Integrin alpha 4/CD49d Products

Description

VLA-4 is a cell surface heterodimer in the integrin superfamily of adhesion receptors. Anti-VLA-4 antibodies inhibited cytolytic T cell activity, with inhibitory activity directed against the effector T cells rather than their targets. Thus, whereas other VLA receptors appear to mediate cell--matrix interactions, VLA-4 may have a cell--cell adhesion function. Alpha 4 stands apart from all other known integrin alpha subunit sequences because (i) alpha 4 has neither an inserted I-domain, nor a disulfide-linked C-terminal fragment, (ii) its sequence is the most unique and (iii) only alpha 4 has a potential protease cleavage site, near the middle of the coding region, which appears responsible for the characteristic 80,000 and 70,000 Mr fragments of alpha 4 (1). Unlike any other integrin alpha subunit, the intact (150 kDa) alpha 4 subunit of VLA-4 can sometimes be cleaved into two noncovalently associated fragments (80 and 70 kDa) (2). The VLA-4 integrins are indispensable for embryogenesis, haematopoiesis and immune responses, possibly because alpha4 regulates cellular functions differently from other integrins through its cytoplasmic tail (3).

Bioinformatics

Entrez	16401 Mouse 16412 Mouse 311144 Rat 3676 Human
Uniprot	AAI56713.1 Human NM_000885 Human NP_000876 Human NP_000876.3 Human P13612 Human
Product By Gene ID	3676
Alternate Names	269C wild type CD49 antigen-like family member D CD49d antigen CD49d CD49Dantigen CD49D, alpha-4 subunit of VLA-4 receptor IA4 integrin alpha 4 integrin alpha-4 subunit integrin alpha-4 Integrin alpha-IV integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) MGC90518 very late activation protein 4 receptor, alpha 4 subunit VLA-4 subunit alpha

Research Areas for Integrin alpha 4/CD49d

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cellular Markers
Cytoskeleton Markers
Phospho-Specific