CCR2 Antibody (475301) [Allophycocyanin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCR2, also known as CD192, is a 38 kDa 7TM chemokine receptor that preferentially binds CCL2, CCL7, and CCL13. CCR2 is expressed by multiple hematopoietic cells, endothelial cells, fibroblasts, neurons, and smooth muscle cells. It functions as an HIV fusion co-factor and facilitates T cell recruitment during inflammation. Two alternate splice forms (CCR2A and CCR2B) differ only by the addition of 14 amino acids to the intracellular carboxyl terminal. Mouse CCR2 shares 67% and 95% aa sequence identity with human and rat CCR2, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Flow Cytometry, IHC.

Showing Publications 1 - 10 of 55. Show All 55 Publications. Collapse Publications.

Publications using FAB5538A	Applications	Species
Kayo Hasegawa, Jorge Luis Montenegro Raudales, Takashi I, Takako Yoshida, Ryo Honma, Mayumi Iwatake et al. Effective-mononuclear cell (E-MNC) therapy alleviates salivary gland damage by suppressing lymphocyte infiltration in Sjögren-like disease Frontiers in Bioengineering and Biotechnology 4/24/2023 [PMID: 37168614]
Li XF, Selli C, Zhou HL et al. Macrophages promote anti-androgen resistance in prostate cancer bone disease The Journal of experimental medicine 4/3/2023 [PMID: 36749798] Details: Dilution used in IHC-P and ICC 1:500
Sabine Spath, Florence Roan, Scott R. Presnell, Barbara Höllbacher, Steven F. Ziegler Profiling of Tregs across tissues reveals plasticity in ST2 expression and hierarchies in tissue-specific phenotypes iScience 9/16/2022 [PMID: 36093048]
AE Geller, R Shrestha, MR Woeste, H Guo, X Hu, C Ding, K Andreeva, JH Chariker, M Zhou, D Tieri, CT Watson, RA Mitchell, HG Zhang, Y Li, RCG Martin Ii, EC Rouchka, J Yan The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression Nature Communications, 2022-02-09;13(1):759. 2022-02-09 [PMID: 35140221] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
M Le Roux, A Ollivier, G Kervoaze, T Beke, L Gillet, M Pichavant, P Gosset IL-20 Cytokines Are Involved in Epithelial Lesions Associated with Virus-Induced COPD Exacerbation in Mice Biomedicines, 2021-12-05;9(12):. 2021-12-05 [PMID: 34944654] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Aleksandra J. Ozga, Melvyn T. Chow, Mateus E. Lopes, Rachel L. Servis, Mauro Di Pilato, Philippe Dehio et al. CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection Immunity 1/1/2022 [PMID: 34847356]
M Flamant, N Mougenot, E Balse, L Le Fèvre, F Atassi, EL Gautier, W Le Goff, M Keck, S Nadaud, C Combadière, A Boissonnas, C Pavoine Early activation of the cardiac CX3CL1/CX3CR1 axis delays beta-adrenergic-induced heart failure Scientific Reports, 2021-09-09;11(1):17982. 2021-09-09 [PMID: 34504250] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
T Methatham, S Tomida, N Kimura, Y Imai, K Aizawa Inhibition of the canonical Wnt signaling pathway by a beta-catenin/CBP inhibitor prevents heart failure by ameliorating cardiac hypertrophy and fibrosis Scientific Reports, 2021-07-21;11(1):14886. 2021-07-21 [PMID: 34290289] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Qi Chen, Si Min Lai, Shaohai Xu, Yingrou Tan, Keith Leong, Dehua Liu et al. Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice EMBO reports 8/4/2021 [PMID: 34196465]
P Mittal, L Wang, T Akimova, CA Leach, JC Clemente, MR Sender, Y Chen, BJ Turunen, WW Hancock The CCR2/MCP-1 Chemokine Pathway and Lung Adenocarcinoma Cancers, 2020-12-11;12(12):. 2020-12-11 [PMID: 33322474] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
J Wu, L Zhang, J Shi, R He, W Yang, A Habtezion, N Niu, P Lu, J Xue Macrophage phenotypic switch orchestrates the inflammation and repair/regeneration following acute pancreatitis injury EBioMedicine, 2020-07-30;58(0):102920. 2020-07-30 [PMID: 32739869] (Mouse)		Mouse
