Recombinant Human IL-7 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-7 (interleukin-7) is a 25 kDa cytokine of the hemopoietin family that plays important roles in lymphocyte differentiation, proliferation, and survival (1-4). Human IL‑7 cDNA encodes 177 amino acids (aa) that include a 25 aa signal peptide (3). Human IL-7 shares approximately 60-63% aa sequence identity with mouse, rat, canine and feline IL-7, and 72-76% with equine, bovine, ovine, and porcine IL-7. Human and mouse IL-7 exhibit cross-species activity (2, 3).

IL-7 is produced by a wide variety of cells in primary and secondary lymphoid tissues, including stromal epithelial cells of the thymus, bone marrow, and intestines (1, 2, 5). Circulating IL-7 is limiting in healthy animals, but increases during lymphopenia (1, 6). IL-7 signals through a complex of the IL-7 Receptor alpha subunit (IL-7 R alpha , also known as CD127) with the common gamma chain ( gamma c) (1). The gamma c is also a subunit of the receptors for IL-2, -4, -9, -15, and -21 (1).

IL-7 R alpha is expressed on double negative (CD4-CD8-) and single positive (CD4+ or CD8+) naïve and memory T cells, but undergoes IL-7-mediated down‑regulation and shedding during antigen-driven T cell proliferation, and is absent on regulatory T cells (1, 2, 6-11). IL-7 contributes to the maintenance of all naïve and memory T cells, mainly by promoting expression of the anti-apoptotic protein Bcl-2 (9-11). It is required for optimal T cell-dendritic cell interaction (6). IL-7 is expressed early in B cell development prior to the appearance of surface IgM (1, 5, 9). In mouse, IL-7 activation of IL-7 R alpha is critical for both T cell and B cell lineage development, while in humans, it is required for T cell but not for B cell development (4, 9, 12, 13). However, IL-7 functions in both mouse and human pro-B cells to suppress premature Ig light chain recombination during proliferative growth (14, 15).

Like other common gamma-chain cytokines like IL-2 and IL-15, IL-7 and its receptor, IL-7R, have been used in a variety of immunotherapy applications, often in fluid tumors and in some instances of solid tumor models (16). Sometimes use of recombinant IL-7 is preferential as current studies and early clinical trials of cancer have found less severe toxicity or side effects upon treatment with IL-7 in comparison to IL-15 or IL-2 (16).

In CAR-T cell therapies, enhanced expression and secretion of human IL-7 and CCL19 have enhanced the ability of T cells to expand and migrate in vitro (17). Engineered CAR T cells expressing IL-7 or a constitutively active IL-7R results in increased efficacy of CAR T anti-tumor effects (16, 18). IL-7 is also frequently used in combination with IL-15 as a supplement in cell culture of CAR T cells to support their expansion (19). Additionally, IL-7/IL-15 in the presence of cord blood-derived T cells helps to maintain their early differentiation state (20).

Monoclonal antibodies against IL-7R or small molecule inhibitors against the IL-7R signaling pathway are commonly used in circumstances of autoimmune diseases to delay disease progression (16).  Also due to its ability to stimulate both adaptive and innate immune cells, treatment with IL-7 has shown improved survival in patients with sepsis who are at risk of deadly secondary infections (21), providing evidence for IL-7 applications beyond cancer immunotherapy.

We have publications tested in 5 confirmed species: Human, Mouse, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque), Primate - Papio cynocephalus (Yellow Baboon).

We have publications tested in 7 applications: Bioassay, CAR-T (Bioassay), CAR-T (Differentiation), Cell Culture, ELISA (Standard), In Vivo, Whole Cells.

Showing Publications 1 - 10 of 155. Show All 155 Publications. Collapse Publications.

