

NACHT, LRR and PYD domains-containing protein 3 (NALP3), Nucleotide-Binding Oligomerization Domain, or Leucine Rich Repeat and Pyrin Domain Containing 3 (NLRP3) (human NLRP3-isoform 2 theoretical molecular weight 118kDa) acts as a cytosolic receptor for stress-signals initiated by a wide variety of pathogen-associated molecular patterns (PAMPS) and danger-associated molecular patterns (DAMPs) (1). NLRP3 belongs to the family of NOD-like receptors, a type of pattern-recognition receptor (PRR) which participates in innate immune responses. The exact mechanisms leading to NLRP3 activation are still not fully resolved. Some proposed mechanisms for NLRP3 inflammasome activation include induced ion channel flux as exemplified by potassium efflux, sodium influx and calcium signaling, generation of mitochondrial reactive oxygen species (ROS), and lysosomal destabilization (2). Activation of NLRP3 induces its association with the adaptor protein Apoptosis-associated Speck-like protein containing CARD (ASC) forming a complex that binds to Caspase-1 (1, 2). The inflammasome complex, comprised of NLRP3, ASC and Caspase 1, induces the processing of pro-IL-1beta and pro-IL-18 and release of the mature inflammatory cytokines IL-1beta and IL-18 and pyroptosis (1-3).

NLRP3 is expressed in a variety of cell types such as monocytes, dendritic cells, lymphocytes and epithelial cells (3). Abnormal NLRP3 activation may occur as the result of inherited mutations and is associated with diseases such as hereditary periodic fevers (HPFs) and familial cold autoinflammatory syndrome (FCAS). Additionally, abnormal NLRP3 activation is associated with a variety of diseases such as gout, obesity, atherosclerosis, Alzheimers, multiple sclerosis and type 2 diabetes (1, 3). NLRP3 inflammasome is regulated by several post-translational modifications (e.g., ubiquitination, phosphorylation and sumoylation) as well as by various interacting proteins (e.g., JNK1, FBXO3, TXNIP, MARK4 and PKD) (4).

References

1. Abderrazak, A., Syrovets, T., Couchie, D., El Hadri, K., Friguet, B., Simmet, T., & Rouis, M. (2015). NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases. Redox Biology. https://doi.org/10.1016/j.redox.2015.01.008

2. Yang, Y., Wang, H., Kouadir, M., Song, H., & Shi, F. (2019). Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. Cell Death and Disease. https://doi.org/10.1038/s41419-019-1413-8

3. Zahid, A., Li, B., Kombe, A. J. K., Jin, T., & Tao, J. (2019). Pharmacological inhibitors of the nlrp3 inflammasome. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2019.02538

4. Kelley, N., Jeltema, D., Duan, Y., & He, Y. (2019). The NLRP3 inflammasome: An overview of mechanisms of activation and regulation. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20133328

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Bovine.

We have publications tested in 13 applications: B/N, ELISA, FLOW, ICC/IF, IF/IHC, IHC, IHC-Fr, IHC-P, IM, IP, KD, KO, WB.

Showing Publications 1 - 10 of 230. Show All 230 Publications. Collapse Publications.

Publications using NBP2-12446	Applications	Species
Sguizzato M, Ferrara F, Baraldo N et al. Bilosomes and Biloparticles for the Delivery of Lipophilic Drugs: A Preliminary Study Antioxidants 2023-11-21 [PMID: 38136145] (ICC/IF, Human)	ICC/IF	Human
Luo M, Peng Y, Lv D et al. LncRNA GAS5 downregulates NLRP3 inflammasome activation-mediated pyroptosis in sepsis-induced myocardial injury by targeting SIRT3/AMPK? Heliyon 2023-12-01 [PMID: 38076153] (IHC-P, Mouse) Details: Mouse hearts: Dilution 1:200	IHC-P	Mouse
McElwain CJ, Musumeci A, Manna S et al. L-ergothioneine reduces mitochondrial-driven NLRP3 activation in gestational diabetes mellitus Journal of reproductive immunology 2023-11-24 [PMID: 38029485] (WB, Human)	WB	Human
Chen T, Du H, Zhou H et al. Yinhuapinggan granule ameliorates lung injury caused by multidrug-resistant Acinetobacter baumannii via inhibiting NF-?B/NLRP3 pathway Heliyon 2023-11-01 [PMID: 38027639] (IHC-P, WB, Mouse) Details: IHC-P Dilution 1:50, WB Dilution 1:500	IHC-P, WB	Mouse
