Recombinant Human BMP-4 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

BMP-4 is a TGF-beta superfamily ligand that is widely expressed from early embryogenesis through adulthood. It plays an important role in mesenchyme formation, epidermal determination, suppression of neural induction, the development of multiple organs, and tissue repair (1-5). The human BMP-4 precursor contains a 273 amino acid (aa) propeptide and a 116 aa mature protein (6). Processing of the propeptide by furin or proprotein convertase 6 enables the formation of the mature disulfide-linked homodimeric BMP-4 and facilitates its secretion. Similar intracellular processes may lead to the formation and recreation of BMP4/BMP7
disulfide-linked heterodimer (7-9). Mature human and mouse BMP-4 share 98% aa sequence identity. Human BMP-4 shares 85% aa sequence identity with human BMP-2 and less than 50% with other human BMPs. Compared to BMP-4 homodimers, BMP-4/BMP-7 heterodimers exhibit a greater potency in inducing osteogenic differentiation (9). In Xenopus, the heterodimers can also induce the formation of mesoderm, whereas BMP-4 homodimers only provide ventralizing signals for existing mesoderm (10). BMP-4 signals through tetrameric complexes composed of type I (primarily Activin RIA or BMPR-IA) and type II (primarily Activin RIIA or BMPR-II) receptors (11, 12). The bioavailability of BMP-4 is regulated by its interaction with multiple proteins and glycosaminoglycans (13-15).

 

We have publications tested in 18 confirmed species: Human, Mouse, Rat, Bovine, Chicken, Equine, Northern White Rhinoceros, Ovine, Porcine, Primate - Callitrix jacchus (Common Marmoset), Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque), Primate - Macaca nemestrina (Southern Pig-tailed Macaque), Rabbit, Rhinoceros, Transgenic Mouse, Xenopus, Zebrafish.

We have publications tested in 8 applications: Binding Assay, Bioassay, Cell Culture, Differentiation, In Vivo, Surface Plasmon Resonance, Tissue Culture, Western Blot.

Showing Publications 1 - 10 of 503. Show All 503 Publications. Collapse Publications.

Publications using 314-BP	Applications	Species
Kruger, RE;Frum, T;Brumm, AS;Hickey, SL;Niakan, KK;Aziz, F;Shammami, MA;Roberts, JG;Ralston, A; Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential prior to implantation in the mouse bioRxiv : the preprint server for biology 2024-01-24 [PMID: 38328075] (Bioassay, Mouse)	Bioassay	Mouse
Johnson, BB;Cosson, MV;Tsansizi, LI;Holmes, TL;Gilmore, T;Hampton, K;Song, OR;Vo, NTN;Nasir, A;Chabronova, A;Denning, C;Peffers, MJ;Merry, CLR;Whitelock, J;Troeberg, L;Rushworth, SA;Bernardo, AS;Smith, JGW; Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes Cell reports 2024-01-09 [PMID: 38198277] (Bioassay, Human)	Bioassay	Human
Gao, L;Behrens, A;Rodschinka, G;Forcelloni, S;Wani, S;Strasser, K;Nedialkova, DD; Selective gene expression maintains human tRNA anticodon pools during differentiation Nature cell biology 2024-01-08 [PMID: 38191669] (Bioassay, Human)	Bioassay	Human
Chang, YH;Wu, KC;Wang, KH;Ding, DC; Assessment of Fallopian Tube Epithelium Features Derived from Induced Pluripotent Stem Cells of Both Fallopian Tube and Skin Origins Cells 2023-11-16 [PMID: 37998370] (Bioassay, Human)	Bioassay	Human
Bisia, AM;Costello, I;Xypolita, ME;Harland, LTG;Kurbel, PJ;Bikoff, EK;Robertson, EJ; A degron-based approach to manipulate Eomes functions in the context of the developing mouse embryo Proceedings of the National Academy of Sciences of the United States of America 2023-10-31 [PMID: 37871215] (Bioassay, Human)	Bioassay	Human
Liu, T;Dai, X;Xu, Y;Guan, T;Hong, L;Zaib, T;Zhou, Q;Cheng, K;Zhou, X;Ma, C;Sun, P; CD22 is a potential target of CAR-NK cell therapy for esophageal squamous cell carcinoma Journal of translational medicine 2023-10-10 [PMID: 37817249] (Bioassay, Human)	Bioassay	Human
Zhang, H;Kafeiti, N;Lee, S;Masarik, K;Zheng, H;Zhan, H; Unlocking the Role of Endothelial MPL Receptor and JAK2V617F Mutation: Insights into Cardiovascular Dysfunction in MPNs and CHIP bioRxiv : the preprint server for biology 2023-07-13 [PMID: 37503259] (Bioassay, Human)	Bioassay	Human
Voss, AJ;Lanjewar, SN;Sampson, MM;King, A;Hill, EJ;Sing, A;Sojka, C;Bhatia, TN;Spangle, JM;Sloan, SA; Identification of ligand-receptor pairs that drive human astrocyte development Nature neuroscience 2023-07-17 [PMID: 37460808] (Bioassay, Human)	Bioassay	Human
Ai, Z;Niu, B;Yin, Y;Xiang, L;Shi, G;Duan, K;Wang, S;Hu, Y;Zhang, C;Zhang, C;Rong, L;Kong, R;Chen, T;Guo, Y;Liu, W;Li, N;Zhao, S;Zhu, X;Mai, X;Li, Y;Wu, Z;Zheng, Y;Fu, J;Ji, W;Li, T; Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids Cell research 2023-07-17 [PMID: 37460804] (Bioassay, Human)	Bioassay	Human
Tresenrider, A;Sridhar, A;Eldred, KC;Cuschieri, S;Hoffer, D;Trapnell, C;Reh, TA; Single-cell sequencing of individual retinal organoids reveals determinants of cell fate heterogeneity bioRxiv : the preprint server for biology 2023-06-03 [PMID: 37398481] (Bioassay, Human)	Bioassay	Human
Alber, AB;Marquez, HA;Ma, L;Kwong, G;Thapa, BR;Villacorta-Martin, C;Lindstrom-Vautrin, J;Bawa, P;Wang, F;Luo, Y;Ikonomou, L;Shi, W;Kotton, DN; Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme Nature communications 2023-06-13 [PMID: 37311756] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Frum, T;Hsu, PP;Hein, RFC;Conchola, AS;Zhang, CJ;Utter, OR;Anand, A;Zhang, Y;Clark, SG;Glass, I;Sexton, JZ;Spence, JR; Opposing roles for TGF?- and BMP-signaling during nascent alveolar differentiation in the developing human lung bioRxiv : the preprint server for biology 2023-05-05 [PMID: 37205521] (Bioassay, Human)	Bioassay	Human
Maeda, Y;Isomura, A;Masaki, T;Kageyama, R; Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21 Cell reports 2023-05-17 [PMID: 37200191] (Bioassay, Human)	Bioassay	Human
Matkovic Leko, I;Schneider, RT;Thimraj, TA;Schrode, N;Beitler, D;Liu, HY;Beaumont, K;Chen, YW;Snoeck, HW; A distal lung organoid model to study interstitial lung disease, viral infection and human lung development Nature protocols 2023-05-10 [PMID: 37165073] (Bioassay, Human)	Bioassay	Human
Majd, H;Amin, S;Ghazizadeh, Z;Cesiulis, A;Arroyo, E;Lankford, K;Majd, A;Farahvashi, S;Chemel, AK;Okoye, M;Scantlen, MD;Tchieu, J;Calder, EL;Le Rouzic, V;Shibata, B;Arab, A;Goodarzi, H;Pasternak, G;Kocsis, JD;Chen, S;Studer, L;Fattahi, F; Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy Cell stem cell 2023-05-04 [PMID: 37146583] (Bioassay, Human)	Bioassay	Human
S Teague, G Primavera, B Chen, E Freeburne, H Khan, K Jo, C Johnson, I Heemskerk The time integral of BMP signaling determines fate in a stem cell model for early human development bioRxiv : the preprint server for biology, 2023-04-10;0(0):. 2023-04-10 [PMID: 37090515] (Bioassay, Human)	Bioassay	Human
A Gehrlein, V Udayar, N Anastasi, ML Morella, I Ruf, D Brugger, S von der Ma, R Thoma, A Rufer, D Heer, N Pfahler, A Jochner, J Niewoehner, L Wolf, M Fueth, M Ebeling, R Villaseñor, Y Zhu, MC Deen, X Shan, Z Ehsaei, V Taylor, E Sidransky, DJ Vocadlo, PO Freskgård, R Jagasia Targeting neuronal lysosomal dysfunction caused by beta-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct Nature Communications, 2023-04-12;14(1):2057. 2023-04-12 [PMID: 37045813] (Bioassay, Human)	Bioassay	Human
S Li, CS Wang, A Montel-Hag, HC Chen, S Lopez, O Zhou, K Dai, S Tsai, W Satyadi, C Botero, C Wong, D Casero, GM Crooks, CS Seet Strength of CAR signaling determines T�cell versus ILC differentiation from pluripotent stem cells Cell Reports, 2023-03-11;42(3):112241. 2023-03-11 [PMID: 36906850] (Bioassay, Human)	Bioassay	Human
Y Fan, J Hackland, A Baggiolini, LY Hung, H Zhao, P Zumbo, P Oberst, AP Minotti, E Hergenrede, S Najjar, Z Huang, NM Cruz, A Zhong, M Sidharta, T Zhou, E de Stanchi, D Betel, RM White, M Gershon, KG Margolis, L Studer hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's disease Cell Stem Cell, 2023-03-02;30(3):264-282.e9. 2023-03-02 [PMID: 36868194] (Bioassay, Human)	Bioassay	Human
Y Fan, J Hackland, A Baggiolini, LY Hung, H Zhao, P Zumbo, P Oberst, AP Minotti, E Hergenrede, S Najjar, Z Huang, NM Cruz, A Zhong, M Sidharta, T Zhou, E de Stanchi, D Betel, RM White, M Gershon, KG Margolis, L Studer hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's disease Cell Stem Cell, 2023;30(3):264-282.e9. 2023 [PMID: 36868194] (Bioassay, Human)	Bioassay	Human
M Shono, K Kishimoto, O Hikabe, M Hayashi, K Semi, Y Takashima, E Sasaki, K Kato, K Hayashi Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling Scientific Reports, 2023-02-23;13(1):3186. 2023-02-23 [PMID: 36823310] (Bioassay, Human)	Bioassay	Human
AR Dicks, GI Maksaev, Z Harissa, A Savadipour, R Tang, N Steward, W Liedtke, CG Nichols, CL Wu, F Guilak Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes Elife, 2023-02-22;12(0):. 2023-02-22 [PMID: 36810131] (Bioassay, Human)	Bioassay	Human
EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar Pervasive environmental chemicals impair oligodendrocyte development bioRxiv : the preprint server for biology, 2023-02-12;0(0):. 2023-02-12 [PMID: 36798415] (Bioassay, Mouse)	Bioassay	Mouse
L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses Viruses, 2022-12-29;15(1):. 2022-12-29 [PMID: 36680128] (Bioassay, Human)	Bioassay	Human
Q Liu, Z Liu, H Gu, Y Ge, X Wu, F Zuo, Q Du, Y Lei, Z Wang, H Lin Comparative study of differentiating human pluripotent stem cells into vascular smooth muscle cells in hydrogel-based culture methods Regenerative Therapy, 2022-12-21;22(0):39-49. 2022-12-21 [PMID: 36618488] (Bioassay, Human)	Bioassay	Human
N Wang, J He, X Feng, S Liao, Y Zhao, F Tang, K Kee Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8 Elife, 2023-01-05;12(0):. 2023-01-05 [PMID: 36602025] (Bioassay, Human)	Bioassay	Human
T Oba, S Okamoto, Y Ueno, M Matsuo, T Tadokoro, S Kobayashi, K Yasumura, S Kagimoto, Y Inaba, H Taniguchi In vitro elastic cartilage reconstruction using human auricular perichondrial chondroprogenitor cell-derived micro 3D spheroids Journal of tissue engineering, 2022-12-23;13(0):2041731422114. 2022-12-23 [PMID: 36582939] (Cell Culture, Human)	Cell Culture	Human
