Siglec-3/CD33 Antibody (44M12D3) - BSA Free

CD33 is a 67 kDa type I transmembrane glycoprotein and a member of the sialoadhesin family of cell surface receptors. It is absent from pluripotent stem cells but appears on myelomonocytic precursors after CD34. It then continues to be expressed on both the myeloid and monocyte lineages, although it is absent on granulocytes. While it has been reported that CD33 can function as a sialic acid-dependent cell adhesion molecule, cells expressing CD33 require desialylation before they can bind cells bearing the appropriate sialoglycoconjugates. This suggests that inhibitory cis interactions may regulate or block any adhesion function. (1-4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, IF/IHC.

Showing Publications 1 - 3 of 3.

Publications using NBP2-22377	Applications	Species
Kendall, TJ;Jimenez-Ramos, M;Turner, F;Ramachandran, P;Minnier, J;McColgan, MD;Alam, M;Ellis, H;Dunbar, DR;Kohnen, G;Konanahalli, P;Oien, KA;Bandiera, L;Menolascina, F;Juncker-Jensen, A;Alexander, D;Mayor, C;Guha, IN;Fallowfield, JA; An integrated gene-to-outcome multimodal database for metabolic dysfunction-associated steatotic liver disease Nature medicine 2023-10-30 [PMID: 37903863]
Bockorny B, Semenisty V, Macarulla T et al. BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial Nat. Med. 2020-05-25 [PMID: 32451495] (ICC/IF, Human)	ICC/IF	Human
Falk A, Yazbeck N, Guibert N et al. Effect of mutant variants of the KRAS gene on PD-L1 expression and on the immune microenvironment and association with clinical outcome in lung adenocarcinoma patients Lung Cancer 2018-07-01 [PMID: 29858030] (IF/IHC, Human)	IF/IHC	Human

Array NBP2-22377

• Siglec-3/CD33 Antibodies
• Siglec-3/CD33 Lysate
• Siglec-3/CD33 Protein
• Siglec-3/CD33 Proteins and Enzymes