Publications using 207-IL	Applications	Species
Ren, J;Liao, X;Lewis, JM;Chang, J;Qu, R;Carlson, KR;Foss, F;Girardi, M; Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-V?2+ T cell malignancy Nature communications 2024-01-15 [PMID: 38225288] (Bioassay, Human)	Bioassay	Human
Huang, Y;Zhu, L;Cheng, S;Dai, R;Huang, C;Song, Y;Peng, B;Li, X;Wen, J;Gong, Y;Hu, Y;Qian, L;Zhu, L;Zhang, F;Yu, L;Yi, C;Gu, W;Ling, Z;Ma, L;Tang, W;Peng, L;Shi, G;Zhang, Y;Sun, B; Solar ultraviolet B radiation promotes ?-MSH secretion to attenuate the function of ILC2s via the pituitary-lung axis Nature communications 2023-09-12 [PMID: 37699899] (Bioassay, Mouse)	Bioassay	Mouse
MP Cabral-Pic, L Papagno, X Lahaye, F Perdomo-Ce, S Volant, E White, V Monceaux, S Llewellyn-, R Fromentin, DA Price, N Chomont, N Manel, A Saez-Cirio, V Appay Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection EBioMedicine, 2023-04-12;91(0):104557. 2023-04-12 [PMID: 37058769] (Bioassay, Human)	Bioassay	Human
S Li, CS Wang, A Montel-Hag, HC Chen, S Lopez, O Zhou, K Dai, S Tsai, W Satyadi, C Botero, C Wong, D Casero, GM Crooks, CS Seet Strength of CAR signaling determines T�cell versus ILC differentiation from pluripotent stem cells Cell Reports, 2023-03-11;42(3):112241. 2023-03-11 [PMID: 36906850] (Bioassay, Human)	Bioassay	Human
T Tate, S Matsumoto, K Nemoto, M Leisegang, S Nagayama, K Obama, Y Nakamura, K Kiyotani Identification of T Cell Receptors Targeting a Neoantigen Derived from Recurrently Mutated FGFR3 Cancers, 2023-02-06;15(4):. 2023-02-06 [PMID: 36831375] (Bioassay, Human)	Bioassay	Human
D Proietto, B Dallan, E Gallerani, V Albanese, S Llewellyn-, DA Price, V Appay, S Pacifico, A Caputo, F Nicoli, R Gavioli Ageing Curtails the Diversity and Functionality of Nascent CD8+ T Cell Responses against SARS-CoV-2 Vaccines, 2023-01-11;11(1):. 2023-01-11 [PMID: 36679999] (Cell Culture, Human)	Cell Culture	Human
Y Kitamura, YI Koma, K Tanigawa, S Tsukamoto, Y Azumi, S Miyako, S Urakami, T Kodama, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki Roles of IL-7R Induced by Interactions between Cancer Cells and Macrophages in the Progression of Esophageal Squamous Cell Carcinoma Cancers, 2023-01-06;15(2):. 2023-01-06 [PMID: 36672342] (Bioassay, Human)	Bioassay	Human
YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells Science Advances, 2022-08-24;8(34):eabn5522. 2022-08-24 [PMID: 36001668] (Bioassay, Human)	Bioassay	Human
R Jing, I Scarfo, MA Najia, E Lummertz d, A Han, M Sanborn, T Bingham, C Kubaczka, DK Jha, M Falchetti, TM Schlaeger, TE North, MV Maus, GQ Daley EZH1 repression generates mature iPSC-derived CAR T�cells with enhanced antitumor activity Cell Stem Cell, 2022-08-04;29(8):1181-1196.e6. 2022-08-04 [PMID: 35931029] (Bioassay, Human)	Bioassay	Human
P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells Cancers, 2022-03-11;14(6):. 2022-03-11 [PMID: 35326601] (Whole Cells, Human)	Whole Cells	Human
GR Campbell, J Zhuang, G Zhang, I Landa, LJ Kubiatowic, D Dehaini, RH Fang, L Zhang, SA Spector CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kill HIV-1-infected cells Theranostics, 2021-08-25;11(18):9009-9021. 2021-08-25 [PMID: 34522224] (Bioassay, Human)	Bioassay	Human
M Pino, S Pereira Ri, A Pagliuzza, K Ghneim, A Khan, E Ryan, JL Harper, CT King, S Welbourn, L Micci, S Aldrete, KA Delman, T Stuart, M Lowe, JM Brenchley, CA Derdeyn, K Easley, RP Sekaly, N Chomont, M Paiardini, VC Marconi Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART PloS Pathogens, 2021-08-27;17(8):e1009825. 2021-08-27 [PMID: 34449812] (Bioassay, Human)	Bioassay	Human
