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Recombinant Mouse TRANCE/RANK L/TNFSF11 (E. coli-expressed)

Name: Recombinant Mouse TRANCE/RANK L/TNFSF11 (E. coli-expressed)
Brand: Novus Biologicals
SKU: 462-TEC
Price: 423 USD

(85 Publications)

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Recombinant Mouse TRANCE/TNFSF11/RANK L (Catalog # 462-TEC) induces osteoclast differentiation of the RAW 264.7 mouse monocyte/macrophage cell line. The ED50 for this effect is 0.5-2 ng/mL.

1 μg/lane of Recombinant Mouse TRANCE/TNFSF11/RANK L was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 19 kDa.

Product Details

Summary

Reactivity	MuSpecies Glossary
Applications	Bioactivity

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Catalog# & Formulation	Size	Price
Carrier Free 462-TEC-010/CF

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Recombinant Mouse TRANCE/RANK L/TNFSF11 (E. coli-expressed) Summary

Details of Functionality	Measured by its ability to induce osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells. The ED₅₀ for this effect is 0.5‑2 ng/mL.
Source	E. coli-derived mouse TRANCE/TNFSF11/RANK L protein Lys158-Asp316, with an N-terminal Met
Accession #	Q3TWY5
N-terminal Sequence	Met
Protein/Peptide Type	Recombinant Proteins
Gene	Tnfsf11
Purity	>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note	<0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions

Bioactivity

Theoretical MW

19 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Publications

Read Publications using
462-TEC in the following applications:

Bioassay
76 publications
Cell Culture
6 publications
Differentiation
3 publications
Flow Cytometry
1 publication

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in NaH₂PO₄, NaCl and EDTA with BSA as a carrier protein.
Purity	>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions	Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse TRANCE/RANK L/TNFSF11 (E. coli-expressed)

CD254 antigen
CD254
ODF
OPGL
OPGLOPTB2
Osteoclast differentiation factor
Osteoprotegerin ligand
RANK L
RANKL
RANKLreceptor activator of nuclear factor kappa B ligand
Receptor activator of nuclear factor kappa-B ligand
sOdf
TNF-related activation-induced cytokine
TNFSF11
TRANCE
TRANCEODFhRANKL2
tumor necrosis factor (ligand) superfamily, member 11
tumor necrosis factor ligand superfamily member 11

Background

TRANCE (receptor activator of NF-kappa B ligand [RANK L], also called TNF-related activation-induced cytokine [TRANCE], osteoprotegrin ligand [OPGL], and osteoclast differentiation factor [ODF]), is a member of the tumor necrosis factor (TNF) family. TRANCE was originally identified as an immediate early gene up-regulated by T cell receptor stimulation. The mouse TRANCE cDNA encodes a type II transmembrane protein of 316 amino acids with a predicted cytoplasmic domain of 48 amino acids and an extracellular domain of 247 amino acids. The extracellular domain contains two potential N-linked glycosylation sites. Mouse and human TRANCE share 85% amino acid identity. TRANCE is primarily expressed in T cells and T cell rich organs, such as thymus and lymph nodes. The multi-functions of TRANCE include induction of activation of the c-jun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis, and lymph node organogenesis. RANK is the cell surface signaling receptor of TRANCE. RANK has been shown to undergo receptor clustering during signal transduction. Osteoprotegrin, a soluble member of the TNF receptor family which binds TRANCE, is a naturally occurring decoy receptor that counterbalances the effects of TRANCE.

Wong, B.R. et al. (1997) J. Biol. Chem. 272:25190.
Anderson, D.M. et al. (1997) Nature 390:175.
Nakagawa, N. et al. (1998) Biochem. Biophys. Res. Commun. 245:382.
Kong, Y-Y. et al. (1999) Nature 397:315.

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Recombinant Mouse
TRANCE/RANK L/TNFSF11 ...

462-TEC

Species: Mu

Applications: Bioactivity

Publications for TRANCE/TNFSF11/RANK L (462-TEC)(85)

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

We have publications tested in 4 applications: Bioassay, Cell Culture, Differentiation, Flow Cytometry.

Filter By Application

Bioassay

(76)

Cell Culture

(6)

Differentiation

(3)

Flow Cytometry

(1)

All Applications

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Human

(3)

Mouse

(81)

Transgenic Mouse

(1)

All Species

Showing Publications 1 - 10 of 85. Show All 85 Publications.

