CCR2 Antibody (475301) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCR2, also known as CD192, is a 38 kDa 7TM chemokine receptor that preferentially binds CCL2, CCL7, and CCL13. CCR2 is expressed by multiple hematopoietic cells, endothelial cells, fibroblasts, neurons, and smooth muscle cells. It functions as an HIV fusion co-factor and facilitates T cell recruitment during inflammation. Two alternate splice forms (CCR2A and CCR2B) differ only by the addition of 14 amino acids to the intracellular carboxyl terminal. Mouse CCR2 shares 67% and 95% aa sequence identity with human and rat CCR2, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: CyTof, Flow Cytometry, Neutralization.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using MAB55381	Applications	Species
Sulczewski, FB;Maqueda-Alfaro, RA;Alcántara-Hernández, M;Perez, OA;Saravanan, S;Yun, TJ;Seong, D;Arroyo Hornero, R;Raquer-McKay, HM;Esteva, E;Lanzar, ZR;Leylek, RA;Adams, NM;Das, A;Rahman, AH;Gottfried-Blackmore, A;Reizis, B;Idoyaga, J; Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses Nature immunology 2023-07-06 [PMID: 37414907] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Fulton, SL;Bendl, J;Gameiro-Ros, I;Fullard, JF;Al-Kachak, A;Lepack, AE;Stewart, AF;Singh, S;Poller, WC;Bastle, RM;Hauberg, ME;Fakira, AK;Chen, M;Cuttoli, RD;Cathomas, F;Ramakrishnan, A;Gleason, K;Shen, L;Tamminga, CA;Milosevic, A;Russo, SJ;Swirski, F;Blitzer, RD;Slesinger, PA;Roussos, P;Maze, I; ZBTB7A regulates MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in orbitofrontal cortex bioRxiv : the preprint server for biology 2023-05-04 [PMID: 37205394] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
SL Kurtz, R De Pascali, AI Meierovics, KL Elkins Deficiency in CCR2 increases susceptibility of mice to infection with an intracellular pathogen, Francisella tularensis LVS, but does not impair development of protective immunity PLoS ONE, 2021-03-24;16(3):e0249142. 2021-03-24 [PMID: 33760886] (Flow Cytometry, Neutralization, Mouse)	Flow Cytometry, Neutralization	Mouse
J Xu, J Wang, X Wang, R Tan, X Qi, Z Liu, H Qu, T Pan, Q Zhan, Y Zuo, W Yang, J Liu Soluble PD-L1 improved direct ARDS by reducing monocyte-derived macrophages Cell Death Dis, 2020-10-30;11(10):934. 2020-10-30 [PMID: 33127884] (CyTof, Mouse)	CyTof	Mouse
DP Regan, JW Coy, KK Chahal, L Chow, JN Kurihara, AM Guth, I Kufareva, SW Dow The Angiotensin Receptor Blocker Losartan Suppresses Growth of Pulmonary Metastases via AT1R-Independent Inhibition of CCR2 Signaling and Monocyte Recruitment J. Immunol., 2019-04-10;0(0):. 2019-04-10 [PMID: 30971441] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
W Yang, X Zhao, Y Tao, Y Wu, F He, L Tang Proteomic analysis reveals a protective role of specific macrophage subsets in liver repair Sci Rep, 2019-02-27;9(1):2953. 2019-02-27 [PMID: 30814596] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
SA Dick, JA Macklin, S Nejat, A Momen, X Clemente-C, MG Althagafi, J Chen, C Kantores, S Hosseinzad, L Aronoff, A Wong, R Zaman, I Barbu, R Besla, KJ Lavine, B Razani, F Ginhoux, M Husain, MI Cybulsky, CS Robbins, S Epelman Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction Nat. Immunol., 2018-12-11;20(1):29-39. 2018-12-11 [PMID: 30538339] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Y Zhan, N Wang, A Vasanthaku, Y Zhang, M Chopin, SL Nutt, A Kallies, AM Lew CCR2 enhances CD25 expression by FoxP3+ regulatory T cells and regulates their abundance independently of chemotaxis and CCR2+ myeloid cells Cell. Mol. Immunol., 2018-12-11;0(0):. 2018-12-11 [PMID: 30538272] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
J Wang, MJ Seo, MB Deci, BR Weil, JM Canty, J Nguyen Effect of CCR2 inhibitor-loaded lipid micelles on inflammatory cell migration and cardiac function after myocardial infarction Int J Nanomedicine, 2018-10-15;13(0):6441-6451. 2018-10-15 [PMID: 30410330] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
J Wu, R Zhang, G Hu, HH Zhu, WQ Gao, J Xue Carbon Monoxide Impairs CD11bLy-6CMonocyte Migration from the Blood to Inflamed Pancreas via Inhibition of the CCL2/CCR2 Axis J. Immunol., 2018-02-09;0(0):. 2018-02-09 [PMID: 29440506] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
CJ Perry, AR Muñoz-Roja, KM Meeth, LN Kellman, RA Amezquita, D Thakral, VY Du, JX Wang, W Damsky, AL Kuhlmann, JW Sher, M Bosenberg, K Miller-Jen, SM Kaech Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity J. Exp. Med., 2018-02-07;0(0):. 2018-02-07 [PMID: 29436395] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
K Mao, AP Baptista, S Tamoutouno, L Zhuang, N Bouladoux, AJ Martins, Y Huang, MY Gerner, Y Belkaid, RN Germain Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism Nature, 2018-01-22;0(0):. 2018-01-22 [PMID: 29364878] (Neutralization, Mouse)	Neutralization	Mouse
EM Putz, AJ Mayfosh, K Kos, DS Barkauskas, K Nakamura, L Town, KJ Goodall, DY Yee, IK Poon, N Baschuk, F Souza-Fons, MD Hulett, MJ Smyth NK cell heparanase controls tumor invasion and immune surveillance J. Clin. Invest., 2017-06-05;0(0):. 2017-06-05 [PMID: 28581441] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
D Sagar, NP Singh, R Ginwala, X Huang, R Philip, M Nagarkatti, P Nagarkatti, K Neumann, J Ruland, AM Andrews, SH Ramirez, ZK Khan, P Jain Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity Sci Rep, 2017-06-02;7(1):2707. 2017-06-02 [PMID: 28578388] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
N Chatziandr, Y Farsakoglu, M Palomino-S, R D'Antuono, DU Pizzagalli, F Sallusto, V Lukacs-Kor, M Uguccioni, D Corti, SJ Turley, A Lanzavecch, MC Carroll, SF Gonzalez Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node Cell Rep, 2017-03-07;18(10):2427-2440. 2017-03-07 [PMID: 28273457] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Siobhán C Cowley MAIT cells promote inflammatory monocyte differentiation into dendritic cells during pulmonary intracellular infection J. Exp. Med., 2016-10-31;0(0):. 2016-10-31 [PMID: 27799620] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Show All 16 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	Flow	Mouse	04/04/2019	View Summary Application Flow Cytometry Sample Tested Lymph node cells Species Mouse Lot B-3-092215F Comments Comments Experimental autoimmune encephalomyelitis was induced in C57BL6/J mice, and periaortic and inguinal lymph node cells were isolated when the animals were at the onset of symptoms. Cells were stained for CCR2, CD45, CD11b, CD11c, CD4, CD8, CX3CR1, CCR5, CCR7, and CXCR4, plus for viability to exclude dead cells. Viable cells stained for CCR2 (blue) and FMO sample for CCR2 (stained for all the markers except for CCR2; red).

Array MAB55381

• CCR2 Antibodies
• CCR2 ELISA Kit
• CCR2 Lysates
• CCR2 Proteins