X Yang, X Zhao, Y Zhu, Y Shen, Y Wang, P Lu, Z Jiang, H Pan, J Yang, J Xun, L Zhao, J Wang, Z Liang, X Shen, Y Liang, Q Lin, H Liang, L Jin, D Zhang, J Liu, B Wang, S Jiang, J Xu, H Wu, H Lu, H Zhu FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat MBio, 2021-07-20;0(0):e0079521. 2021-07-20 [PMID: 34281390] (Bioassay, Human)	Bioassay	Human
AS Bear, T Blanchard, J Cesare, MJ Ford, LP Richman, C Xu, ML Baroja, S McCuaig, C Costeas, K Gabunia, J Scholler, AD Posey, MH O'Hara, A Smole, DJ Powell, BA Garcia, RH Vonderheid, GP Linette, BM Carreno Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting Nature Communications, 2021-07-16;12(1):4365. 2021-07-16 [PMID: 34272369] (Bioassay, Human)	Bioassay	Human
R Basar, N Uprety, E Ensley, M Daher, K Klein, F Martinez, F Aung, M Shanley, B Hu, E Gokdemir, AK Nunez Cort, M Mendt, F Reyes Silv, S Acharya, T Laskowski, L Muniz-Feli, PP Banerjee, Y Li, S Li, L Melo Garci, P Lin, H Shaim, SG Yates, D Marin, I Kaur, S Rao, D Mak, A Lin, Q Miao, J Dou, K Chen, RE Champlin, EJ Shpall, K Rezvani Generation of glucocorticoid-resistant SARS-CoV-2 T�cells for adoptive cell therapy Cell Reports, 2021-07-07;36(3):109432. 2021-07-07 [PMID: 34270918] (Bioassay, Human)	Bioassay	Human
J Boustani, ELM Joseph, E Martin, S Benhmida, B Lecoester, F Tochet, C Mirjolet, C Chevalier, D Thibouw, N Vulquin, S Servagi, X Sun, O Adotévi Cisplatin-based chemoradiation decreases telomerase-specific CD4 TH1 response but increases immune suppressive cells in peripheral blood BMC immunology, 2021-06-18;22(1):38. 2021-06-18 [PMID: 34144673] (Bioassay, Human)	Bioassay	Human
F Nicoli, S Pacifico, E Gallerani, E Marzola, V Albanese, V Finessi, S Llewellyn-, DA Price, V Appay, P Marconi, R Guerrini, A Caputo, R Gavioli Use of a Novel Peptide Welding Technology Platform for the Development of B- and T-Cell Epitope-Based Vaccines Vaccines, 2021-05-19;9(5):. 2021-05-19 [PMID: 34069535] (Bioassay, Human)	Bioassay	Human
S Jung, E Appleton, M Ali, GM Church, A Del Sol A computer-guided design tool to increase the efficiency of cellular conversions Nature Communications, 2021-03-12;12(1):1659. 2021-03-12 [PMID: 33712564] (Bioassay, Human)	Bioassay	Human
E Kidzeru, MA Gasper, D Shao, PT Edlefsen, N Lejarcegui, E Havyariman, K Urdahl, S Gantt, H Horton, H Jaspan, A Gervassi Myeloid-derived suppressor cells and their association with vaccine immunogenicity in South African infants Journal of leukocyte biology, 2021-01-21;0(0):. 2021-01-21 [PMID: 33477200] (Bioassay, Human)	Bioassay	Human
Roudko V, Bozkus C, Orfanelli T, McClain C, Carr C, O'Donnell T, Chakraborty L, Samstein R, Huang K, Blank S, Greenbaum B, Bhardwaj N Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable Tumors. Cell, 2020-11-30;183(6):1634-1649.e17. 2020-11-30 [PMID: 33259803] (Bioassay, Human)	Bioassay	Human
S Nagel, C Pommerenke, C Meyer, RAF MacLeod, HG Drexler Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia PLoS ONE, 2020-10-13;15(10):e0240120. 2020-10-13 [PMID: 33048949] (Cell Culture, Human)	Cell Culture	Human
M Matsushita, S Saito, S Yokoe, D Ichikawa, Y Hattori Characteristics of a Novel Target Antigen Against Myeloma Cells for Immunotherapy Vaccines (Basel), 2020-10-02;8(4):. 2020-10-02 [PMID: 33023190] (Bioassay, Human)	Bioassay	Human
H Zhu, RH Blum, D Bernareggi, EH Ask, Z Wu, HJ Hoel, Z Meng, C Wu, KL Guan, KJ Malmberg, DS Kaufman Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In�Vivo Persistence and Enhances Anti-tumor Activity Cell Stem Cell, 2020-06-11;0(0):. 2020-06-11 [PMID: 32531207] (Bioassay, Human)	Bioassay	Human
CR Maldini, K Gayout, RS Leibman, DL Dopkin, JP Mills, X Shan, JA Glover, JL Riley HIV-Resistant and HIV-Specific CAR-Modified CD4+ T Cells Mitigate HIV Disease Progression and Confer CD4+ T Cell Help In�Vivo Mol. Ther., 2020-05-15;0(0):. 2020-05-15 [PMID: 32454027] (CAR-T (Differentiation), Human)	CAR-T (Differentiation)	Human
