Name: CCR6 Antibody (53103)
Brand: Novus Biologicals
SKU: MAB195
Price: 479 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	Flow, IHC, CyTOF-ready
Clone	53103
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated
Concentration	LYOPH

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 FAB195U-100UG

Alexa Fluor 405 FAB195V-100UG

Alexa Fluor 488 FAB195G-100UG

Alexa Fluor 532 FAB195X

Alexa Fluor 594 FAB195T-100

Alexa Fluor 647 FAB195R-100UG

Alexa Fluor 700 FAB195N-100UG

Alexa Fluor 750 FAB195S-100UG

Allophycocyanin FAB195A-025

Allophycocyanin FAB195A-100

Allophycocyanin/Cy7 FAB195APCCY7

Biotin FAB195B

CoraFluor 1 FAB195CL1

DyLight 350 FAB195D

DyLight 405 FAB195E

DyLight 488 FAB195K

DyLight 550 FAB195L

DyLight 594 FAB195M

DyLight 650 FAB195W

DyLight 680 FAB195Y

DyLight 755 FAB195Z

HRP FAB195H

Janelia Fluor 525 FAB195JF525

Janelia Fluor 549 FAB195I

Janelia Fluor 646 FAB195J

Janelia Fluor 669 FAB195JF669

PE/Atto594 FAB195PEATT594

PE/Cy5.5 FAB195PECY55

PE/Cy7 FAB195PECY7

PerCP (Peridinin-chlorophyll Protein Complex) FAB195C-025

PerCP (Peridinin-chlorophyll Protein Complex) FAB195C-100

Phycoerythrin FAB195P-100

Phycoerythrin FAB195P-025

mFluor Violet 450 SE FAB195MFV450

mFluor Violet 500 SE FAB195MFV500

mFluor Violet 610 SE FAB195MFV610

Catalog# & Formulation	Size	Price
Carrier Free FAB195T-100

Carrier Free FAB195N-100UG

Carrier Free FAB195R-100UG

Carrier Free FAB195S-100UG

Carrier Free FAB195U-100UG

Carrier Free FAB195V-100UG

Carrier Free MAB195-500

Carrier Free MAB195-SP

Carrier Free FAB195C-025

Carrier Free FAB195A-100

Carrier Free FAB195A-025

Carrier Free FAB195P-100

Carrier Free FAB195P-025

Carrier Free FAB195C-100

Carrier Free FAB195G-100UG

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB195U-100UG
Alexa Fluor 405	FAB195V-100UG
Alexa Fluor 488	FAB195G-100UG
Alexa Fluor 532	FAB195X
Alexa Fluor 594	FAB195T-100
Alexa Fluor 647	FAB195R-100UG
Alexa Fluor 700	FAB195N-100UG
Alexa Fluor 750	FAB195S-100UG
Allophycocyanin	FAB195A-100
Allophycocyanin	FAB195A-025
Allophycocyanin/Cy7	FAB195APCCY7
Biotin	FAB195B
CoraFluor 1	FAB195CL1
DyLight 350	FAB195D
DyLight 405	FAB195E
DyLight 488	FAB195K
DyLight 550	FAB195L
DyLight 594	FAB195M
DyLight 650	FAB195W
DyLight 680	FAB195Y
DyLight 755	FAB195Z
HRP	FAB195H
Janelia Fluor 525	FAB195JF525
Janelia Fluor 549	FAB195I
Janelia Fluor 646	FAB195J
Janelia Fluor 669	FAB195JF669
PE/Atto594	FAB195PEATT594
PE/Cy5.5	FAB195PECY55
PE/Cy7	FAB195PECY7
PerCP (Peridinin-chlorophyll Protein Complex)	FAB195C-025
PerCP (Peridinin-chlorophyll Protein Complex)	FAB195C-100
Phycoerythrin	FAB195P-100
Phycoerythrin	FAB195P-025
mFluor Violet 450 SE	FAB195MFV450
mFluor Violet 500 SE	FAB195MFV500
mFluor Violet 610 SE	FAB195MFV610

CCR6 Antibody (53103)

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CCR6 Antibody (53103) Summary

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Alternate Names for CCR6 Antibody (53103)

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Publications for CCR6 Antibody (MAB195)(37)

