Doublecortin Antibody

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 applications: IF/IHC, Immunohistochemistry.

Showing Publications 1 - 5 of 5.

Publications using NBP1-72042	Applications	Species
Napier M, Kumar A, Szulist N et al. P2X7 expression patterns in the developing Fmr1-knockout mouse hippocampus. Hippocampus 2024-09-13 [PMID: 39269925]
Juliana Campo Garcia, Roemel Jeusep Bueno, Maren Salla, Ivette Martorell-Serra, Bibiane Seeger, Nilufar Akbari, Pia Sperber, Harald Stachelscheid, Carmen Infante-Duarte, Friedemann Paul, Sarah C. Starossom Establishment of a high-content compatible platform to assess effects of monocyte-derived factors on neural stem cell proliferation and differentiation Scientific Reports 2024-05-28 [PMID: 38806485]
Jim�nez-Madrona E, Morado-D�az CJ, Talaver�n R et al. Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells Frontiers in Neuroscience 2023-08-16 [PMID: 37655012] (Immunohistochemistry)	Immunohistochemistry
O'Donnell Jc, Purvis Em, Helm Kvt Et Al. An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement Communications biology 2021-07-15 [PMID: 34267315] (IF/IHC)	IF/IHC
Evangelisti C, Florian MC, Massimi I et al. MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness. FASEB J 2009-12-01 [PMID: 19713529]

Array NBP1-72042

• Doublecortin Antibodies
• Doublecortin ELISA Kit
• Doublecortin Lysates
• Doublecortin Proteins