S Yoo, EJ Lee, NX Thang, H La, H Lee, C Park, DW Han, SJ Uhm, H Song, JT Do, Y Choi, K Hong INO80 Is Required for the Cell Cycle Control, Survival, and Differentiation of Mouse ESCs by Transcriptional Regulation International Journal of Molecular Sciences, 2022-12-06;23(23):. 2022-12-06 [PMID: 36499727] (Bioassay, Mouse)	Bioassay	Mouse
M Hayashi, V Zywitza, Y Naitou, N Hamazaki, F Goeritz, R Hermes, S Holtze, G Lazzari, C Galli, J Stejskal, S Diecke, TB Hildebrand, K Hayashi Robust induction of primordial germ cells of white rhinoceros on the brink of extinction Science Advances, 2022-12-09;8(49):eabp9683. 2022-12-09 [PMID: 36490332] (Bioassay, Rhinoceros)	Bioassay	Rhinoceros
JE Kaserman, RB Werder, F Wang, T Matte, MI Higgins, M Dodge, J Lindstrom-, P Bawa, A Hinds, E Bullitt, IS Caballero, X Shi, RE Gerszten, N Brunetti-P, M Liesa, C Villacorta, AN Hollenberg, DN Kotton, AA Wilson Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity Cell Reports, 2022-12-06;41(10):111775. 2022-12-06 [PMID: 36476855] (Bioassay, Human)	Bioassay	Human
JP Borges, RSR Sætra, A Volchuk, M Bugge, P Devant, B Sporsheim, BR Kilburn, CL Evavold, JC Kagan, NM Goldenberg, TH Flo, BE Steinberg Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death Elife, 2022-12-05;11(0):. 2022-12-05 [PMID: 36468682] (Cell Culture, Mouse)	Cell Culture	Mouse
D Shang, T Lan, Y Wang, X Li, Q Liu, H Dong, B Xu, H Cheng, R Zhou PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders Cell & bioscience, 2022-12-01;12(1):194. 2022-12-01 [PMID: 36457060] (Cell Culture, Human)	Cell Culture	Human
Kunitomi A, Hirohata R, Arreola V, Osawa M, Kato T, Nomura M, Kawaguchi J, Hara H, Kusano K, Takashima Y, Takahashi K, Fukuda K, Takasu N, Yamanaka S Improved Sendai viral system for reprogramming to naive pluripotency. Cell Rep Methods, 2022-10-17;2(11):100317. 2022-10-17 [PMID: 36447645] (Bioassay, Human)	Bioassay	Human
Z Li, F Fang, Y Long, Q Zhao, X Wang, Z Ye, T Meng, X Gu, W Xiang, C Xiong, H Li The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate Cell & bioscience, 2022-11-04;12(1):181. 2022-11-04 [PMID: 36333732] (Bioassay, Human)	Bioassay	Human
K Leng, IVL Rose, H Kim, W Xia, W Romero-Fer, B Rooney, M Koontz, E Li, Y Ao, S Wang, M Krawczyk, J Tcw, A Goate, Y Zhang, EM Ullian, MV Sofroniew, SPJ Fancy, MS Schrag, ES Lippmann, M Kampmann CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states Nature Neuroscience, 2022-10-27;25(11):1528-1542. 2022-10-27 [PMID: 36303069] (Bioassay, Human)	Bioassay	Human
J Li, A Wiesinger, L Fokkert, BJ Boukens, AO Verkerk, VM Christoffe, GJJ Boink, HD Devalla Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models Journal of tissue engineering, 2022-10-18;13(0):2041731422112. 2022-10-18 [PMID: 36277058] (Bioassay, Human)	Bioassay	Human
YS Yang, JM Kim, J Xie, S Chaugule, C Lin, H Ma, E Hsiao, J Hong, H Chun, EM Shore, FS Kaplan, G Gao, JH Shim Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery Oncogene, 2022-10-19;13(1):6175. 2022-10-19 [PMID: 36258013] (Bioassay, Human)	Bioassay	Human
A Beucher, I Miguel-Esc, D Balboa, MG De Vas, MA Maestro, J Garcia-Hur, A Bernal, R Gonzalez-F, P Vargiu, H Heyn, P Ravassard, S Ortega, J Ferrer The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A Nature Cell Biology, 2022-10-06;0(0):. 2022-10-06 [PMID: 36202974] (Bioassay, Human)	Bioassay	Human
J Liu, Z Liu, J Zhang, X Chen, J Chen, L Sui, J Yu Ibrutinib Inhibits Angiogenesis and Tumorigenesis in a BTK-Independent Manner Pharmaceutics, 2022-09-05;14(9):. 2022-09-05 [PMID: 36145624] (Bioassay, Human)	Bioassay	Human
E Luce, C Steichen, S Abed, A Weber, P Leboulch, L Maouche-Ch, A Dubart-Kup Successful Derivation of Hepatoblasts, Cholangiocytes and Hepatocytes from Simian Induced Pluripotent Stem Cells International Journal of Molecular Sciences, 2022-09-17;23(18):. 2022-09-17 [PMID: 36142774] (Bioassay, Human)	Bioassay	Human
D Yang, J Gomez-Garc, S Funakoshi, T Tran, I Fernandes, GD Bader, MA Laflamme, GM Keller Modeling human multi-lineage heart field development with pluripotent stem cells Cell Stem Cell, 2022-09-01;29(9):1382-1401.e8. 2022-09-01 [PMID: 36055193] (Bioassay, Human)	Bioassay	Human
Y Tang, DJ Kwiatkowsk, EP Henske Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment Nature Communications, 2022-08-26;13(1):5018. 2022-08-26 [PMID: 36028490] (Bioassay, Mouse)	Bioassay	Mouse
S Martin, KC Allan, O Pinkard, T Sweet, PJ Tesar, J Coller Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay Nature Communications, 2022-08-25;13(1):5003. 2022-08-25 [PMID: 36008413] (Bioassay, Mouse)	Bioassay	Mouse
Z Ai, X Xiang, Y Xiang, I Szczerbins, Y Qian, X Xu, C Ma, Y Su, B Gao, H Shen, MN Bin Ramli, D Chen, Y Liu, JJ Hao, HH Ng, D Zhang, YS Chan, W Liu, H Liang Kr�ppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency Cell Reports, 2022-08-23;40(8):111240. 2022-08-23 [PMID: 36001968] (Cell Culture, Human)	Cell Culture	Human
K Kishimoto, K Iwasawa, A Sorel, C Ferran-Her, L Han, M Morimoto, JM Wells, T Takebe, AM Zorn Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems Nature Protocols, 2022-08-17;0(0):. 2022-08-17 [PMID: 35978039] (Cell Culture, Human)	Cell Culture	Human
X Fan, L Cyganek, K Nitschke, S Uhlig, P Nuhn, K Bieback, D Duerschmie, I El-Battraw, X Zhou, I Akin Functional Characterization of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells International Journal of Molecular Sciences, 2022-07-31;23(15):. 2022-07-31 [PMID: 35955642] (Bioassay, Human)	Bioassay	Human
R Jing, I Scarfo, MA Najia, E Lummertz d, A Han, M Sanborn, T Bingham, C Kubaczka, DK Jha, M Falchetti, TM Schlaeger, TE North, MV Maus, GQ Daley EZH1 repression generates mature iPSC-derived CAR T�cells with enhanced antitumor activity Cell Stem Cell, 2022-08-04;29(8):1181-1196.e6. 2022-08-04 [PMID: 35931029] (Bioassay, Human)	Bioassay	Human
Z Shonibare, M Monavarian, K O'Connell, D Altomare, A Shelton, S Mehta, R Jaskula-Sz, R Phaeton, MD Starr, R Whitaker, A Berchuck, AB Nixon, RC Arend, NY Lee, CR Miller, N Hempel, K Mythreye Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer Oncogene, 2022-07-26;40(4):111066. 2022-07-26 [PMID: 35905726] (Bioassay, Human)	Bioassay	Human
KJ Ng, J Lim, YN Tan, D Quek, Z Lim, N Pantelirei, C Clavel Sox2 in the dermal papilla regulates hair follicle pigmentation Oncogene, 2022-07-19;40(3):111100. 2022-07-19 [PMID: 35858560] (In Vivo, Mouse)	In Vivo	Mouse
YK Cho, YC Yoon, H Im, Y Son, M Kim, A Saha, C Choi, J Lee, S Lee, JH Kim, YP Kang, YS Jung, HK Ha, JK Seong, JG Granneman, SW Kwon, YH Lee Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism Nature Communications, 2022-07-14;13(1):4084. 2022-07-14 [PMID: 35835749] (Bioassay, Human)	Bioassay	Human
D Ávila-Gonz, W Portillo, CP Barragán-Á, G Hernandez-, E Flores-Gar, A Molina-Her, NE Díaz-Martí, NF Díaz The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells Elife, 2022-07-11;11(0):. 2022-07-11 [PMID: 35815953] (Bioassay, Human)	Bioassay	Human
M Ohgushi, N Taniyama, A Vandenbon, M Eiraku Delamination of trophoblast-like syncytia from the amniotic ectodermal analogue in human primed embryonic stem cell-based differentiation model Cell Reports, 2022-06-21;39(12):110973. 2022-06-21 [PMID: 35732132] (Bioassay, Human)	Bioassay	Human
Y Tsujisaka, T Hatani, C Okubo, R Ito, A Kimura, M Narita, K Chonabayas, S Funakoshi, A Lucena-Cac, T Toyoda, K Osafune, T Kimura, H Saito, Y Yoshida Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting Stem Cell Reports, 2022-06-09;0(0):. 2022-06-09 [PMID: 35688152] (Bioassay, Human)	Bioassay	Human
Y Hayashi, KC Kawabata, Y Tanaka, Y Uehara, Y Mabuchi, K Murakami, A Nishiyama, S Kiryu, Y Yoshioka, Y Ota, T Sugiyama, K Mikami, M Tamura, T Fukushima, S Asada, R Takeda, Y Kunisaki, T Fukuyama, K Yokoyama, T Uchida, M Hagihara, N Ohno, K Usuki, A Tojo, Y Katayama, S Goyama, F Arai, T Tamura, T Nagasawa, T Ochiya, D Inoue, T Kitamura MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis Cell Reports, 2022-05-10;39(6):110805. 2022-05-10 [PMID: 35545056] (Bioassay, Human)	Bioassay	Human
J Jeong, TH Kim, M Kim, YK Jung, KS Kim, S Shim, H Jang, WI Jang, SB Lee, D Choi Elimination of Reprogramming Transgenes Facilitates the Differentiation of Induced Pluripotent Stem Cells into Hepatocyte-like Cells and Hepatic Organoids Biology, 2022-03-23;11(4):. 2022-03-23 [PMID: 35453693] (Bioassay, Human)	Bioassay	Human
JM Rivera-Arb, C Cofiño-Fab, V Schwach, T Boonen, SA Ten Den, K Vermeul, A van den Be, LI Segerink, MC Ribeiro, R Passier Contractility analysis of human engineered 3D heart tissues by an automatic tracking technique using a standalone application PLoS ONE, 2022-04-14;17(4):e0266834. 2022-04-14 [PMID: 35421132] (Bioassay, Human)	Bioassay	Human
BK Gage, S Merlin, C Olgasi, A Follenzi, GM Keller Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors Cell Reports, 2022-04-05;39(1):110621. 2022-04-05 [PMID: 35385743] (Bioassay, Human)	Bioassay	Human
J Krumm, K Sekine, P Samaras, A Brazovskaj, M Breunig, R Yasui, A Kleger, H Taniguchi, M Wilhelm, B Treutlein, JG Camp, B Kuster High temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte development Cell Reports, 2022-03-29;38(13):110604. 2022-03-29 [PMID: 35354033] (Bioassay, Human)	Bioassay	Human
Z Wang, HP McWilliams, H Reza, JR Ostberg, W Chen, X Wang, C Huynh, V Vyas, WC Chang, R Starr, JR Wagner, B Aguilar, X Yang, X Wu, J Wang, W Chen, E Koelker-Wo, CS Seet, A Montel-Hag, GM Crooks, SJ Forman, CE Brown 3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T�cells Cell Stem Cell, 2022-03-11;0(0):. 2022-03-11 [PMID: 35278370] (Bioassay, Human)	Bioassay	Human
V Zywitza, E Rusha, D Shaposhnik, J Ruiz-Orera, N Telugu, V Rishko, M Hayashi, G Michel, L Wittler, J Stejskal, S Holtze, F Göritz, R Hermes, J Wang, Z Izsvák, S Colleoni, G Lazzari, C Galli, TB Hildebrand, K Hayashi, S Diecke, M Drukker Na�ve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction Scientific Reports, 2022-03-08;12(1):3100. 2022-03-08 [PMID: 35260583] (Bioassay, Northern White Rhinoceros)	Bioassay	Northern White Rhinoceros
K Uehara, M Koyanagi-A, T Koide, T Itoh, T Aoi Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids Stem Cell Reports, 2022-03-03;0(0):. 2022-03-03 [PMID: 35245440] (Bioassay, Human)	Bioassay	Human