Publications using 462-TEC	Applications	Species
Li, Z;Yang, X;Fu, R;Wu, Z;Xu, S;Jiao, J;Qian, M;Zhang, L;Wu, C;Xie, T;Yao, J;Wu, Z;Li, W;Ma, G;You, Y;Chen, Y;Zhang, HK;Cheng, Y;Tang, X;Wu, P;Lian, G;Wei, H;Zhao, J;Xu, J;Ai, L;Siwko, S;Wang, Y;Ding, J;Song, G;Luo, J;Liu, M;Xiao, J; Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src Nature communications 2024-02-12 [PMID: 38346942] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Lima Teixeira, JF;Henning, P;Cintra Magalhães, FA;Coletto-Nunes, G;Floriano-Marcelino, T;Westerlund, A;Movérare-Skrtic, S;Oliveira, GJPL;Lerner, UH;Souza, PPC; Osteoprotective effect by interleukin-4 (IL-4) on lipoprotein-induced periodontitis Cytokine 2023-10-26 [PMID: 37898012] (Bioassay, Mouse)	Bioassay	Mouse
Sun, H;Wang, S;Tan, W;Li, Y;Ren, Q;Liu, Y;Huang, Y;Shi, C;Li, J; Echinococcus granulosus promotes bone resorption by increasing osteoclasts differentiation Acta tropica 2023-09-16 [PMID: 37722448] (Bioassay, Mouse)	Bioassay	Mouse
Chen, K;Chen, X;Lang, C;Yuan, X;Huang, J;Li, Z;Xu, M;Wu, K;Zhou, C;Li, Q;Zhu, C;Liu, L;Shang, X; CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90? complex Experimental & molecular medicine 2023-09-01 [PMID: 37653038] (Differentiation, Mouse)	Differentiation	Mouse
Kim, SY;Kim, YJ;Kim, S;Momeni, M;Lee, A;Treanor, A;Kim, S;Kim, RH;Park, NH; GV1001 Inhibits the Severity of the Ligature-Induced Periodontitis and the Vascular Lipid Deposition Associated with the Periodontitis in Mice International journal of molecular sciences 2023-08-08 [PMID: 37628753] (Bioassay, Mouse)	Bioassay	Mouse
Stavre, Z;Kim, JM;Yang, YS;N�ndel, K;Chaugule, S;Sato, T;Park, KH;Gao, G;Gravallese, EM;Shim, JH; Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis Proceedings of the National Academy of Sciences of the United States of America 2023-05-09 [PMID: 37141171] (Bioassay, Mouse)	Bioassay	Mouse
X Ji, J Hong, W Yang, M Yao, J Wang, G Jiang, Y Wang, C Li, J Lin, H Mou, C Li, S Li, Y Chen, M Shi, W Wang, F Lu, H Wu, X Zhao, Y Qi, S Yan GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux Redox Biology, 2023-02-27;61(0):102635. 2023-02-27 [PMID: 36870110] (Bioassay, Mouse)	Bioassay	Mouse
H Choi, L Yang, Y Liu, JK Jeong, ES Cho Npp1 prevents external tooth root resorption by regulation of cervical cementum integrity Scientific Reports, 2022-12-07;12(1):21158. 2022-12-07 [PMID: 36477209] (Cell Culture, Mouse)	Cell Culture	Mouse
Y Cheng, H Liu, J Li, Y Ma, C Song, Y Wang, P Li, Y Chen, Z Zhang Evaluation of culture conditions for osteoclastogenesis in RAW264.7 cells PLoS ONE, 2022-11-17;17(11):e0277871. 2022-11-17 [PMID: 36395187] (Bioassay, Mouse)	Bioassay	Mouse
A Duxfield, J Munkley, MD Briggs, EP Dennis CRELD2 is a novel modulator of calcium release and calcineurin-NFAT signalling during osteoclast differentiation Scientific Reports, 2022-08-16;12(1):13884. 2022-08-16 [PMID: 35974042] (Bioassay, Mouse)	Bioassay	Mouse
Y Zhang, M Yang, S Zhang, Z Yang, Y Zhu, Y Wang, Z Chen, X Lv, Z Huang, Y Xie, L Cai BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1 Cell & bioscience, 2022-05-26;12(1):70. 2022-05-26 [PMID: 35619122] (Bioassay, Mouse)	Bioassay	Mouse
N Imerb, C Thonusin, W Pratchayas, B Arunsak, W Nawara, B Ongnok, R Aeimlapa, N Charoenpha, N Chattipako, SC Chattipako D-galactose-induced aging aggravates obesity-induced bone dyshomeostasis Scientific Reports, 2022-05-20;12(1):8580. 2022-05-20 [PMID: 35595806] (Bioassay, Mouse)	Bioassay	Mouse
