ING1 Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

ING1 (Inhibitor of Growth 1; also p33^ING1b and ING1A) is a 32 kDa member of the ING family of tumor suppressors. It is very widely expressed, and participates in multiple cell functions. When bound to p53, ING1 inhibits cell growth; when complexed to GADD45, ING1 enhances DNA nucleotide excision repair; and when associated with HAT, ING1 promotes hyperacetylation of histones H3 and H4. Human ING1 is 279 amino acids (aa) in length. It contains a PIP-PBD region (aa 5‑45), an NLS (aa 142‑158), and a plant homeodomain (PHD) (aa 210‑259). Phosphorylation occurs on Ser126 and Ser199. There are at least three isoform variants. p47^ING1a contains a 190 aa substitution for aa 1‑46, p27^ING1d shows a deletion of aa 2‑45, and p24^ING1c has an alternate start site at Met70. Over aa 213‑327, human ING1 shares 82% aa identity with mouse ING1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array AF5758

• ING1 Antibodies
• ING1 ELISA Kit
• ING1 Lysates
• ING1 Proteins