LOX propeptide Antibody - BSA Free

Lysyl oxidase (LOX) is a critical enzyme in extracellular matrix biosynthesis as well as in the maintainance of normal bone phenotype. It is synthesized/secreted as a 50-kD proenzyme 'pro-LOX' which is then processed to 30-kD mature enzyme 'LOX' and 18-kD lysyl oxidase propeptide 'LOX-PP' by extracellular procollagen C-proteinases (BMP1, Tll1, and Tll2). LOX-PP has been proposed to implicate in the maintenance of inactive state of LOX within the secretory pathway and to act as intramolecular chaperones which facilitate the accurate protein folding/targeting to correct destinations. LOX-PP involves tumor suppression by inhibiting RAS-dependent cellular transformation and its expression has also been associated with inhibition of anchorage-independent progression as well as migration and growth suppression xenografts in Her-2/neu-driven breast cancer. LOX-PP also inhibits PI3K/AKT and ERK1/2 MAP kinase pathways, as well as the levels of downstream NF-kB/cyclin D1 signals in certain cancers - breast, pancreatic, lung, prostate and oral cancers. LOX-PP has also been shown to inhibit DNA synthesis in rat's VSMCs cultures, osteoblast proliferation and FGF-2 signaling.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 2 applications: IP, WB.

Showing Publications 1 - 7 of 7.

Publications using NBP1-30327	Applications	Species
Sato S, Zhao Y, Imai M et al. Inhibition of CIN85-Mediated Invasion by a Novel SH3 Domain Binding Motif in the Lysyl Oxidase Propeptide. PLoS One. 2013-10-22 [PMID: 24167568] (WB, Human)	WB	Human
Yokoyama U, Minamisawa S, Shioda A et al. Prostaglandin E2 inhibits elastogenesis in the ductus arteriosus via EP4 signaling Circulation et al. 2014-01-28 [PMID: 24146253] (WB, Rat) Details: LOX propeptide/ pro-LOX antibody used for WB on lysates of rat's ductus arteriosus smooth muscle cells (DASMCs) treated or not with AE1-329.	WB	Rat
Sanchez-Morgan N, Kirsch KH, Trackman PC, Sonenshein GE. The Lysyl Oxidase Propeptide Interacts with the Receptor-Type Protein Tyrosine Phosphatase-Kappa (RPTP-{kappa}) and Inhibits {beta}-Catenin Transcriptional Activity in Lung Cancer Cells. Mol Cell Biol. 2011-06-20 [PMID: 21690299] (WB, Human)	WB	Human
Mahapatra S Secretion of Cardioprotective Factors from Cardiac Inducing Colonies (Cics) Derived from Germline Pluripotent Stem Cells (Hgpscs) to Combat Myocardial Fibrosis Thesis Jul 13 1905 (WB)	WB
Mahapatra S Secretion of Cardioprotective Factors from Cardiac Inducing Colonies (Cics) Derived from Germline Pluripotent Stem Cells (Hgpscs) to Combat Myocardial Fibrosis Thesis 1905-07-13 (WB)	WB
Mahapatra S, Sharma MVR, Brownson B et al. Cardiac inducing colonies halt fibroblast activation and induce cardiac/endothelial cells to move and expand via paracrine signaling Molecular biology of the cell 2022-06-02 [PMID: 35653297] (WB, Human)	WB	Human
Sato S, Trackman PC, Maki JM et al. The Ras Signaling Inhibitor LOX-PP Interacts with Hsp70 and c-Raf To Reduce Erk Activation and Transformed Phenotype of Breast Cancer Cells. Mol. Cell. Biol. 2011-01-01 [PMID: 21536655] (WB, IP, Human)	WB, IP	Human

Array NBP1-30327

• LOX propeptide Antibodies
• LOX propeptide Protein