X Hu, C Lin, N Ruan, Z Huang, Y Zhang, X Hu Operation of the Atypical Canonical Bone Morphogenetic Protein Signaling Pathway During Early Human Odontogenesis Frontiers in Physiology, 2022-02-08;13(0):823275. 2022-02-08 [PMID: 35211032] (Cell Culture, Human)	Cell Culture	Human
MC Ribeiro, JM Rivera-Arb, C Cofiño-Fab, V Schwach, RH Slaats, SA Ten Den, K Vermeul, A van den Be, JM Pérez-Poma, LI Segerink, JA Guadix, R Passier A New Versatile Platform for Assessment of Improved Cardiac Performance in Human-Engineered Heart Tissues Journal of personalized medicine, 2022-02-04;12(2):. 2022-02-04 [PMID: 35207702] (Bioassay, Human)	Bioassay	Human
XJ Li, C Morgan, LA Goff, A Doetzlhofe Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea Science Advances, 2022-02-11;8(6):eabj7651. 2022-02-11 [PMID: 35148175] (Bioassay, Mouse)	Bioassay	Mouse
C Budjan, S Liu, A Ranga, S Gayen, O Pourquié, S Hormoz Paraxial mesoderm organoids model development of human somites Elife, 2022-01-28;11(0):. 2022-01-28 [PMID: 35088712] (Cell Culture, Human)	Cell Culture	Human
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X Xiang, Y Tao, J DiRusso, FM Hsu, J Zhang, Z Xue, J Pontis, D Trono, W Liu, AT Clark Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections Nature Communications, 2022-01-24;13(1):463. 2022-01-24 [PMID: 35075135] (Bioassay, Human)	Bioassay	Human
JJ Kathiriya, C Wang, M Zhou, A Brumwell, M Cassandras, CJ Le Saux, M Cohen, KD Alysandrat, B Wang, P Wolters, M Matthay, DN Kotton, HA Chapman, T Peng Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells Nature Cell Biology, 2021-12-30;0(0):. 2021-12-30 [PMID: 34969962] (Bioassay, Human)	Bioassay	Human
N Yucer, R Ahdoot, MJ Workman, AH Laperle, MS Recouvreux, K Kurowski, DJ Naboulsi, V Liang, Y Qu, JT Plummer, SA Gayther, S Orsulic, BY Karlan, CN Svendsen Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis Cell Reports, 2021-12-28;37(13):110146. 2021-12-28 [PMID: 34965417] (Bioassay, Human)	Bioassay	Human
AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells Cell Stem Cell, 2021-12-01;0(0):. 2021-12-01 [PMID: 34856121] (Bioassay, Human)	Bioassay	Human
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AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients Cells, 2021-11-10;10(11):. 2021-11-10 [PMID: 34831322] (Bioassay, Human)	Bioassay	Human
RJ Geusz, A Wang, DK Lam, NK Vinckier, KD Alysandrat, DA Roberts, J Wang, S Kefalopoul, A Ramirez, Y Qiu, J Chiou, KJ Gaulton, B Ren, DN Kotton, M Sander Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors Nature Communications, 2021-11-17;12(1):6636. 2021-11-17 [PMID: 34789735] (Bioassay, Human)	Bioassay	Human
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X Duan, X Tang, MS Nair, T Zhang, Y Qiu, W Zhang, P Wang, Y Huang, J Xiang, H Wang, RE Schwartz, DD Ho, T Evans, S Chen An airway organoid-based screen identifies a role for the HIF1alpha-glycolysis axis in SARS-CoV-2 infection Cell Reports, 2021-10-15;37(6):109920. 2021-10-15 [PMID: 34731648] (Bioassay, Human)	Bioassay	Human
M Zheng, S Erhardt, D Ai, J Wang Bmp Signaling Regulates Hand1 in a Dose-Dependent Manner during Heart Development International Journal of Molecular Sciences, 2021-09-11;22(18):. 2021-09-11 [PMID: 34576009] (Bioassay, Mouse)	Bioassay	Mouse
Y Fan, Z Min, S Alsolami, Z Ma, E Zhang, W Chen, K Zhong, W Pei, X Kang, P Zhang, Y Wang, Y Zhang, L Zhan, H Zhu, C An, R Li, J Qiao, T Tan, M Li, Y Yu Generation of human blastocyst-like structures from pluripotent stem cells Cell Discovery, 2021-09-07;7(1):81. 2021-09-07 [PMID: 34489415] (Bioassay, Human)	Bioassay	Human
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R Sun, L He, H Lee, A Glinka, C Andresen, D Hübschmann, I Jeremias, K Müller-Dec, C Pabst, C Niehrs RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia Cell Reports, 2021-08-17;36(7):109559. 2021-08-17 [PMID: 34407399] (Bioassay, Human)	Bioassay	Human
K Sattler, I El-Battraw, L Cyganek, S Lang, H Lan, X Li, Z Zhao, J Utikal, T Wieland, M Borggrefe, X Zhou, I Akin TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes Scientific Reports, 2021-07-19;11(1):14689. 2021-07-19 [PMID: 34282193] (Bioassay, Human)	Bioassay	Human
M Sato, A Inohaya, E Yasuda, H Mogami, Y Chigusa, K Kawasaki, Y Kawamura, Y Ueda, H Takai, M Mandai, E Kondoh Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells Scientific Reports, 2021-07-08;11(1):14167. 2021-07-08 [PMID: 34239021] (Bioassay, Human)	Bioassay	Human
MN Wosczyna, EE Perez Carb, MW Wagner, S Paredes, CT Konishi, L Liu, TT Wang, RA Walsh, Q Gan, CS Morrissey, TA Rando Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells Cell Stem Cell, 2021-05-03;0(0):. 2021-05-03 [PMID: 33945794] (Bioassay, Mouse)	Bioassay	Mouse
A Mithal, AJ Hume, J Lindstrom-, C Villacorta, J Olejnik, E Bullitt, A Hinds, E Mühlberger, G Mostoslavs Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response Stem Cell Reports, 2021-04-13;16(4):940-953. 2021-04-13 [PMID: 33852884] (Bioassay, Human)	Bioassay	Human
S Io, M Kabata, Y Iemura, K Semi, N Morone, A Minagawa, B Wang, I Okamoto, T Nakamura, Y Kojima, C Iwatani, H Tsuchiya, B Kaswandy, E Kondoh, S Kaneko, K Woltjen, M Saitou, T Yamamoto, M Mandai, Y Takashima Capturing human trophoblast development with naive pluripotent stem cells in�vitro Cell Stem Cell, 2021-04-07;28(6):1023-1039.e13. 2021-04-07 [PMID: 33831365] (Bioassay, Human)	Bioassay	Human
G Campostrin, V Meraviglia, E Giacomelli, RWJ van Helden, L Yiangou, RP Davis, M Bellin, VV Orlova, CL Mummery Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells Nature Protocols, 2021-03-26;0(0):. 2021-03-26 [PMID: 33772245] (Bioassay, Human)	Bioassay	Human
AL Rodrigues, HY Liu, YW Chen, M Porotto, A Moscona, HW Snoeck The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D Nature Protocols, 2021-03-01;0(0):. 2021-03-01 [PMID: 33649566] (Bioassay, Human)	Bioassay	Human
W Yuan, Z Yao, V Veerapandi, X Yang, X Wang, D Chen, L Ma, C Li, Y Zheng, F Luo, XY Zhao The histone demethylase KDM2B regulates human primordial germ cell-like cells specification International journal of biological sciences, 2021-01-01;17(2):527-538. 2021-01-01 [PMID: 33613110] (Bioassay, Human)	Bioassay	Human
X Wang, Y Xiang, Y Yu, R Wang, Y Zhang, Q Xu, H Sun, ZA Zhao, X Jiang, X Wang, X Lu, D Qin, Y Quan, J Zhang, N Shyh-Chang, H Wang, N Jing, W Xie, L Li Formative pluripotent stem cells show features of epiblast cells poised for gastrulation Cell Research, 2021-02-19;0(0):. 2021-02-19 [PMID: 33608671] (Bioassay, Mouse)	Bioassay	Mouse
T Wang, AR Pine, AG Kotini, H Yuan, L Zamparo, DT Starczynow, C Leslie, EP Papapetrou Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets Cell Stem Cell, 2021-02-10;0(0):. 2021-02-10 [PMID: 33571445] (Bioassay, Human)	Bioassay	Human
TM Lu, S Houghton, T Magdeldin, JGB Durán, AP Minotti, A Snead, A Sproul, DT Nguyen, J Xiang, HA Fine, Z Rosenwaks, L Studer, S Rafii, D Agalliu, D Redmond, R Lis Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate Proceedings of the National Academy of Sciences of the United States of America, 2021-02-23;118(8):. 2021-02-23 [PMID: 33542154] (Bioassay, Human)	Bioassay	Human
PP Shah, W Lv, JH Rhoades, A Poleshko, D Abbey, MA Caporizzo, R Linares-Sa, JG Heffler, N Sayed, D Thomas, Q Wang, LJ Stanton, K Bedi, MP Morley, TP Cappola, AT Owens, KB Margulies, DB Frank, JC Wu, DJ Rader, W Yang, BL Prosser, K Musunuru, R Jain Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes Cell Stem Cell, 2021-02-01;0(0):. 2021-02-01 [PMID: 33529599] (Bioassay, Human)	Bioassay	Human
C Prajapati, M Ojala, H Lappi, K Aalto-Setä, M Pekkanen-M Electrophysiological evaluation of human induced pluripotent stem cell-derived cardiomyocytes obtained by different methods Stem Cell Research, 2021-01-15;51(0):102176. 2021-01-15 [PMID: 33485184] (Bioassay, Human)	Bioassay	Human
CL Wu, A Dicks, N Steward, R Tang, DB Katz, YR Choi, F Guilak Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis Nature Communications, 2021-01-13;12(1):362. 2021-01-13 [PMID: 33441552] (Bioassay, Human)	Bioassay	Human
M Souidi, Y Sleiman, I Acimovic, J Pribyl, A Charrabi, V Baecker, V Scheuerman, M Pesl, S Jelinkova, P Skladal, P Dvorak, A Lacampagne, V Rotrekl, AC Meli Oxygen Is an Ambivalent Factor for the Differentiation of Human Pluripotent Stem Cells in Cardiac 2D Monolayer and 3D Cardiac Spheroids International Journal of Molecular Sciences, 2021-01-11;22(2):. 2021-01-11 [PMID: 33440843] (Bioassay, Human)	Bioassay	Human
H Fang, S Geng, M Hao, Q Chen, M Liu, C Liu, Z Tian, C Wang, T Takebe, JL Guan, Y Chen, Z Guo, W He, J Diao Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells Nature Communications, 2021-01-04;12(1):109. 2021-01-04 [PMID: 33397937] (Bioassay, Human)	Bioassay	Human
S Monkley, JK Krishnaswa, M Göransson, M Clausen, J Meuller, K Thörn, R Hicks, S Delaney, L Stjernborg Optimised generation of iPSC-derived macrophages and dendritic cells that are functionally and transcriptionally similar to their primary counterparts PLoS ONE, 2020-12-17;15(12):e0243807. 2020-12-17 [PMID: 33332401] (Cell Culture, Human)	Cell Culture	Human
K Uchimura, H Wu, Y Yoshimura, BD Humphreys Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling Cell Reports, 2020-12-15;33(11):108514. 2020-12-15 [PMID: 33326782] (Bioassay, Human)	Bioassay	Human
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VS Adusumilli, TL Walker, RW Overall, GM Klatt, SA Zeidan, S Zocher, DG Kirova, K Ntitsias, TJ Fischer, AM Sykes, S Reinhardt, A Dahl, J Mansfeld, AE Rünker, G Kempermann ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence Cell Stem Cell, 2020-12-03;0(0):. 2020-12-03 [PMID: 33275875] (Cell Culture, Mouse)	Cell Culture	Mouse
AL Rocha, TI de Lima, GP de Souza, RO Corrêa, DL Ferrucci, B Rodrigues, C Lopes-Ramo, D Nilsson, TL Knittel, PR Castro, MF Fernandes, F Dos Santos, RB Parmigiani, LR Silveira, HF Carvalho, J Auwerx, MAR Vinolo, J Boucher, MA Mori Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression Science Advances, 2020-12-02;6(49):. 2020-12-02 [PMID: 33268375] (Cell Culture, Human)	Cell Culture	Human
