Osterix/Sp7 Antibody (764704)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Osterix, also known as Sp7, is an approximately 45 kDa transcription factor that is required for osteogenesis and bone homeostasis. Osterix cooperates with BMP-6 in the differentiation of osteoblasts from mesenchymal stem cells by regulating the transcription of several genes involved in osteoblast differentiation and function (i.e. SATB2, Collagen V, and SOST). The transcription of Osterix is induced by BMP-2, IGF-I, and parathyroid hormone, while its activity is regulated by Akt and p38 MAPK-mediated phoshorylation. Osterix contains a transactivation domain (aa 141-210) and three zinc finger domains (aa 294-318, aa 324-348, and aa 354-376). Alternative splicing generates a short isoform that lacks the N-terminal 18 amino acids. Within aa 19-288, human Osterix shares 94% aa sequence identity with mouse and rat Osterix.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Immunocytochemistry, Western Blot.

Showing Publications 1 - 5 of 5.

Publications using MAB7547	Applications	Species
Ríos, S;González, LG;Saez, CG;Smith, PC;Escobar, LM;Martínez, CE; L-PRF Secretome from Both Smokers/Nonsmokers Stimulates Angiogenesis and Osteoblast Differentiation In Vitro Biomedicines 2024-04-16 [PMID: 38672228] (Western Blot, Immunocytochemistry, Human)	Western Blot, Immunocytochemistry	Human
Gabriella Nilsson Hall, Luís Freitas Mendes, Charikleia Gklava, Liesbet Geris, Frank P. Luyten, Ioannis Papantoniou Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing Advanced Science 2020-01-01 [PMID: 31993293]
Victor Häussling, Sebastian Deninger, Laura Vidoni, Helen Rinderknecht, Marc Ruo beta , Christian Arnscheidt et al. Impact of Four Protein Additives in Cryogels on Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells Bioengineering (Basel) 2019-08-07 [PMID: 31394780]
Marie K. Reumann, Caren Linnemann, Romina H. Aspera-Werz, Sigrid Arnold, Manuel Held, Claudine Seeliger et al. Donor Site Location Is Critical for Proliferation, Stem Cell Capacity, and Osteogenic Differentiation of Adipose Mesenchymal Stem/Stromal Cells: Implications for Bone Tissue Engineering International Journal of Molecular Sciences 2018-06-26 [PMID: 29949865]
Chenguang Niu, Keyong Yuan, Rui Ma, Li Gao, Wenxin Jiang, Xuchen Hu et al. Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway Molecular Medicine Reports 2017-10-01 [PMID: 28791361]

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Michela Rossi	WB	Human	05/25/2020	View Summary Application Western Blot Sample Tested Saos2 Cells Species Human Lot cgpv0116124

Array MAB7547

• Osterix/Sp7 Antibodies
• Osterix/Sp7 ELISA Kits
• Osterix/Sp7 Proteins