Y Sato-Okaba, K Isoda, B Heissig, T Kadoguchi, K Akita, K Kitamura, K Shimada, K Hattori, H Daida Low-dose oral cyclophosphamide therapy reduces atherosclerosis progression by decreasing inflammatory cells in a murine model of atherosclerosis Int J Cardiol Heart Vasc, 2020-05-10;28(0):100529. 2020-05-10 [PMID: 32577494] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
SR Jung, TM Ashhurst, PK West, B Viengkhou, NJC King, IL Campbell, MJ Hofer Contribution of STAT1 to innate and adaptive immunity during type I interferon-mediated lethal virus infection PLoS Pathog., 2020-04-20;16(4):e1008525. 2020-04-20 [PMID: 32310998] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Anders Etzerodt, Morgane Moulin, Thomas Koed Doktor, Marcello Delfini, Noushine Mossadegh-Keller, Marc Bajenoff et al. Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer Journal of Experimental Medicine 4/6/2020 [PMID: 31951251]
Mingjuan Wu, Jun Liu, Fanying Li, Shuoya Huang, Jingxin He, Yunxia Xue et al. Antibiotic-induced dysbiosis of gut microbiota impairs corneal development in postnatal mice by affecting CCR2 negative macrophage distribution Mucosal Immunology 1/1/2020 [PMID: 31434991]
Suzanne E. Hickman, Joseph El Khoury Analysis of the Microglial Sensome Methods Mol. Biol. 9/27/2019 [PMID: 31392695]
Lim J, Park H, Heisler J et al. Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins Elife 7/9/2019 [PMID: 31287416]
JA Santamaria, S Zeng, JB Greer, MJ Beckman, AM Seifert, NA Cohen, JQ Zhang, MH Crawley, BL Green, JK Loo, JH Maltbaek, RP DeMatteo Csf1r or Mer inhibition delays liver regeneration via suppression of Kupffer cells PLoS ONE, 2019-05-01;14(5):e0216275. 2019-05-01 [PMID: 31042769] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
J Li, S Wada, LK Weaver, C Biswas, EM Behrens, Z Arany Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis JCI Insight, 2019-03-07;5(0):. 2019-03-07 [PMID: 30843872] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
MB Uccellini, A García-Sas ISRE-Reporter Mouse Reveals High Basal and Induced Type I IFN Responses in Inflammatory Monocytes Cell Rep, 2018-12-04;25(10):2784-2796.e3. 2018-12-04 [PMID: 30517866] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Jun Liu, Mingjuan Wu, Jingxin He, Chengju Xiao, Yunxia Xue, Ting Fu et al. Antibiotic-Induced Dysbiosis of Gut Microbiota Impairs Corneal Nerve Regeneration by Affecting CCR2-Negative Macrophage Distribution The American Journal of Pathology 12/1/2019 [PMID: 30470496]
F Madouri, O Barada, G Kervoaze, F Trottein, M Pichavant, P Gosset Production of Interleukin-20 cytokines limits bacterial clearance and lung inflammation during infection by Streptococcus pneumoniae EBioMedicine, 2018-10-22;0(0):. 2018-10-22 [PMID: 30361066] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Anne-Katrien Stark, Anita Chandra, Krishnendu Chakraborty, Rafeah Alam, Valentina Carbonaro, Jonathan Clark et al. PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner Nature Communications 8/9/2018 [PMID: 30093657]
Abudureyimujiang Aili, Jie Zhang, Jia Wu, Haoming Wu, Xiuyuan Sun, Qihua He et al. CCR2 Signal Facilitates Thymic Egress by Priming Thymocyte Responses to Sphingosine-1-Phosphate Frontiers in Immunology 6/7/2018 [PMID: 29930553]
HM Hsiao, R Fernandez, S Tanaka, W Li, JH Spahn, S Chiu, M Akbarpour, D Ruiz-Perez, Q Wu, C Turam, D Scozzi, T Takahashi, HP Luehmann, V Puri, GRS Budinger, AS Krupnick, AV Misharin, KJ Lavine, Y Liu, AE Gelman, A Bharat, D Kreisel Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1? J. Clin. Invest., 2018-05-21;128(7):2833-2847. 2018-05-21 [PMID: 29781811] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
M Chen, J Zhao, IH Ali, S Marry, J Augustine, M Bhuckory, A Lynch, A Kissenpfen, H Xu SOCS3 deficiency in myeloid cells promotes retinal degeneration and angiogenesis through arginase-1 up-regulation in experimental autoimmune uveoretinitis Am. J. Pathol., 2018-02-13;0(0):. 2018-02-13 [PMID: 29452101] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