P Cai, S Yan, Y Lu, X Zhou, X Wang, M Wang, Z Yin Carnosol inhibits osteoclastogenesis inï¿½vivo and inï¿½vitro by blocking the RANKL?induced NF?kappaB signaling pathway Molecular Medicine Reports, 2022-05-20;26(1):. 2022-05-20 [PMID: 35593299] (Bioassay, Mouse)	Bioassay	Mouse
Z Cui, C Feng, J Chen, Y Wang, Q Meng, S Zhao, Y Zhang, D Feng, Z Li, S Sun Network Pharmacology Deciphers the Action of Bioactive Polypeptide in Attenuating Inflammatory Osteolysis via the Suppression of Oxidative Stress and Restoration of Bone Remodeling Balance Oxidative Medicine and Cellular Longevity, 2022-04-14;2022(0):4913534. 2022-04-14 [PMID: 35578727] (Bioassay, Mouse)	Bioassay	Mouse
Y Ma, R Di, H Zhao, R Song, H Zou, Z Liu P2X7 receptor knockdown suppresses osteoclast differentiation by inhibiting autophagy and Ca2+/calcineurin signaling Molecular Medicine Reports, 2022-03-10;25(5):. 2022-03-10 [PMID: 35266012] (Cell Culture, Mouse)	Cell Culture	Mouse
C Yang, H Tao, H Zhang, Y Xia, J Bai, G Ge, W Li, W Zhang, L Xiao, Y Xu, Z Wang, Y Gu, H Yang, Y Liu, D Geng TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss Autophagy, 2022-03-24;0(0):. 2022-03-24 [PMID: 35255774] (Cell Culture, Mouse)	Cell Culture	Mouse
JM Kim, YS Yang, J Xie, O Lee, J Kim, J Hong, B Boldyreff, O Filhol, H Chun, MB Greenblatt, G Gao, JH Shim Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes Cell Death and Differentiation, 2022-02-15;0(0):. 2022-02-15 [PMID: 35169297] (Bioassay, Mouse)	Bioassay	Mouse
ANM Mamun-Or-R, TT Lucy, M Yagi, Y Yonei Inhibitory Effects of Astaxanthin on CML-HSA-Induced Inflammatory and RANKL-Induced Osteoclastogenic Gene Expression in RAW 264.7 Cells Biomedicines, 2021-12-27;10(1):. 2021-12-27 [PMID: 35052734] (Bioassay, Mouse)	Bioassay	Mouse
J Gu, X Zhang, C Zhang, Y Li, J Bian, X Liu, Y Yuan, H Zou, X Tong, Z Liu Galectin-3 Contributes to the Inhibitory Effect of lalpha,25-(OH)2D3 on Osteoclastogenesis International Journal of Molecular Sciences, 2021-12-11;22(24):. 2021-12-11 [PMID: 34948130] (Bioassay, Mouse)	Bioassay	Mouse
S Zhou, Q Dai, X Huang, A Jin, Y Yang, X Gong, H Xu, X Gao, L Jiang STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis Nature Communications, 2021-11-25;12(1):6891. 2021-11-25 [PMID: 34824272] (Bioassay, Mouse)	Bioassay	Mouse
Y Zhang, S Zhang, Y Wang, Z Yang, Z Chen, N Wen, M Yang, Z Huang, Y Xie, L Cai ULK1 Suppresses Osteoclast Differentiation and Bone Resorption via Inhibiting Syk-JNK through DOK3 Oxidative Medicine and Cellular Longevity, 2021-11-15;2021(0):2896674. 2021-11-15 [PMID: 34820053] (Bioassay, Mouse)	Bioassay	Mouse
Z Liu, H Wang, Y Hou, Y Yang, J Jia, J Wu, Z Zuo, T Gao, S Ren, Y Bian, S Liu, J Fu, Y Sun, J Li, M Yamamoto, Q Zhang, Y Xu, J Pi CNC-bZIP protein NFE2L1 regulates osteoclast differentiation in antioxidant-dependent and independent manners Redox Biology, 2021-11-06;48(0):102180. 2021-11-06 [PMID: 34763297] (Bioassay, Mouse)	Bioassay	Mouse
KH Nilsson, P Henning, ME Shahawy, M Nethander, TL Andersen, C Ejersted, J Wu, KL Gustafsson, A Koskela, J Tuukkanen, PPC Souza, J Tuckermann, M Lorentzon, LE Ruud, T Lehtimäki, JH Tobias, S Zhou, UH Lerner, JB Richards, S Movérare-S, C Ohlsson RSPO3 is important for trabecular bone and fracture risk in mice and humans Nature Communications, 2021-08-13;12(1):4923. 2021-08-13 [PMID: 34389713] (Bioassay, Mouse)	Bioassay	Mouse