F Hsiao, J Frouard, A Gramatica, G Xie, S Telwatte, GQ Lee, P Roychoudhu, R Schwarzer, X Luo, SA Yukl, S Lee, R Hoh, SG Deeks, RB Jones, M Cavrois, WC Greene, NR Roan Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection PLoS Pathog., 2020-04-30;16(4):e1008450. 2020-04-30 [PMID: 32353080] (Cell Culture, Human)	Cell Culture	Human
A Mitra, MC Andrews, W Roh, MP De Macedo, CW Hudgens, F Carapeto, S Singh, A Reuben, F Wang, X Mao, X Song, K Wani, S Tippen, KS Ng, A Schalck, DA Sakellario, E Chen, SM Reddy, CN Spencer, D Wiesnoski, LD Little, C Gumbs, ZA Cooper, EM Burton, P Hwu, MA Davies, J Zhang, C Bernatchez, N Navin, P Sharma, JP Allison, JA Wargo, C Yee, MT Tetzlaff, WJ Hwu, AJ Lazar, PA Futreal Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma Nat Commun, 2020-04-15;11(1):1839. 2020-04-15 [PMID: 32296058] (Cell Culture, Human)	Cell Culture	Human
DM Tufa, T Shank, AM Yingst, GD Trahan, S Shim, J Lake, R Woods, K Jones, MR Verneris Prolactin Acts on Myeloid Progenitors to Modulate SMAD7 Expression and Enhance Hematopoietic Stem Cell Differentiation into the NK Cell Lineage Sci Rep, 2020-04-14;10(1):6335. 2020-04-14 [PMID: 32286456] (Bioassay, Human)	Bioassay	Human
J Wang, F Hasan, AC Frey, HS Li, J Park, K Pan, C Haymaker, C Bernatchez, DA Lee, SS Watowich, C Yee Histone deacetylase inhibitors and IL21 cooperate to reprogram human effector CD8+ T cells to memory T cells Cancer Immunol Res, 2020-03-25;0(0):. 2020-03-25 [PMID: 32213626] (Bioassay, Human)	Bioassay	Human
A Kunz, U Gern, A Schmitt, B Neuber, L Wang, A Hückelhove, B Michels, S Hofmann, C Müller-Tid, P Dreger, M Schmitt, ML Schubert Optimized Assessment of qPCR-Based Vector Copy Numbers as a Safety Parameter for GMP-Grade CAR T Cells and Monitoring of Frequency in Patients Mol Ther Methods Clin Dev, 2020-02-20;17(0):448-454. 2020-02-20 [PMID: 32201711] (Cell Culture, Human)	Cell Culture	Human
H Bolouri, M Young, J Beilke, R Johnson, B Fox, L Huang, CC Santini, CM Hill, AVV Vries, PT Shannon, A Dervan, P Sivakumar, M Trotter, D Bassett, A Ratushny Integrative network modeling reveals mechanisms underlying T cell exhaustion Sci Rep, 2020-02-05;10(1):1915. 2020-02-05 [PMID: 32024856] (Bioassay, Human)	Bioassay	Human
N Borthwick, S Silva-Arri, A Llano, M Takiguchi, C Brander, T Hanke Novel Nested Peptide Epitopes Recognized by CD4+ T Cells Induced by HIV-1 Conserved-Region Vaccines Vaccines (Basel), 2020-01-16;8(1):. 2020-01-16 [PMID: 31963212] (Bioassay, Human)	Bioassay	Human
NL Truex, RL Holden, BY Wang, PG Chen, S Hanna, Z Hu, K Shetty, O Olive, D Neuberg, N Hacohen, DB Keskin, PA Ott, CJ Wu, BL Pentelute Automated Flow Synthesis of Tumor Neoantigen Peptides for Personalized Immunotherapy Sci Rep, 2020-01-20;10(1):723. 2020-01-20 [PMID: 31959774] (Cell Culture, Human)	Cell Culture	Human
C Seillet, K Luong, J Tellier, N Jacquelot, RD Shen, P Hickey, VC Wimmer, L Whitehead, K Rogers, GK Smyth, AL Garnham, ME Ritchie, GT Belz The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity Nat. Immunol., 2019-12-23;0(0):. 2019-12-23 [PMID: 31873294] (Cell Culture, Mouse)	Cell Culture	Mouse
DN Nguyen, TL Roth, PJ Li, PA Chen, R Apathy, MR Mamedov, LT Vo, VR Tobin, D Goodman, E Shifrut, JA Bluestone, JM Puck, FC Szoka, A Marson Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency Nat. Biotechnol., 2019-12-09;0(0):. 2019-12-09 [PMID: 31819258] (Cell Culture, Human)	Cell Culture	Human
A Guvenel, A Jozwik, S Ascough, SK Ung, S Paterson, M Kalyan, Z Gardener, E Bergstrom, S Kar, MS Habibi, A Paras, J Zhu, M Park, J Dhariwal, M Almond, EH Wong, A Sykes, J Del Rosari, MB Trujillo-T, P Mallia, J Sidney, B Peters, OM Kon, A Sette, SL Johnston, PJ Openshaw, C Chiu Epitope-specific airway-resident CD4+ T cell dynamics during experimental human RSV infection J. Clin. Invest., 2020-01-02;0(0):. 2020-01-02 [PMID: 31815739] (Cell Culture, Human)	Cell Culture	Human
