TrkC Antibody

Neurotrophic tyrosine kinase receptor type 3 (NTRK3), commonly known as TRKC, is a member of the protein kinase superfamily, the tyrosine (Tyr) protein kinase family, and more specifically, the insulin receptor subfamily. TRKC is a single pass type I membrane protein that phosphorylates itself (via ligand-mediated auto-phosphorylation) and other proteins in the MAPK pathway upon neurotrophin binding. Mutations to the TRKC gene have been correlated with the development of medulloblastomas, secretory breast carcinomas, and other cancers. TRKC has several transcript variants that encode different isoforms (A= 94.4kDa, B= 68.4kDa, C= 92.8kDa, and D= 93.3kDa), and each isoform has unique signaling properties. Cell differentiation that plays a role in the development of proprioceptive neurons originates via signaling through TRKC. The TRKC protein contains two Ig-like C2-type immunoglobulin-like domains, two leucine-rich repeats (LRR), one leucine rich repeat C-terminal (LRRCT) domain, and one protein kinase domain.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NB100-98829

• TrkC Antibodies
• TrkC Antibody Pair
• TrkC ELISA Kits
• TrkC Lysate
• TrkC Proteins
• TrkC Proteins and Enzymes