C Fang, JW Guo, YJ Wang, XQ Li, H Zhang, J Cui, Y Hu, YY Jing, X Chen, JC Su Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion Acta pharmacologica Sinica, 2021-08-11;0(0):. 2021-08-11 [PMID: 34381182] (Bioassay, Mouse)	Bioassay	Mouse
K Wang, CR Donnelly, C Jiang, Y Liao, X Luo, X Tao, S Bang, A McGinnis, M Lee, MJ Hilton, RR Ji STING suppresses bone cancer pain via immune and neuronal modulation Nature Communications, 2021-07-27;12(1):4558. 2021-07-27 [PMID: 34315904] (Bioassay, Mouse)	Bioassay	Mouse
H Chen, G Shen, Q Shang, P Zhang, D Yu, X Yu, Z Zhang, W Zhao, Z Wu, F Tang, Liang, X Jiang, H Ren Plastrum testudinis extract suppresses osteoclast differentiation via the NF-&kappaB signaling pathway and ameliorates senile osteoporosis Journal of ethnopharmacology, 2021-05-08;276(0):114195. 2021-05-08 [PMID: 33974944] (Bioassay, Mouse)	Bioassay	Mouse
P Xue, X Hu, E Chang, L Wang, M Chen, TH Wu, DJ Lee, BL Foster, HC Tseng, CC Ko Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response Experimental & Molecular Medicine, 2021-04-16;0(0):. 2021-04-16 [PMID: 33864025] (Bioassay, Mouse)	Bioassay	Mouse
H Wei, Y Xu, Y Wang, L Xu, C Mo, L Li, B Shen, Y Sun, P Cheng, L Yang, Y Pang, A Qin, Y Cao, SJ Morrison, R Yue Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target Cell Rep, 2020-10-13;33(2):108252. 2020-10-13 [PMID: 33053358] (Bioassay, Mouse)	Bioassay	Mouse
Y Chen, Y Wang, R Tang, J Yang, C Dou, Y Dong, D Sun, C Zhang, L Zhang, Y Tang, Q Dai, F Luo, J Xu, S Dong Dendritic cells-derived interferon-lambda1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis Cell Death Dis, 2020-06-02;11(6):414. 2020-06-02 [PMID: 32488049] (Bioassay, Mouse)	Bioassay	Mouse
K Wang, Y Gu, Y Liao, S Bang, CR Donnelly, O Chen, X Tao, AJ Mirando, MJ Hilton, RR Ji PD-1 blockade inhibits osteoclast formation and murine bone cancer pain J. Clin. Invest., 2020-07-01;0(0):. 2020-07-01 [PMID: 32484460] (Bioassay, Mouse)	Bioassay	Mouse
JM Kim, YS Yang, KH Park, X Ge, R Xu, N Li, M Song, H Chun, S Bok, JF Charles, O Filhol-Coc, B Boldyreff, T Dinter, PB Yu, N Kon, W Gu, T Takarada, MB Greenblatt, JH Shim A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation Nat Commun, 2020-05-08;11(1):2289. 2020-05-08 [PMID: 32385263] (Bioassay, Mouse)	Bioassay	Mouse
T Du, Z Yan, S Zhu, G Chen, L Wang, Z Ye, W Wang, Q Zhu, Z Lu, X Cao QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism Cell Death Dis, 2020-05-07;11(5):330. 2020-05-07 [PMID: 32382069] (Bioassay, Mouse)	Bioassay	Mouse
SJ Kim, YT Jeong, SR Jeong, M Park, HS Go, MY Kim, JK Seong, KW Kim, JT Seo, CH Kim, JH Lee, SJ Moon Neural regulation of energy and bone homeostasis by the synaptic adhesion molecule Calsyntenin-3 Exp. Mol. Med., 2020-05-07;0(0):. 2020-05-07 [PMID: 32382066] (Bioassay, Mouse)	Bioassay	Mouse
IS Kang, JS Jang, C Kim Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation Sci Rep, 2020-04-27;10(1):7024. 2020-04-27 [PMID: 32341385] (Bioassay, Human)	Bioassay	Human
W Lei, R Duan, J Li, X Liu, A Huston, BF Boyce, Z Yao The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice Sci Rep, 2020-04-24;10(1):7004. 2020-04-24 [PMID: 32332865] (Bioassay, Mouse)	Bioassay	Mouse
S Kiyohara, N Sakai, K Handa, T Yamakawa, K Ishikawa, M Chatani, A Karakawa, Y Azetsu, M Munakata, M Ozeki, T Negishi-Ko, M Takami Effects of N-methyl-D-aspartate receptor antagonist MK-801 (dizocilpine) on bone homeostasis in mice J Oral Biosci, 2020-04-11;0(0):. 2020-04-11 [PMID: 32289529] (Cell Culture, Mouse)	Cell Culture	Mouse