Gao Q, Gao Z, Su M et al. Umbilical Cord Mesenchymal Stem Cells Overexpressing Heme Oxygenase-1 Promotes Symptoms Recovery in Cystitis Rats by Alleviating Neuroinflammation Stem cells international 2023-11-14 [PMID: 38020203]
Wei J, Leng L, Sui Y et al. Phenolic acids from Prunella vulgaris alleviate cardiac remodeling following myocardial infarction partially by suppressing NLRP3 activation Phytotherapy research : PTR 2023-11-22 [PMID: 37992723]
Song G, Wang J, Liu J, Ruan Y Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO-1 signaling pathway Redox Biology 2023-10-01 [PMID: 37931471] (IHC-P, Rat) Details: IHC-P dilution 1:50; WB Dilution 1:500	IHC-P	Rat
Hitomi M, Venegas J, Kang SC, Eng C Differential cell cycle checkpoint evasion by PTEN germline mutations associated with dichotomous phenotypes of cancer versus autism spectrum disorder Oncogene 2023-11-01 [PMID: 37907589]
Liang Y, Zhou Y, Wang J, He Y Downregulation of fibromodulin attenuates inflammatory signaling and atrial fibrosis in spontaneously hypertensive rats with atrial fibrillation via inhibiting TLR4/NLRP3 signaling pathway Immunity, inflammation and disease 2023-10-01 [PMID: 37904680] (WB, Rat) Details: Dilutions 1:250	WB	Rat
Yang L, Lu P, Qi X et al. Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice iScience 2023-09-01 [PMID: 37860765] (WB, Mouse)	WB	Mouse
Li L, Li S, Pan Z et al. Bilirubin impacts microglial autophagy via the Akt-mTOR signaling pathway Journal of neurochemistry 2023-10-19 [PMID: 37858960]
Wu Q, Meng W, Zhu B et al. VEGFC ameliorates salt-sensitive hypertension and hypertensive nephropathy by inhibiting NLRP3 inflammasome via activating VEGFR3-AMPK dependent autophagy pathway Cellular and molecular life sciences : CMLS 2023-10-14 [PMID: 37837447]
Liu SJ, Guo BD, Gao QH et al. Ursolic acid alleviates chronic prostatitis via regulating NLRP3 inflammasome-mediated Caspase-1/GSDMD pyroptosis pathway Phytotherapy research : PTR 2023-10-09 [PMID: 37807970]
Chen JW, Shan TK, Wei TW et al. SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice Archives of toxicology 2023-12-01 [PMID: 37798514] (WB, Mouse)	WB	Mouse
Sun Y, Lv D, Xie Y et al. PINK1-mediated mitophagy induction protects against preeclampsia by decreasing ROS and trophoblast pyroptosis Placenta 2023-09-10 [PMID: 37788592] (IHC-P, Human) Details: 1:1000 dilution	IHC-P	Human
Omatsu M, Nakanishi Y, Iwane K et al. THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer Nat Commun 2023-09-25 [PMID: 37749092]
Chen W, Luo Y, Quan J et al. PM2.5 induces renal tubular injury by activating NLRP3-mediated pyroptosis Ecotoxicology and environmental safety 2023-09-22 [PMID: 37742582] (IHC, Mouse)	IHC	Mouse
Fan H, Tian H, Jin F et al. CypD induced ROS output promotes intracranial aneurysm formation and rupture by 8-OHdG/NLRP3/MMP9 pathway Redox Biol 2023-09-12 [PMID: 37717465] (ICC/IF)	ICC/IF
Lan T, Zeng Q, Zhu Y et al. Xin-Li formula attenuates heart failure induced by a combination of hyperlipidemia and myocardial infarction in rats via Treg immunomodulation and NLRP3 inflammasome inhibition Journal of Traditional and Complementary Medicine 2023-09-01 [PMID: 37693100]
Seo HW, Ha TY, Ko G et al. Scutellaria baicalensis Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke Mice Cells 2023-08-23 [PMID: 37681864]
Konaka H, Kato Y, Hirano T et al. Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome The EMBO journal 2023-09-04 [PMID: 37661814] (WB, KO, Mouse)	WB, KO	Mouse
Wei H, Liu B, Yin C et al. Electroacupuncture improves gout arthritis pain via attenuating ROS-mediated NLRP3 inflammasome overactivation Chinese medicine 2023-07-18 [PMID: 37464384] (WB, Mouse)	WB	Mouse
Jin BR, Lim CY, Kim HJ et al. Antioxidant mitoquinone suppresses benign prostatic hyperplasia by regulating the AR-NLRP3 pathway Redox Biology 2023-09-01 [PMID: 37454529] (WB, ICC/IF)	WB, ICC/IF
Park JH, Hwang JW, Lee HJ et al. Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation by modulating NLRP3, DYRK1A, and GSK3?/? Frontiers in Immunology 2023-06-26 [PMID: 37435081] (ICC/IF)	ICC/IF
