Integrin alpha 4/CD49d Antibody - BSA Free

The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. Despite its predicted molecular weight, Integrin alpha4 will often run at higher molecular weight in SDS-PAGE. At least two isoforms are known to exist. The immunogen to this antibody is within the Integrin alpha4 recombinant protein fragment and thus will recognize it.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: Block/Neutralize, ICC/IF, Immunocytochemistry/ Immunofluorescence, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using NBP1-77333	Applications	Species
Hight-Warburton W, Felix R, Burton A et al. ?4/?9 Integrins Coordinate Epithelial Cell Migration Through Local Suppression of MAP Kinase Signaling Pathways Frontiers in Cell and Developmental Biology 2021-11-25 [PMID: 34900996] (Western Blot, Block/Neutralize, Immunocytochemistry/ Immunofluorescence)	Western Blot, Block/Neutralize, Immunocytochemistry/ Immunofluorescence
Asai M, Koike Y, Kuwatsuka Y et al. Multifaceted array-based keloidal gene expression profiling reveals specific MDFI upregulation in keloid lesions Clinical and experimental dermatology 2021-04-26 [PMID: 33899950]
Garrido-Gomez T, Ona K, Kapidzic M et al. Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion. Development. 2017-03-01 [PMID: 28232601] (ICC/IF, Human)	ICC/IF	Human
Genbacev O, Larocque N, Ona K et al. Integrin a4-positive human trophoblast progenitors: functional characterization and transcriptional regulation. Hum. Reprod. 2016-06-01 [PMID: 27083540] (ICC/IF)	ICC/IF

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	ixodes scapularis	07/07/2020	View Summary Application Western Blot Sample Tested ISE6 Species ixodes scapularis Lot 4837-1003

Array NBP1-77333

• Integrin alpha 4/CD49d Antibodies
• Integrin alpha 4/CD49d ELISA Kit
• Integrin alpha 4/CD49d Lysate
• Integrin alpha 4/CD49d Proteins