Recombinant Human BMP-6 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Bone Morphogenetic Protein 6 (BMP-6), also known as Vgr-1, is a member of the BMP subfamily of TGF-beta superfamily proteins. BMPs are involved in a wide range of processes including embryogenesis, tissue morphogenesis, cell differentiation and migration, and tumorigenesis (1). Human BMP-6 is synthesized as a 513 amino acid (aa) precursor protein that is cleaved at the dibasic cleavage site (RxxR) to release the 18 kDa C-terminal mature protein. Biologically active BMP-6 consists of a disulfide-linked homodimer of the mature protein, although it can also form heterodimers with mature BMP-2 (2, 3). Mature human BMP-6 shares 96% and 98% aa sequence identity with mouse and rat BMP-6, respectively. Cellular responses to BMP-6 are mediated by hetero-oligomeric complexes of type I (Activin RIA/ALK-2 and BMPR-IA/ALK-3) and type II (Activin RIIA and BMPR-II) serine/threonine kinase receptors (4, 5). BMP-6 induces the expression of Noggin and is subsequently antagonized by Noggin (6). BMP-6 induces a wide range of cellular responses. It promotes osteoblast differentiation from mesenchymal stem cells (7), chondrocyte maturation (8), Ang II-induced aldosterone production in the adrenal cortex (4), hormone production and responsiveness in ovarian granulosa cells (9), iNOS and TNF-alpha production in macrophages (5), the cell death of B cells (10), and neurite outgrowth (11). BMP-6 expression is induced in astrocytes surrounding sites of brain injury where it functions as a neuroprotectant (11, 12). It enhances tumor progression by promoting local angiogenesis and differentiation of immune tolerizing M2 macrophages (13-15). Through interactions with the BMP coreceptor RGM-C/Hemojuvelin, BMP-6 plays an important role in iron homeostasis by promoting Hepcidin expression and preventing serum iron overload (16). Heterodimers of BMP-2 and BMP-6 show increased potency at inducing osteoblastic calcium deposition, chondrogenesis, and in vivo bone formation compared to either BMP-2 or BMP-6 homodimers (3).

We have publications tested in 7 confirmed species: Human, Mouse, Bovine, Goat, Ovine, Porcine,  Human.

We have publications tested in 5 applications: Binding Assay, Bioassay, Cell Culture, In Vivo, Surface Plasmon Resonance.

Showing Publications 1 - 10 of 72. Show All 72 Publications. Collapse Publications.

Publications using 507-BP	Applications	Species
Alves, J;Schwinn, M;Machleidt, T;Goueli, SA;Cali, JJ;Zegzouti, H; Monitoring phosphorylation and acetylation of CRISPR-mediated HiBiT-tagged endogenous proteins Scientific reports 2024-01-25 [PMID: 38272933] (Bioassay, Human)	Bioassay	Human
Soejima, Y;Iwata, N;Nishioka, R;Honda, M;Nakano, Y;Yamamoto, K;Suyama, A;Otsuka, F; Interaction of Orexin and Bone Morphogenetic Proteins in Steroidogenesis by Human Adrenocortical Cells International journal of molecular sciences 2023-08-08 [PMID: 37628739] (Bioassay, Human)	Bioassay	Human
M Bigorra Mi, E Charlebois, S Tsyplenkov, C Fillebeen, K Pantopoulo Cardiac Hamp mRNA Is Predominantly Expressed in the Right Atrium and Does Not Respond to Iron International Journal of Molecular Sciences, 2023-03-08;24(6):. 2023-03-08 [PMID: 36982241] (Bioassay, Human)	Bioassay	Human