Kim, D;Ban, KY;Lee, GH;Jun, HS; Lysophosphatidic Acid Induces Podocyte Pyroptosis in Diabetic Nephropathy by an Increase of Egr1 Expression via Downregulation of EzH2 International journal of molecular sciences 2023-06-09 [PMID: 37373116] (ICC/IF, WB)	ICC/IF, WB
Yang X, Chen Z, Luo Z et al. STING deletion alleviates podocyte injury through suppressing inflammation by targeting NLRP3 in diabetic kidney disease Cellular signalling 2023-06-15 [PMID: 37329999] (IHC, Mouse)	IHC	Mouse
Lien CF, Lin CS, Shyue SK et al. Peroxisome proliferator-activated receptor ? improves the features of atherosclerotic plaque vulnerability by regulating smooth muscle cell phenotypic switching British journal of pharmacology 2023-03-21 [PMID: 36942453]
de Dios C, Abadin X, Roca-Agujetas V et al. Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis Translational neurodegeneration 2023-03-09 [PMID: 36895045] (WB, Mouse, Human)	WB	Mouse, Human
Kim M, Kim J, Lee K et al. Magnolia officinalis bark extract improves depressive-like behavior in DSS-induced colitis mice Journal of Functional Foods 2023-09-01 [PMID: 36552643] (ICC/IF, Mouse)	ICC/IF	Mouse
Perez-Cremades D, Bueno-Beti C, Garcia-Gimenez JL et al. Extracellular histones trigger oxidative stress-dependent induction of the NF-kB/CAM pathway via TLR4 in endothelial cells Journal of physiology and biochemistry 2022-12-05 [PMID: 36464762] (WB, Human)	WB	Human
Theivanthiran B, Yarla N, Haykal T et al. Tumor-intrinsic NLRP3-HSP70-TLR4 axis drives premetastatic niche development and hyperprogression during anti-PD-1 immunotherapy Science Translational Medicine 2022-11-23 [PMID: 36417489]
Varadharajulu G, Victor D, Venkadassalapathy S et al. Expression of NLRP3 and superoxide dismutase-2 (SOD2) in the gingival tissues of periodontitis patients with and without type 2 diabetes mellitus: a case-control study International Journal of Diabetes in Developing Countries 2023-11-27
Hong Liang Lin, Sheng Wang, Kota Sato, Yu Qiao Zhang, Bei Ting He, Jing Xu, Toru Nakazawa, Yong Jie Qin, Hong Yang Zhang Uric acid–driven NLRP3 inflammasome activation triggers lens epithelial cell senescence and cataract formation Cell Death Discovery 2024-03-09 [PMID: 38461179]
Quan JH, Gao FF, Ma TZ et al. Toxoplasma gondii induces pyroptosis in human placental trophoblast and amniotic cells by inducing ROS production and activation of cathepsin B and NLRP1/NLRP3/NLRC4/AIM2 inflammasome The American journal of pathology 2023-09-21 [PMID: 37741453] (IHC-P, Mouse)	IHC-P	Mouse
Hong Zhou, Qun Zhang, Chenyang Liu, Jiahao Fan, Wen Huang, Nan Li, Mingxia Yang, Hong Wang, Weiping Xie, Hui Kong NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica-induced lung fibrosis International Journal of Molecular Medicine 2024-03-01 [PMID: 38240085]
Liu J, Liu B, He X et al. Dendorbium Nobile Lindl. Alkaloids Suppress NF-kappa B and NLRP3 Signaling Pathways to Attenuate Lipopolysaccharide-induced Neuroinflammation scientificarchives.com 2020-01-01 (ICC/IF, Mouse)	ICC/IF	Mouse
Huang J, Ju B, An Q et al. VDR inhibits NLRP3 signal in lupus nephritis by competitively binding with importin 4 to suppress NF-kappa B nuclear translocation Research Square Sep 10 2020 (WB, Mouse)	WB	Mouse
Inés Muela-Zarzuela, Juan Miguel Suarez-Rivero, Andrea Gallardo-Orihuela, Chun Wang, Kumi Izawa, Marta de Gregorio-Procopio, Isabelle Couillin, Bernhard Ryffel, Jiro Kitaura, Alberto Sanz, Thomas von Zglinicki, Gabriel Mbalaviele, Mario D Cordero NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024-06-21 [PMID: 38907167]
Yubin Lee, Boran Yoon, Sumin Son, Eunbin Cho, Kyung Bo Kim, Eun Young Choi, Dong-Eun Kim, Alessandro Poggi Inhibition of Immunoproteasome Attenuates NLRP3 Inflammasome Response by Regulating E3 Ubiquitin Ligase TRIM31 Cells 2024-04-13 [PMID: 38667290]
Andrea Mencarelli, Pradeep Bist, Hae Woong Choi, Hanif Javanmard Khameneh, Alessandra Mortellaro, Soman N Abraham Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components. Nature immunology 2024-04-11 [PMID: 38486019]
