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CXCR6 Antibody (56811) [DyLight 488]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready
Clone
56811
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 488

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CXCR6 Antibody (56811) [DyLight 488] Summary

Immunogen
NS0 mouse myeloma cell line transfected with human CXCR6
Met1-Leu342
Accession # O00574
Specificity
Stains human CXCR6 transfectants but not irrelevant transfectants.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
CXCR6
Purity
Protein A or G purified from ascites
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Applications/Dilutions

Dilutions
  • CyTOF-reported
  • Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from ascites

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for CXCR6 Antibody (56811) [DyLight 488]

  • Bonzo
  • BONZOG-protein coupled receptor bonzo
  • CD186 antigen
  • CD186
  • CDw186
  • chemokine (C-X-C motif) receptor 6
  • C-X-C chemokine receptor type 6
  • CXCR6
  • CXC-R6
  • CXCR-6
  • G protein-coupled receptor
  • STRL33
  • STRL33G-protein coupled receptor STRL33
  • TYMSTRCD186

Background

Coreceptor usage of primary human immunodeficiency virus type 1 (HIV-1) isolates varies according to biological phenotype. The chemokine receptors CCR5 and CXCR4 are the major coreceptors that, together with CD4, govern HIV-1 entry into cells. Some HIV-1, HIV-2, and SIV isolates of different genetic subtypes and biological phenotypes use other chemokine receptors, such as CXCR6, a T-lymphocyte-expressed seven-transmembrane domain receptor that mediates fusion, entry, and trafficking of tumor-infiltrating lymphocytes. CXCR6 has been identified in human blood (T-lymphocytes, activated peripheral blood lymphocytes, monocyte-derived dendritic cells, primitive cord blood cells), placental trophoblasts, T-lymphocytes and dendritic cells in the skin, lymphoid tissues, and in fetal brain astrocytes. ESTs have been isolated from human normal placenta, liver/spleen, and pregnant uterus libraries, and human cancer kidney and uterus libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CXCR6