N Ozeki, M Mizuno, S Yanada, T Okada, R Kubota, Y Kushida, H Furuoka, K Endo, H Katano, K Nakamura, S Ohya, H Koga, I Sekiya Autologous Synovial Mesenchymal Stem Cell Transplantation Suppresses Inflammation Caused by Synovial Harvesting and Promotes Healing in a Micro Minipig Repaired Meniscus Model Transplantation Proceedings, 2023-03-10;0(0):. 2023-03-10 [PMID: 36906438] (Bioassay, Porcine)	Bioassay	Porcine
L Wang, Y Wang, B Li, Y Zhang, S Song, W Ding, D Xu, Z Zhao BMP6 regulates AMH expression via SMAD1/5/8 in goat ovarian granulosa cells Theriogenology, 2022-11-30;197(0):167-176. 2022-11-30 [PMID: 36525856] (Bioassay, Goat)	Bioassay	Goat
Y Soejima, N Iwata, N Nakayama, S Hirata, Y Nakano, K Yamamoto, A Suyama, K Oguni, T Nada, S Fujisawa, F Otsuka Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells International Journal of Molecular Sciences, 2022-08-29;23(17):. 2022-08-29 [PMID: 36077179] (Bioassay, Mouse)	Bioassay	Mouse
ALM Caldwell, L Sancho, J Deng, A Bosworth, A Miglietta, JK Diedrich, MN Shokhirev, NJ Allen Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders Nature Neuroscience, 2022-08-30;25(9):1163-1178. 2022-08-30 [PMID: 36042312] (Bioassay, Mouse)	Bioassay	Mouse
Y Hayashi, KC Kawabata, Y Tanaka, Y Uehara, Y Mabuchi, K Murakami, A Nishiyama, S Kiryu, Y Yoshioka, Y Ota, T Sugiyama, K Mikami, M Tamura, T Fukushima, S Asada, R Takeda, Y Kunisaki, T Fukuyama, K Yokoyama, T Uchida, M Hagihara, N Ohno, K Usuki, A Tojo, Y Katayama, S Goyama, F Arai, T Tamura, T Nagasawa, T Ochiya, D Inoue, T Kitamura MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis Cell Reports, 2022-05-10;39(6):110805. 2022-05-10 [PMID: 35545056] (Bioassay, Human)	Bioassay	Human
Y Soejima, N Iwata, Y Nakano, K Yamamoto, A Suyama, T Nada, F Otsuka Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells International Journal of Molecular Sciences, 2021-10-17;22(20):. 2021-10-17 [PMID: 34681844] (Cell Culture, Human)	Cell Culture	Human
P Jiang, Y Zhang, B Ru, Y Yang, T Vu, R Paul, A Mirza, G Altan-Bonn, L Liu, E Ruppin, L Wakefield, KW Wucherpfen Systematic investigation of cytokine signaling activity at the tissue and single-cell levels Nature methods, 2021-09-30;18(10):1181-1191. 2021-09-30 [PMID: 34594031] (Bioassay, Human)	Bioassay	Human
R Kumar, AV Grinberg, H Li, TH Kuo, D Sako, L Krishnan, K Liharska, J Li, R Grenha, MC Maguire, SD Briscoe, RS Pearsall, BR Herrin, RNVS Suragani, R Castonguay Functionally diverse heteromeric traps for ligands of the transforming growth factor-beta superfamily Scientific Reports, 2021-09-15;11(1):18341. 2021-09-15 [PMID: 34526551] (Bioassay, Human)	Bioassay	Human
E Charlebois, K Pantopoulo Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes PLoS ONE, 2021-06-23;16(6):e0253475. 2021-06-23 [PMID: 34161397] (Cell Culture, Human)	Cell Culture	Human
S Nürnberger, C Schneider, C Keibl, B Schädl, P Heimel, X Monforte, AH Teuschl, M Nalbach, PJ Thurner, J Grillari, H Redl, S Wolbank Repopulation of decellularised articular cartilage by laser-based matrix engraving EBioMedicine, 2021-01-19;0(0):103196. 2021-01-19 [PMID: 33483297] (Bioassay, Human)	Bioassay	Human
