We would like an anti-RUNX2 for IHC-P which share cross reactivity with Rat, but not with Human.

Name: RUNX2/CBFA1 Antibody (232902) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB2006
Rating: 4 (1 reviews)

Question

Accepted Answer

We don't have any data for our RUNX2 antibodies that confirms they will NOT detect the human protein. When we can confirm that an antibody will not react with a certain species, we display a (-) sign on the datasheet. Otherwise, if the species is not listed it means that it has not been tested.

At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	ICC/IF
Clone	232902
Clonality	Monoclonal
Host	Rat
Conjugate	Unconjugated
Concentration	LYOPH

Catalog# & Formulation	Size	Price
Carrier Free MAB2006-SP

Immunogen	E. coli-derived recombinant human RUNX2/CBFA1 isoform 2 Lys233-Tyr418 Accession # Q13950
Specificity	Detects human RUNX2/CBFA1.
Source	N/A
Isotype	IgG2b
Clonality	Monoclonal
Host	Rat
Gene	RUNX2
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

RUNX2/CBFA1 Antibody (232902) [Unconjugated]

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RUNX2/CBFA1 Antibody (232902) [Unconjugated] Summary

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Publications for RUNX2/CBFA1 Antibody (MAB2006)(28)

Review for RUNX2/CBFA1 Antibody (MAB2006) (1) 41

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Bioinformatics

Publications using MAB2006	Applications	Species
Q Song, Y Yang, D Jiang, Z Qin, C Xu, H Wang, J Huang, L Chen, R Luo, X Zhang, Y Huang, L Xu, Z Yu, S Tan, M Deng, R Xue, J Qie, K Li, Y Yin, X Yue, X Sun, J Su, F He, C Ding, Y Hou Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues Oncogene, 2022-07-18;13(1):4167. 2022-07-18 [PMID: 35851595] (IHC, Human)	IHC	Human
C Xu, VV Dinh, K Kruse, HW Jeong, EC Watson, S Adams, F Berkenfeld, M Stehling, SJ Rasouli, R Fan, R Chen, I Bedzhov, Q Chen, K Kato, ME Pitulescu, RH Adams Induction of osteogenesis by bone-targeted Notch activation Elife, 2022-02-04;11(0):. 2022-02-04 [PMID: 35119364] (IHC, Mouse)	IHC	Mouse
Francesca Marta Elli, Deborah Mattinzoli, Camilla Lucca, Matteo Piu, Maria A. Maffini, Jole Costanza et al. Novel Pathogenetic Variants in PTHLH and TRPS1 Genes Causing Syndromic Brachydactyly Journal of Bone and Mineral Research 2022-03-01 [PMID: 34897794]
M Minguzzi, V Panichi, S D'Adamo, S Cetrullo, L Cattini, F Flamigni, E Mariani, RM Borzì Pleiotropic Roles of NOTCH1 Signaling in the Loss of Maturational Arrest of Human Osteoarthritic Chondrocytes International Journal of Molecular Sciences, 2021-11-05;22(21):. 2021-11-05 [PMID: 34769441] (IHC, Human)	IHC	Human
Akitoshi Hara, Katsuhiro Kato, Toshikazu Ishihara, Hiroki Kobayashi, Naoya Asai, Shinji Mii et al. Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity Genes to Cells 2021-07-01 [PMID: 33960573]
J Yao, X Wu, X Qiao, D Zhang, L Zhang, JA Ma, X Cai, KI Boström, Y Yao Shifting osteogenesis in vascular calcification JCI Insight, 2021-05-24;0(0):. 2021-05-24 [PMID: 33848269] (Western Blot, Mouse)	Western Blot	Mouse
