p62/SQSTM1 Antibody (864807) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

SQSTM1 (Sequestrome-1), also called p62, is a widely expressed, stress-inducible, multifunctional 62 kDa intracellular protein. The 440 amino acid (aa) human SQSTM1 contains multiple adaptor domains that allow interaction with proteins in NGF/NFkB and other signaling pathways (notably TRAF6, atypical protein kinase C family and Src family), polyubiquitin, proteasome subunits and many others. It contains numerous regulatory phosphorylation sites and a dimerization site. SQSTM1 shuttles ubiquitinylated proteins to the proteasome and is important in autophagy and apoptosis. Its dysregulation is associated with Paget’s disease of bone, Parkinson’s and Alzheimer’s diseases, and cancers. Within aa 344-440, which includes the ubiquitin-binding domain, human SQSTM1 shares 100% aa sequence identity with mouse and rat SQSTM1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 5 applications: ICC, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 19. Show All 19 Publications. Collapse Publications.

Publications using MAB8028	Applications	Species
Dos Santos, C;Cambraia, A;Shrestha, S;Cutler, M;Cottam, M;Perkins, G;Lev-Ram, V;Roy, B;Acree, C;Kim, KY;Deerinck, T;Dean, D;Cartailler, JP;MacDonald, PE;Hetzer, M;Ellisman, M;Arrojo E Drigo, R; Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice Nature communications 2024-10-21 [PMID: 39433757] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Ayoubi, R;Alshafie, W;Shlaifer, I;Southern, K;McPherson, PS;Laflamme, C;NeuroSGC/YCharOS/EDDU collaborative group, ; The identification of high-performing antibodies for Sequestosome-1 for use in Western blot, immunoprecipitation and immunofluorescence F1000Research 2024-07-10 [PMID: 39006307] (Immunoprecipitation, Western Blot, Immunocytochemistry, Human)	Immunoprecipitation, Western Blot, Immunocytochemistry	Human
Fang, L;Chen, WC;Jaksch, P;Molino, A;Saglia, A;Roth, M;Lambers, C; Treprostinil Reconstitutes Mitochondrial Organisation and Structure in Idiopathic Pulmonary Fibrosis Cells International journal of molecular sciences 2023-07-29 [PMID: 37569523] (Western Blot, Human)	Western Blot	Human
Barcena ML, Tonini G, Haritonow N et al. Sex and age differences in AMPK phosphorylation, mitochondrial homeostasis, and inflammation in hearts from inflammatory cardiomyopathy patients Aging cell 6/26/2023 [PMID: 37365150]
Mohammed S, Thadathil N, Ohene-Marfo P et al. Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis Molecular cancer research : MCR 5/19/2023 [PMID: 37204757]
Mitsui, K;Hishiyama, S;Jain, A;Kotoda, Y;Abe, M;Matsukawa, T;Kotoda, M; Role of macrophage autophagy in postoperative pain and inflammation in mice Journal of neuroinflammation 2023-05-02 [PMID: 37131209] (Western Blot, Mouse)	Western Blot	Mouse
L Fang, M Zhang, J Li, L Zhou, M Tamm, M Roth Airway Smooth Muscle Cell Mitochondria Damage and Mitophagy in COPD via ERK1/2 MAPK International Journal of Molecular Sciences, 2022-11-12;23(22):. 2022-11-12 [PMID: 36430467] (Western Blot, Human)	Western Blot	Human
Morena Scotece, Carlos Vaamonde-García, Ana Victoria Lechuga-Vieco, Alberto Centeno Cortés, María Concepción Jiménez Gómez, Purificación Filgueira-Fernández et al. mtDNA variability determines spontaneous joint aging damage in a conplastic mouse model Aging (Albany NY) 8/15/2022 [PMID: 35779570]
Guo Y, Chomiak AA, Hong Y et al. Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration iScience 7/15/2022 [PMID: 35754718]
K Zhao, A Schäfer, Z Zhang, K Elsässer, C Culmsee, L Zhong, A Pagenstech, C Nimsky, JW Bartsch Inhibition of Carbonic Anhydrase 2 Overcomes Temozolomide Resistance in Glioblastoma Cells International Journal of Molecular Sciences, 2021-12-23;23(1):. 2021-12-23 [PMID: 35008590] (Western Blot, Human)	Western Blot	Human
Lars E. Larsen, Marjolein A.W. van den Boogert, Wilson A. Rios-Ocampo, Jos C. Jansen, Donna Conlon, Patrick L.E. Chong et al. Defective Lipid Droplet–Lysosome Interaction Causes Fatty Liver Disease as Evidenced by Human Mutations in TMEM199 and CCDC115 Cellular and Molecular Gastroenterology and Hepatology 1/1/2022 [PMID: 34626841]
P Mergenthal, S Hariharan, JM Pemberton, C Lourenco, LZ Penn, DW Andrews Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning PLoS computational biology, 2021-02-22;17(2):e1008630. 2021-02-22 [PMID: 33617523] (ICC, Human)	ICC	Human
EJ Yun, S Kim, JT Hsieh, ST Baek Wnt/&beta-catenin signaling pathway induces autophagy-mediated temozolomide-resistance in human glioblastoma Cell Death Dis, 2020-09-17;11(9):771. 2020-09-17 [PMID: 32943609] (Western Blot, Human)	Western Blot	Human
Maria Laura A. Perez Vidakovics, Agustín E. Ure, Paula N. Arrías, Víctor Romanowski, Ricardo M. Gómez Junín virus induces autophagy in human A549 cells PLOS ONE 6/19/2019 [PMID: 31216340]
Walker D, Tang T, Lue L Increased expression of toll-like receptor 3, an anti-viral signaling molecule, and related genes in Alzheimer's disease brains. Exp Neurol, 2018-08-01;309(0):91-106. 8/1/2018 [PMID: 30076830]
Dagmar E. Ehrnhoefer, Dale D. O. Martin, Mandi E. Schmidt, Xiaofan Qiu, Safia Ladha, Nicholas S. Caron et al. Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease Acta Neuropathologica Communications 12/1/2018 [PMID: 29510748]
Costa F, Vescovini R, Bolzoni M et al. Lenalidomide increases human dendritic cell maturation in multiple myeloma patients targeting monocyte differentiation and modulating mesenchymal stromal cell inhibitory properties Oncotarget 8/8/2017 [PMID: 28881793]
Z Li, EK Fan, J Liu, MJ Scott, Y Li, S Li, W Xie, TR Billiar, MA Wilson, Y Jiang, P Wang, J Fan Cold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma Cell Death Dis, 2017-05-11;8(5):e2775. 2017-05-11 [PMID: 28492546] (Western Blot, Mouse)	Western Blot	Mouse
Suraiya Saleem Tribbles Pseudokinase 3 Induces Both Apoptosis and Autophagy in Amyloid-? induced Neuronal Death J. Biol. Chem, 2016-12-23;0(0):. 2016-12-23 [PMID: 28011637] (ICC, Western Blot, Mouse, Rat)	ICC, Western Blot	Mouse, Rat
Show All 19 Publications. Collapse Publications.

Array MAB8028

• p62/SQSTM1 Antibodies
• p62/SQSTM1 ELISA Kit
• p62/SQSTM1 Lysate
• p62/SQSTM1 Proteins