S Shin, J Lee, Y Kwon, KS Park, JH Jeong, SJ Choi, SI Bang, JW Chang, C Lee Comparative Proteomic Analysis of the Mesenchymal Stem Cells Secretome from Adipose, Bone Marrow, Placenta and Wharton's Jelly International Journal of Molecular Sciences, 2021-01-15;22(2):. 2021-01-15 [PMID: 33467726] (Bioassay, Human)	Bioassay	Human
JW Hwang, NK Lee, JH Yang, HJ Son, SI Bang, JW Chang, DL Na A Comparison of Immune Responses Exerted Following Syngeneic, Allogeneic, and Xenogeneic Transplantation of Mesenchymal Stem Cells into the Mouse Brain Int J Mol Sci, 2020-04-26;21(9):. 2020-04-26 [PMID: 32357509] (Cell Culture, Human)	Cell Culture	Human
A Krouwels, JD Iljas, AHM Kragten, WJA Dhert, FC Öner, MA Tryfonidou, LB Creemers Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration Int J Mol Sci, 2020-04-14;21(8):. 2020-04-14 [PMID: 32295299] (Bioassay, Human)	Bioassay	Human
P An, J Wang, H Wang, L Jiang, J Wang, J Min, F Wang Gnpat does not play an essential role in systemic iron homeostasis in murine model J. Cell. Mol. Med., 2020-02-28;0(0):. 2020-02-28 [PMID: 32108988] (Cell Culture, Human)	Cell Culture	Human
H Yin, L Kalra, Z Lai, MC Guimaro, L Aber, BM Warner, D Michael, N Zhang, J Cabrera-Pe, A Karim, WD Swaim, S Afione, A Voigt, CQ Nguyen, PB Yu, DB Bloch, JA Chiorini Inhibition of bone morphogenetic protein 6 receptors ameliorates Sj�gren's syndrome in mice Sci Rep, 2020-02-19;10(1):2967. 2020-02-19 [PMID: 32076051] (Bioassay, Human)	Bioassay	Human
D Seo, SM Jung, JS Park, J Lee, J Ha, M Kim, SH Park The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway EBioMedicine, 2019-11-01;49(0):55-71. 2019-11-01 [PMID: 31685442] (Cell Culture, Human)	Cell Culture	Human
S Gooding, SWZ Olechnowic, EV Morris, AE Armitage, J Arezes, J Frost, E Repapi, JR Edwards, N Ashley, C Waugh, N Gray, E Martinez-H, PJ Lim, SR Pasricha, H Knowles, AJ Mead, K Ramasamy, H Drakesmith, CM Edwards Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease Nat Commun, 2019-10-04;10(1):4533. 2019-10-04 [PMID: 31586071] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
J Ren, M Smid, J Iaria, DCF Salvatori, H van Dam, HJ Zhu, JWM Martens, P Ten Dijke Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression Breast Cancer Res., 2019-09-18;21(1):109. 2019-09-18 [PMID: 31533776] (Bioassay, Human)	Bioassay	Human
M Malinverno, C Maderna, A Abu Taha, M Corada, F Orsenigo, M Valentino, F Pisati, C Fusco, P Graziano, M Giannotta, QC Yu, YA Zeng, MG Lampugnani, PU Magnusson, E Dejana Endothelial cell clonal expansion in the development of cerebral cavernous malformations Nat Commun, 2019-06-24;10(1):2761. 2019-06-24 [PMID: 31235698] (Bioassay, Mouse)	Bioassay	Mouse
A Moghieb, L Tesfay, S Nie, M Gritsenko, TL Fillmore, JM Jacobs, RD Smith, FM Torti, SV Torti, T Shi, C Ansong A Targeted Mass Spectrometric Assay for Reliable Sensitive Hepcidin Quantification Sci Rep, 2019-05-13;9(1):7264. 2019-05-13 [PMID: 31086210] (Bioassay, Human)	Bioassay	Human
S Nürnberger, C Lindner, J Maier, K Strohmeier, C Wurzer, P Slezak, S Suessner, W Holnthoner, H Redl, S Wolbank, E Priglinger Adipose-tissue-derived therapeutic cells in their natural environment as an autologous cell therapy strategy: the microtissue-stromal vascular fraction Eur Cell Mater, 2019-02-22;37(0):113-133. 2019-02-22 [PMID: 30793275] (Bioassay, Human)	Bioassay	Human