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Bioinformatics

Additional Information	Clone 53103 was used by HLDA to establish CD designation
Immunogen	NS0 mouse myeloma cell line transfected with human CCR6 Met1-Met374 Accession # P51684
Specificity	Detects human CCR6. Stains human CCR6 transfectants but not the parental cell line in flow cytometry. Does not cross-react with transfectants expressing human CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CXCR1, CXCR2, CXCR3, CXCR4, or STRL33.
Source	N/A
Isotype	IgG2b
Clonality	Monoclonal
Host	Mouse
Gene	CCR6
Purity Statement	Protein A or G purified from ascites
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Publications using MAB195	Applications	Species
A Woestemeie, P Scognamigl, Y Zhao, J Wagner, F Muscate, C Casar, F Siracusa, F Cortesi, T Agalioti, S Müller, A Sagebiel, L Konczalla, R Wahib, KF Karstens, AD Giannou, A Duprée, S Wolter, MN Wong, AK Mühlig, AA Bielecka, V Bansal, T Zhang, O Mann, VG Puelles, TB Huber, AW Lohse, JR Izbicki, NW Palm, S Bonn, S Huber, N Gagliani Multicytokine-producing CD4+ T cells characterize the livers of patients with NASH JCI Insight, 2023-01-10;8(1):. 2023-01-10 [PMID: 36625344] (IHC, Human)	IHC	Human
T Balzano, P Leone, G Ivaylova, MC Castro, L Reyes, C Ramón, M Malaguarne, M Llansola, V Felipo Rifaximin Prevents T-Lymphocytes and Macrophages Infiltration in Cerebellum and Restores Motor Incoordination in Rats with Mild Liver Damage Biomedicines, 2021-08-12;9(8):. 2021-08-12 [PMID: 34440206] (IHC, Rat)	IHC	Rat
Jennifer P. Bharucha, Lingling Sun, Wuyuan Lu, Suzanne Gartner, Alfredo Garzino-Demo Human Beta-Defensin 2 and 3 Inhibit HIV-1 Replication in Macrophages Frontiers in Cellular and Infection Microbiology 7/1/2021 [PMID: 34277460]
F Facciotti, P Larghi, R Bosotti, C Vasco, N Gagliani, C Cordiglier, S Mazzara, V Ranzani, E Rottoli, S Curti, A Penatti, B Karnani, Y Kobayashi, M Crosti, M Bombaci, JP van Hambur, G Rossetti, R Gualtierot, M Gerosa, S Gatti, S Torretta, L Pignataro, SW Tas, S Abrignani, M Pagani, F Grassi, PL Meroni, RA Flavell, J Geginat Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+B helper T cells in systemic lupus erythematosus Proc. Natl. Acad. Sci. U.S.A., 2020-03-17;117(13):7305-7316. 2020-03-17 [PMID: 32184325] (IHC, Human)	IHC	Human
T Balzano, J Forteza, P Molina, J Giner, A Monzó, J Sancho-Jim, A Urios, C Montoliu, V Felipo The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons Sci Rep, 2018-02-14;8(1):3004. 2018-02-14 [PMID: 29445232] (IHC-P, Human)	IHC-P	Human
XP Zhang, ZJ Hu, AH Meng, GC Duan, QT Zhao, J Yang Role of CCL20/CCR6 and the ERK signaling pathway in lung adenocarcinoma Oncol Lett, 2017-10-23;14(6):8183-8189. 2017-10-23 [PMID: 29250193] (IHC-P, Human)	IHC-P	Human
B Soto, T Gallastegi, C Rodríguez, J Martínez-G, JR Escudero, L Vila, M Camacho Circulating CCL20 as a New Biomarker of Abdominal Aortic Aneurysm Sci Rep, 2017-12-11;7(1):17331. 2017-12-11 [PMID: 29229985] (IHC-P, Human)	IHC-P	Human
R Diao, T Wang, KL Fok, X Li, Y Ruan, MK Yu, Y Cheng, Y Chen, H Chen, L Mou, X Cai, Y Wang, Z Cai, X Zeng, HC Chan CCR6 is required for ligand-induced CatSper activation in human sperm Oncotarget, 2017-09-05;8(53):91445-91458. 2017-09-05 [PMID: 29207656] (ICC, Human)	ICC	Human
J Dunham, N van Driel, BJ Eggen, C Paul, BA 't Hart, JD Laman, YS Kap Analysis of the cross-talk of Epstein-Barr virus-infected B cells with T cells in the marmoset Clin Transl Immunology, 2017-02-10;6(2):e127. 2017-02-10 [PMID: 28243437] (Flow Cytometry, Primate)	Flow Cytometry	Primate