JD Ventura, J Beloor, E Allen, T Zhang, KA Haugh, PD Uchil, C Ochsenbaue, C Kieffer, P Kumar, TJ Hope, W Mothes Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice PLoS Pathog., 2019-12-05;15(12):e1008161. 2019-12-05 [PMID: 31805155] (Cell Culture, Human)	Cell Culture	Human
ZY Li, JJ Zhou, CL Luo, LM Zhang Activation of TGR5 alleviates inflammation in rheumatoid arthritis peripheral blood mononuclear cells and in mice with collagen II?induced arthritis Mol Med Rep, 2019-09-26;20(5):4540-4550. 2019-09-26 [PMID: 31702035] (Cell Culture, Human)	Cell Culture	Human
ER Wonderlich, K Subramania, B Cox, A Wiegand, C Lackman-Sm, MJ Bale, M Stone, R Hoh, MF Kearney, F Maldarelli, SG Deeks, MP Busch, RG Ptak, DA Kulpa Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals PLoS Pathog., 2019-10-14;15(10):e1008074. 2019-10-14 [PMID: 31609991] (Bioassay, Human)	Bioassay	Human
JH Bernink, Y Ohne, MBM Teunissen, J Wang, J Wu, L Krabbendam, C Guntermann, R Volckmann, J Koster, S van Tol, I Ramirez, Y Shrestha, MA de Rie, H Spits, X Romero Ros, AA Humbles c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies Nat. Immunol., 2019-07-01;0(0):. 2019-07-01 [PMID: 31263279] (Cell Culture, Human)	Cell Culture	Human
HJ Yoo, Y Liu, L Wang, ML Schubert, JM Hoffmann, S Wang, B Neuber, A Hückelhove, U Gern, A Schmitt, C Müller-Tid, P Dreger, A Mokhir, M Schmitt, L Sellner Tumor-Specific Reactive Oxygen Species Accelerators Improve Chimeric Antigen Receptor T Cell Therapy in B Cell Malignancies Int J Mol Sci, 2019-05-18;20(10):. 2019-05-18 [PMID: 31109083] (CAR-T (Bioassay), Human)	CAR-T (Bioassay)	Human
SR Ferdosi, R Ewaisha, F Moghadam, S Krishna, JG Park, MR Ebrahimkha, S Kiani, KS Anderson Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes Nat Commun, 2019-04-23;10(1):1842. 2019-04-23 [PMID: 31015529] (Bioassay, Human)	Bioassay	Human
HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis Nat Commun, 2019-02-12;10(1):709. 2019-02-12 [PMID: 30755603] (Bioassay, Human)	Bioassay	Human
K Kuranda, S Caillat-Zu, S You, R Mallone In�Vitro Expansion of Anti-viral T Cells from Cord Blood by Accelerated Co-cultured Dendritic Cells Mol Ther Methods Clin Dev, 2018-12-31;13(0):112-120. 2018-12-31 [PMID: 30740473] (Bioassay, Human)	Bioassay	Human
C Ammer-Herr, U Kulkarni, N Andreas, M Ungelenk, S Ravens, C Hübner, A Kather, I Kurth, M Bauer, T Kamradt Sepsis induces long-lasting impairments in CD4+ T-cell responses despite rapid numerical recovery of T-lymphocyte populations PLoS ONE, 2019-02-07;14(2):e0211716. 2019-02-07 [PMID: 30730978] (Mouse)		Mouse
S Whelan, E Ophir, MF Kotturi, O Levy, S Ganguly, L Leung, I Vaknin, S Kumar, L Dassa, K Hansen, D Bernados, B Murter, A Soni, JM Taube, AN Fader, TL Wang, IM Shih, M White, DM Pardoll, SC Liang PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function Cancer Immunol Res, 2019-01-18;0(0):. 2019-01-18 [PMID: 30659054] (Bioassay, Human)	Bioassay	Human
J Fu, J Zuber, M Martinez, B Shonts, A Obradovic, H Wang, SP Lau, A Xia, EE Waffarn, K Frangaj, TM Savage, MT Simpson, S Yang, XV Guo, M Miron, T Senda, K Rogers, A Rahman, SH Ho, Y Shen, A Griesemer, DL Farber, T Kato, M Sykes Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool Cell Stem Cell, 2018-11-29;0(0):. 2018-11-29 [PMID: 30503142] (Bioassay, Human)	Bioassay	Human
S Krishna, P Ulrich, E Wilson, F Parikh, P Narang, S Yang, AK Read, S Kim-Schulz, JG Park, M Posner, MA Wilson Say, A Sikora, KS Anderson Human papilloma virus specific immunogenicity and dysfunction of CD8+ T cells in head and neck cancer Cancer Res., 2018-08-28;0(0):. 2018-08-28 [PMID: 30154146] (Bioassay, Human)	Bioassay	Human