J Lee, SJ Kwon, JH Kim, H Jang, NK Lee, JW Hwang, JH Kim, JW Chang, DL Na Cerebrospinal fluid from Alzheimer's disease patients as an optimal formulation for therapeutic application of mesenchymal stem cells in Alzheimer's disease Sci Rep, 2019-01-24;9(1):564. 2019-01-24 [PMID: 30679696] (Bioassay, Human)	Bioassay	Human
Y Ogata, Y Mabuchi, K Shinoda, Y Horiike, M Mizuno, K Otabe, EG Suto, N Suzuki, I Sekiya, C Akazawa Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage Regen Ther, 2018-01-23;8(0):20-28. 2018-01-23 [PMID: 30271862] (Bioassay, Human)	Bioassay	Human
T Peeters, S Monteagudo, P Tylzanowsk, FP Luyten, R Lories, F Cailotto SMOC2 inhibits calcification of osteoprogenitor and endothelial cells PLoS ONE, 2018-06-13;13(6):e0198104. 2018-06-13 [PMID: 29897942] (Bioassay, Human)	Bioassay	Human
SR Pasricha, PJ Lim, TL Duarte, C Casu, D Oosterhuis, K Mleczko-Sa, M Suciu, AR Da Silva, K Al-Hourani, J Arezes, K McHugh, S Gooding, JN Frost, K Wray, A Santos, G Porto, E Repapi, N Gray, SJ Draper, N Ashley, E Soilleux, P Olinga, MU Muckenthal, JR Hughes, S Rivella, TA Milne, AE Armitage, H Drakesmith Hepcidin is regulated by promoter-associated histone acetylation and HDAC3 Nat Commun, 2017-09-01;8(1):403. 2017-09-01 [PMID: 28864822] (Bioassay, Human)	Bioassay	Human
C Sallon, I Callebaut, I Boulay, J Fontaine, D Logeart-Av, C Henriquet, M Pugnière, X Cayla, P Monget, G Harichaux, V Labas, S Canepa, C Taragnat Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells J. Biol. Chem., 2017-07-26;0(0):. 2017-07-26 [PMID: 28747434] (Bioassay, Mouse)	Bioassay	Mouse
CG Mitrofan, SL Appleby, GB Nash, Z Mallat, ER Chilvers, PD Upton, NW Morrell Bone morphogenetic protein (BMP) 9 and BMP10 enhance tumor necrosis factor-?-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2 J. Biol. Chem., 2017-06-23;0(0):. 2017-06-23 [PMID: 28646109] (Bioassay, Human)	Bioassay	Human
LK Bollum, K Huse, MP Oksvold, B Bai, VI Hilden, L Forfang, SO Yoon, S Wälchli, EB Smeland, JH Myklebust BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-? receptor type I ALK5 PLoS ONE, 2017-05-10;12(5):e0177188. 2017-05-10 [PMID: 28489883] (Bioassay, Human)	Bioassay	Human
K Breitkopf-, C Meyer, C König, H Gaitantzi, A Addante, M Thomas, E Wiercinska, C Cai, Q Li, F Wan, C Hellerbran, NA Valous, M Hahnel, C Ehlting, JG Bode, S Müller-Boh, U Klingmülle, J Altenöder, I Ilkavets, MJ Goumans, LJ Hawinkels, SJ Lee, M Wieland, C Mogler, MP Ebert, B Herrera, H Augustin, A Sánchez, S Dooley, P Ten Dijke BMP-9 interferes with liver regeneration and promotes liver fibrosis Gut, 2017-03-23;0(0):. 2017-03-23 [PMID: 28336518] (Mouse)		Mouse
DW Hammers, M Merscham-B, JY Hsiao, S Engst, JJ Hartman, HL Sweeney Supraphysiological levels of GDF11 induce striated muscle atrophy EMBO Mol Med, 2017-04-01;0(0):. 2017-04-01 [PMID: 28270449] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
YS Choi, YB Park, CW Ha, JA Kim, JC Heo, WJ Han, SY Oh, SJ Choi Different characteristics of mesenchymal stem cells isolated from different layers of full term placenta PLoS ONE, 2017-02-22;12(2):e0172642. 2017-02-22 [PMID: 28225815] (Bioassay, Human)	Bioassay	Human