Y Zhang, K Yang, J Yang, Y Lao, L Deng, G Deng, J Yi, X Sun, Q Wang SENP3 Suppresses Osteoclastogenesis by De-conjugating SUMO2/3 from IRF8 in Bone Marrow-Derived Monocytes Cell Rep, 2020-02-11;30(6):1951-1963.e4. 2020-02-11 [PMID: 32049023] (Bioassay, Mouse)	Bioassay	Mouse
JS Brunner, L Vulliard, M Hofmann, M Kieler, A Lercher, A Vogel, M Russier, JB Brüggenthi, M Kerndl, V Saferding, B Niederreit, A Junza, A Frauenstei, C Scholtysek, Y Mikami, K Klavins, G Krönke, A Bergthaler, JJ O'Shea, T Weichhart, F Meissner, JS Smolen, P Cheng, O Yanes, J Menche, PJ Murray, O Sharif, S Blüml, G Schabbauer Environmental arginine controls multinuclear giant cell metabolism and formation Nat Commun, 2020-01-22;11(1):431. 2020-01-22 [PMID: 31969567] (Cell Culture, Mouse)	Cell Culture	Mouse
SK Pore, ER Hahm, SH Kim, KB Singh, L Nyiranshut, JD Latoche, CJ Anderson, J Adamik, DL Galson, KR Weiss, RJ Watters, B Lee, PN Kumta, SV Singh A Novel Sulforaphane-Regulated Gene Network in Suppression of Breast Cancer-Induced Osteolytic Bone Resorption Mol. Cancer Ther., 2019-11-29;0(0):. 2019-11-29 [PMID: 31784454] (Bioassay, Mouse)	Bioassay	Mouse
N Shang, J Wu Egg White Ovotransferrin Attenuates RANKL-Induced Osteoclastogenesis and Bone Resorption Nutrients, 2019-09-19;11(9):. 2019-09-19 [PMID: 31546863] (Bioassay, Mouse)	Bioassay	Mouse
L Li, AH Ameri, S Wang, KH Jansson, OM Casey, Q Yang, ML Beshiri, L Fang, RG Lake, S Agarwal, AN Alilin, W Xu, J Yin, K Kelly EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis Oncogene, 2019-07-16;0(0):. 2019-07-16 [PMID: 31312026] (Cell Culture, Mouse)	Cell Culture	Mouse
SW Wong, BW Huang, X Hu, E Ho Kim, JP Kolb, RJ Padilla, P Xue, L Wang, TH Oguin, PA Miguez, HC Tseng, CC Ko, J Martinez Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease Cell Death Differ., 2019-05-10;0(0):. 2019-05-10 [PMID: 31076632] (Bioassay, Mouse)	Bioassay	Mouse
A Bergsma, SS Ganguly, ME Wiegand, D Dick, BO Williams, CK Miranti Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82 Bone Rep, 2019-01-30;10(0):100196. 2019-01-30 [PMID: 30788390] (Bioassay, Mouse)	Bioassay	Mouse
D Muschter, AS Beiderbeck, T Späth, C Kirschneck, A Schröder, S Grässel Sensory Neuropeptides and their Receptors Participate in Mechano-Regulation of Murine Macrophages Int J Mol Sci, 2019-01-24;20(3):. 2019-01-24 [PMID: 30682804] (Bioassay, Mouse)	Bioassay	Mouse
JD Jones, BP Sinder, D Paige, FN Soki, AJ Koh, S Thiele, Y Shiozawa, LC Hofbauer, S Daignault, H Roca, LK McCauley Trabectedin Reduces Skeletal Prostate Cancer Tumor Size in Association with Effects on M2 Macrophages and Efferocytosis Neoplasia, 2018-12-31;21(2):172-184. 2018-12-31 [PMID: 30591422] (Bioassay, Mouse)	Bioassay	Mouse
NKY Wee, BP Sinder, S Novak, X Wang, C Stoddard, BG Matthews, I Kalajzic Skeletal phenotype of the neuropeptide Y knockout mouse Neuropeptides, 2018-11-30;73(0):78-88. 2018-11-30 [PMID: 30522780] (Bioassay, Mouse)	Bioassay	Mouse
KM Lee, KH Park, JS Hwang, M Lee, DS Yoon, HA Ryu, HS Jung, KW Park, J Kim, SW Park, SH Kim, YM Chun, WJ Choi, JW Lee Inhibition of STAT5A promotes osteogenesis by DLX5 regulation Cell Death Dis, 2018-11-14;9(11):1136. 2018-11-14 [PMID: 30429452] (Bioassay, Mouse)	Bioassay	Mouse
HC Wang, P Wang, YW Chen, Y Zhang Bevacizumab or fibronectin gene editing inhibits the osteoclastogenic effects of fibroblasts derived from human radicular cysts Acta Pharmacol. Sin., 2018-10-31;0(0):. 2018-10-31 [PMID: 30382180] (Bioassay, Mouse)	Bioassay	Mouse
