STAT6 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the Jak/STAT signal transduction pathway and mediates cytokine signaling by IL-4. IL-4 activation leads to tyrosine phosphorylation and accumulation in the nucleus of STAT6 homo and heterodimers. STAT6 acts as a signal transducer in the cytoplasm and, upon phosphorylation at Y641, translocates to the nucleus and binds to the DNA consensus site TTCN₄GAA. Knockout studies in mice suggest that STAT6 functions in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. STAT6 transcriptional activation occurs by binding p100 and p160 class (NcoA1, Src-1) co-activators. Gene expression studies indicate that STAT6 mediates cell proliferation and anti-apoptotic effects of IL-4.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: Bioassay, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using AF2167	Applications	Species
Khan, F;Lin, Y;Ali, H;Pang, L;Dunterman, M;Hsu, WH;Frenis, K;Grant Rowe, R;Wainwright, DA;McCortney, K;Billingham, LK;Miska, J;Horbinski, C;Lesniak, MS;Chen, P; Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression Nature communications 2024-03-05 [PMID: 38443336] (Western Blot, Mouse)	Western Blot	Mouse
Chen, P;Khan, F;Lin, Y;Ali, H;Pang, L;Dunterman, M;Hsu, WH;Frenis, K;Rowe, RG;Wainwright, D;McCortney, K;Billingham, L;Miska, J;Horbinski, C;Lesniak, M; LDHA-regulated tumor-macrophage symbiosis promotes glioblastoma progression Research square 2023-10-05 [PMID: 37886538] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
SK Mishra, JJ Wheeler, S Pitake, H Ding, C Jiang, T Fukuyama, JS Paps, P Ralph, J Coyne, M Parkington, J DeBrecht, LC Ehrhardt-H, GP Cruse, W Bäumer, RR Ji, MC Ko, T Olivry Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch Cell Rep, 2020-04-07;31(1):107472. 4/7/2020 [PMID: 32268102]
S Hu, C Marshall, J Darby, W Wei, AB Lyons, H Körner Absence of Tumor Necrosis Factor Supports Alternative Activation of Macrophages in the Liver after Infection with Front Immunol, 2018-01-19;9(0):1. 2018-01-19 [PMID: 29403488] (Western Blot, Mouse)	Western Blot	Mouse

Array AF2167

• STAT6 Antibodies
• STAT6 ELISA Kits
• STAT6 Lysate
• STAT6 Proteins