Fei Gao, Dian Xiong, Zhaorui Sun, Jingbo Shao, Dong Wei, Shinan Nie ARC DPBNPs suppress LPS-induced acute lung injury via inhibiting macrophage pyroptosis and M1 polarization by ERK pathway in mice. International immunopharmacology 2024-04-10 [PMID: 38457983]
Clara Bartra, Yi Yuan, Kristijan Vuraić, Haydeé Valdés-Quiroz, Pau Garcia-Baucells, Mark Slevin, Ylenia Pastorello, Cristina Suñol, Coral Sanfeliu Resveratrol Activates Antioxidant Protective Mechanisms in Cellular Models of Alzheimer's Disease Inflammation. Antioxidants (Basel, Switzerland) 2024-01-31 [PMID: 38397775]
Wu S, Liao J, Hu G et al. Corilagin alleviates LPS-induced sepsis through inhibiting pyroptosis via targeting TIR domain of MyD88 and binding CARD of ASC in macrophages Biochemical pharmacology 2023-09-13 [PMID: 37714273]
Liu Y, Wang Y, Chen L et al. Effect of electroacupuncture on NF- kappa B and NLRP3 inflammasome in uterine tissues of rats with primary dysmenorrhea J. Acupunct. Tuina. Sci. 2019-06-18 (Rat)		Rat
Gastaldi S, Rocca C, Gianquinto E et al. Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation European Journal of Medicinal Chemistry 2023-06-01 [PMID: 37290185]
Fang L, Ohashi K, Hayakawa S et al. Adipolin protects against renal injury via PPAR?-dependent reduction of inflammasome activation iScience 2023-05-01 [PMID: 37250342]
Cui S, Wu H, He Q et al. Fucoxanthin alleviated atherosclerosis by regulating PI3K/AKT and TLR4/NF?B mediated pyroptosis in endothelial cells International immunopharmacology 2023-05-24 [PMID: 37235964] (ICC/IF, Mouse)	ICC/IF	Mouse
Liu S, Ge J, Chu Y et al. Identification of hub cuproptosis related genes and immune cell infiltration characteristics in periodontitis Frontiers in immunology 2023-05-05 [PMID: 37215133] (IHC-P, Human)	IHC-P	Human
Tang G, Li S, Xu Y et al. Renal herb formula protects against hyperuricemic nephropathy by inhibiting apoptosis and inflammation Phytomedicine 2023-04-01 [PMID: 37167821]
Wei B, Su Z, Yang H et al. Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by alleviating pyroptosis in vitro and in vivo rat models Biology direct 2023-05-10 [PMID: 37165439] (WB, Rat)	WB	Rat
Zheng S, Zhang K, Zhang Y et al. Human Umbilical Cord Mesenchymal Stem Cells Inhibit Pyroptosis of Renal Tubular Epithelial Cells through miR-342-3p/Caspase1 Signaling Pathway in Diabetic Nephropathy Stem cells international 2023-04-04 [PMID: 37056456] (WB, Rat)	WB	Rat
Yan YQ, Zheng R, Liu Y et al. Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease Aging cell 2023-04-07 [PMID: 37029500] (IP, Mouse)	IP	Mouse
Wu M, Ding H, Tang X et al. Efficiency of a novel thermosensitive enema in situ hydrogel carrying Periplaneta americana extracts for the treatment of ulcerative colitis Frontiers in pharmacology 2023-02-08 [PMID: 36843930] (WB)	WB
Park E, Choi H, Truong CS, Jun HS The Inhibition of Autophagy and Pyroptosis by an Ethanol Extract of Nelumbo nucifera Leaf Contributes to the Amelioration of Dexamethasone-Induced Muscle Atrophy Nutrients 2023-02-04 [PMID: 36839161] (WB, Mouse)	WB	Mouse
Chen MB, Li MH, Wu LY et al. Oridonin employs interleukin 1 receptor type 2 to treat noise-induced hearing loss by blocking inner ear inflammation Biochemical pharmacology 2023-02-16 [PMID: 36806583] (IHC-Fr, WB, Mouse)	IHC-Fr, WB	Mouse
Wang Y, Sadike D, Huang B et al. Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-?B pathway in LPC-induced demyelination Journal of neuroinflammation 2023-02-18 [PMID: 36803990] (IHC, Mouse)	IHC	Mouse
Muela-Zarzuela IS, Suarez-Rivero JM, Gallardo-Orihuela A et al. NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype bioRxiv : the preprint server for biology 2023-02-10 [PMID: 36798300] (WB, Human)	WB	Human
Zhang H, Xie Z, Peng Y et al. PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration Ecotoxicology and environmental safety 2023-03-01 [PMID: 36764072] (WB, IHC, Mouse)	WB, IHC	Mouse