Y Mödinger, A Rapp, J Pazmandi, A Vikman, K Holzmann, M Haffner-Lu, M Huber-Lang, A Ignatius C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast-inducing chemokine CXCL10 J. Cell. Mol. Med., 2018-09-24;0(0):. 2018-09-24 [PMID: 30247799] (Bioassay, Mouse)	Bioassay	Mouse
GT Ma, SK Lee, KK Park, J Park, SH Son, M Jung, WY Chung Artemisinin-Daumone Hybrid Inhibits Cancer Cell-Mediated Osteolysis by Targeting Cancer Cells and Osteoclasts Cell. Physiol. Biochem., 2018-09-11;49(4):1460-1475. 2018-09-11 [PMID: 30205376] (Bioassay, Mouse)	Bioassay	Mouse
JM Ubellacker, N Baryawno, N Severe, MJ DeCristo, J Sceneay, JN Hutchinson, MT Haider, CS Rhee, Y Qin, WM Gregory, AC Garrido-Ca, I Holen, JE Brown, RE Coleman, DT Scadden, SS McAllister Modulating bone marrow hematopoietic lineage potential to prevent bone metastasis in breast cancer Cancer Res., 2018-07-31;0(0):. 2018-07-31 [PMID: 30065048] (Bioassay, Mouse)	Bioassay	Mouse
T Niedermair, S Schirner, R Seebröker, RH Straub, S Grässel Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts Sci Rep, 2018-06-15;8(1):9199. 2018-06-15 [PMID: 29907830] (Bioassay, Mouse)	Bioassay	Mouse
Z Yu, LE Surface, CY Park, MA Horlbeck, GA Wyant, M Abu-Remail, TR Peterson, DM Sabatini, JS Weissman, EK O'Shea Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates Elife, 2018-05-10;7(0):. 2018-05-10 [PMID: 29745899] (Bioassay, Mouse)	Bioassay	Mouse
D Gr?evi?, M Sironi, S Valentino, L Deban, H Cvija, A Inforzato, N Kova?i?, V Katavi?, T Kelava, I Kalajzi?, A Mantovani, B Bottazzi The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair Front Immunol, 2018-03-05;9(0):417. 2018-03-05 [PMID: 29556234] (Bioassay, Mouse)	Bioassay	Mouse
T Ishii, M Ruiz-Torru, A Ikeda, S Shindo, A Movila, H Mawardi, A Albassam, RA Kayal, AA Al-Dharrab, K Egashira, W Wisitrasam, K Yamamoto, AI Mira, K Sueishi, X Han, MA Taubman, T Miyamoto, T Kawai OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9 FASEB J., 2018-03-13;0(0):fj201701424R. 2018-03-13 [PMID: 29533736] (Bioassay, Mouse)	Bioassay	Mouse
ZK Jia, HY Li, YL Liang, LA Potempa, SR Ji, Y Wu Monomeric C-Reactive Protein Binds and Neutralizes Receptor Activator of NF-?B Ligand-Induced Osteoclast Differentiation Front Immunol, 2018-02-19;9(0):234. 2018-02-19 [PMID: 29520264] (Bioassay, Mouse)	Bioassay	Mouse
A Mediero, T Wilder, L Shah, BN Cronstein Adenosine Areceptor (A2AR) stimulation modulates expression of semaphorins 4D and 3A, regulators of bone homeostasis FASEB J., 2018-02-02;0(0):fj201700217R. 2018-02-02 [PMID: 29394106] (Differentiation, Differentiation, Mouse)	Differentiation, Differentiation	Mouse
Q Ye, G Li, S Liu, Y Guan, Y Li, J Li, H Jia, X Li, Q Li, R Huang, H Wang, Y Zhang Targeted disruption of adenosine kinase in myeloid monocyte cells increases osteoclastogenesis and bone resorption in mice Int. J. Mol. Med., 2018-01-17;0(0):. 2018-01-17 [PMID: 29344645] (Bioassay, Mouse)	Bioassay	Mouse
CJ Kim, SH Shin, BJ Kim, CH Kim, JH Kim, HM Kang, BS Park, IR Kim The Effects of Kaempferol-Inhibited Autophagy on Osteoclast Formation Int J Mol Sci, 2018-01-02;19(1):. 2018-01-02 [PMID: 29301320] (Bioassay, Mouse)	Bioassay	Mouse
D Quach, F Collins, N Parameswar, L McCabe, RA Britton Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice mSphere, 2018-01-03;3(1):. 2018-01-03 [PMID: 29299532] (Bioassay, Mouse)	Bioassay	Mouse