W Szczeklik, B Jakie?a, K Wawrzycka-, M Sanak, M Hubalewska, A Padjas, M Surmiak, K Szczeklik, J Sznajd, J Musia? Skewing towards Treg and Th2 responses is a characteristic feature of sustained remission in ANCA-positive granulomatosis with polyangiitis Eur. J. Immunol, 2017-02-27;0(0):. 2017-02-27 [PMID: 28155222] (Flow Cytometry, Human)	Flow Cytometry	Human
Valentina Cecchinato Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization J. Immunol, 2016-11-28;0(0):. 2016-11-28 [PMID: 27895171] (IHC-P, Primate - Macaca mulatta (Rhesus Macaque))	IHC-P	Primate - Macaca mulatta (Rhesus Macaque)
Shang L, Duan L, Perkey KE et al. Epithelium-innate immune cell axis in mucosal responses to SIV Mucosal Immunol 7/20/2016 [PMID: 27435105]
CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition Br J Cancer, 2016-05-05;0(0):. 2016-05-05 [PMID: 27149649] (Bioassay, Flow Cytometry, IHC-P, Human)	Bioassay, Flow Cytometry, IHC-P	Human
Schanz A, Red-Horse K, Hess A, Baston-Bust D, Heiss C, Krussel J Oxygen regulates human cytotrophoblast migration by controlling chemokine and receptor expression. Placenta, 2014-09-26;35(12):1089-94. 2014-09-26 [PMID: 25293376] (Western Blot, Human)	Western Blot	Human
Liu , Jinlin, Ke , Fang, Xu , Zhenyao, Liu , Zhaoyuan, Zhang , Lingyun, Yan , Sha, Wang , Zhe, Wang , Hong, Wang , Honglin CCR6 is a prognostic marker for overall survival in patients with colorectal cancer, and its overexpression enhances metastasis in vivo. PLoS ONE, 2014-06-30;9(6):e101137. 2014-06-30 [PMID: 24979261] (IHC, Mouse)	IHC	Mouse
Nandi , Bisweswa, Pai , Christin, Huang , Qin, Prabhala , Rao H, Munshi , Nikhil C, Gold , Jason S CCR6, the sole receptor for the chemokine CCL20, promotes spontaneous intestinal tumorigenesis. PLoS ONE, 2014-05-27;9(5):e97566. 2014-05-27 [PMID: 24866282] (IHC-P, Mouse)	IHC-P	Mouse
Malard F, Bossard C, Brissot E, Chevallier P, Guillaume T, Delaunay J, Mosnier J, Moreau P, Gregoire M, Gaugler B, Mohty M Increased Th17/Treg ratio in chronic liver GVHD. Bone Marrow Transplant, 2014-01-13;49(4):539-44. 2014-01-13 [PMID: 24419519] (IHC-P, Human)	IHC-P	Human
Malard F, Bossard C, Brissot E, Chevallier P, Guillaume T, Delaunay J, Mosnier J, Moreau P, Gregoire M, Gaugler B, Mohty M Increased plasmacytoid dendritic cells and RORgammat-expressing immune effectors in cutaneous acute graft-versus-host disease. J Leukoc Biol, 2013-08-29;94(6):1337-43. 2013-08-29 [PMID: 23990625] (IHC-P, Human)	IHC-P	Human
BIN CHEN, DUO ZHANG, JIAN ZHOU, QING LI, LIN ZHOU, SHI-MIN LI et al. High CCR6/CCR7 expression and Foxp3+ Treg cell number are positively related to the progression of laryngeal squamous cell carcinoma Oncology Reports 9/1/2013 [PMID: 23835793]
Pedro Caballero-Campo, Mariano G. Buffone, Fabian Benencia, José R. Conejo-García, Paolo F. Rinaudo, George L. Gerton A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis Journal of Cellular Physiology 8/2/2013 [PMID: 23765988]
Mazerolles F, Picard C, Kracker S, Fischer A, Durandy A Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency. J Allergy Clin Immunol, 2013-02-10;131(4):1146-56, 1156. 2013-02-10 [PMID: 23403044] (Flow Cytometry, Human)	Flow Cytometry	Human
Miyagaki T, Sugaya M, Suga H, Kamata M, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma. Clin. Cancer Res., 2011-11-02;17(24):7529-38. 2011-11-02 [PMID: 22048239] (IHC-P, Human)	IHC-P	Human