Lin W, Li Z, Liang G et al. TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer's disease via TFEB/TFE3 activation Journal of neuroinflammation 2023-02-02 [PMID: 36732771] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Yue RZ, Li YJ, Su BH et al. Atorvastatin reduces contrast media-induced pyroptosis of renal tubular epithelial cells by inhibiting the TLR4/MyD88/NF-?B signaling pathway BMC nephrology 2023-02-02 [PMID: 36732683] (WB)	WB
Zhou J, Zhang C, Fang X et al. Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane induced cognitive dysfunction in elderly rats Research Square 2022-08-10 [PMID: 36709248] (WB, Rat)	WB	Rat
Xiao Q, Kang Z, Liu C et al. Panax notoginseng Saponins Attenuate Cerebral Ischemia-Reperfusion Injury via Mitophagy-Induced Inhibition of NLRP3 Inflammasome in Rats Frontiers in Bioscience-Landmark 2022-11-03 [PMID: 36472098] (WB, Rat) Details: Dilution used 1:500	WB	Rat
Lin J, Lai X, Fan X et al. Oridonin Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting GSDMD-Mediated Pyroptosis Genes 2022-11-17 [PMID: 36421808] (WB, Mouse) Details: Dilutions: 1:1000	WB	Mouse
Li S, Li H, Zhangdi H et al. Hair follicle-MSC-derived small extracellular vesicles as a novel remedy for acute pancreatitis Journal of controlled release : official journal of the Controlled Release Society 2022-11-19 [PMID: 36402231] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Kim J, Kim SJ, Jeong HR et al. Inhibiting EGFR/HER-2 ameliorates neuroinflammatory responses and the early stage of tau pathology through DYRK1A Frontiers in Immunology 2022-10-20 [PMID: 36341365] (B/N)	B/N
Kornelius E, Tsou SH, Chang CC et al. Liraglutide Attenuates Glucolipotoxicity-Induced RSC96 Schwann Cells' Inflammation and Dysfunction Biomolecules 2022-09-21 [PMID: 36291547] (ICC/IF)	ICC/IF
Zheng L, Xu H, Zheng F et al. Intervention time decides the status of autophagy, NLRP3 activity and apoptosis in macrophages induced by ox-LDL Lipids in health and disease 2022-10-25 [PMID: 36284323] (ICC/IF, Human)	ICC/IF	Human
Yamashita S, Takasu C, Morine Y et al. Characteristic submucosal alteration in biliary carcinogenesis of pancreaticobiliary maljunction with a focus on inflammasome activation Journal of hepato-biliary-pancreatic sciences 2022-10-19 [PMID: 36259178]
Li M, Wu L, Chen M et al. Co-activation of Caspase-1 and Caspase-8 in CMV-induced SGN death by inflammasome-associated pyroptosis and apoptosis International immunopharmacology 2022-10-14 [PMID: 36244217] (IF/IHC, Mouse)	IF/IHC	Mouse
Vargas-Pozada EE, Ramos-Tovar E, Rodriguez-Callejas JD et al. Caffeine Inhibits NLRP3 Inflammasome Activation by Downregulating TLR4/MAPK/NF-?B Signaling Pathway in an Experimental NASH Model International Journal of Molecular Sciences 2022-09-01 [PMID: 36077357] (ICC/IF, WB, IHC)	ICC/IF, WB, IHC
Li HL, Li T, Chen ZQ, Li L Tanshinone IIA reduces pyroptosis in rats with coronary microembolization by inhibiting the TLR4/MyD88/NF-?B/NLRP3 pathway The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022-09-01 [PMID: 36039734] (WB, IHC, Rat)	WB, IHC	Rat
Zhou Z, Ying C, Zhou X et al. Aerobic exercise training alleviates renal injury in db/db mice through inhibiting Nox4-mediated NLRP3 inflammasome activation Experimental gerontology 2022-08-22 [PMID: 36007721] (WB, Mouse)	WB	Mouse
Eggelbusch M, Shi A, Broeksma BC et al. The NLRP3 inflammasome contributes to inflammation-induced morphological and metabolic alterations in skeletal muscle Journal of cachexia, sarcopenia and muscle 2022-08-17 [PMID: 35978267] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Wu J, Chen S, Wu P et al. Cathepsin B/HSP70 complex induced by Ilexsaponin I suppresses NLRP3 inflammasome activation in myocardial ischemia/reperfusion injury Phytomedicine 2022-07-01 [PMID: 35952578] (WB, Rat)	WB	Rat
Yoon B, Yun Y, Kim KB, Kim DE Inhibition of immunoproteasome attenuates NLRP3 inflammasome formation in tumor necrosis factor alpha-stimulated intestinal epithelial cell Biochemical and biophysical research communications 2022-10-08 [PMID: 35944388]
