GFI-1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human GFI-1 is a 55 kDa, 422 amino acid (aa) nuclear, zinc-finger transcriptional regulator. It contains an N-terminal SNAG domain, an Ala/Gly-rich region, and a C‑terminus with six C2H2-type zinc finger motifs. GFI-1 binds DNA in a sequence-specific manner. GFI-1 functions as a transcription repressor in lymphoid cells and is required for neutrophil maturation. It also regulates self-renewal and is essential for the functional integrity of hematopoietic stem cells. Over the region used for immunization, human GFI-1 shares less than 50% amino acid sequence homology with human GFI-1B. It also shares 79% and 89% aa sequence identity with mouse and canine GFI-1, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: ICC, Western Blot.

Showing Publications 1 - 5 of 5.

Publications using AF3540	Applications	Species
Anne Helness, Jennifer Fraszczak, Charles Joly-Beauparlant, Halil Bagci, Christian Trahan, Kaifee Arman et al. GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors Communications Biology 2021-12-02 [PMID: 34857890]
S Vieira-Sil, G Falony, E Belda, T Nielsen, J Aron-Wisne, R Chakaroun, SK Forslund, K Assmann, M Valles-Col, TTD Nguyen, S Proost, E Prifti, V Tremaroli, N Pons, E Le Chateli, F Andreelli, JP Bastard, LP Coelho, N Galleron, TH Hansen, JS Hulot, C Lewinter, HK Pedersen, B Quinquis, C Rouault, H Roume, JE Salem, NB Søndertoft, S Touch, ME Dumas, SD Ehrlich, P Galan, JP Gøtze, T Hansen, JJ Holst, L Køber, I Letunic, J Nielsen, JM Oppert, M Stumvoll, H Vestergaar, JD Zucker, P Bork, O Pedersen, F Bäckhed, K Clément, J Raes Statin therapy is associated with lower prevalence of gut microbiota dysbiosis Nature, 2020-05-06;581(7808):310-315. 2020-05-06 [PMID: 32433607] (Western Blot, Mouse)	Western Blot	Mouse
MB Duran Alon, I Lopez Hern, MA de la Fuen, J Garcia-San, F Giraldez, T Schimmang Transcription factor induced conversion of human fibroblasts towards the hair cell lineage PLoS ONE, 2018-07-06;13(7):e0200210. 2018-07-06 [PMID: 29979748] (ICC, Human)	ICC	Human
Olsson A, Venkatasubramanian M, Chaudhri V, Aronow B, Salomonis N, Singh H, Grimes H Single-cell analysis of mixed-lineage states leading to a binary cell fate choice. Nature, 2016-08-31;537(7622):698-702. 2016-08-31 [PMID: 27580035] (Western Blot, Mouse)	Western Blot	Mouse
Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1 PLoS ONE, 2016-07-28;11(7):e0160344. 2016-07-28 [PMID: 27467586] (Western Blot, Mouse)	Western Blot	Mouse

Array AF3540

• GFI-1 Antibodies
• GFI-1 Lysates
• GFI-1 Protein