J Qiu, S Nordling, HH Vasavada, EC Butcher, KK Hirschi Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification Cell Rep, 2020-12-01;33(9):108465. 2020-12-01 [PMID: 33264627] (Cell Culture, Human)	Cell Culture	Human
T Chitiashvi, I Dror, R Kim, FM Hsu, R Chaudhari, E Pandolfi, D Chen, S Liebscher, K Schenke-La, K Plath, A Clark Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation Nature Cell Biology, 2020-11-30;22(12):1436-1446. 2020-11-30 [PMID: 33257808] (Bioassay, Human)	Bioassay	Human
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EP Nora, L Caccianini, G Fudenberg, K So, V Kameswaran, A Nagle, A Uebersohn, B Hajj, AL Saux, A Coulon, LA Mirny, KS Pollard, M Dahan, BG Bruneau Molecular basis of CTCF binding polarity in genome folding Nat Commun, 2020-11-05;11(1):5612. 2020-11-05 [PMID: 33154377] (Bioassay, Mouse)	Bioassay	Mouse
H Lee, C Seidl, R Sun, A Glinka, C Niehrs R-spondins are BMP receptor antagonists in Xenopus early embryonic development Nat Commun, 2020-11-04;11(1):5570. 2020-11-04 [PMID: 33149137] (Bioassay, Human)	Bioassay	Human
VA Gazit, EA Swietlicki, MU Liang, A Surti, R McDaniel, M Geisman, DM Alvarado, MA Ciorba, G Bochicchio, O Ilahi, J Kirby, WJ Symons, NO Davidson, MS Levin, DC Rubin Stem cell and niche regulation in human short bowel syndrome JCI Insight, 2020-12-03;5(23):. 2020-12-03 [PMID: 33141758] (Cell Culture, Human)	Cell Culture	Human
H Fukushima, M Yoshioka, M Kawatou, V López-Dávi, M Takeda, Y Kanda, Y Sekino, Y Yoshida, JK Yamashita Specific induction and long-term maintenance of high purity ventricular cardiomyocytes from human induced pluripotent stem cells PLoS ONE, 2020-11-02;15(11):e0241287. 2020-11-02 [PMID: 33137106] (Bioassay, Human)	Bioassay	Human
L Pellegrini, A Albecka, DL Mallery, MJ Kellner, D Paul, AP Carter, LC James, MA Lancaster SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids Cell Stem Cell, 2020-10-13;0(0):. 2020-10-13 [PMID: 33113348] (Bioassay, Human)	Bioassay	Human
FJ Hawkins, S Suzuki, ML Beermann, C Barillà, R Wang, C Villacorta, A Berical, JC Jean, J Le Suer, T Matte, C Simone-Roa, Y Tang, TM Schlaeger, AM Crane, N Matthias, SXL Huang, SH Randell, J Wu, JR Spence, G Carraro, BR Stripp, A Rab, EJ Sorsher, A Horani, SL Brody, BR Davis, DN Kotton Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells Cell Stem Cell, 2020-10-23;0(0):. 2020-10-23 [PMID: 33098807] (Bioassay, Human)	Bioassay	Human
KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function Cell Stem Cell, 2020-10-21;0(0):. 2020-10-21 [PMID: 33091368] (Bioassay, Mouse)	Bioassay	Mouse
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CS Park, LP Nguyen, D Yong Development of Colonic Organoids Containing Enteric Nerves or Blood Vessels from Human Embryonic Stem Cells Cells, 2020-09-29;9(10):. 2020-09-29 [PMID: 33003541] (Bioassay, Human)	Bioassay	Human
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EI Crosse, S Gordon-Key, S Rybtsov, A Binagui-Ca, H Felchle, NC Nnadi, K Kirschner, T Chandra, S Tamagno, DJ Webb, F Rossi, RA Anderson, A Medvinsky Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development Cell Stem Cell, 2020-09-17;0(0):. 2020-09-17 [PMID: 32946788] (Bioassay, Human)	Bioassay	Human
AFM Dost, AL Moye, M Vedaie, LM Tran, E Fung, D Heinze, C Villacorta, J Huang, R Hekman, JH Kwan, BC Blum, SM Louie, SP Rowbotham, J Sainz de A, ME Piper, PJ Bhetariya, RT Bronson, A Emili, G Mostoslavs, GA Fishbein, WD Wallace, K Krysan, SM Dubinett, J Yanagawa, DN Kotton, CF Kim Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells Cell Stem Cell, 2020-09-04;27(4):663-678.e8. 2020-09-04 [PMID: 32891189] (Bioassay, Mouse)	Bioassay	Mouse
L Han, P Chaturvedi, K Kishimoto, H Koike, T Nasr, K Iwasawa, K Giesbrecht, PC Witcher, A Eicher, L Haines, Y Lee, JM Shannon, M Morimoto, JM Wells, T Takebe, AM Zorn Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis Nat Commun, 2020-08-27;11(1):4158. 2020-08-27 [PMID: 32855417] (Bioassay, Human)	Bioassay	Human
F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2 Res Sq, 2020-09-15;0(0):. 2020-09-15 [PMID: 32839764] (Bioassay, Human)	Bioassay	Human
L Zhang, J Avery, A Yin, AM Singh, TS Cliff, H Yin, S Dalton Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State Cell Stem Cell, 2020-08-11;0(0):. 2020-08-11 [PMID: 32783886] (Bioassay, Human)	Bioassay	Human
S Grosswendt, H Kretzmer, ZD Smith, AS Kumar, S Hetzel, L Wittler, S Klages, B Timmermann, S Mukherji, A Meissner Epigenetic regulator function through mouse gastrulation Nature, 2020-07-29;584(7819):102-108. 2020-07-29 [PMID: 32728215] (Bioassay, Mouse)	Bioassay	Mouse
AS Ibrahim, K Hussein, F Wang, M Wan, N Saad, M Essa, I Kim, A Shakoor, LA Owen, MM DeAngelis, M Al-Shabraw Bone Morphogenetic Protein (BMP)4 But Not BMP2 Disrupts the Barrier Integrity of Retinal Pigment Epithelia and Induces Their Migration: A Potential Role in Neovascular Age-Related Macular Degeneration J Clin Med, 2020-07-19;9(7):. 2020-07-19 [PMID: 32707711] (Bioassay, Human)	Bioassay	Human
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J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response bioRxiv, 2020-08-06;0(0):. 2020-08-06 [PMID: 32637964] (Bioassay, Human)	Bioassay	Human
H Zhu, RH Blum, D Bernareggi, EH Ask, Z Wu, HJ Hoel, Z Meng, C Wu, KL Guan, KJ Malmberg, DS Kaufman Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In�Vivo Persistence and Enhances Anti-tumor Activity Cell Stem Cell, 2020-06-11;0(0):. 2020-06-11 [PMID: 32531207] (Bioassay, Human)	Bioassay	Human
J Wesely, AG Kotini, F Izzo, H Luo, H Yuan, J Sun, M Georgomano, A Zviran, AG Deslaurier, N Dusaj, SD Nimer, C Leslie, DA Landau, MG Kharas, EP Papapetrou Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells Cell Rep, 2020-06-02;31(9):107688. 2020-06-02 [PMID: 32492433] (Cell Culture, Human)	Cell Culture	Human
K Takahashi, D Jeong, S Wang, M Narita, X Jin, M Iwasaki, SD Perli, BR Conklin, S Yamanaka Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells Cell Rep, 2020-06-02;31(9):107715. 2020-06-02 [PMID: 32492424] (Bioassay, Mouse)	Bioassay	Mouse
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T Pan, M Martinez, KM Hubka, JH Song, SC Lin, G Yu, YC Lee, GE Gallick, SM Tu, DA Harrington, MC Farach-Car, SH Lin, RL Satcher Cabozantinib Reverses Renal Cell Carcinoma-Mediated Osteoblast Inhibition in Three-Dimensional Co-culture In Vitro and Reduces Bone Osteolysis In Vivo Mol. Cancer Ther., 2020-03-27;0(0):. 2020-03-27 [PMID: 32220969] (Cell Culture, Human)	Cell Culture	Human
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M Riedl, C Witzmann, M Koch, S Lang, M Kerschbaum, F Baumann, W Krutsch, D Docheva, V Alt, C Pfeifer Attenuation of Hypertrophy in Human MSCs via Treatment with a Retinoic Acid Receptor Inverse Agonist Int J Mol Sci, 2020-02-20;21(4):. 2020-02-20 [PMID: 32093330] (Cell Culture, Human)	Cell Culture	Human
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Y Wang, L Lifshitz, K Gellatly, CL Vinton, K Busman-Sah, S McCauley, P Vangala, K Kim, A Derr, S Jaiswal, A Kucukural, P McDonel, PW Hunt, T Greenough, J Houghton, M Somsouk, JD Estes, JM Brenchley, M Garber, SG Deeks, J Luban HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells Nat. Immunol., 2020-02-17;21(3):274-286. 2020-02-17 [PMID: 32066947] (Cell Culture, Human)	Cell Culture	Human
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A Horváth, T Christ, JT Koivumäki, M Prondzynsk, ATL Zech, M Spohn, U Saleem, I Mannhardt, B Ulmer, E Girdauskas, C Meyer, A Hansen, T Eschenhage, MD Lemoine Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (Ibk,Ca) Cells, 2020-01-20;9(1):. 2020-01-20 [PMID: 31968557] (Bioassay, Human)	Bioassay	Human
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J Grajcarek, J Monlong, Y Nishinaka-, M Nakamura, M Nagai, S Matsuo, D Lougheed, H Sakurai, MK Saito, G Bourque, K Woltjen Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations Nat Commun, 2019-10-24;10(1):4856. 2019-10-24 [PMID: 31649251] (Bioassay, Human)	Bioassay	Human
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V Veschi, LR Mangiapane, A Nicotra, S Di Franco, E Scavo, T Apuzzo, DS Sardina, M Fiori, A Benfante, ML Colorito, G Cocorullo, F Giuliante, C Cipolla, G Pistone, MR Bongiorno, A Rizzo, CM Tate, X Wu, S Rowlinson, LF Stancato, M Todaro, R De Maria, G Stassi Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant Oncogene, 2019-10-07;0(0):. 2019-10-07 [PMID: 31591478] (Bioassay, Human)	Bioassay	Human
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M Nasri, M Ritter, P Mir, B Dannenmann, N Aghaallaei, D Amend, V Makaryan, Y Xu, B Fletcher, R Bernhard, I Steiert, K Hahnel, J Berger, I Koch, B Sailer, K Hipp, C Zeidler, M Klimiankou, B Bajoghli, DC Dale, K Welte, J Skokowa CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients Haematologica, 2019-06-27;0(0):. 2019-06-27 [PMID: 31248972] (Bioassay, Human)	Bioassay	Human
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AD Senft, EK Bikoff, EJ Robertson, I Costello Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse Nat Commun, 2019-03-06;10(1):1089. 2019-03-06 [PMID: 30842446] (Bioassay, Mouse)	Bioassay	Mouse
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TR Broda, KW McCracken, JM Wells Generation of human antral and fundic gastric organoids from pluripotent stem cells Nat Protoc, 2019-01-01;14(1):28-50. 2019-01-01 [PMID: 30470820] (Bioassay, Human)	Bioassay	Human
CC Weng, PY Ding, YH Liu, JR Hawse, M Subramania, CC Wu, YC Lin, CY Chen, WC Hung, KH Cheng Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis Oncogene, 2018-11-22;0(0):. 2018-11-22 [PMID: 30467381] (Bioassay, Mouse)	Bioassay	Mouse
P Ray, AS Chin, KE Worley, J Fan, G Kaur, M Wu, LQ Wan Intrinsic cellular chirality regulates left-right symmetry breaking during cardiac looping Proc. Natl. Acad. Sci. U.S.A., 2018-11-20;0(0):. 2018-11-20 [PMID: 30459275] (Bioassay, Chicken)	Bioassay	Chicken
JM Pattison, SP Melo, SN Piekos, JL Torkelson, E Bashkirova, MR Mumbach, C Rajasingh, HH Zhen, L Li, E Liaw, D Alber, AJ Rubin, G Shankar, X Bao, HY Chang, PA Khavari, AE Oro Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment Nat. Genet., 2018-11-05;0(0):. 2018-11-05 [PMID: 30397335] (Bioassay, Human)	Bioassay	Human