Tabandeh MR, Jozaie S, Ghotbedin Z, Gorani S Dimethyl itaconic acid improves viability and steroidogenesis and suppresses cytokine production in LPS-treated bovine ovarian granulosa cells by regulating TLR4/nfk beta, NLRP3, JNK signaling pathways Research in veterinary science 2022-08-01 [PMID: 35933803] (WB, Bovine)	WB	Bovine
Beltran-Garcia J, Osca-Verdegal R, Perez-Cremades D et al. Extracellular Histones Activate Endothelial NLRP3 Inflammasome and are Associated with a Severe Sepsis Phenotype Journal of inflammation research 2022-07-25 [PMID: 35915852] (WB, Human)	WB	Human
Luo M, Hu Y, Lv D et al. Recurrent Hypoglycemia Impaired Vascular Function in Advanced T2DM Rats by Inducing Pyroptosis Oxidative medicine and cellular longevity 2022-07-23 [PMID: 35915611] (IF/IHC, WB, Rat) Details: WB Dilution: 1:1000, IHC Dilution: 1:200	IF/IHC, WB	Rat
Zhou L, Zhang J, Han X et al. CysLT2R Antagonist HAMI 3379 Ameliorates Post-Stroke Depression through NLRP3 Inflammasome/Pyroptosis Pathway in Gerbils Brain sciences 2022-07-24 [PMID: 35892417]
Ge C, Zhao Y, Liang Y, He Y Silencing of TLR4 Inhibits Atrial Fibrosis and Susceptibility to Atrial Fibrillation via Downregulation of NLRP3-TGF-Beta in Spontaneously Hypertensive Rats Disease markers 2022-07-11 [PMID: 35860690] (WB, Rat) Details: Sprague-Dawley (SD) neonatal rats (1–3 days old), total protein was extracted from left atrial tissue and atrium fibroblasts, antibody used at 1:250	WB	Rat
Xie D, Hu G, Chen C et al. Loss of sphingosine kinase 2 protects against cisplatin induced-kidney injury American journal of physiology. Renal physiology 2022-07-14 [PMID: 35834271]
Mavrogiannis E, Hagdorn Q, Bazioti V et al. Pirfenidone ameliorates pulmonary arterial pressure and neointimal remodeling in experimental pulmonary arterial hypertension by suppressing NLRP3 inflammasome activation Pulmonary Circulation 2022-06-17 [PMID: 35833096] (IF/IHC, Rat)	IF/IHC	Rat
Zhou H, Zhang W, Qin D et al. Activation of NLRP3 inflammasome contributes to the inflammatory response to allergic rhinitis via macrophage pyroptosis International immunopharmacology 2022-07-06 [PMID: 35809382] (IHC-P, WB, Human, Mouse)	IHC-P, WB	Human, Mouse
Liu B, Wang D, Cao Y et al. MitoTEMPO protects against podocyte injury by inhibiting NLRP3 inflammasome via PINK1/Parkin pathway-mediated mitophagy European journal of pharmacology 2022-08-15 [PMID: 35792172] (IHC-Fr, Rat)	IHC-Fr	Rat
Liu X, Fan T, Guan J et al. Dopamine relieves inflammatory responses through the D2 receptor after electroacupuncture at ST36 in a mouse model of chronic obstructive pulmonary disease Acupuncture in medicine : journal of the British Medical Acupuncture Society 2022-07-01 [PMID: 35775581]
Saieva S, Taglialatela G Near-infrared light reduces glia activation and modulates neuroinflammation in the brains of diet-induced obese mice Scientific reports 2022-06-27 [PMID: 35761012] (ICC/IF, Mouse)	ICC/IF	Mouse
Wang C, Wang Y, Song D et al. Therapeutic Effects of Modified Si-Miao-Yong-An Decoction in the Treatment of Rat Myocardial Ischemia/Reperfusion Injury Evidence-Based Complementary and Alternative Medicine 2022-06-06 [PMID: 35707475]
Al-Qazazi R, Lima PDA, Prisco SZ Et al. Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension Am J Respir Crit Care Med 2022-06-14 [PMID: 35699679] (WB, ICC/IF, FLOW, Human, Rat) Details: Citation using the Alexa Fluor 700 version of this antibody.	WB, ICC/IF, FLOW	Human, Rat
Zhang Y, Chen R, Hu Q et al. Electroacupuncture Ameliorates Mechanical Allodynia of a Rat Model of CRPS-I via Suppressing NLRP3 Inflammasome Activation in Spinal Cord Dorsal Horn Neurons Frontiers in Cellular Neuroscience 2022-05-25 [PMID: 35693886] (WB)	WB
Yu W, Zong S, Zhou P et al. Cochlear Marginal Cell Pyroptosis Is Induced by Cisplatin via NLRP3 Inflammasome Activation Frontiers in Immunology 2022-04-20 [PMID: 35529876] (ICC/IF)	ICC/IF
Lian H, Fang X, Li Q et al. NLRP3 Inflammasome-Mediated Pyroptosis Pathway Contributes to the Pathogenesis of Candida albicans Keratitis Frontiers in medicine 2022-04-06 [PMID: 35463001] (ICC/IF, Mouse)	ICC/IF	Mouse
