STAT6 Products

Description

Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the Janus family tyrosine kinases (Jak)/ STAT signal transduction pathway and mediates cytokine signaling by IL 4 and IL-13 (1). STAT6 (predicted molecular weight 94kDa) has been found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL-4. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT6 is tyrosine phosphorylated (Tyr641) in response to cellular interaction with IL-4. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 and Th9 immune response (2). Loss of STAT6 impairs IL-4 mediated functions including Th2 helper T cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation. Diseases associated with STAT6 include malignant hemangiopericytoma and nut allergies.

References

1. Waqas, S. F. H., Ampem, G., & Roszer, T. (2019). Analysis of IL-4/STAT6 Signaling in Macrophages. Methods Mol Biol, 1966, 211-224. doi:10.1007/978-1-4939-9195-2_17

2. Goenka, S., & Kaplan, M. H. (2011). Transcriptional regulation by STAT6. Immunol Res, 50(1), 87-96. doi:10.1007/s12026-011-8205-2

Bioinformatics

Entrez	20852 Mouse 362896 Rat 6778 Human
Uniprot	NM_003153 Human NP_003144 Human NP_003144.3 Human P42226 Human
Product By Gene ID	6778
Alternate Names	D12S1644 EC 2.4.1.227 EC 2.7.7.6 IL-4 Stat IL-4-STAT signal transducer and activator of transcription 6 signal transducer and activator of transcription 6, interleukin-4 induced STAT, interleukin-4 induced STAT, interleukin4-induced STAT6B STAT6C transcription factor IL-4 STAT

Research Areas for STAT6

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Asthma
Epitope Tags
Immunology
Phospho-Specific
Signal Transduction

Related STAT6 Blog Posts

Check out the latest blog posts on STAT6.

Signal Transducer and Activator of Transcription STAT6: More than a Player in Allergic Inflammation By Jamshed Arslan, Pharm. D., PhD. What is STAT6?The cellular pathway comprising tyrosine kinase Janus Kinase (JAK) and the transcription factor STAT connect extracellular signals from various cytokines, hormones an...    Read more.

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