Oe Y, Mitsui S, Sato E, Shibata N, Kisu K, Sekimoto A, Miyazaki M, Sato H, Ito S, Takahashi N Lack of Endothelial Nitric Oxide Synthase Accelerates Ectopic Calcification in Uremic Mice Fed an Adenine and High Phosphorus Diet. Am J Pathol, 2020-11-04;191(2):283-293. 2020-11-04 [PMID: 33159888] (IHC, Mouse)	IHC	Mouse
S Supakul, K Yao, H Ochi, T Shimada, K Hashimoto, S Sunamura, Y Mabuchi, M Tanaka, C Akazawa, T Nakamura, A Okawa, S Takeda, S Sato Pericytes as a Source of Osteogenic Cells in Bone Fracture Healing Int J Mol Sci, 2019-03-02;20(5):. 2019-03-02 [PMID: 30832329] (IHC-Fr, Mouse)	IHC-Fr	Mouse
AGE Day, WR Francis, K Fu, IL Pieper, O Guy, Z Xia Osteogenic Potential of Human Umbilical Cord Mesenchymal Stem Cells on Coralline Hydroxyapatite/Calcium Carbonate Microparticles Stem Cells Int, 2018-09-05;2018(0):4258613. 2018-09-05 [PMID: 30254682] (IHC, Human)	IHC	Human
Jiewen Dai, Jiawen Si, Ningjuan Ouyang, Jianfei Zhang, Dandan Wu, Xudong Wang et al. Dental and periodontal phenotypes of Dlx2 overexpression in mice Molecular Medicine Reports 2017-05-01 [PMID: 28447749]
G Lisignoli, E Lambertini, C Manferdini, E Gabusi, L Penolazzi, F Paolella, M Angelozzi, V Casagranda, R Piva Collagen type XV and the 'osteogenic status' J. Cell. Mol. Med, 2017-03-22;0(0):. 2017-03-22 [PMID: 28332281] (Flow Cytometry, Human)	Flow Cytometry	Human
UH Langen, ME Pitulescu, JM Kim, R Enriquez-G, KK Sivaraj, AP Kusumbe, A Singh, J Di Russo, MG Bixel, B Zhou, L Sorokin, JM Vaquerizas, RH Adams Cell-matrix signals specify bone endothelial cells during developmental osteogenesis Nat. Cell Biol, 2017-02-20;19(3):189-201. 2017-02-20 [PMID: 28218908] (IHC, Mouse)	IHC	Mouse
P Leucht The Selective Serotonin Re-Uptake Inhibitor Fluoxetine Directly Inhibits Osteoblast Differentiation and Mineralization During Fracture Healing in Mice J. Bone Miner. Res., 2017-02-27;0(0):. 2017-02-27 [PMID: 27869327] (IHC-P, Mouse)	IHC-P	Mouse
Mary Catherine Wallingford, Jia Jun Chia, Elizabeth M. Leaf, Suhaib Borgeia, Nicholas W. Chavkin, Chenphop Sawangmake et al. SLC20A2 DEFICIENCY IN MICE LEADS TO ELEVATED PHOSPHATE LEVELS IN CEREBROSPINAL FLUID AND GLYMPHATIC PATHWAY-ASSOCIATED ARTERIOLAR CALCIFICATION, AND RECAPITULATES HUMAN IDIOPATHIC BASAL GANGLIA CALCIFICATION Brain Pathology 2017-01-01 [PMID: 26822507]
Alexei Y. Savinov, Maryam Salehi, Manisha C. Yadav, Ilian Radichev, José Luis Millán, Olga V. Savinova Transgenic Overexpression of Tissue‐Nonspecific Alkaline Phosphatase (TNAP) in Vascular Endothelium Results in Generalized Arterial Calcification Journal of the American Heart Association 2015-12-16 [PMID: 26675253]
Guemes M, Garcia A, Rigueur D, Runke S, Wang W, Zhao G, Mayorga V, Atti E, Tetradis S, Peault B, Lyons K, Miranda-Carboni G, Krum S GATA4 is essential for bone mineralization via ERalpha and TGFbeta/BMP pathways. J Bone Miner Res, 2014-12-01;29(12):2676-87. 2014-12-01 [PMID: 24932701] (IHC-P, Mouse)	IHC-P	Mouse