Wu Z, Zhou G, Wang H, Yao P Inhibition of KIF23 Alleviates IPAH by Targeting Pyroptosis and Proliferation of PASMCs International journal of molecular sciences [PMID: 35457254]
Fang J, Ouyang M, Qu Y et al. Advanced glycation end products promote melanogenesis via activating NLRP3 in ammasome in human dermal fibroblasts The Journal of investigative dermatology 2022-04-11 [PMID: 35421403]
Zhang C, Huang Y, Ouyang F et al. Extracellular vesicles derived from mesenchymal stem cells alleviate neuroinflammation and mechanical allodynia in interstitial cystitis rats by inhibiting NLRP3 inflammasome activation Journal of neuroinflammation 2022-04-06 [PMID: 35387668] (WB, Rat)	WB	Rat
Zou R, Nie C, Pan S et al. Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy Free radical biology & medicine 2022-03-15 [PMID: 35304269] (WB, IHC-P, Mouse)	WB, IHC-P	Mouse
Shiau AL, Fang SY, Hsu CH et al. Prothymosin alpha Gene Transfer Modulates Myocardial Remodeling after Ischemia-Reperfusion Injury Acta Cardiologica Sinica 2022-03-01 [PMID: 35273440] (WB, Rat)	WB	Rat
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Kadono K, Uchida Y, Hirao H et al. Thrombomodulin attenuates inflammatory damage due to liver ischemia and reperfusion injury in mice in TLR4-dependent manner. Am. J. Transplant. 2016-07-28 [PMID: 27467205] (WB)	WB
Lampropoulou V, Sergushichev A, Bambouskova M et al. Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation Cell Metab. 2016-07-12 [PMID: 27374498] (WB, Mouse)	WB	Mouse
Li Y, Zhou ZH, Chen MH et al. Inhibition of Mitochondrial Fission and NOX2 Expression Prevent NLRP3 Inflammasome Activation in the Endothelium: The Role of Corosolic Acid Action in the. Antioxid Redox Signal. 2016-03-22 [PMID: 26869350]
Ge CX, Yu R, Xu MX et al. Betaine prevented fructose-induced NAFLD by regulating LXRa/PPARa pathway and alleviating ER stress in rats. Eur. J. Pharmacol. 2015-11-21 [PMID: 26593707] (WB, Rat) Details: NLRP3/NALP3 was used for WB analysis of liver tissue lysates from Sprague-Dawley rats that were fed with fructose and/or Betaine (a naturally occurring compound in wheat bran, wheat germ, spinach, pretzels, shrimp and wheat bread). Fructose enhanced the expression of NLRP3 while Betaine reversed this effect (Fig. 8E).	WB	Rat
Kim SK, Joe Y, Chen Y et al. Carbon monoxide decreases interleukin-1B levels in the lung through the induction of pyrin. Cell. Mol. Immunol. 2017-04-01 [PMID: 26435068] (WB, Human)	WB	Human
Lu C, Zhang F, Xu W et al. Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes. IUBMB Life. 2015-08-01 [PMID: 26305715] (WB, Rat) Details: NLRP3 antibody was used for WB on lysates of liver tissues from Rats treated with vehicle, ethanol and/or curcumin (Figure 1E). NLRP3 was considered as a proinflammatory signal molecules in this study.	WB	Rat
Li J, Wang Y, Wang Y et al. Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction J. Mol. Cell. Cardiol. 2015-07-18 [PMID: 26196303] (WB, Rat)	WB	Rat
Wang X, Li R, Wang X, Fu Q, Ma. Umbelliferone ameliorates cerebral ischemia-reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome. Neurosci Lett. 2015-07-23 [PMID: 26071904] (Rat)		Rat
Li Y, Yang J, Chen MH et al. Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner. Pharmacol Res. 2015-09-01 [PMID: 26054569]
Zhao Y, Li Q, Zhao W et al. Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium. J Ethnopharmacol. 2015-07-01 [PMID: 25922268] (WB, Human)	WB	Human
Li Y, Li J, Li S et al. Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. Toxicol. Appl. Pharmacol. 2015-03-16 [PMID: 25791922] (WB, Mouse)	WB	Mouse
Gabrielli E, Pericolini E, Luciano E et al. Aspartyl proteinases of Candida albicans induce caspase-11: implication in promoting inflammatory response Infect. Immun. 2015-02-23 [PMID: 25712931] (WB, Mouse) Details: NLRP3/NALP3 antibody used for WB analysis of lysates from RAW 264.7 cells that were pretreated for 1 hours in the presence or absence of 40 uM IC-11 and then cultured for 30 minutes - 4 hours in the presence or absence of 10 ug LPS with 5 uM ATP, 20ug/ml Sap2 or 20ug/ml Sap6 (Figure 2A).	WB	Mouse
