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Noggin Antibody (A7)

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Immunohistochemistry-Paraffin: Noggin Antibody (A7) [NBP3-41763] - DAB staining on IHC-P; Sample: Human Glioma Tissue; Primary Ab: 30ug/ml NBP3-41763; Second Ab: 2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal ...read more
Western Blot: Noggin Antibody (A7) [NBP3-41763] - Sample: Recombinant Noggin, Human.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clone
A7
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1 mg/ml

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Noggin Antibody (A7) Summary

Immunogen
Immunized with recombinant Human Noggin (Uniprot#: Q13253; Gln28-Cys232 (Uniprot#: Q13253)
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
NOG
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 5-30ug/mL
  • Western Blot 0.5-3ug/mL

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.01M PBS, pH7.4, 50% glycerol
Preservative
0.05% Proclin 300
Concentration
1 mg/ml
Purity
Protein A or G purified

Alternate Names for Noggin Antibody (A7)

  • NOG
  • Noggin
  • SYM1
  • symphalangism 1 (proximal)
  • synostoses (multiple) syndrome 1
  • SYNS1
  • SYNS1A

Background

Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol NOG