JGW Smith, T Owen, JR Bhagwan, D Mosqueira, E Scott, I Mannhardt, A Patel, R Barriales-, L Monserrat, A Hansen, T Eschenhage, SE Harding, S Marston, C Denning Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits Stem Cell Reports, 2018-11-01;0(0):. 2018-11-01 [PMID: 30392975] (Bioassay, Human)	Bioassay	Human
SS Adkar, CL Wu, VP Willard, A Dicks, A Ettyreddy, N Steward, N Bhutani, CA Gersbach, F Guilak Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing Stem Cells, 2018-10-31;0(0):. 2018-10-31 [PMID: 30378731] (Bioassay, Human)	Bioassay	Human
A Buskin, L Zhu, V Chichagova, B Basu, S Mozaffari-, D Dolan, A Droop, J Collin, R Bronstein, S Mehrotra, M Farkas, G Hilgen, K White, KT Pan, A Treumann, D Hallam, K Bialas, G Chung, C Mellough, Y Ding, N Krasnogor, S Przyborski, S Zwolinski, J Al-Aama, S Alharthi, Y Xu, G Wheway, K Szymanska, M McKibbin, CF Inglehearn, DJ Elliott, S Lindsay, RR Ali, DH Steel, L Armstrong, E Sernagor, H Urlaub, E Pierce, R Lührmann, SN Grellschei, CA Johnson, M Lako Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa Nat Commun, 2018-10-12;9(1):4234. 2018-10-12 [PMID: 30315276] (Bioassay, Human)	Bioassay	Human
A Yoney, F Etoc, A Ruzo, T Carroll, JJ Metzger, I Martyn, S Li, C Kirst, ED Siggia, AH Brivanlou WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids Elife, 2018-10-12;7(0):. 2018-10-12 [PMID: 30311909] (Bioassay, Human)	Bioassay	Human
Y Zhang, Y Yang, M Jiang, SX Huang, W Zhang, D Al Alam, S Danopoulos, M Mori, YW Chen, R Balasubram, SM Chuva de S, C Serra, M Bialecka, E Kim, S Lin, ALR Toste de C, PN Riccio, WV Cardoso, X Zhang, HW Snoeck, J Que 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling Cell Stem Cell, 2018-09-20;0(0):. 2018-09-20 [PMID: 30244870] (Bioassay, Human)	Bioassay	Human
L Delsing, P Dönnes, J Sánchez, M Clausen, D Voulgaris, A Falk, A Herland, G Brolén, H Zetterberg, R Hicks, J Synnergren Barrier properties and transcriptome expression in human iPSC-derived models of the blood-brain barrier Stem Cells, 2018-11-05;0(0):. 2018-11-05 [PMID: 30171748] (Bioassay, Human)	Bioassay	Human
K Kirino, T Nakahata, T Taguchi, MK Saito Efficient derivation of sympathetic neurons from human pluripotent stem cells with a defined condition Sci Rep, 2018-08-27;8(1):12865. 2018-08-27 [PMID: 30150715] (Bioassay, Human)	Bioassay	Human
AD Senft, I Costello, HW King, AW Mould, EK Bikoff, EJ Robertson Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming Cell Rep, 2018-08-21;24(8):1977-1985.e7. 2018-08-21 [PMID: 30134160] (Bioassay, Mouse)	Bioassay	Mouse
A Di Baldass, MA D'Amico, P Izzicupo, G Gaggi, S Guarnieri, MA Mariggiò, I Antonucci, B Corneo, D Sirabella, L Stuppia, B Ghinassi Cardiomyocytes Derived from Human CardiopoieticAmniotic Fluids Sci Rep, 2018-08-13;8(1):12028. 2018-08-13 [PMID: 30104705] (Bioassay, Human)	Bioassay	Human
Z Xu, X He, X Shi, Y Xia, X Liu, H Wu, P Li, H Zhang, W Yin, X Du, L Li, Y Li Analysis of differentially expressed genes among human hair follicle-derived iPSCs, induced hepatocyte-like cells, and primary hepatocytes Stem Cell Res Ther, 2018-08-09;9(1):211. 2018-08-09 [PMID: 30092828] (Bioassay, Human)	Bioassay	Human
L Devito, M Donne, N Kolundzic, P Khurana, C Hobbs, G Kaddour, S Dubrac, R Gruber, M Schmuth, T Mauro, D Ilic Induced pluripotent stem cell line from an atopic dermatitis patient heterozygous for c.2282del4 mutation in filaggrin: KCLi001-A Stem Cell Res, 2018-07-25;31(0):122-126. 2018-07-25 [PMID: 30075366] (Bioassay, Human)	Bioassay	Human
E Magro-Lope, C Palmer, J Manso, I Liste, A Zambrano Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids Stem Cell Res Ther, 2018-07-11;9(1):186. 2018-07-11 [PMID: 29996941] (Bioassay, Human)	Bioassay	Human
K Koefoed, J Skat-Rørda, P Andersen, CB Warzecha, M Pye, TA Andersen, KD Ajbro, E Bendsen, M Narimatsu, F Vilhardt, LB Pedersen, JL Wrana, RH Anderson, K Møllgård, ST Christense, LA Larsen The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development Sci Rep, 2018-06-22;8(1):9542. 2018-06-22 [PMID: 29934521] (Bioassay, Human)	Bioassay	Human
J Li, F Xing, F Chen, L He, KF So, Y Liu, J Xiao Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages Cell Transplant, 2018-06-13;0(0):9636897187803. 2018-06-13 [PMID: 29895168] (Bioassay, Human)	Bioassay	Human
H Jun, H Yu, J Gong, J Jiang, X Qiao, E Perkey, DI Kim, MP Emont, AG Zestos, JS Cho, J Liu, RT Kennedy, I Maillard, XZS Xu, J Wu An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling Nat. Med., 2018-05-21;0(0):. 2018-05-21 [PMID: 29785025] (Bioassay, Human)	Bioassay	Human
X Guo, Y Xu, Z Wang, Y Wu, J Chen, G Wang, C Lu, W Jia, J Xi, S Zhu, Z Jiapaer, X Wan, Z Liu, S Gao, J Kang A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis Cell Stem Cell, 2018-05-10;0(0):. 2018-05-10 [PMID: 29754779] (Bioassay, Mouse)	Bioassay	Mouse
YC Chen, CL Tsai, YH Wei, YT Wu, WT Hsu, HC Lin, YC Hsu ATOH1/RFX1/RFX3 transcription factors facilitate the differentiation and characterisation of inner ear hair cell-like cells from patient-specific induced pluripotent stem cells harbouring A8344G mutation of mitochondrial DNA Cell Death Dis, 2018-04-01;9(4):437. 2018-04-01 [PMID: 29740017] (Bioassay, Human)	Bioassay	Human
R Okamoto, K Takayama, N Akita, Y Nagamoto, D Hosokawa, S Iizuka, F Sakurai, H Suemizu, K Ohashi, H Mizuguchi Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B Cell Transplant, 2018-02-01;27(2):299-309. 2018-02-01 [PMID: 29637813] (Bioassay, Human)	Bioassay	Human
V Pursani, D Bhartiya, V Tanavde, M Bashir, P Sampath Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage Stem Cell Res Ther, 2018-04-10;9(1):97. 2018-04-10 [PMID: 29631608] (Bioassay, Human)	Bioassay	Human
Y Jin, Y Liu, Z Li, K Santostefa, J Shi, X Zhang, D Wu, Z Cheng, W Wu, N Terada, S Jin, F Bai Enhanced differentiation of human pluripotent stem cells into cardiomyocytes by bacteria-mediated transcription factors delivery PLoS ONE, 2018-03-26;13(3):e0194895. 2018-03-26 [PMID: 29579079] (Bioassay, Human)	Bioassay	Human
JS Esser, RE Steiner, M Deckler, H Schmitt, B Engert, S Link, A Charlet, C Patterson, C Bode, Q Zhou, M Moser Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial-venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells FEBS J., 2018-03-09;0(0):. 2018-03-09 [PMID: 29473997] (Bioassay, Human)	Bioassay	Human
EJ Ostrin, DR Little, KN Gerner-Mau, EA Sumner, R Ríos-Corzo, E Ambrosio, SE Holt, NR Forcioli-C, H Akiyama, SM Hanash, S Kimura, SXL Huang, J Chen Beta-Catenin maintains lung epithelial progenitors after lung specification Development, 2018-03-09;0(0):. 2018-03-09 [PMID: 29440304] (Bioassay, Human)	Bioassay	Human
F Wang, V Zachar, CP Pennisi, T Fink, Y Maeda, J Emmersen Hypoxia Enhances Differentiation of Adipose Tissue-Derived Stem Cells toward the Smooth Muscle Phenotype Int J Mol Sci, 2018-02-08;19(2):. 2018-02-08 [PMID: 29419805] (Bioassay, Human)	Bioassay	Human
T Yamashita, K Takayama, F Sakurai, H Mizuguchi Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells Biochem. Biophys. Res. Commun., 2018-02-01;0(0):. 2018-02-01 [PMID: 29409945] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
C Long, H Li, M Tiburcy, C Rodriguez-, V Kyrychenko, H Zhou, Y Zhang, YL Min, JM Shelton, PPA Mammen, NY Liaw, WH Zimmermann, R Bassel-Dub, JW Schneider, EN Olson Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing Sci Adv, 2018-01-31;4(1):eaap9004. 2018-01-31 [PMID: 29404407] (Bioassay, Human)	Bioassay	Human
A Kondrashov, M Duc Hoang, J Smith, J Bhagwan, G Duncan, D Mosqueira, M Munoz, NTN Vo, C Denning Simplified footprint-free Cas9/CRISPR editing of cardiac-associated genes in human pluripotent stem cells Stem Cells Dev., 2018-03-12;0(0):. 2018-03-12 [PMID: 29402189] (Bioassay, Human)	Bioassay	Human
A Yachie-Kin, K Onishi, J Ostblom, MA Langley, E Posfai, J Rossant, PW Zandstra Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions Mol. Syst. Biol., 2018-01-29;14(1):e7952. 2018-01-29 [PMID: 29378814] (Bioassay, Mouse)	Bioassay	Mouse
L Tengroth, J Arebro, O Larsson, C Bachert, SK Georén, LO Cardell Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps Sci Rep, 2018-01-24;8(1):1561. 2018-01-24 [PMID: 29367682] (Bioassay, Human)	Bioassay	Human
RA Sierra, NP Hoverter, RN Ramirez, LM Vuong, A Mortazavi, BJ Merrill, ML Waterman, PJ Donovan TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency Development, 2018-02-23;0(0):. 2018-02-23 [PMID: 29361574] (Bioassay, Human)	Bioassay	Human
JJ Gell, J Zhao, D Chen, TJ Hunt, AT Clark PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation Stem Cell Res, 2018-01-04;27(0):46-56. 2018-01-04 [PMID: 29324254] (Bioassay, Human)	Bioassay	Human
JP Matson, R Dumitru, P Coryell, RM Baxley, W Chen, K Twaroski, BR Webber, J Tolar, AK Bielinsky, JE Purvis, JG Cook Rapid DNA replication origin licensing protects stem cell pluripotency Elife, 2017-11-17;6(0):. 2017-11-17 [PMID: 29148972] (Bioassay, Human)	Bioassay	Human
A Taguchi, R Nishinakam Higher-Order Kidney Organogenesis from Pluripotent Stem Cells Cell Stem Cell, 2017-11-09;0(0):. 2017-11-09 [PMID: 29129523] (Bioassay, Human)	Bioassay	Human
J Li, I Minami, M Shiozaki, L Yu, S Yajima, S Miyagawa, Y Shiba, N Morone, S Fukushima, M Yoshioka, S Li, J Qiao, X Li, L Wang, H Kotera, N Nakatsuji, Y Sawa, Y Chen, L Liu Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium Stem Cell Reports, 2017-10-26;0(0):. 2017-10-26 [PMID: 29107590] (Bioassay, Human)	Bioassay	Human
C Krendl, D Shaposhnik, V Rishko, C Ori, C Ziegenhain, S Sass, L Simon, NS Müller, T Straub, KE Brooks, SL Chavez, W Enard, FJ Theis, M Drukker GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency Proc. Natl. Acad. Sci. U.S.A., 2017-10-25;0(0):. 2017-10-25 [PMID: 29078328] (Bioassay, Human)	Bioassay	Human
OH Ocaña, H Coskun, C Minguillón, P Murawala, EM Tanaka, J Galcerán, R Muñoz-Cháp, MA Nieto A right-handed signalling pathway drives heart looping in vertebrates Nature, 2017-09-06;549(7670):86-90. 2017-09-06 [PMID: 28880281] (Bioassay, Zebrafish)	Bioassay	Zebrafish