Zhang X, Zhang JH, Chen XY et al. ROS-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation Antioxid. Redox Signal. 2015-01-20 [PMID: 25602171] (IF/IHC, Rat)	IF/IHC	Rat
Wang C, Pan Y, Zhang QY, Wang FM, Kong LD. Quercetin and Allopurinol Ameliorate Kidney Injury in STZ-Treated Rats with Regulation of Renal NLRP3 Inflammasome Activation and Lipid Accumulation PLoS One 2012-01-01 [PMID: 22701621] (WB, Rat)	WB	Rat
Ji K, Liu W, Yin W et al. A new class of potent liver injury protective compounds: Structural elucidation, total synthesis and bioactivity study Acta Pharmaceutica Sinica B 2023-05-01 (WB, Mouse)	WB	Mouse
Song J, Li J, Hou F et al. Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells. Metab. Clin. Exp. 2014-11-28 [PMID: 25499441] (WB, Human)	WB	Human
Wu J, Xu X, Li Y et al. Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells. Eur J Pharmacol. 2014-12-15 [PMID: 25446924]
Joshi S, Wang W, Peck AB, Khan SR. Activation of the NLRP3 Inflammasome in Association with Calcium Oxalate Crystal Induced Reactive Oxygen Species in Kidneys. J Urol. 2015-05-01 [PMID: 25437532] (IHC-P, Rat)	IHC-P	Rat
Chattergoon MA, Latanich R, Quinn J et al. HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon. PLoS Pathog. 2014-05-01 [PMID: 24788318] (WB, Human) Details: Primary human monocytes derived from PBMC, Fig S6A. NALP3 was detected at ~120 kDa. The specificity of the NALP3 pAb was validated with NALP3 siRNA.	WB	Human
Doi T, Doi S, Nakashima A et al. Mizoribine Ameliorates Renal Injury and Hypertension along with the Attenuation of Renal Caspase-1 Expression in Aldosterone-Salt-Treated Rats. PLoS ONE 2014-04-03 [PMID: 24695748] (WB, Rat)	WB	Rat
Serti E, Werner JM, Chattergoon M et al. Monocytes Activate Natural killer Cells via Inflammasome-Induced Interleukin 18 in Response to Hepatitis C Virus Replication. Gastroenterology. 2014-03-28 [PMID: 24685721] (WB, Human) Details: Human PBMC, Fig 6A. NALP3 was detected between the 100 and 120 kDa markers. Note the specificity of the NALP3 pAb was validated with NALP3-siNRA.	WB	Human
Fan S, Wang Y, Lu J Luteoloside suppresses proliferation and metastasis of hepatocellular carcinoma cells by inhibition of NLRP3 inflammasome PLoS One 2014-02-26 [PMID: 24587153] (WB, Human)	WB	Human
Fan CY, Wang MX, Ge CX et al. Betaine supplementation protects against high-fructose-induced renal injury in rats. J Nutr Biochem 2013-12-04 [PMID: 24456735] (WB, Rat)	WB	Rat
Pietrella D, Pandey N, Gabrielli E et al. Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome. Eur J Immunol. 2013-03-01 [PMID: 23280543] (WB, Human) Details: WB: Fig 5A & B (human primary monocytes), Fig 5C & D (human primary monocytes transfected with siNALP3 or siScrambled Control). Note: The specificity of the NALP3 antibody was validated by WB in human monocytes by siNALP3 knockdown (Fig 5C & D).	WB	Human
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Images	Ratings	Applications	Species	Date	Details
Enlarge	3 reviewed by: Verified Customer	WB	Rat	10/05/2020	View Summary Application Western Blot Sample Tested Placental tissue Species Rat Lot G Comments Comments Rat placenta lysates, reduced and denatured; 100 ug total protein resolved on 10% SDS-acrylamide gel. Transfer onto 0.22 um nitrocellulose membrane. Blocking with Rockland blocking reagent. Incubate membrane overnight at 4C with 1:500 dilution of NLRP3/NALP3 antibody. Washes with PBS-0.1% tween 20. Incubate for one hour at room temp with 1:10 000 LiCor IRDye 800CW donkey anti-rabbit IgG. Images taken with Odyssey V3.0.
Enlarge	4 reviewed by: Verified Customer	WB	Mouse	08/06/2016	View Summary Application Western Blot Species Mouse Lot PO number； E0496223
Enlarge	4 reviewed by: Chunhui Sun	WB	Human	03/26/2015	View Summary Application Western Blot Sample Tested Whole cell lysate Species Human
Enlarge	5 reviewed by: Chunhui Sun	WB	Human	01/29/2015	View Summary Application Western Blot Sample Tested Whole cell lysate Species Human

Array NBP2-12446

• NLRP3/NALP3 Antibodies
• NLRP3/NALP3 ELISA Kit
• NLRP3/NALP3 Lysates
• NLRP3/NALP3 Proteins