Ramasamy S, Kusumbe A, Wang L, Adams R Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature, 2014-03-12;507(7492):376-80. 2014-03-12 [PMID: 24647000] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Kusumbe A, Ramasamy S, Adams R Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature, 2014-03-12;507(7492):323-8. 2014-03-12 [PMID: 24646994] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Fang Y, Ginsberg C, Seifert M, Agapova O, Sugatani T, Register T, Freedman B, Monier-Faugere M, Malluche H, Hruska K CKD-induced wingless/integration1 inhibitors and phosphorus cause the CKD-mineral and bone disorder. J Am Soc Nephrol, 2014-02-27;25(8):1760-73. 2/27/2014 [PMID: 24578135]
Yifu Fang, Charles Ginsberg, Toshifumi Sugatani, Marie-Claude Monier-Faugere, Hartmut Malluche, Keith A. Hruska Early chronic kidney disease–mineral bone disorder stimulates vascular calcification Kidney International 2014-01-01 [PMID: 23884339]
Wang L, Benedito R, Bixel M, Zeuschner D, Stehling M, Savendahl L, Haigh J, Snippert H, Clevers H, Breier G, Kiefer F, Adams R Identification of a clonally expanding haematopoietic compartment in bone marrow. EMBO J, 2012-11-27;32(2):219-30. 2012-11-27 [PMID: 23188081] (IHC, Mouse)	IHC	Mouse
Ngoc Nguyen, Veena Naik, Mei Y. Speer Diabetes mellitus accelerates cartilaginous metaplasia and calcification in atherosclerotic vessels of LDLr mutant mice Cardiovascular Pathology 2013-03-01 [PMID: 22818582]
Pai A, Leaf EM, El-Abbadi M, Giachelli CM Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease. Am. J. Pathol., 2011-02-01;178(2):764-73. 2011-02-01 [PMID: 21281809] (IHC-P, Mouse)	IHC-P	Mouse
Todoerti K, Lisignoli G, Storti P, Agnelli L, Novara F, Manferdini C, Codeluppi K, Colla S, Crugnola M, Abeltino M, Bolzoni M, Sgobba V, Facchini A, Lambertenghi-Deliliers G, Zuffardi O, Rizzoli V, Neri A, Giuliani N Distinct transcriptional profiles characterize bone microenvironment mesenchymal cells rather than osteoblasts in relationship with multiple myeloma bone disease. Exp. Hematol., 2009-12-04;38(2):141-53. 2009-12-04 [PMID: 19963035] (ICC, Human)	ICC	Human
El-Abbadi MM, Pai AS, Leaf EM, Yang HY, Bartley BA, Quan KK, Ingalls CM, Liao HW, Giachelli CM Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin. Kidney Int., 2009-03-25;75(12):1297-307. 2009-03-25 [PMID: 19322138] (IHC-P, Mouse)	IHC-P	Mouse
Ruiz SA, Chen CS Emergence of patterned stem cell differentiation within multicellular structures. Stem Cells, 2008-08-14;26(11):2921-7. 2008-08-14 [PMID: 18703661] (ICC, Human)	ICC	Human
Krum SA, Miranda-Carboni GA, Hauschka PV, Carroll JS, Lane TF, Freedman LP, Brown M Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival. EMBO J., 2008-01-24;27(3):535-45. 2008-01-24 [PMID: 18219273] (IHC-P, Mouse)	IHC-P	Mouse
Curran JM, Chen R, Hunt JA The guidance of human mesenchymal stem cell differentiation in vitro by controlled modifications to the cell substrate. Biomaterials, 2006-06-02;27(27):4783-93. 2006-06-02 [PMID: 16735063] (ICC, Human)	ICC	Human
Show All 28 Publications. Collapse Publications.

	Verified Customer 02/16/2015
Application:	Flow
Species:	Human

Gene Symbol	RUNX2
Uniprot	Q13950()