SR Kim, JM Lewis, BM Cyrenne, PF Monico, FN Mirza, KR Carlson, FM Foss, M Girardi BET inhibition in advanced cutaneous T cell lymphoma is synergistically potentiated by BCL2 inhibition or HDAC inhibition Oncotarget, 2018-06-26;9(49):29193-29207. 2018-06-26 [PMID: 30018745] (Bioassay, Human)	Bioassay	Human
X Zhao, S Sankaran, J Yap, CT Too, ZZ Ho, G Dolton, M Legut, EC Ren, AK Sewell, A Bertoletti, PA MacAry, J Brzostek, NRJ Gascoigne Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling Nat Commun, 2018-07-13;9(1):2716. 2018-07-13 [PMID: 30006605] (Bioassay, Human)	Bioassay	Human
LK Thampy, KE Remy, AH Walton, Z Hong, K Liu, R Liu, V Yi, CD Burnham, RS Hotchkiss Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration PLoS ONE, 2018-06-26;13(6):e0199497. 2018-06-26 [PMID: 29944697] (Bioassay, Human)	Bioassay	Human
DJHF Knapp, CA Hammond, T Hui, MTJ van Loenho, F Wang, N Aghaeepour, PH Miller, M Moksa, GM Rabu, PA Beer, D Pellacani, RK Humphries, C Hansen, M Hirst, CJ Eaves Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential Nat. Cell Biol., 2018-05-25;20(6):710-720. 2018-05-25 [PMID: 29802403] (Bioassay, Human)	Bioassay	Human
M Nakajima, M Kawaguchi, M Matsuyama, K Ota, J Fujita, S Matsukura, SK Huang, Y Morishima, Y Ishii, H Satoh, T Sakamoto, N Hizawa Transcription Elongation Factor P-TEFb Is Involved in IL-17F Signaling in Airway Smooth Muscle Cells Int. Arch. Allergy Immunol., 2018-04-12;0(0):. 2018-04-12 [PMID: 29649811] (Cell Culture, Human)	Cell Culture	Human
D Chennamadh, NA Saavedra-A, LJ Carreño, MJ Guberman-P, P Arora, T Yongqing, HF Koay, DI Godfrey, S Keshipeddy, SK Richardson, S Sundararaj, JH Lo, X Wen, JA Gascón, W Yuan, J Rossjohn, J Le Nours, SA Porcelli, AR Howell Dual Modifications of ?-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity Cell Chem Biol, 2018-03-22;0(0):. 2018-03-22 [PMID: 29576533] (Bioassay, Human)	Bioassay	Human
S Zheng, E Papalexi, A Butler, W Stephenson, R Satija Molecular transitions in early progenitors during human cord blood hematopoiesis Mol. Syst. Biol., 2018-03-15;14(3):e8041. 2018-03-15 [PMID: 29545397] (Bioassay, Human)	Bioassay	Human
T Kato, T Matsuda, Y Ikeda, JH Park, M Leisegang, S Yoshimura, T Hikichi, M Harada, M Zewde, S Sato, K Hasegawa, K Kiyotani, Y Nakamura Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells Oncotarget, 2018-01-13;9(13):11009-11019. 2018-01-13 [PMID: 29541393] (Bioassay, Human)	Bioassay	Human
D Vignali, E Cantarelli, C Bordignon, A Canu, A Citro, A Annoni, L Piemonti, P Monti Detection and Characterization of CD8+ Autoreactive Memory Stem T Cells in Patients with Type 1 Diabetes Diabetes, 2018-03-05;0(0):. 2018-03-05 [PMID: 29506985] (Cell Culture, Human)	Cell Culture	Human
N Terrazzini, P Mantegani, F Kern, C Fortis, A Mondino, S Caserta IL-7 unveils pathogen-specific T cells by enhancing antigen-recall responses J. Infect. Dis., 2018-05-25;0(0):. 2018-05-25 [PMID: 29506153] (Cell Culture, Human)	Cell Culture	Human
U Kulkarni, C Herrmenau, SJ Win, M Bauer, T Kamradt IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells PLoS ONE, 2018-02-21;13(2):e0192304. 2018-02-21 [PMID: 29466409] (In Vivo, Mouse)	In Vivo	Mouse
C Thepmalee, A Panya, M Junking, T Chieochans, PT Yenchitsom Inhibition of IL-10 and TGF-? receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells Hum Vaccin Immunother, 2018-02-21;0(0):0. 2018-02-21 [PMID: 29420117] (Bioassay, Human)	Bioassay	Human
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Dong J, Chang H, Ivascu C, Qian Y, Rezai S, Okhrimenko A, Cosmi L, Maggi L, Eckhardt F, Wu P, Sieper J, Alexander T, Annunziato F, Gossen M, Li J, Radbruch A, Thiel A Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-gamma memory in human CD4(+) T lymphocytes. Eur J Immunol, 2013-03-01;43(3):793-804. 2013-03-01 [PMID: 23255246] (Bioassay, Human)	Bioassay	Human