HC Park, YB Son, SL Lee, GJ Rho, YH Kang, BW Park, SH Byun, SC Hwang, IA Cho, YC Cho, IY Sung, DK Woo, JH Byun Effects of Osteogenic-Conditioned Medium from Human Periosteum-Derived Cells on Osteoclast Differentiation Int J Med Sci, 2017-11-02;14(13):1389-1401. 2017-11-02 [PMID: 29200953] (Human)		Human
V Kram, TM Kilts, N Bhattachar, L Li, MF Young Small leucine rich proteoglycans, a novel link to osteoclastogenesis Sci Rep, 2017-10-03;7(1):12627. 2017-10-03 [PMID: 28974711] (Bioassay, Mouse)	Bioassay	Mouse
EL Stattin, P Henning, J Klar, E McDermott, C Stecksen-B, PE Sandström, TG Kellgren, P Rydén, G Hallmans, T Lönnerholm, A Ameur, MH Helfrich, FP Coxon, N Dahl, J Wikström, UH Lerner SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts Sci Rep, 2017-06-07;7(1):3012. 2017-06-07 [PMID: 28592808] (Bioassay, Human)	Bioassay	Human
F Strålberg, A Kassem, F Kasprzykow, M Abrahamson, A Grubb, C Lindholm, UH Lerner Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors J. Leukoc. Biol, 2017-02-14;0(0):. 2017-02-14 [PMID: 28196851] (Bioassay, Mouse)	Bioassay	Mouse
Erivan S Ramos-Juni Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice J. Bone Miner. Res, 2017-03-01;0(0):. 2017-03-01 [PMID: 28029186] (Bioassay, Mouse)	Bioassay	Mouse
Sarit Batsir Dynamics of the sealing zone in cultured osteoclasts Cytoskeleton (Hoboken), 2017-02-08;0(0):. 2017-02-08 [PMID: 27997747] (Bioassay, Mouse)	Bioassay	Mouse
Tumor Cell-Derived Exosomes from the Prostate Cancer Cell Line TRAMP-C1 Impair Osteoclast Formation and Differentiation PLoS ONE, 2016-11-10;11(11):e0166284. 2016-11-10 [PMID: 27832183] (Bioassay, Mouse)	Bioassay	Mouse
Khor E, Fanshawe B, Qi Y, Zolotukhin S, Kulkarni R, Enriquez R, Purtell L, Lee N, Wee N, Croucher P, Campbell L, Herzog H, Baldock P Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome. PLoS ONE, 2016-01-29;11(1):e0148155. 2016-01-29 [PMID: 26824232] (Bioassay, Mouse)	Bioassay	Mouse
Beier E, Sheu T, Dang D, Holz J, Ubayawardena R, Babij P, Puzas J Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt/beta-CATENIN SIGNALING PATHWAY. J Biol Chem, 2015-05-14;290(29):18216-26. 2015-05-14 [PMID: 25975268] (Bioassay, Mouse)	Bioassay	Mouse
Fowler T, Kamalakar A, Akel N, Kurten R, Suva L, Gaddy D Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures. J Cell Sci, 2015-01-20;128(4):683-94. 2015-01-20 [PMID: 25609708] (Bioassay, Mouse)	Bioassay	Mouse
Mediero A, Ramkhelawon B, Perez-Aso M, Moore K, Cronstein B Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation. J Bone Miner Res, 2015-05-01;30(5):837-54. 2015-05-01 [PMID: 25483983] (Bioassay, Mouse)	Bioassay	Mouse
Abe T, Shin J, Hosur K, Udey M, Chavakis T, Hajishengallis G Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8. J Immunol, 2014-06-23;193(3):1383-91. 2014-06-23 [PMID: 24958900] (Bioassay, Mouse)	Bioassay	Mouse
Schwarzer R, Nickel N, Godau J, Willie B, Duda G, Schwarzer R, Cirovic B, Leutz A, Manz R, Bogen B, Dorken B, Jundt F Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model. Blood Cancer J, 2014-06-13;4(0):e217. 2014-06-13 [PMID: 24927406] (Bioassay, Mouse)	Bioassay	Mouse
Zhang H, Hilton M, Anolik J, Welle S, Zhao C, Yao Z, Li X, Wang Z, Boyce B, Xing L NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-kappaB. J Clin Invest, 2014-06-02;124(7):3200-14. 2014-06-02 [PMID: 24892805] (Bioassay, Mouse)	Bioassay	Mouse