Pandya AD, Al-Jaderi Z, Hoglund RA, Holmoy T, Harbo HF, Norgauer J, Maghazachi AA Identification of human NK17/NK1 cells. PLoS ONE, 2011-10-21;6(10):e26780. 2011-10-21 [PMID: 22039549] (Flow Cytometry, Human)	Flow Cytometry	Human
Kim S, Lewis C, Nadel JA CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J. Immunol., 2011-02-07;186(6):3392-400. 2011-02-07 [PMID: 21300824] (Western Blot, Human)	Western Blot	Human
Charles J, Di Domizio J, Salameire D, Bendriss-Vermare N, Aspord C, Muhammad R, Lefebvre C, Plumas J, Leccia MT, Chaperot L Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor. J. Invest. Dermatol., 2010-03-11;130(6):1646-56. 2010-03-11 [PMID: 20220766] (IHC-P, Human)	IHC-P	Human
Franciszkiewicz K, Le Floc'h A, Jalil A, Vigant F, Robert T, Vergnon I, Mackiewicz A, Benihoud K, Validire P, Chouaib S, Combadiere C, Mami-Chouaib F Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer Res., 2009-07-28;69(15):6249-55. 2009-07-28 [PMID: 19638592] (Flow Cytometry, Human)	Flow Cytometry	Human
Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J. Exp. Med., 2008-12-29;206(1):249-58. 2008-12-29 [PMID: 19114666] (Blocking, Human)	Blocking	Human
Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J. Immunol., 2007-09-15;179(6):3724-33. 2007-09-15 [PMID: 17785809] (Flow Cytometry, Human)	Flow Cytometry	Human
Bergeron A, El-Hage F, Kambouchner M, Lecossier D, Tazi A Characterisation of dendritic cell subsets in lung cancer micro-environments. Eur. Respir. J., 2006-08-09;28(6):1170-7. 2006-08-09 [PMID: 16899480] (IHC, Human)	IHC	Human
Marchal-Somme J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, Crestani B, Soler P Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis. J. Immunol., 2006-05-15;176(10):5735-9. 2006-05-15 [PMID: 16670278] (IHC-Fr, Human)	IHC-Fr	Human
Lim HW, Hillsamer P, Kim CH Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J. Clin. Invest., 2004-12-01;114(11):1640-9. 2004-12-01 [PMID: 15578096] (ICC, Human)	ICC	Human
Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, Stingl G, Rot A, Maurer D Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J. Immunol., 2004-12-01;173(11):6592-602. 2004-12-01 [PMID: 15557149] (Flow Cytometry, Human)	Flow Cytometry	Human
Page G, Miossec P Paired synovium and lymph nodes from rheumatoid arthritis patients differ in dendritic cell and chemokine expression. J. Pathol., 2004-09-01;204(1):28-38. 2004-09-01 [PMID: 15307135] (IHC-P, Human)	IHC-P	Human
Page G, Sattler A, Kersten S, Thiel A, Radbruch A, Miossec P Plasma cell-like morphology of Th1-cytokine-producing cells associated with the loss of CD3 expression. Am. J. Pathol., 2004-02-01;164(2):409-17. 2004-02-01 [PMID: 14742247] (ICC, IHC-P, Human)	ICC, IHC-P	Human
Annels NE, Willemze AJ, van der Velden VH, Faaij CM, van Wering E, Sie-Go DM, Egeler RM, van Tol MJ, RÃƒÂ©vÃƒÂ©sz T Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL. Blood, 2003-12-04;103(7):2806-8. 2003-12-04 [PMID: 14656893] (Flow Cytometry, Human)	Flow Cytometry	Human
Maki W, Morales RE, Carroll VA, Telford WG, Knibbs RN, Stoolman LM, Hwang ST CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells. J. Immunol., 2002-09-01;169(5):2346-53. 2002-09-01 [PMID: 12193700] (ICC, Human)	ICC	Human
Campbell J, Qin S, Unutmaz D, Soler D, Murphy K, Hodge M, Wu L, Butcher E Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. J Immunol, 2001-06-01;166(11):6477-82. 2001-06-01 [PMID: 11359797] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 37 Publications. Collapse Publications.

Gene Symbol	CCR6
Uniprot	P51684()