Alonzo , Francis, Kozhaya , Lina, Rawlings , Stephen, Reyes-Robles , Tamara, DuMont , Ashley L, Myszka , David G, Landau , Nathanie, Unutmaz , Derya, Torres , Victor J CCR5 is a receptor for Staphylococcus aureus leukotoxin ED. Nature, 2012-12-12;493(7430):51-5. 2012-12-12 [PMID: 23235831] (Cell Culture, Human)	Cell Culture	Human
Brusic , Ana, Hainz , Ursula, Wadleigh , Martha, Neuberg , Donna, Su , Mei, Canning , Christin, Deangelo , Daniel J, Stone , Richard, Lee , Jeng-Shi, Mulligan , Richard, Ritz , Jerome, Dranoff , Glenn, Sasada , Tetsuro, Wu , Catherin Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients. Oncoimmunology, 2012-10-01;1(7):1095-1103. 2012-10-01 [PMID: 23170257] (Bioassay, Human)	Bioassay	Human
Venet F, Foray A, Villars-Mechin A, Malcus C, Poitevin-Later F, Lepape A, Monneret G IL-7 Restores Lymphocyte Functions in Septic Patients. J Immunol, 2012-10-10;189(10):5073-81. 2012-10-10 [PMID: 23053510] (Bioassay, Human)	Bioassay	Human
Inderberg-Suso E, Trachsel S, Lislerud K, Rasmussen A, Gaudernack G Widespread CD4+ T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001. Oncoimmunology, 2012-08-01;1(5):670-686. 2012-08-01 [PMID: 22934259] (Bioassay, Human)	Bioassay	Human
Mujib S, Jones RB, Lo C, Aidarus N, Clayton K, Sakhdari A, Benko E, Kovacs C, Ostrowski MA Antigen-independent induction of Tim-3 expression on human T cells by the common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway. J. Immunol., 2012-03-14;188(8):3745-56. 2012-03-14 [PMID: 22422881] (Bioassay, Human)	Bioassay	Human
Nielsen N, Odum N, Urso B, Lanier LL, Spee P Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A. PLoS ONE, 2012-02-22;7(2):e31959. 2012-02-22 [PMID: 22384114] (Bioassay, Human)	Bioassay	Human
Donnelly , O G, Errington-Mais , F, Steele , L, Hadac , E, Jennings , V, Scott , K, Peach , H, Phillips , R M, Bond , J, Pandha , H, Harrington , K, Vile , R, Russell , S, Selby , P, Melcher , A A Measles virus causes immunogenic cell death in human melanoma. Gene Ther, 2011-12-15;20(1):7-15. 2011-12-15 [PMID: 22170342] (Bioassay, Human)	Bioassay	Human
Ichii , Michiko, Frank , Mark Bar, Iozzo , Renato V, Kincade , Paul W The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells. Blood, 2011-11-23;119(7):1683-92. 2011-11-23 [PMID: 22117039] (Bioassay, Human)	Bioassay	Human
Milpied P, Massot B, Renand A, Diem S, Herbelin A, Leite-de-Moraes M, Rubio MT, Hermine O IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression. Blood, 2011-06-08;118(11):2993-3002. 2011-06-08 [PMID: 21653940] (Bioassay, Mouse)	Bioassay	Mouse
Zhang HH, Song K, Rabin RL, Hill BJ, Perfetto SP, Roederer M, Douek DC, Siegel RM, Farber JM CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response. J. Immunol., 2010-10-27;185(11):6646-63. 2010-10-27 [PMID: 20980630] (Bioassay, Human)	Bioassay	Human
Unsinger J, McGlynn M, Kasten KR, Hoekzema AS, Watanabe E, Muenzer JT, McDonough JS, Tschoep J, Ferguson TA, McDunn JE, Morre M, Hildeman DA, Caldwell CC, Hotchkiss RS IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J. Immunol., 2010-03-03;184(7):3768-79. 2010-03-03 [PMID: 20200277] (In Vivo, Mouse)	In Vivo	Mouse
Erlendsson LS, Muench MO, Hellman U, Hrafnkelsdottir SM, Jonsson A, Balmer Y, Mantyla E, Orvar BL Barley as a green factory for the production of functional Flt3 ligand. Biotechnol J, 2010-02-01;5(2):163-71. 2010-02-01 [PMID: 19844912] (Bioassay, Human)	Bioassay	Human
Lotem M, Machlenkin A, Hamburger T, Nissan A, Kadouri L, Frankenburg S, Gimmon Z, Elias O, David IB, Kuznetz A, Shiloni E, Peretz T Autologous melanoma vaccine induces antitumor and self-reactive immune responses that affect patient survival and depend on MHC class II expression on vaccine cells. Clin. Cancer Res., 2009-07-14;15(15):4968-77. 2009-07-14 [PMID: 19602547] (Bioassay, Human)	Bioassay	Human
