SMAD6 Antibody

SMADs are members of the MAD-related family of molecules. MAD-related proteins are a family of intracellular proteins that are essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily. SMADs can be divided into receptor-regulated SMADs (R-SMADs: SMAD1, SMAD2, SMAD5, SMAD8 and SMAD9), common-mediator SMAD (co-SMAD: SMAD4), and inhibitory SMADs (I-SMADs: SMAD6 and SMAD7). SMAD1, SMAD5, SMAD8 and SMAD9 have high degrees of homology and antibodies are available that recognize sequences common to all of them. SMAD8 and SMAD9 are typically used as alternate names for one another in the literature. Human SMAD1 is a 465 amino acid protein; GenBank Accession No. AAP36050.1. Human SMAD2 is a 467 amino acid protein; GenBank Accession No. AAC51918.1 Human SMAD3 is a 425 amino acid protein; GenBank Accession No. NP_005893.1 Human SMAD4 is a 552 amino acid protein GenBank Accession No. NP_005350.1. Human SMAD5 is a 465 amino acid protein; GenBank Accession No. AAC50791.1. Human SMAD6 is a 496 amino acid protein; GenBank Accession No. AAH12986.1 Human SMAD7 is a 426 amino acid protein; GenBank Accession No. AAB81354.1 Mouse SMAD8 is a 430 amino acid protein; GenBank Accession No. AAN85445.1 Human SMAD9 is a 430 amino acid protein; GenBank Accession No. NP_005896.1

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Sheep.

We have publications tested in 3 applications: IF/IHC, IHC-P, WB.

Showing Publications 1 - 10 of 10.

Publications using NB100-56440	Applications	Species
Zuidhof H, Müller C, Kortman G et al. Oncogenic functions of the m6A demethylase FTO in breast cancer cells involving translational upregulation of C/EBP?-LIP bioRxiv 2023-09-23 (WB, Human)	WB	Human
Zhang X, Hu Z, Wang X Et Al. ANXA10 promotes melanoma metastasis by suppressing E3 ligase TRIM41-directed PKD1 degradation Cancer letters 2021-07-26 [PMID: 34324862]
Zagorka Vitic, Hazem Safory, Vukasin M Jovanovic, Yael Sarusi, Alexandra Stavsky, Joy Kahn, Alona Kuzmina, Lilah Toker, Daniel Gitler, Ran Taube, Roland H Friedel, Simone Engelender, Claude Brodski BMP5/7 protect dopaminergic neurons in an alpha -synuclein mouse model of Parkinson’s disease Brain 2021-02-01 [PMID: 33253359]
Nakano Y, Hasegawa T, Kashino C et al. Aldosterone enhances progesterone biosynthesis regulated by bone morphogenetic protein in rat granulosa cells J. Steroid Biochem. Mol. Biol. 2020-08-21 [PMID: 32828828] (WB, Rat)	WB	Rat
Childs AJ, Kinnell HL, Collins CS et al. BMP signaling in the human fetal ovary is developmentally regulated and promotes primordial germ cell apoptosis. Stem Cells. 2010-08-01 [PMID: 20506112] (IHC-P, Human) Details: SMAD6 (IMG-555). IHC (Bouin's fixed, paraffin-embedded): Human fetal ovary, Fig 3A-3D.	IHC-P	Human
Hogg K, Etherington SL, Young JM et al. Inhibitor of differentiation (Id) genes are expressed in the steroidogenic cells of the ovine ovary and are differentially regulated by members of the transforming growth factor-beta family. Endocrinology [PMID: 20032053] (IF/IHC, Sheep) Details: Used the Azide Free form of this antibody.	IF/IHC	Sheep
Yoshiura S, Ohtsuka T, Takenaka Y et al. Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum. Proc Natl Acad Sci U S A. 2007-07-03 [PMID: 17592117] (WB, Mouse) Details: WB, Fig 3 (mouse C3HIOT1/2 fibroblasts).	WB	Mouse
Wang Q, Wei X, Zhu T et al. Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2. J Biol Chem. 2007-04-06 [PMID: 17215250] (WB, Mouse) Details: WB, Fig. 1 (2C12 mouse myoblast/osteoblast cells).	WB	Mouse
Yamaguchi H, Zhu J, Yu T et al. Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation. Toxicology. 2006-09-21 [PMID: 16860915]
Shen R, Chen M, Wang YJ et al. Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation. J Biol Chem. 2006-02-10 [PMID: 16299379] (WB) Details: [WB, Fig 2f (COS monkey kidney cells, 2C12 mouse myoblast/osteoblast cells), WB, Fig 5a (Specificity of antibody validated by shRNA knockdown in 2T3 cells)]	WB

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Mouse	08/02/2021	View Summary Application Western Blot Sample Tested Lung tissue Species Mouse Lot C-1
Enlarge	5 reviewed by: Verified Customer	WB	Mouse	06/10/2019	View Summary Application Western Blot Sample Tested Adult Mouse Lung Tissue Species Mouse Lot c-1

Array NB100-56440

• SMAD6 Antibodies
• SMAD6 ELISA Kit
• SMAD6 Lysate
• SMAD6 Proteins