N Yucer, M Holzapfel, T Jenkins Vo, L Lenaeus, L Ornelas, A Laury, D Sareen, R Barrett, BY Karlan, CN Svendsen Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium Sci Rep, 2017-09-06;7(1):10741. 2017-09-06 [PMID: 28878359] (Bioassay, Human)	Bioassay	Human
NG Kooreman, PE de Almeida, JP Stack, RV Nelakanti, S Diecke, NY Shao, RJ Swijnenbur, V Sanchez-Fr, E Matsa, C Liu, AJ Connolly, JF Hamming, PHA Quax, MA Brehm, DL Greiner, LD Shultz, JC Wu Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics Cell Rep, 2017-08-22;20(8):1978-1990. 2017-08-22 [PMID: 28834758] (Bioassay, Human)	Bioassay	Human
J Xing, Y Cao, Y Yu, H Li, Z Song, H Yu In Vitro Micropatterned Human Pluripotent Stem Cell Test (�P-hPST) for Morphometric-Based Teratogen Screening Sci Rep, 2017-08-17;7(1):8491. 2017-08-17 [PMID: 28819231] (Bioassay, Human)	Bioassay	Human
NJ Palpant, Y Wang, B Hadland, RJ Zaunbreche, M Redd, D Jones, L Pabon, R Jain, J Epstein, WL Ruzzo, Y Zheng, I Bernstein, A Margolin, CE Murry Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis Cell Rep, 2017-08-15;20(7):1597-1608. 2017-08-15 [PMID: 28813672] (Bioassay, Human)	Bioassay	Human
R McLennan, CM Bailey, LJ Schumacher, JM Teddy, JA Morrison, JC Kasemeier-, LA Wolfe, MM Gogol, RE Baker, PK Maini, PM Kulesa DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion J. Cell Biol., 2017-08-15;216(10):3339-3354. 2017-08-15 [PMID: 28811280] (Bioassay, Chicken, Human)	Bioassay	Chicken, Human
Y Shao, K Taniguchi, RF Townshend, T Miki, DL Gumucio, J Fu A pluripotent stem cell-based model for post-implantation human amniotic sac development Nat Commun, 2017-08-08;8(1):208. 2017-08-08 [PMID: 28785084] (Bioassay, Human)	Bioassay	Human
KM Tsang, JS Hyun, KT Cheng, M Vargas, D Mehta, M Ushio-Fuka, L Zou, KV Pajcini, J Rehman, AB Malik Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1? Stem Cell Reports, 2017-08-03;0(0):. 2017-08-03 [PMID: 28781077] (Bioassay, Human)	Bioassay	Human
JH Lee, SI Protze, Z Laksman, PH Backx, GM Keller Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations Cell Stem Cell, 2017-08-03;21(2):179-194.e4. 2017-08-03 [PMID: 28777944] (Bioassay, Human)	Bioassay	Human
C Sallon, I Callebaut, I Boulay, J Fontaine, D Logeart-Av, C Henriquet, M Pugnière, X Cayla, P Monget, G Harichaux, V Labas, S Canepa, C Taragnat Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells J. Biol. Chem., 2017-07-26;0(0):. 2017-07-26 [PMID: 28747434] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
P Scerbo, L Marchal, L Kodjabachi Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2 Elife, 2017-06-27;6(0):. 2017-06-27 [PMID: 28654420] (In Vivo, Xenopus)	In Vivo	Xenopus
AG Freire, A Waghray, F Soares-da-, TP Resende, DF Lee, CF Pereira, DS Nascimento, IR Lemischka, P Pinto-do-Ó Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate Stem Cell Reports, 2017-06-22;0(0):. 2017-06-22 [PMID: 28648899] (Bioassay, Mouse)	Bioassay	Mouse
E Aberdam, I Petit, L Sangari, D Aberdam Induced pluripotent stem cell-derived limbal epithelial cells (LiPSC) as a cellular alternative for in vitro ocular toxicity testing PLoS ONE, 2017-06-22;12(6):e0179913. 2017-06-22 [PMID: 28640863] (Bioassay, Human)	Bioassay	Human
A Campbell, JM Hogestyn, CJ Folts, B Lopez, C Pröschel, D Mock, M Mayer-Prös Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration Sci Rep, 2017-06-21;7(1):3978. 2017-06-21 [PMID: 28638124] (Bioassay, Human)	Bioassay	Human
K Ogura-Ochi, S Fujisawa, N Iwata, M Komatsubar, Y Nishiyama, N Tsukamoto-, K Inagaki, J Wada, F Otsuka Regulatory role of melatonin and BMP-4 in prolactin production by rat pituitary lactotrope GH3 cells Peptides, 2017-06-13;0(0):. 2017-06-13 [PMID: 28627372] (Bioassay, Rat)	Bioassay	Rat
D Jung, J Xiong, M Ye, X Qin, L Li, S Cheng, M Luo, J Peng, J Dong, F Tang, W Shen, MM Matzuk, K Kee In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells Nat Commun, 2017-06-12;8(0):15680. 2017-06-12 [PMID: 28604658] (Bioassay, Human)	Bioassay	Human
G Yücel, Z Zhao, I El-Battraw, H Lan, S Lang, X Li, F Buljubasic, WH Zimmermann, L Cyganek, J Utikal, U Ravens, T Wieland, M Borggrefe, XB Zhou, I Akin Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes Sci Rep, 2017-06-07;7(1):2935. 2017-06-07 [PMID: 28592841] (Bioassay, Human)	Bioassay	Human
K Kajiwara, T Tanemoto, S Wada, J Karibe, N Ihara, Y Ikemoto, T Kawasaki, Y Oishi, O Samura, K Okamura, S Takada, H Akutsu, H Sago, A Okamoto, A Umezawa Fetal Therapy Model of Myelomeningocele with Three-Dimensional Skin Using Amniotic Fluid Cell-Derived Induced Pluripotent Stem Cells Stem Cell Reports, 2017-06-06;8(6):1701-1713. 2017-06-06 [PMID: 28591652] (Bioassay, Human)	Bioassay	Human
D Jeziorowsk, V Fontaine, C Jouve, E Villard, S Dussaud, D Akbar, V Letang, P Cervello, JM Itier, MP Pruniaux, JS Hulot Differential Sarcomere and Electrophysiological Maturation of Human iPSC-Derived Cardiac Myocytes in Monolayer vs. Aggregation-Based Differentiation Protocols Int J Mol Sci, 2017-06-01;18(6):. 2017-06-01 [PMID: 28587156] (Bioassay, Human)	Bioassay	Human
N Rahman, PM Brauer, L Ho, T Usenko, M Tewary, JC Zúñiga-Pfl, PW Zandstra Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence Nat Commun, 2017-05-25;8(0):15380. 2017-05-25 [PMID: 28541275] (Bioassay, Human)	Bioassay	Human
JW Park, L Yan, C Stoddard, X Wang, Z Yue, L Crandall, T Robinson, Y Chang, K Denton, E Li, B Jiang, Z Zhang, K Martins-Ta, SP Yee, H Nie, F Gu, W Si, T Xie, L Yue, RH Xu Recapitulating and Correcting Marfan Syndrome in a Cellular Model Int. J. Biol. Sci., 2017-04-10;13(5):588-603. 2017-04-10 [PMID: 28539832] (Bioassay, Human)	Bioassay	Human
R Kumar, A Gont, TJ Perkins, JEL Hanson, IAJ Lorimer Induction of senescence in primary glioblastoma cells by serum and TGF? Sci Rep, 2017-05-19;7(1):2156. 2017-05-19 [PMID: 28526854] (Bioassay, Human)	Bioassay	Human
K Breckwoldt, D Letuffe-Br, I Mannhardt, T Schulze, B Ulmer, T Werner, A Benzin, B Klampe, MC Reinsch, S Laufer, A Shibamiya, M Prondzynsk, G Mearini, D Schade, S Fuchs, C Neuber, E Krämer, U Saleem, ML Schulze, ML Rodriguez, T Eschenhage, A Hansen Differentiation of cardiomyocytes and generation of human engineered heart tissue Nat Protoc, 2017-05-11;12(6):1177-1197. 2017-05-11 [PMID: 28492526] (Bioassay, Human)	Bioassay	Human
LK Bollum, K Huse, MP Oksvold, B Bai, VI Hilden, L Forfang, SO Yoon, S Wälchli, EB Smeland, JH Myklebust BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-? receptor type I ALK5 PLoS ONE, 2017-05-10;12(5):e0177188. 2017-05-10 [PMID: 28489883] (Bioassay, Human)	Bioassay	Human
MT Uemura, M Ihara, T Maki, T Nakagomi, S Kaji, K Uemura, T Matsuyama, RN Kalaria, A Kinoshita, R Takahashi Pericyte-derived Bone Morphogenetic Protein 4 Underlies White Matter Damage after Chronic Hypoperfusion Brain Pathol., 2017-05-31;0(0):. 2017-05-31 [PMID: 28470822] (Bioassay, Mouse)	Bioassay	Mouse
F Hawkins, P Kramer, A Jacob, I Driver, DC Thomas, KB McCauley, N Skvir, AM Crane, AA Kurmann, AN Hollenberg, S Nguyen, BG Wong, AS Khalil, SX Huang, S Guttentag, JR Rock, JM Shannon, BR Davis, DN Kotton Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells J. Clin. Invest., 2017-05-02;127(6):2277-2294. 2017-05-02 [PMID: 28463226] (Bioassay, Human)	Bioassay	Human
S Mitani, K Takayama, Y Nagamoto, K Imagawa, F Sakurai, M Tachibana, R Sumazaki, H Mizuguchi Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling Mol. Ther., 2017-04-24;25(6):1420-1433. 2017-04-24 [PMID: 28462819] (Bioassay, Human)	Bioassay	Human
E Raja, A Komuro, R Tanabe, S Sakai, Y Ino, N Saito, T Todo, M Morikawa, H Aburatani, D Koinuma, C Iwata, K Miyazono Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells Oncogene, 2017-05-01;0(0):. 2017-05-01 [PMID: 28459464] (Bioassay, Human)	Bioassay	Human
K Low, LY Wong, M Maldonado, C Manjunath, CB Horner, M Perez, NV Myung, J Nam Physico-electrochemical Characterization of Pluripotent Stem Cells during Self-Renewal or Differentiation by a Multi-modal Monitoring System Stem Cell Reports, 2017-04-27;0(0):. 2017-04-27 [PMID: 28457888] (Bioassay, Human)	Bioassay	Human
S Warrier, M Van der Je, G Duggal, L Tilleman, E Sutherland, J Taelman, M Popovic, S Lierman, S Chuva De S, A Van Soom, L Peelman, F Van Nieuwe, DIM De Coninck, B Menten, P Mestdagh, J Van de Som, D Deforce, P De Sutter, B Heindryckx Direct comparison of distinct naive pluripotent states in human embryonic stem cells Nat Commun, 2017-04-21;8(0):15055. 2017-04-21 [PMID: 28429706] (Bioassay, Human)	Bioassay	Human
BW Ellis, A Acun, UI Can, P Zorlutuna Human iPSC-derived myocardium-on-chip with capillary-like flow for personalized medicine Biomicrofluidics, 2017-03-16;11(2):024105. 2017-03-16 [PMID: 28396709] (Bioassay, Human)	Bioassay	Human
JH Lee, S Laronde, TJ Collins, Z Shapovalov, B Tanasijevi, JD McNicol, A Fiebig-Com, YD Benoit, JB Lee, RR Mitchell, M Bhatia Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency Cell Rep, 2017-04-04;19(1):20-35. 2017-04-04 [PMID: 28380358] (Bioassay, Human)	Bioassay	Human
LA Ahrens, D Vonwil, J Christense, VP Shastri Gelatin device for the delivery of growth factors involved in endochondral ossification PLoS ONE, 2017-04-05;12(4):e0175095. 2017-04-05 [PMID: 28380024] (Bioassay, Human)	Bioassay	Human
F Sakurai, S Mitani, T Yamamoto, K Takayama, M Tachibana, K Watashi, T Wakita, S Iijima, Y Tanaka, H Mizuguchi Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection Sci Rep, 2017-04-04;7(0):45698. 2017-04-04 [PMID: 28374759] (Bioassay, Human)	Bioassay	Human
KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling Cell Stem Cell, 2017-03-30;0(0):. 2017-03-30 [PMID: 28366587] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
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Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication PLoS ONE, 2016-12-15;11(12):e0168334. 2016-12-15 [PMID: 27977771] (Bioassay, Human)	Bioassay	Human
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Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes Stem Cells Transl Med, 2016-01-01;0(0):. 2016-01-01 [PMID: 27591141] (Bioassay, Human)	Bioassay	Human
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The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling Stem Cell Res Ther, 2016-08-17;7(1):115. 2016-08-17 [PMID: 27530160] (Bioassay, Human)	Bioassay	Human