Cattaruzza L, Gloghini A, Olivo K, Di Francia R, Lorenzon D, De Filippi R, Carbone A, Colombatti A, Pinto A, Aldinucci D Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma. Int. J. Cancer, 2009-09-01;125(5):1092-101. 2009-09-01 [PMID: 19391137] (Bioassay, Human)	Bioassay	Human
Yammani RR, Long D, Loeser RF Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes. Arthritis Rheum., 2009-03-01;60(3):792-800. 2009-03-01 [PMID: 19248116] (Bioassay, Human)	Bioassay	Human
Spiegl N, Didichenko S, McCaffery P, Langen H, Dahinden CA Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid. Blood, 2008-05-21;112(9):3762-71. 2008-05-21 [PMID: 18495959] (Bioassay, Human)	Bioassay	Human
Gendron S, Boisvert M, Chetoui N, Aoudjit F alpha1beta1 integrin and interleukin-7 receptor up-regulate the expression of RANKL in human T cells and enhance their osteoclastogenic function. Immunology, 2008-05-13;125(0):359. 2008-05-13 [PMID: 18479350] (Bioassay, Human)	Bioassay	Human
Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62. 2008-03-01 [PMID: 18327985] (ELISA (Standard))	ELISA (Standard)
McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Yun G, Lutz CT, Wagner JE, Miller JS Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15. Exp. Hematol., 2008-03-04;36(5):598-608. 2008-03-04 [PMID: 18295962] (Bioassay, Human)	Bioassay	Human
Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P Ultrasensitive flow-based immunoassays using single-molecule counting. Clin. Chem., 2007-09-21;53(11):1990-5. 2007-09-21 [PMID: 17890441] (ELISA (Standard))	ELISA (Standard)
Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-02-08;109(10):4272-9. 2007-02-08 [PMID: 17289812] (ELISA (Standard))	ELISA (Standard)
Kersten C, Dosen G, Myklebust JH, Sivertsen EA, Hystad ME, Smeland EB, Rian E BMP-6 inhibits human bone marrow B lymphopoiesis--upregulation of Id1 and Id3. Exp. Hematol., 2006-01-01;34(1):72-81. 2006-01-01 [PMID: 16413393] (Bioassay, Human)	Bioassay	Human
Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, Kufe D Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism. J. Immunol., 2005-02-15;174(4):2376-86. 2005-02-15 [PMID: 15699174] (Bioassay, Human)	Bioassay	Human
Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol., 2004-09-01;173(5):3482-91. 2004-09-01 [PMID: 15322213] (Bioassay, Human)	Bioassay	Human
Locher CP, Witt SA, Ashlock BM, Polacino P, Hu SL, Shiboski S, Schmidt AM, Agy MB, Anderson DM, Staprans SI, zur Megede J, Levy JA Human immunodeficiency virus type 2 DNA vaccine provides partial protection from acute baboon infection. Vaccine, 2004-06-02;22(17):2261-72. 2004-06-02 [PMID: 15149785] (Bioassay, Primate - Papio cynocephalus (Yellow Baboon))	Bioassay	Primate - Papio cynocephalus (Yellow Baboon)
O'Connor DH Escape in one of two cytotoxic T-lymphocyte epitopes bound by a high-frequency major histocompatibility complex class I molecule, Mamu-A*02: a paradigm for virus evolution and persistence? J. Virol., 2002-11-01;76(22):11623-36. 2002-11-01 [PMID: 12388723] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Favre D, Blouin V, Provost N, Spisek R, Porrot F, Bohl D, Marme F, Cherel Y, Salvetti A, Hurtrel B, Heard JM, Riviere Y, Moullier P Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus. J. Virol., 2002-11-01;76(22):11605-11. 2002-11-01 [PMID: 12388721] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))	Bioassay	Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
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Array 207-IL

• IL-7 Antibodies
• IL-7 Antibody Pair
• IL-7 ELISA Kit
• IL-7 Lysate
• IL-7 Proteins
• IL-7 ELISAs
• IL-7 Proteins and Enzymes