BIN1 Antibody (2F11)

BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NBP2-21675	Applications	Species
Maartje Westhoff, Silvia G. del Villar, Taylor L. Voelker, Phung N. Thai, Heather C. Spooner, Alexandre D. Costa, Padmini Sirish, Nipavan Chiamvimonvat, Eamonn J. Dickson, Rose E. Dixon BIN1 knockdown rescues systolic dysfunction in aging male mouse hearts Nature Communications 2024-04-25 [PMID: 38664444]

Array NBP2-21675

• BIN1 Antibodies
• BIN1 ELISA Kits
• BIN1 Lysates
• BIN1 Proteins