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Jiang D, Aguiar R MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-beta1/SMAD5 signaling module. Blood, 2013-10-17;123(1):86-93. 2013-10-17 [PMID: 24136167] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
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Fujiwara , Tohru, Ikeda , Takashi, Nagasaka , Yuki, Okitsu , Yoko, Katsuoka , Yuna, Fukuhara , Noriko, Onishi , Yasushi, Ishizawa , Kenichi, Ichinohasama , Ryo, Tomosugi , Naohisa, Harigae , Hideo A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease. PLoS ONE, 2013-09-27;8(9):e75568. 2013-09-27 [PMID: 24086573] (Bioassay, Human)	Bioassay	Human
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Kawabata K, Ehata S, Komuro A, Takeuchi K, Miyazono K TGF-beta-induced apoptosis of B-cell lymphoma Ramos cells through reduction of MS4A1/CD20. Oncogene, 2012-06-04;32(16):2096-106. 2012-06-04 [PMID: 22665052] (Bioassay, Human)	Bioassay	Human
Kim M, Yoon S, Lee S Gremlin-1 induces BMP-independent tumor cell proliferation, migration, and invasion. PLoS ONE, 2012-04-13;7(4):e35100. 2012-04-13 [PMID: 22514712] (Binding Assay, Human)	Binding Assay	Human
Yao Y, Jumabay M, Ly A, Radparvar M, Wang AH, Abdmaulen R, Bostrom KI Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. Blood, 2012-04-03;119(21):5037-47. 2012-04-03 [PMID: 22474252] (Bioassay, Human)	Bioassay	Human
Cheung C, Bernardo AS, Trotter MW Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility. Nat. Biotechnol., 2012-01-15;30(2):165-73. 2012-01-15 [PMID: 22252507] (Bioassay, Human)	Bioassay	Human
Joubin , Katherin, Richardson , Amelia, Novoa , Natalia, Tu , Edmund, Tomishima , Mark J The endothelial cell line bEnd.3 maintains human pluripotent stem cells. Stem Cells Dev, 2012-02-21;21(12):2312-21. 2012-02-21 [PMID: 22224974] (Bioassay, Human)	Bioassay	Human
Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells. Gene Ther, 2011-11-10;19(10):1035-40. 2011-11-10 [PMID: 22071967] (Bioassay, Human)	Bioassay	Human
Wong RC, Pollan S, Fong H, Ibrahim A, Smith EL, Ho M, Laslett AL, Donovan PJ A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells. Stem Cells, 2011-10-01;29(10):1517-27. 2011-10-01 [PMID: 21898682] (Bioassay, Human)	Bioassay	Human
Huse K, Bakkebo M, Oksvold MP, Forfang L, Hilden VI, Stokke T, Smeland EB, Myklebust JH Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7. Eur. J. Immunol., 2011-10-18;41(11):3135-45. 2011-10-18 [PMID: 21898381] (Bioassay, Human)	Bioassay	Human
Maegdefrau U, Arndt S, Kivorski G, Hellerbrand C, Bosserhoff AK Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma. Lab. Invest., 2011-08-22;91(11):1615-23. 2011-08-22 [PMID: 21863061] (Bioassay, Human)	Bioassay	Human
Niwa A, Heike T, Umeda K A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors. PLoS ONE, 2011-07-27;6(7):e22261. 2011-07-27 [PMID: 21818303] (Bioassay, Human)	Bioassay	Human
Rochira JA, Matluk NN, Adams TL, Karaczyn AA, Oxburgh L, Hess ST, Verdi JM A small peptide modeled after the NRAGE repeat domain inhibits XIAP-TAB1-TAK1 signaling for NF-kappaB activation and apoptosis in P19 cells. PLoS ONE, 2011-07-18;6(7):e20659. 2011-07-18 [PMID: 21789165] (Bioassay, Human)	Bioassay	Human
Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth. J. Biol. Chem., 2011-07-07;286(34):30034-46. 2011-07-07 [PMID: 21737454] (Surface Plasmon Resonance, Human, Mouse)	Surface Plasmon Resonance	Human, Mouse
Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A Down-regulation of Kruppel-like Factor-4 (KLF4) by MicroRNA-143/145 Is Critical for Modulation of Vascular Smooth Muscle Cell Phenotype by Transforming Growth Factor-{beta} and Bone Morphogenetic Protein 4. J. Biol. Chem., 2011-06-13;286(32):28097-110. 2011-06-13 [PMID: 21673106] (Bioassay, Human)	Bioassay	Human
Geens M, Sermon KD Sertoli cell-conditioned medium induces germ cell differentiation in human embryonic stem cells. J. Assist. Reprod. Genet., 2011-02-12;0(0):. 2011-02-12 [PMID: 21318592] (Bioassay, Human)	Bioassay	Human
Zhang Q, Jiang J, Han P, Yuan Q, Zhang J, Zhang X, Xu Y, Cao H, Meng Q, Chen L, Tian T, Wang X, Li P, Hescheler J, Ji G, Ma Y Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals. Cell Res., 2010-11-23;21(4):579-87. 2010-11-23 [PMID: 21102549] (Bioassay, Human)	Bioassay	Human
Klim JR, Li L, Wrighton PJ A defined glycosaminoglycan-binding substratum for human pluripotent stem cells. Nat. Methods, 2010-11-14;7(12):989-94. 2010-11-14 [PMID: 21076418] (Bioassay, Human)	Bioassay	Human
Tolar J, Park I, Xia L, Lees C, Peacock B, Webber B, McElmurry R, Eide C, Orchard P, Kyba M, Osborn M, Lund T, Wagner J, Daley G, Blazar B Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome). Blood, 2010-10-29;117(3):839-47. 2010-10-29 [PMID: 21037085] (Bioassay, Human)	Bioassay	Human
Roelandt P, Pauwelyn KA, Sancho-Bru P Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE, 2010-08-11;5(8):e12101. 2010-08-11 [PMID: 20711405] (Cell Culture, Human)	Cell Culture	Human
Martino MM, Hubbell JA The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain. FASEB J., 2010-07-29;24(12):4711-21. 2010-07-29 [PMID: 20671107] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
Stewart A, Guan H, Yang K BMP-3 promotes mesenchymal stem cell proliferation through the TGF-beta/activin signaling pathway. J. Cell. Physiol., 2010-06-01;223(3):658-66. 2010-06-01 [PMID: 20143330] (Bioassay, Mouse)	Bioassay	Mouse
Rai D, Kim SW, McKeller MR Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc. Natl. Acad. Sci. U.S.A., 2010-02-01;107(7):3111-6. 2010-02-01 [PMID: 20133617] (Bioassay, Human)	Bioassay	Human
Chng Z, Teo A, Pedersen RA, Vallier L SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells. Cell Stem Cell, 2010-01-08;6(1):59-70. 2010-01-08 [PMID: 20074535] (Bioassay, Human)	Bioassay	Human
Lanner F, Lee KL, Sohl M, Holmborn K, Yang H, Wilbertz J, Poellinger L, Rossant J, Farnebo F Heparan sulfation-dependent fibroblast growth factor signaling maintains embryonic stem cells primed for differentiation in a heterogeneous state. Stem Cells, 2010-02-01;28(2):191-200. 2010-02-01 [PMID: 19937756] (Bioassay, Human)	Bioassay	Human
Grcevic D, Kusec R, Kovacic N, Lukic A, Lukic IK, Ivcevic S, Nemet D, Seiwerth RS, Ostojic SK, Croucher PI, Marusic A Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes. Leuk. Res., 2009-11-18;34(6):742-51. 2009-11-18 [PMID: 19926132] (Bioassay, Human)	Bioassay	Human
Sugiura K, Su YQ, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells. Biol. Reprod., 2009-06-24;81(5):833-41. 2009-06-24 [PMID: 19553596] (Bioassay, Mouse)	Bioassay	Mouse
Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc. Natl. Acad. Sci. U.S.A., 2009-05-29;106(24):9826-30. 2009-05-29 [PMID: 19482945] (Bioassay, Human)	Bioassay	Human
Sellers DL, Maris DO, Horner PJ Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury. J. Neurosci., 2009-05-20;29(20):6722-33. 2009-05-20 [PMID: 19458241] (In Vivo, Mouse)	In Vivo	Mouse
Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, Bhupatiraju A, Lee YT, Goodnough JB, Harandi O, Ganz T, Paulson RF, Miller JL Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood, 2009-05-04;114(1):181-6. 2009-05-04 [PMID: 19414861] (Bioassay, Human)	Bioassay	Human
Herrera B, Inman GJ A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol., 2009-03-19;10(0):20. 2009-03-19 [PMID: 19298647] (Bioassay, Mouse)	Bioassay	Mouse
Kelly MA, Hirschi KK Signaling hierarchy regulating human endothelial cell development. Arterioscler. Thromb. Vasc. Biol., 2009-02-12;29(5):718-24. 2009-02-12 [PMID: 19213939] (Bioassay, Human)	Bioassay	Human
Stevens KR, Pabon L, Muskheli V Scaffold-free human cardiac tissue patch created from embryonic stem cells. Tissue Eng Part A, 2009-06-01;15(6):1211-22. 2009-06-01 [PMID: 19063661] (Bioassay, Human)	Bioassay	Human
Bernardo AS, Cho CH, Mason S, Docherty HM, Pedersen RA, Vallier L, Docherty K Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells. Stem Cells, 2009-02-01;27(2):341-51. 2009-02-01 [PMID: 19056911] (Bioassay, Mouse)	Bioassay	Mouse
Yao Y, Shao ES, Jumabay M, Shahbazian A, Ji S, Bostrom KI High-density lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2. Arterioscler. Thromb. Vasc. Biol., 2008-10-23;28(12):2266-74. 2008-10-23 [PMID: 18948634] (Bioassay, Bovine, Human)	Bioassay	Bovine, Human
Boswell BA, Overbeek PA, Musil LS Essential role of BMPs in FGF-induced secondary lens fiber differentiation. Dev. Biol., 2008-09-18;324(2):202-12. 2008-09-18 [PMID: 18848538] (Bioassay, Chicken)	Bioassay	Chicken
Levine AJ, Levine ZJ, Brivanlou AH GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses. Dev. Biol., 2008-09-18;325(1):43-8. 2008-09-18 [PMID: 18823971] (Bioassay, Xenopus)	Bioassay	Xenopus
Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature, 2008-08-21;454(7207):1000-4. 2008-08-21 [PMID: 18719589] (Bioassay, Mouse)	Bioassay	Mouse
Jeanpierre S, Nicolini FE, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, Maguer-Satta V BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood, 2008-07-29;112(8):3154-63. 2008-07-29 [PMID: 18664625] (Bioassay, Human)	Bioassay	Human
Wu Z, Zhang W, Chen G, Cheng L, Liao J, Jia N, Gao Y, Dai H, Yuan J, Cheng L, Xiao L Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells. J. Biol. Chem., 2008-07-02;283(36):24991-5002. 2008-07-02 [PMID: 18596037] (Bioassay, Human)	Bioassay	Human
Kane R, Godson C, O'Brien C Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis. Mol. Vis., 2008-06-20;14(0):1138-48. 2008-06-20 [PMID: 18587495] (Binding Assay, Bioassay, Human)	Binding Assay, Bioassay	Human
Saeki K, Yogiashi Y, Nakahara M, Nakamura N, Matsuyama S, Koyanagi A, Yagita H, Koyanagi M, Kondo Y, Yuo A Highly efficient and feeder-free production of subculturable vascular endothelial cells from primate embryonic stem cells. J. Cell. Physiol., 2008-10-01;217(1):261-80. 2008-10-01 [PMID: 18551514] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))	Bioassay	Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell, 2008-06-05;2(6):602-12. 2008-06-05 [PMID: 18522853] (Bioassay, Human)	Bioassay	Human