SV Torti, E Lemler, BK Mueller, A Popp, FM Torti Effects of Anti-repulsive Guidance Molecule C (RGMc/Hemojuvelin) Antibody on Hepcidin and Iron in Mouse Liver and Tumor Xenografts Clin Exp Pharmacol, 2016-11-17;6(6):. 2016-11-17 [PMID: 28203489] (Bioassay, Human)	Bioassay	Human
Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication PLoS ONE, 2016-12-15;11(12):e0168334. 2016-12-15 [PMID: 27977771] (Bioassay, Human)	Bioassay	Human
B Kim, HS Kim, S Kim, G Haegeman, BK Tsang, DN Dhanasekar, YS Song Adipose Stromal Cells from Visceral and Subcutaneous Fat Facilitate Migration of Ovarian Cancer Cells via IL-6/JAK2/STAT3 Pathway Cancer Res Treat, 2016-07-18;49(2):338-349. 2016-07-18 [PMID: 27456942] (Bioassay, Human)	Bioassay	Human
Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing Proc Natl Acad Sci USA, 2016-07-18;0(0):. 2016-07-18 [PMID: 27432980] (Bioassay, Human)	Bioassay	Human
Aquaporin gene therapy corrects Sj�gren's syndrome phenotype in mice Proc Natl Acad Sci USA, 2016-05-02;113(20):5694-9. 2016-05-02 [PMID: 27140635] (Bioassay, Human)	Bioassay	Human
Tesfay L, Clausen K, Kim J, Hegde P, Wang X, Miller L, Deng Z, Blanchette N, Arvedson T, Miranti C, Babitt J, Lin H, Peehl D, Torti F, Torti S Hepcidin regulation in prostate and its disruption in prostate cancer. Cancer Res, 2015-04-09;75(11):2254-63. 2015-04-09 [PMID: 25858146] (Bioassay, Human)	Bioassay	Human
Nio-Kobayashi J, Trendell J, Giakoumelou S, Boswell L, Nicol L, Kudo M, Sakuragi N, Iwanaga T, Duncan W Bone morphogenetic proteins are mediators of luteolysis in the human corpus luteum. Endocrinology, 2015-01-30;156(4):1494-503. 2015-01-30 [PMID: 25635621] (Bioassay, Human)	Bioassay	Human
Zumbrennen-Bullough K, Wu Q, Core A, Canali S, Chen W, Theurl I, Meynard D, Babitt J MicroRNA-130a is up-regulated in mouse liver by iron deficiency and targets the bone morphogenetic protein (BMP) receptor ALK2 to attenuate BMP signaling and hepcidin transcription. J Biol Chem, 2014-07-07;289(34):23796-808. 2014-07-07 [PMID: 25002578] (Bioassay, Human)	Bioassay	Human
Ye K, Felimban R, Traianedes K, Moulton S, Wallace G, Chung J, Quigley A, Choong P, Myers D Chondrogenesis of infrapatellar fat pad derived adipose stem cells in 3D printed chitosan scaffold. PLoS ONE, 2014-06-11;9(6):e99410. 2014-06-11 [PMID: 24918443] (Bioassay, Human)	Bioassay	Human
Liu G, Liu Y, Lian W, Zhao Z, Yi T, Zhou H Reduced BMP6 expression by DNA methylation contributes to EMT and drug resistance in breast cancer cells. Oncol Rep, 2014-05-29;32(2):581-8. 2014-05-29 [PMID: 24890613] (Bioassay, Human)	Bioassay	Human
Jakobsen R, Ostrup E, Zhang X, Mikkelsen T, Brinchmann J Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling. PLoS ONE, 2014-05-09;9(5):e96615. 2014-05-09 [PMID: 24816923] (Bioassay, Human)	Bioassay	Human
Sharma A, Huard C, Vernochet C, Ziemek D, Knowlton K, Tyminski E, Paradis T, Zhang Y, Jones J, von Schack D, Brown C, Milos P, Coyle A, Tremblay F, Martinez R Brown fat determination and development from muscle precursor cells by novel action of bone morphogenetic protein 6. PLoS ONE, 2014-03-21;9(3):e92608. 2014-03-21 [PMID: 24658703] (Bioassay, Mouse)	Bioassay	Mouse
