Jak1 Antibody [Unconjugated]

This product is sold under license from Millipore Corporation under the following US or foreign patents: 5,821,069; 5,658,791; EP0560890. This product shall not be used to commercially screen drug molecules being developed as JAK1 or JAK2 inhibitors. Any such activity will be outside the scope of the research use only label license.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Janus Kinase 1 (Jak1) belongs to a family of protein tyrosine kinases that couple to cytokine receptors and are activated by ligand binding to these receptors. Activation of Jak1 occurs via phosphorylation at two adjacent tyrosine residues, Y1022 and Y1023, within the kinase domain. Jaks activate members of the STAT family of transcription factors by phosphorylating critical tyrosine regulatory sites. Jak1 is required for the activation of STAT1 and STAT2 in response to interferon alpha .

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Immunoprecipitation, Western Blot.

Showing Publications 1 - 3 of 3.

Publications using AF602	Applications	Species
Masahiro Yasuda, Sivapratha Nagappan-Chettiar, Erin M. Johnson-Venkatesh, Hisashi Umemori An activity-dependent determinant of synapse elimination in the mammalian brain Neuron 4/1/2021 [PMID: 33770504]
Christos Petropoulo Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes J Cell Biol, 2016-06-06;213(5):585-99. 6/6/2016 [PMID: 27269065]
Kulms D, Schwarz T Ultraviolet radiation inhibits interleukin-2-induced tyrosine phosphorylation and the activation of STAT5 in T lymphocytes. J. Biol. Chem., 2001-01-23;276(16):12849-55. 2001-01-23 [PMID: 11278301] (Immunoprecipitation, Western Blot, Mouse)	Immunoprecipitation, Western Blot	Mouse

Array AF602

• Jak1 Antibodies
• Jak1 ELISA Kit
• Jak1 Lysate
• Jak1 Protein