CB Toomey, M Landowski, M Klingeborn, U Kelly, J Deans, H Dong, O Harrabi, T Van Blarco, YA Yeung, R Grishanin, JC Lin, DR Saban, C Bowes Rick Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration Invest. Ophthalmol. Vis. Sci., 2018-02-01;59(2):662-673. 2018-02-01 [PMID: 29392311] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Motohiko Kadoki, Ashwini Patil, Cornelius C. Thaiss, Donald J. Brooks, Surya Pandey, Deeksha Deep et al. Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues Cell 10/5/2017 [PMID: 28942919]
SM Steinberg, T Shabaneh, P Zhang, V Martyanov, Z Li, B Malik, T Wood, A Boni, A Molodtsov, CV Angeles, TJ Curiel, M Whitfield, MJ Turk Myeloid cells that impair immunotherapy are restored in melanomas which acquire resistance to BRAF inhibitors Cancer Res, 2017-02-15;0(0):. 2017-02-15 [PMID: 28202513] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
J Liu, Y Xue, D Dong, C Xiao, C Lin, H Wang, F Song, T Fu, Z Wang, J Chen, H Pan, Y Li, D Cai, Z Li CCR2(-) and CCR2(+) corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion Mucosal Immunol, 2017-01-25;0(0):. 2017-01-25 [PMID: 28120849] (Flow Cytometry, IHC, Mouse)	Flow Cytometry, IHC	Mouse
Stéphanie Lacotte Impact of myeloid-derived suppressor cell on Kupffer cells from mouse livers with hepatocellular carcinoma Oncoimmunology, 2016-09-20;5(11):e1234565. 2016-09-20 [PMID: 27999748] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Kevin T. Breen, Sarah R. Anderson, Michael R. Steele, David J. Calkins, Alejandra Bosco, Monica L. Vetter Loss of Fractalkine Signaling Exacerbates Axon Transport Dysfunction in a Chronic Model of Glaucoma Frontiers in Neuroscience 11/24/2016 [PMID: 27932942]
Olga Barreiro Pivotal role for skin trans-endothelial radio-resistant anti-inflammatory macrophages in tissue repair Elife, 2016-06-15;5(0):. 2016-06-15 [PMID: 27304075] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Alternatively activated macrophages determine repair of the infarcted adult murine heart J Clin Invest, 2016-05-03;0(0):. 2016-05-03 [PMID: 27140396] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Monocyte Trafficking, Engraftment, and Delivery of Nanoparticles and an Exogenous Gene into the Acutely Inflamed Brain Tissue - Evaluations on Monocyte-Based Delivery System for the Central Nervous System PLoS ONE, 2016-04-26;11(4):e0154022. 2016-04-26 [PMID: 27115998] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Ava Vila-Leahey, Dakota Rogers, Jean S. Marshall The impact of ranitidine on monocyte responses in the context of solid tumors Oncotarget 3/8/2016 [PMID: 26863636]
Pena CG, Nakada Y, Saatcioglu HD et al. LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment. J Clin Invest 11/2/2015 [PMID: 26413869]
Koyama M, Cheong M, Markey K, Gartlan K, Kuns R, Locke K, Lineburg K, Teal B, Leveque-El Mouttie L, Bunting M, Vuckovic S, Zhang P, Teng M, Varelias A, Tey S, Wockner L, Engwerda C, Smyth M, Belz G, McColl S, MacDonald K, Hill G Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease. J Exp Med, 2015-07-13;212(8):1303-21. 2015-07-13 [PMID: 26169940] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
M. E. Mikucki, D. T. Fisher, J. Matsuzaki, J. J. Skitzki, N. B. Gaulin, J. B. Muhitch et al. Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints Nature Communications 6/25/2015 [PMID: 26109379]
Christopher B. Toomey, Una Kelly, Daniel R. Saban, Catherine Bowes Rickman Regulation of age-related macular degeneration-like pathology by complement factor H Proceedings of the National Academy of Sciences 6/9/2015 [PMID: 25991857]
Patel , Jyoti, McNeill , Eileen, Douglas , Gillian, Hale , Ashley B, de Bono , Joseph, Lee , Regent, Iqbal , Asif J, Regan-Komito , Daniel, Stylianou , Elena, Greaves , David R, Channon , Keith M RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling. Nat Commun, 2015-03-18;6(0):6614. 2015-03-18 [PMID: 25782711] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Watson N, Schneider K, Massa P SHP-1-dependent macrophage differentiation exacerbates virus-induced myositis. J Immunol, 2015-02-13;194(6):2796-809. 