Tiwari , Meenaksh, Sharma , Lokendra, Vanegas , Difernan, Callaway , Danielle, Bai , Yidong, Lechleiter , James D, Herman , Brian A nonapoptotic role for CASP2/caspase 2: modulation of autophagy. Autophagy, 2014-06-01;10(6):1054-70. 2014-06-01 [PMID: 24879153] (Bioassay, Mouse)	Bioassay	Mouse
Xiu Y, Xu H, Zhao C, Li J, Morita Y, Yao Z, Xing L, Boyce B Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation. J Clin Invest, 2013-12-09;124(1):297-310. 2013-12-09 [PMID: 24316970] (Bioassay, Mouse)	Bioassay	Mouse
Stalvey M, Clines K, Havasi V, McKibbin C, Dunn L, Chung W, Clines G Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease. PLoS ONE, 2013-11-13;8(11):e80098. 2013-11-13 [PMID: 24236172] (Bioassay, Mouse)	Bioassay	Mouse
Sun Q, Sammut B, Wang F, Kurihara N, Windle J, Roodman G, Galson D TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation. J Bone Miner Res, 2014-01-01;29(1):90-102. 2014-01-01 [PMID: 23794264] (Bioassay, Mouse)	Bioassay	Mouse
Muruganandan S, Dranse H, Rourke J, McMullen N, Sinal C Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis. Stem Cells, 2013-10-01;31(10):2172-82. 2013-10-01 [PMID: 23766088] (Bioassay, Mouse)	Bioassay	Mouse
Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y Macrophage infiltration predicts a poor prognosis for human ewing sarcoma. Am. J. Pathol., 2011-07-21;179(3):1157-70. 2011-07-21 [PMID: 21771572] (Bioassay, Mouse)	Bioassay	Mouse
Kulkarni RN, Bakker AD, Everts V, Klein-Nulend J Inhibition of osteoclastogenesis by mechanically loaded osteocytes: involvement of MEPE. Calcif. Tissue Int., 2010-08-20;87(5):461-8. 2010-08-20 [PMID: 20725825] (Bioassay, Mouse)	Bioassay	Mouse
Binder NB, Niederreiter B, Hoffmann O, Stange R, Pap T, Stulnig TM, Mack M, Erben RG, Smolen JS, Redlich K Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis. Nat. Med., 2009-03-29;15(4):417-24. 2009-03-29 [PMID: 19330010] (Bioassay, Flow Cytometry, Mouse)	Bioassay, Flow Cytometry	Mouse
Johansson MK, de Vries TJ, Schoenmaker T, Ehinger M, Brun AC, Fasth A, Karlsson S, Everts V, Richter J Hematopoietic stem cell-targeted neonatal gene therapy reverses lethally progressive osteopetrosis in oc/oc mice. Blood, 2007-03-01;109(12):5178-85. 2007-03-01 [PMID: 17332244] (Bioassay, Mouse)	Bioassay	Mouse
de Vries TJ, Schoenmaker T, Wattanaroonwong N, van den Hoonaard M, Nieuwenhuijse A, Beertsen W, Everts V Gingival fibroblasts are better at inhibiting osteoclast formation than periodontal ligament fibroblasts. J. Cell. Biochem., 2006-05-15;98(2):370-82. 2006-05-15 [PMID: 16440316] (Bioassay, Mouse)	Bioassay	Mouse
Liao TS, Yurgelun MB, Chang SS, Zhang HZ, Murakami K, Blaine TA, Parisien MV, Kim W, Winchester RJ, Lee FY Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone. J. Orthop. Res., 2005-01-01;23(1):203-9. 2005-01-01 [PMID: 15607894] (Bioassay, Mouse)	Bioassay	Mouse
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The diverse functions of RANKL/TRANCE/TNFSF11
RANKL (also known as TNF-related activation-induced cytokine), or receptor activator of nuclear factor-?B ligand, was first discovered as a key player in the RANKL/RANK/OPG osteoclast formation pathway. Osteoclasts are large multinucleate cells t... Read full blog post.

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Gene Symbol	Tnfsf11
Uniprot	Q3TWY5()

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Recombinant Mouse TRANCE/RANK L/TNFSF11 (E. coli-expressed)

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