Olsen O, Wader K, Misund K, Vatsveen T, Ro T, Mylin A, Turesson I, Stordal B, Moen S, Standal T, Waage A, Sundan A, Holien T Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer J, 2014-03-21;4(0):e196. 2014-03-21 [PMID: 24658374] (Bioassay, Human)	Bioassay	Human
Lee G, Kang D, Ha Y, Jung Y, Chung J, Min K, Kim T, Moon K, Chung J, Lee D, Kim W, Kim I Prostate cancer bone metastases acquire resistance to androgen deprivation via WNT5A-mediated BMP-6 induction. Br J Cancer, 2014-02-11;110(6):1634-44. 2014-02-11 [PMID: 24518599] (Bioassay, Human)	Bioassay	Human
Mleczko-Sanecka K, Roche F, Da Silva A, Call D, D'Alessio F, Ragab A, Lapinski P, Ummanni R, Korf U, Oakes C, Damm G, D'Alessandro L, Klingmuller U, King P, Boutros M, Hentze M, Muckenthaler M Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood, 2014-01-02;123(10):1574-85. 2014-01-02 [PMID: 24385536] (Bioassay, Human)	Bioassay	Human
Brady K, Dickinson S, Guillot P, Polak J, Blom A, Kafienah W, Hollander A Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis. Stem Cells Dev, 2013-12-04;23(5):541-54. 2013-12-04 [PMID: 24172175] (Bioassay, Human)	Bioassay	Human
Long , Jianyin, Badal , Shawn S, Wang , Yin, Chang , Benny H, Rodriguez , Antony, Danesh , Farhad R MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney. J Biol Chem, 2013-10-25;288(51):36202-14. 2013-10-25 [PMID: 24163368] (Bioassay, Human)	Bioassay	Human
Glister C, Satchell L, Bathgate R, Wade J, Dai Y, Ivell R, Anand-Ivell R, Rodgers R, Knight P Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. Proc Natl Acad Sci U S A, 2013-03-25;110(15):E1426-35. 2013-03-25 [PMID: 23530236] (Bioassay, Bovine)	Bioassay	Bovine
Huse K, Bakkebo M, Walchli S, Oksvold M, Hilden V, Forfang L, Bredahl M, Liestol K, Alizadeh A, Smeland E, Myklebust J Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma. PLoS ONE, 2012-10-01;7(10):e46117. 2012-10-01 [PMID: 23049692] (Bioassay, Human)	Bioassay	Human
Wu , Qifang, Sun , Chia Chi, Lin , Herbert, Babitt , Jodie L Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS ONE, 2012-09-27;7(9):e46307. 2012-09-27 [PMID: 23029472] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
Erceg S, Lukovic D, Moreno-Manzano V, Stojkovic M, Bhattacharya S Derivation of cerebellar neurons from human pluripotent stem cells. Curr Protoc Stem Cell Biol, 2012-03-01;20(0):1H.51. 2012-03-01 [PMID: 22415839] (Bioassay, Human)	Bioassay	Human
Mottershead D, Ritter L, Gilchrist R Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15. Mol Hum Reprod, 2011-09-12;18(3):121-8. 2011-09-12 [PMID: 21911477] (Bioassay, Mouse)	Bioassay	Mouse
Huse K, Bakkebo M, Oksvold MP, Forfang L, Hilden VI, Stokke T, Smeland EB, Myklebust JH Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7. Eur. J. Immunol., 2011-10-18;41(11):3135-45. 2011-10-18 [PMID: 21898381] (Bioassay, Human)	Bioassay	Human
Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth. J. Biol. Chem., 2011-07-07;286(34):30034-46. 2011-07-07 [PMID: 21737454] (Surface Plasmon Resonance, Human, Mouse)	Surface Plasmon Resonance	Human, Mouse