2015-02-13 [PMID: 25681345] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Djukic M, Sostmann N, Bertsch T, Mecke M, Nessler S, Manig A, Hanisch U, Triebel J, Bollheimer L, Sieber C, Nau R Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice. J Neuroinflammation, 2015-01-07;12(0):208. 2015-01-07 [PMID: 25563481] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Habbeddine M, Verbeke P, Karaz S, Bobe P, Kanellopoulos-Langevin C Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface. PLoS ONE, 2014-09-26;9(9):e107267. 2014-09-26 [PMID: 25259859] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Bryant J, Lerret N, Wang J, Kang H, Tasch J, Zhang Z, Luo X Preemptive donor apoptotic cell infusions induce IFN-gamma-producing myeloid-derived suppressor cells for cardiac allograft protection. J Immunol, 2014-05-07;192(12):6092-101. 2014-05-07 [PMID: 24808363] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Sonali Pal-Ghosh, Ahdeah Pajoohesh-Ganji, A. Sue Menko, Hye-young Oh, Gauri Tadvalkar, Daniel R. Saban et al. Cytokine Deposition Alters Leukocyte Morphology and Initial Recruitment of Monocytes and gamma δT Cells After Corneal Injury Investigative Opthalmology & Visual Science 4/28/2014 [PMID: 24677104]
Sonali Pal-Ghosh, Ahdeah Pajoohesh-Ganji, A. Sue Menko, Hye-young Oh, Gauri Tadvalkar, Daniel R. Saban et al. Cytokine Deposition Alters Leukocyte Morphology and Initial Recruitment of Monocytes and gamma δT Cells After Corneal Injury Investigative Opthalmology & Visual Science 2014-04-28 [PMID: 24677104] (Flow Cytometry)	Flow Cytometry
Olekhnovitch R, Ryffel B, Muller A, Bousso P Collective nitric oxide production provides tissue-wide immunity during Leishmania infection. J Clin Invest, 2014-03-10;124(4):1711-22. 2014-03-10 [PMID: 24614106] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Crane , Meredith, Daley , Jean M, van Houtte , Olivier, Brancato , Samielle, Henry , William, Albina , Jorge E The monocyte to macrophage transition in the murine sterile wound. PLoS ONE, 2014-01-22;9(1):e86660. 2014-01-22 [PMID: 24466192] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Mikami , Norihisa, Sueda , Kaori, Ogitani , Yusuke, Otani , Ippei, Takatsuji , Miku, Wada , Yasuko, Watanabe , Keiko, Yoshikawa , Rintaro, Nishioka , Satoshi, Hashimoto , Nagisa, Miyagi , Yayoi, Fukada , So-ichir, Yamamoto , Hiroshi, Tsujikawa , Kazutake Calcitonin gene-related peptide regulates type IV hypersensitivity through dendritic cell functions. PLoS ONE, 2014-01-21;9(1):e86367. 2014-01-21 [PMID: 24466057] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Ribes S, Meister T, Ott M, Redlich S, Janova H, Hanisch U, Nessler S, Nau R Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection. J Neuroinflammation, 2014-01-23;11(0):14. 2014-01-23 [PMID: 24456653] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
van Nieuwenhuijze A, Coghill E, Gray D, Prato S, Metcalf D, Alexander W, Wicks I Transgenic expression of GM-CSF in T cells causes disseminated histiocytosis. Am J Pathol, 2013-10-30;184(1):184-99. 2013-10-30 [PMID: 24183847] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Domingos-Pereira S, Decrausaz L, Derre L, Bobst M, Romero P, Schiller J, Jichlinski P, Nardelli-Haefliger D Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice. Mucosal Immunol, 2012-09-12;6(2):393-404. 2012-09-12 [PMID: 22968420] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Schiraldi M, Raucci A, Munoz LM, Livoti E, Celona B, Venereau E, Apuzzo T, De Marchis F, Pedotti M, Bachi A, Thelen M, Varani L, Mellado M, Proudfoot A, Bianchi ME, Uguccioni M HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4. J. Exp. Med., 2012-02-27;209(3):551-63. 2012-02-27 [PMID: 22370717] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Calcitonin gene-related peptide is an important regulator of cutaneous immunity: effect on dendritic cell and T cell functions. J. Immunol., 2011-05-06;186(12):6886-93. 2011-05-06 [PMID: 21551361] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Show All 55 Publications. Collapse Publications.

Array FAB5538A

• CCR2 Antibodies
• CCR2 ELISA Kit
• CCR2 Lysates
• CCR2 Proteins