Recombinant Mouse TrkB Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Tropomyocin receptor kinase B (TrkB), also named Neurotrophic tyrosine kinase receptor type 3 (NTRK3) is a member of a nerve growth factor tyrosine kinase receptor family. There are three members of the Trk family, TrkA, TrkB and TrkC, and they bind a group of structurally related, secreted proteins termed neurotrophins, which play an important role in the development and function of the nervous system. The Trk family shares a conserved structural motif consisting of two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, a single transmembrane domain and an intracellular tyrosine kinase domain (3). Natural splice variants of the different Trks, lacking the first cysteine-rich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described (4). Mature mouse TrkB consists of a 398 amino acid (aa) extracellular domain (ECD) which shares 89% and 97% aa identity with human and rat TrkB, respectively. Each Trk family member exhibits different ligand specificities: TrkA binds NGF and NT-3, TrkB binds BDNF, NT-3 and NT-4/5, and TrkC only binds NT-3 (1, 2). The biological activities of the neurotrophins are mediated by binding to and activating two unrelated receptor types: the p75 neurotrophin receptor (p75NTR) and the Trk family of receptors (1, 2). P75NTR is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF16. It binds all neurotrophins with low-affinity to transduce cellular signaling pathways that synergize or antagonize those activated by the Trk receptors. TrkB is primarily expressed in the nervous system (5). However, low levels of TrkB expression have also been observed in a wide variety of tissues (pancreas, kidneys, ovary) outside the nervous system (7). Trk receptor interactions with NGF play major roles in the development of the sympathetic nervous system and are essential for neuronal survival in vivo (8). Agonists of TrkB have shown enhanced endogenous analgesia by restoring stimuli-response activity in spinal nerve damaged rats (9) and inhibition of the Trk receptors may have a range of therapeutic implications (10).

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: Bioassay, In Vivo.

Showing Publications 1 - 2 of 2.

Publications using 10266-TB	Applications	Species
X Ding, FF Liao, L Su, X Yang, W Yang, QH Ren, JZ Zhang, HM Wang Sciatic nerve block downregulates the BDNF pathway to alleviate the neonatal incision-induced exaggeration of incisional pain via decreasing microglial activation Brain, Behavior, and Immunity, 2022-07-16;105(0):204-224. 2022-07-16 [PMID: 35853558] (In Vivo, Rat)	In Vivo	Rat
C Frick, S Fink, D Schmidbaue, F Rousset, H Eickhoff, A Tropitzsch, B Kramer, P Senn, R Glueckert, H Rask-Ander, KH Wiesmüller, H Löwenheim, M Müller Age-Dependency of Neurite Outgrowth in Postnatal Mouse Cochlear Spiral Ganglion Explants Brain Sci, 2020-08-21;10(9):. 2020-08-21 [PMID: 32839381] (Bioassay, Mouse)	Bioassay	Mouse

Array 10266-TB

• TrkB Antibodies
• TrkB Antibody Pair
• TrkB ELISA Kits
• TrkB Lysates
• TrkB Proteins
• TrkB Proteins and Enzymes
• TrkB ELISAs