Meynard D, Vaja V, Sun CC, Corradini E, Chen S, Lopez-Otin C, Grgurevic L, Hong CC, Stirnberg M, Gutschow M, Vukicevic S, Babitt JL, Lin HY Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood, 2011-05-26;118(3):747-56. 2011-05-26 [PMID: 21622652] (Bioassay, Human)	Bioassay	Human
Martino MM, Hubbell JA The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain. FASEB J., 2010-07-29;24(12):4711-21. 2010-07-29 [PMID: 20671107] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
Grcevic D, Kusec R, Kovacic N, Lukic A, Lukic IK, Ivcevic S, Nemet D, Seiwerth RS, Ostojic SK, Croucher PI, Marusic A Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes. Leuk. Res., 2009-11-18;34(6):742-51. 2009-11-18 [PMID: 19926132] (Bioassay, Human)	Bioassay	Human
Campbell BK, Kendall NR, Baird DT Effect of direct ovarian infusion of bone morphogenetic protein 6 (BMP6) on ovarian function in sheep. Biol. Reprod., 2009-07-29;81(5):1016-23. 2009-07-29 [PMID: 19641181] (In Vivo, Ovine)	In Vivo	Ovine
Sugiura K, Su YQ, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells. Biol. Reprod., 2009-06-24;81(5):833-41. 2009-06-24 [PMID: 19553596] (Bioassay, Mouse)	Bioassay	Mouse
Herrera B, Inman GJ A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol., 2009-03-19;10(0):20. 2009-03-19 [PMID: 19298647] (Bioassay, Mouse)	Bioassay	Mouse
Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature, 2008-08-21;454(7207):1000-4. 2008-08-21 [PMID: 18719589] (Bioassay, Mouse)	Bioassay	Mouse
Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bachinger HP, Sakai LY Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J. Biol. Chem., 2008-03-13;283(20):13874-88. 2008-03-13 [PMID: 18339631] (Binding Assay, Surface Plasmon Resonance, Human)	Binding Assay, Surface Plasmon Resonance	Human
Pi X, Ren R, Kelley R, Zhang C, Moser M, Bohil AB, Divito M, Cheney RE, Patterson C Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors. J. Cell Biol., 2007-12-24;179(7):1569-82. 2007-12-24 [PMID: 18158328] (Bioassay, Mouse)	Bioassay	Mouse
Zilberberg L, ten Dijke P, Sakai L, Rifkin D A rapid and sensitive bioassay to measure bone morphogenetic protein activity. BMC Cell Biol, 2007-09-19;8(0):41. 2007-09-19 [PMID: 17880711] (Bioassay)	Bioassay
Salero E, Hatten ME Differentiation of ES cells into cerebellar neurons. Proc. Natl. Acad. Sci. U.S.A., 2007-02-09;104(8):2997-3002. 2007-02-09 [PMID: 17293457] (Bioassay, Mouse)	Bioassay	Mouse
Kersten C, Dosen G, Myklebust JH, Sivertsen EA, Hystad ME, Smeland EB, Rian E BMP-6 inhibits human bone marrow B lymphopoiesis--upregulation of Id1 and Id3. Exp. Hematol., 2006-01-01;34(1):72-81. 2006-01-01 [PMID: 16413393] (Bioassay, Human)	Bioassay	Human
Oren A, Toporik A, Biton S, Almogy N, Eshel D, Bernstein J, Savitsky K, Rotman G hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. Gene, 2004-04-28;331(0):17-31. 2004-04-28 [PMID: 15094188] (Bioassay, Human)	Bioassay	Human
Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, Bautch VL, Conlon FL, Patterson C BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol. Cell. Biol., 2003-08-01;23(16):5664-79. 2003-08-01 [PMID: 12897139] (Bioassay, Mouse)	Bioassay	Mouse
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Array 507-BP

• BMP-6 Antibodies
• BMP-6 ELISA Kits
• BMP-6 Lysate
• BMP-6 Protein
• BMP-6 ELISA
• BMP-6 Proteins and Enzymes