Sun Y, Pollard S, Conti L, Toselli M, Biella G, Parkin G, Willatt L, Falk A, Cattaneo E, Smith A Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture. Mol. Cell. Neurosci., 2008-03-18;38(2):245-58. 2008-03-18 [PMID: 18450476] (Bioassay, Human)	Bioassay	Human
Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature, 2008-04-23;453(7194):524-8. 2008-04-23 [PMID: 18432194] (Bioassay, Human)	Bioassay	Human
Boswell BA, Lein PJ, Musil LS Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells. Mol. Biol. Cell, 2008-04-09;19(6):2631-41. 2008-04-09 [PMID: 18400943] (Bioassay, Chicken)	Bioassay	Chicken
Chen G, Ye Z, Yu X, Zou J, Mali P, Brodsky RA, Cheng L Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins. Cell Stem Cell, 2008-04-10;2(4):345-55. 2008-04-10 [PMID: 18397754] (Bioassay, Human)	Bioassay	Human
Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bachinger HP, Sakai LY Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J. Biol. Chem., 2008-03-13;283(20):13874-88. 2008-03-13 [PMID: 18339631] (Binding Assay, Surface Plasmon Resonance, Human)	Binding Assay, Surface Plasmon Resonance	Human
Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev., 2008-01-15;22(2):152-65. 2008-01-15 [PMID: 18198334] (Bioassay, Human)	Bioassay	Human
Anderson BC, Christiansen SP, McLoon LK Myogenic growth factors can decrease extraocular muscle force generation: a potential biological approach to the treatment of strabismus. Invest. Ophthalmol. Vis. Sci., 2008-01-01;49(1):221-9. 2008-01-01 [PMID: 18172096] (In Vivo, Rabbit)	In Vivo	Rabbit
Zhang P, Li J, Tan Z, Wang C, Liu T, Chen L, Yong J, Jiang W, Sun X, DU L, Ding M, Deng H Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood, 2007-11-27;111(4):1933-41. 2007-11-27 [PMID: 18042803] (Bioassay, Human)	Bioassay	Human
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 2007-11-30;131(5):861-72. 2007-11-30 [PMID: 18035408] (Bioassay, Human)	Bioassay	Human
Southwood M, Jeffery TK, Yang X, Upton PD, Hall SM, Atkinson C, Haworth SG, Stewart S, Reynolds PN, Long L, Trembath RC, Morrell NW Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J. Pathol., 2008-01-01;214(1):85-95. 2008-01-01 [PMID: 17992660] (Bioassay, Human)	Bioassay	Human
Zode GS, Clark AF, Wordinger RJ Activation of the BMP canonical signaling pathway in human optic nerve head tissue and isolated optic nerve head astrocytes and lamina cribrosa cells. Invest. Ophthalmol. Vis. Sci., 2007-11-01;48(11):5058-67. 2007-11-01 [PMID: 17962458] (Bioassay, Western Blot, Human)	Bioassay, Western Blot	Human
Kavanagh KD, Evans AR, Jernvall J Predicting evolutionary patterns of mammalian teeth from development. Nature, 2007-09-27;449(7161):427-32. 2007-09-27 [PMID: 17898761] (Bioassay, Mouse)	Bioassay	Mouse
Zilberberg L, ten Dijke P, Sakai L, Rifkin D A rapid and sensitive bioassay to measure bone morphogenetic protein activity. BMC Cell Biol, 2007-09-19;8(0):41. 2007-09-19 [PMID: 17880711] (Bioassay)	Bioassay
Fuller ML, DeChant AK, Rothstein B, Caprariello A, Wang R, Hall AK, Miller RH Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. Ann. Neurol., 2007-09-01;62(3):288-300. 2007-09-01 [PMID: 17696121] (Bioassay, In Vivo, Rat)	Bioassay, In Vivo	Rat
Stavridis MP, Lunn JS, Collins BJ, Storey KG A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification. Development, 2007-08-01;134(16):2889-94. 2007-08-01 [PMID: 17660197] (Bioassay, Mouse)	Bioassay	Mouse
Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature, 2007-06-27;448(7150):196-9. 2007-06-27 [PMID: 17597760] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood, 2007-05-31;110(6):2182-9. 2007-05-31 [PMID: 17540841] (Bioassay, Mouse)	Bioassay	Mouse
Rajesh</LastName><ForeNam D</Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells, 2007-02-01;25(2):490-9. 2007-02-01 [PMID: 17284653] (Bioassay, Human, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Human, Primate - Macaca mulatta (Rhesus Macaque)
Knobloch J, Shaughnessy JD, Ruther U Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway. FASEB J., 2007-02-05;21(7):1410-21. 2007-02-05 [PMID: 17283219] (Bioassay, Chicken)	Bioassay	Chicken
Stabile H, Mitola S, Moroni E, Belleri M, Nicoli S, Coltrini D, Peri F, Pessi A, Orsatti L, Talamo F, Castronovo V, Waltregny D, Cotelli F, Ribatti D, Presta M Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor. Blood, 2006-10-31;109(5):1834-40. 2006-10-31 [PMID: 17077323] (Bioassay, Mouse)	Bioassay	Mouse
Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development, 2006-10-11;133(22):4463-73. 2006-10-11 [PMID: 17035289] (Bioassay, Mouse)	Bioassay	Mouse
Bonafede A, Kohler T, Rodriguez-Niedenfuhr M, Brand-Saberi B BMPs restrict the position of premuscle masses in the limb buds by influencing Tcf4 expression. Dev. Biol., 2006-06-15;299(2):330-44. 2006-06-15 [PMID: 17005177] (In Vivo, Chicken)	In Vivo	Chicken
Lindsley RC, Gill JG, Kyba M, Murphy TL, Murphy KM Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development, 2006-08-30;133(19):3787-96. 2006-08-30 [PMID: 16943279] (Bioassay, Mouse)	Bioassay	Mouse
Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C Multipotent adult progenitor cells from swine bone marrow. Stem Cells, 2006-08-24;24(11):2355-66. 2006-08-24 [PMID: 16931778] (Bioassay, Porcine)	Bioassay	Porcine
Kiyono M, Shibuya M Inhibitory Smad transcription factors protect arterial endothelial cells from apoptosis induced by BMP4. Oncogene, 2006-05-29;25(54):7131-7. 2006-05-29 [PMID: 16732319] (Bioassay, In Vivo, Human, Mouse)	Bioassay, In Vivo	Human, Mouse
Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, Izawa K, Dong Y, Hashiguchi T, Soda Y, Maeda T, Suehiro Y, Tanioka Y, Nakazaki Y, Tani K Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells. Stem Cells, 2006-05-25;24(9):2014-22. 2006-05-25 [PMID: 16728561] (Bioassay, Primate - Callitrix jacchus (Common Marmoset))	Bioassay	Primate - Callitrix jacchus (Common Marmoset)
Spicer LJ, Aad PY, Allen D, Mazerbourg S, Hsueh AJ Growth differentiation factor-9 has divergent effects on proliferation and steroidogenesis of bovine granulosa cells. J. Endocrinol., 2006-05-01;189(2):329-39. 2006-05-01 [PMID: 16648300] (Bioassay, Bovine)	Bioassay	Bovine
Maeshima A, Vaughn DA, Choi Y, Nigam SK Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev. Biol., 2006-04-27;295(2):473-85. 2006-04-27 [PMID: 16643884] (Bioassay, Rat)	Bioassay	Rat
Yao S, Chen S, Clark J, Hao E, Beattie GM, Hayek A, Ding S Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc. Natl. Acad. Sci. U.S.A., 2006-04-21;103(18):6907-12. 2006-04-21 [PMID: 16632596] (Bioassay, Human)	Bioassay	Human
Reversade B, De Robertis EM Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell, 2005-12-16;123(6):1147-60. 2005-12-16 [PMID: 16360041] (In Vivo, Xenopus)	In Vivo	Xenopus
Holzschuh J, Wada N, Wada C, Schaffer A, Javidan Y, Tallafuss A, Bally-Cuif L, Schilling TF Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish. Development, 2005-08-01;132(16):3731-42. 2005-08-01 [PMID: 16077092] (In Vivo, Xenopus)	In Vivo	Xenopus
Ng RK, Gurdon JB Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer. Proc. Natl. Acad. Sci. U.S.A., 2005-01-31;102(6):1957-62. 2005-01-31 [PMID: 15684086] (Bioassay, Xenopus)	Bioassay	Xenopus
Pierre A, Pisselet C, Dupont J, Mandon-Pepin B, Monniaux D, Monget P, Fabre S Molecular basis of bone morphogenetic protein-4 inhibitory action on progesterone secretion by ovine granulosa cells. J. Mol. Endocrinol., 2004-12-01;33(3):805-17. 2004-12-01 [PMID: 15591037] (Bioassay, Ovine)	Bioassay	Ovine
Blair DG, Plisov S, Vasiliev G, Perantoni AO, Athanasiou M, Wu JY, Oppenheim JJ Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis. J. Immunol., 2004-11-15;173(10):5914-7. 2004-11-15 [PMID: 15528323] (Bioassay, Human)	Bioassay	Human
Marklund M, Sjodal M, Beehler BC, Jessell TM, Edlund T, Gunhaga L Retinoic acid signalling specifies intermediate character in the developing telencephalon. Development, 2004-08-04;131(17):4323-32. 2004-08-04 [PMID: 15294870] (Bioassay, Chicken)	Bioassay	Chicken
Oren A, Toporik A, Biton S, Almogy N, Eshel D, Bernstein J, Savitsky K, Rotman G hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. Gene, 2004-04-28;331(0):17-31. 2004-04-28 [PMID: 15094188] (Bioassay, Human)	Bioassay	Human
Althini S, Usoskin D, Kylberg A, Kaplan PL, Ebendal T Blocked MAP kinase activity selectively enhances neurotrophic growth responses. Mol. Cell. Neurosci., 2004-02-01;25(2):345-54. 2004-02-01 [PMID: 15019950] (Bioassay, Chicken)	Bioassay	Chicken
Binnerts ME, Wen X, Cante-Barrett K, Bright J, Chen HT, Asundi V, Sattari P, Tang T, Boyle B, Funk W, Rupp F Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins. Biochem. Biophys. Res. Commun., 2004-03-05;315(2):272-80. 2004-03-05 [PMID: 14766204] (Bioassay, Mouse)	Bioassay	Mouse
Wakamatsu Y, Endo Y, Osumi N, Weston JA Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development. Dev. Dyn., 2004-01-01;229(1):74-86. 2004-01-01 [PMID: 14699579] (Bioassay, Chicken)	Bioassay	Chicken
Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, Bautch VL, Conlon FL, Patterson C BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol. Cell. Biol., 2003-08-01;23(16):5664-79. 2003-08-01 [PMID: 12897139] (Bioassay, Mouse)	Bioassay	Mouse
Ahn SH, Kim CS, Suk HJ, Lee YJ, Choi SH, Chai JK, Kim CK, Han SB, Cho KS Effect of recombinant human bone morphogenetic protein-4 with carriers in rat calvarial defects. J. Periodontol., 2003-06-01;74(6):787-97. 2003-06-01 [PMID: 12886988] (In Vivo, Rat)	In Vivo	Rat
Viti J, Gulacsi A, Lillien L Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J. Neurosci., 2003-07-02;23(13):5919-27. 2003-07-02 [PMID: 12843296] (Bioassay, Mouse)	Bioassay	Mouse
Fischer A, Viebahn C, Blum M FGF8 acts as a right determinant during establishment of the left-right axis in the rabbit. Curr. Biol., 2002-10-29;12(21):1807-16. 2002-10-29 [PMID: 12419180] (Bioassay, Rabbit)	Bioassay	Rabbit
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Array 314-BP

• BMP-4 Antibodies
• BMP-4 ELISA Kits
• BMP-4 Lysates
• BMP-4 Proteins
• BMP-4 Proteins and Enzymes
• BMP-4 ELISAs